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Select item 111274941.

CD38 Deficiency Protects Mouse Retinal Ganglion Cells Through Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion and Optic Nerve Crush Models

Yulian Pang, Haijian Hu, Ke Xu, Ting Cao, Zhiruo Wang, Jiahe Nie, Haina Zheng, Hongdou Luo, Feifei Wang, Chan Xiong, Ke-Yu Deng, Hong-Bo Xin, Xu Zhang

Invest Ophthalmol Vis Sci. 2024 May; 65(5): 36. Published online 2024 May 22. doi: 10.1167/iovs.65.5.36

PMCID:: PMC11127494

Abstract Article PDF–9.9M

Select item 110499882.

Smooth-Muscle-Cell-Specific Deletion of CD38 Protects Mice from AngII-Induced Abdominal Aortic Aneurysm through Inhibiting Vascular Remodeling

Zhen-Ping Yu, Yi-Kai Wang, Xiao-Yu Wang, Li-Na Gong, Hui-Lan Tan, Mei-Xiu Jiang, Ling-Fang Wang, Guan-Hui Yu, Ke-Yu Deng, Hong-Bo Xin

Int J Mol Sci. 2024 Apr; 25(8): 4356. Published online 2024 Apr 15. doi: 10.3390/ijms25084356

PMCID:: PMC11049988

Abstract Article PDF–4.1M

Select item 107989033.

NADase CD38 is a key determinant of ovarian aging

Qingling Yang, Wenhui Chen, Luping Cong, Mengchen Wang, Hui Li, Huan Wang, Xiaoyan Luo, Jing Zhu, Xinxin Zeng, Zhenye Zhu, Yining Xu, Min Lei, Yanqing Zhao, Chenlu Wei, Yingpu Sun

Nat Aging. 2024; 4(1): 110–128. Published online 2023 Dec 21. doi: 10.1038/s43587-023-00532-9

PMCID:: PMC10798903

Abstract Article PDF–12M

Select item 106507074.

CD38 Deficiency Alleviates Diabetic Cardiomyopathy by Coordinately Inhibiting Pyroptosis and Apoptosis

Ling-Fang Wang, Qian Li, Ke Wen, Qi-Hang Zhao, Ya-Ting Zhang, Jia-Le Zhao, Qi Ding, Xiao-Hui Guan, Yun-Fei Xiao, Ke-Yu Deng, Hong-Bo Xin

Int J Mol Sci. 2023 Nov; 24(21): 16008. Published online 2023 Nov 6. doi: 10.3390/ijms242116008

PMCID:: PMC10650707

Abstract Article PDF–3.6M

Select item 105628035.

CD38 regulates ovarian function and fecundity via NAD⁺ metabolism

Rosalba Perrone, Prasanna Vadhana Ashok Kumaar, Lauren Haky, Cosmo Hahn, Rebeccah Riley, Julia Balough, Giuliana Zaza, Bikem Soygur, Kaitlyn Hung, Leandro Prado, Herbert G. Kasler, Ritesh Tiwari, Hiroyuki Matsui, Genesis Vega Hormazabal, Indra Heckenbach, Morten Scheibye-Knudsen, Francesca E. Duncan, Eric Verdin

iScience. 2023 Oct 20; 26(10): 107949. Published online 2023 Sep 16. doi: 10.1016/j.isci.2023.107949

PMCID:: PMC10562803

Abstract Article PDF–7.0M

Select item 101348796.

Cell-Intrinsic CD38 Expression Sustains Exhausted CD8⁺ T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection

Julia M. DeRogatis, Emily N. Neubert, Karla M. Viramontes, Monique L. Henriquez, Dequina A. Nicholas, Roberto Tinoco

J Virol. 2023 Apr; 97(4): e00225-23. Published online 2023 Apr 11. doi: 10.1128/jvi.00225-23

PMCID:: PMC10134879

Abstract Article PDF–4.0M

Select item 96467797.

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng

Cell Death Dis. 2022 Nov; 13(11): 944. Published online 2022 Nov 9. doi: 10.1038/s41419-022-05383-7

PMCID:: PMC9646779

Abstract Article PDF–3.7M

Select item 96381468.

Extracellular vesicles from pristane-treated CD38-deficient mice express an anti-inflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice

Paula Carrillo-Rodríguez, José-Ángel Robles-Guirado, Adrián Cruz-Palomares, Miguel Ángel Palacios-Pedrero, Elena González-Paredes, Alex Más-Ciurana, Carolina Franco-Herrera, Paloma A. Ruiz-de-Castroviejo-Teba, Antonio Lario, Victoria Longobardo, Laura Montosa-Hidalgo, María M. Pérez-Sánchez-Cañete, María-Mercedes Corzo-Corbera, Sandra Redondo-Sánchez, Ana-Belén Jodar, Francisco J. Blanco, Esther Zumaquero, Ramón Merino, Jaime Sancho, Mercedes Zubiaur

Front Immunol. 2022; 13: 1013236. Published online 2022 Oct 24. doi: 10.3389/fimmu.2022.1013236

PMCID:: PMC9638146

Abstract Article PDF–21M

Select item 90874679.

CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis

Jin‐jin Ma, Jun Ying, Jin‐yu Wang, Tao‐tao Xu, Han‐ting Xia, Hong‐ting Jin, Lu‐wei Xiao, Wen‐jun Shang, Wei‐qian Wang, Jian‐yin Feng

Orthop Surg. 2022 May; 14(5): 946–954. Published online 2022 Apr 20. doi: 10.1111/os.13258

PMCID:: PMC9087467

Abstract Article PDF–6.3M

Select item 903510610.

Benefits in cardiac function by CD38 suppression: improvement in NAD⁺ levels, exercise capacity, heart rate variability and protection against catecholamine induced ventricular arrhythmias

Guillermo Agorrody, Thais R. Peclat, Gonzalo Peluso, Luis A. Gonano, Leonardo Santos, Wim van Schooten, Claudia C. S. Chini, Carlos Escande, Eduardo N. Chini, Paola Contreras

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: J Mol Cell Cardiol. 2022 May; 166: 11–22. Published online 2022 Feb 1. doi: 10.1016/j.yjmcc.2022.01.008

PMCID:: PMC9035106

Abstract Article PDF–1.5M

Select item 884514211.

CD38-mediated Inhibition of Bruton’s Tyrosine Kinase in Macrophages Prevents Endotoxemic Lung Injury

Joseph Farahany, Yoshikazu Tsukasaki, Amitabha Mukhopadhyay, Manish Mittal, Saroj Nepal, Chinnaswamy Tiruppathi, Asrar B. Malik

Am J Respir Cell Mol Biol. 2022 Feb; 66(2): 183–195. Published online 2021 Oct 27. doi: 10.1165/rcmb.2021-0272OC

PMCID:: PMC8845142

Abstract Article PDF–1.5M

Select item 875203112.

CD38 ecto-enzyme in immune cells is induced during aging regulating NAD⁺ and NMN levels

Claudia C.S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor Jankowski, Tamara Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini

Nat Metab. Author manuscript; available in PMC 2022 Jan 11.

Published in final edited form as: Nat Metab. 2020 Nov; 2(11): 1284–1304. Published online 2020 Nov 16. doi: 10.1038/s42255-020-00298-z

PMCID:: PMC8752031

Abstract Article PDF–6.2M

Select item 851370213.

Critical Role of Astrocyte NAD⁺ Glycohydrolase in Myelin Injury and Regeneration

Monica R. Langley, Chan-Il Choi, Thais R. Peclat, Yong Guo, Whitney L. Simon, Hyesook Yoon, Laurel Kleppe, Claudia F. Lucchinetti, Claudia C. S. Chini, Eduardo N. Chini, Isobel A. Scarisbrick

J Neurosci. 2021 Oct 13; 41(41): 8644–8667. doi: 10.1523/JNEUROSCI.2264-20.2021

PMCID:: PMC8513702

Abstract Article PDF–12M

Select item 819253314.

CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice

Lu Gan, Demin Liu, Jing Liu, Erya Chen, Chan Chen, Lian Liu, Hang Hu, Xiaohui Guan, Wen Ma, Yanzi Zhang, Yarong He, Bofu Liu, Songling Tang, Wei Jiang, Jianxin Xue, Hongbo Xin

Signal Transduct Target Ther. 2021; 6: 223. Published online 2021 Jun 11. doi: 10.1038/s41392-021-00625-0

PMCID:: PMC8192533

Abstract Article PDF–6.1M

Select item 777055415.

Targeting CD38-dependent NAD⁺ metabolism to mitigate multiple organ fibrosis

Bo Shi, Wenxia Wang, Benjamin Korman, Li Kai, Qianqian Wang, Jun Wei, Swarna Bale, Roberta Goncalves Marangoni, Swati Bhattacharyya, Stephen Miller, Dan Xu, Mahzad Akbarpour, Paul Cheresh, Daniele Proccissi, Demirkan Gursel, Jair Machado Espindola-Netto, Claudia C.S. Chini, Guilherme C. de Oliveira, Johann E. Gudjonsson, Eduardo N. Chini, John Varga

iScience. 2021 Jan 22; 24(1): 101902. Published online 2020 Dec 7. doi: 10.1016/j.isci.2020.101902

PMCID:: PMC7770554

Abstract Article PDF–4.3M

Select item 768613216.

CD38 in cancer-associated fibroblasts promotes pro-tumoral activity

Bar Ben Baruch, Einav Mantsur, Janusz Franco-Barraza, Eran Blacher, Edna Cukierman, Reuven Stein

Lab Invest. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Lab Invest. 2020 Dec; 100(12): 1517–1531. Published online 2020 Jul 1. doi: 10.1038/s41374-020-0458-8

PMCID:: PMC7686132

Abstract Article PDF–2.3M

Select item 757659417.

Deletion of CD38 and supplementation of NAD⁺ attenuate axon degeneration in a mouse facial nerve axotomy model

Yuji Takaso, Masao Noda, Tsuyoshi Hattori, Jureepon Roboon, Miyako Hatano, Hisashi Sugimoto, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida, Makoto Ito, Tomokazu Yoshizaki, Osamu Hori

Sci Rep. 2020; 10: 17795. Published online 2020 Oct 20. doi: 10.1038/s41598-020-73984-3

PMCID:: PMC7576594

Abstract Article PDF–2.4M

Select item 718051818.

CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions

Xingyue Zhang, Lingfei Li, Qiong Zhang, Qinglin Wei, Jiezhi Lin, Jiezhi Jia, Junhui Zhang, Tiantian Yan, Yanling Lv, Xupin Jiang, Peng Zhang, Huapei Song, Dongxia Zhang, Yuesheng Huang

Front Cell Dev Biol. 2020; 8: 191. Published online 2020 Apr 17. doi: 10.3389/fcell.2020.00191

PMCID:: PMC7180518

Abstract Article PDF–5.3M

Select item 708983219.

Evaluation of the NAD⁺ biosynthetic pathway in ALS patients and effect of modulating NAD⁺ levels in hSOD1-linked ALS mouse models

Benjamin A. Harlan, Kelby M. Killoy, Mariana Pehar, Liping Liu, Johan Auwerx, Marcelo R. Vargas

Exp Neurol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Exp Neurol. 2020 May; 327: 113219. Published online 2020 Jan 31. doi: 10.1016/j.expneurol.2020.113219

PMCID:: PMC7089832

Abstract Article PDF–1.7M

Select item 692969220.

Alzheimer’s disease pathology is attenuated in a CD38 deficient mouse model

Eran Blacher, Tulin Dadali, Alina Bespalko, Viola J Haupenthal, Marcus O. W. Grimm, Tobias Hartmann, Frances E. Lund, Reuven Stein, Ayelet Levy

Ann Neurol. Author manuscript; available in PMC 2019 Dec 24.

Published in final edited form as: Ann Neurol. 2015 Jul; 78(1): 88–103. Published online 2015 May 25. doi: 10.1002/ana.24425

PMCID:: PMC6929692

Abstract Article PDF–2.1M

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