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Select item 110886511.

Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway

Yiyang Che, Yuuki Shimizu, Takumi Hayashi, Junya Suzuki, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Toyoaki Murohara

Sci Rep. 2024; 14: 10777. Published online 2024 May 11. doi: 10.1038/s41598-024-61710-2

PMCID:: PMC11088651

Abstract Article PDF–9.4M

Select item 110270882.

Circadian Influence on the Microbiome Improves Heart Failure Outcomes

Priya Mistry, Cristine J. Reitz, Tarak Nath Khatua, Mina Rasouli, Kaitlyn Oliphant, Martin E Young, Emma Allen-Vercoe, Tami A. Martino

J Mol Cell Cardiol. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: J Mol Cell Cardiol. 2020 Dec; 149: 54–72. Published online 2020 Sep 19. doi: 10.1016/j.yjmcc.2020.09.006

PMCID:: PMC11027088

Abstract Article PDF–3.1M

Select item 102974593.

Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease

Elliot Jokl, Jessica Llewellyn, Kara Simpson, Oluwatobi Adegboye, James Pritchett, Leo Zeef, Ian Donaldson, Varinder S. Athwal, Huw Purssell, Oliver Street, Lucy Bennett, Indra Neil Guha, Neil A. Hanley, Qing-Jun Meng, Karen Piper Hanley

Cells. 2023 Jun; 12(12): 1582. Published online 2023 Jun 8. doi: 10.3390/cells12121582

PMCID:: PMC10297459

Abstract Article PDF–4.5M

Select item 88664364.

Effects of fatty acid metabolites on nocturia

Tatsuya Ihara, Hiroshi Shimura, Sachiko Tsuchiya, Mie Kanda, Satoru Kira, Norifumi Sawada, Masayuki Takeda, Takahiko Mitsui, Eiji Shigetomi, Yoichi Shinozaki, Schuichi Koizumi

Sci Rep. 2022; 12: 3050. Published online 2022 Feb 23. doi: 10.1038/s41598-022-07096-5

PMCID:: PMC8866436

Abstract Article PDF–3.2M

Select item 86322835.

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress

Inna Rabinovich-Nikitin, Mina Rasouli, Cristine J. Reitz, Illana Posen, Victoria Margulets, Rimpy Dhingra, Tarak N. Khatua, James A. Thliveris, Tami A. Martino, Lorrie A. Kirshenbaum

Autophagy. 2021; 17(11): 3794–3812. Published online 2021 Aug 7. doi: 10.1080/15548627.2021.1938913

PMCID:: PMC8632283

Abstract Article PDF–11M

Select item 81020636.

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

Takashi Ogino, Naoya Matsunaga, Takahiro Tanaka, Tomohito Tanihara, Hideki Terajima, Hikari Yoshitane, Yoshitaka Fukada, Akito Tsuruta, Satoru Koyanagi, Shigehiro Ohdo

eLife. 2021; 10: e66155. Published online 2021 Apr 23. doi: 10.7554/eLife.66155

PMCID:: PMC8102063

Abstract Article PDF–4.1M

Select item 67727267.

The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse

Erik Naylor, Bernard M. Bergmann, Kristyn Krauski, Phyllis C. Zee, Joseph S. Takahashi, Martha Hotz Vitaterna, Fred W. Turek

J Neurosci. 2000 Nov 1; 20(21): 8138–8143. doi: 10.1523/JNEUROSCI.20-21-08138.2000

PMCID:: PMC6772726

Abstract Article PDF–178K

Select item 64354748.

Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock^Δ19 mutant mice

Yanli Wang, Ke Lv, Hailong Chen, Mei Zhao, Guohua Ji, Yongliang Zhang, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Qu

Biosci Rep. 2018 Dec 21; 38(6): BSR20180233. Prepublished online 2018 Nov 9. Published online 2018 Dec 7. doi: 10.1042/BSR20180233

PMCID:: PMC6435474

Abstract Article PDF–1.4M

Select item 64288119.

The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock^∆19/∆19 Mice With Implications for Circadian Medicine

Austin T. H. Duong, Cristine J. Reitz, Emma L. Louth, Samantha D. Creighton, Mina Rasouli, Ashley Zwaiman, Jeffrey T. Kroetsch, Steffen-Sebastian Bolz, Boyer D. Winters, Craig D. C. Bailey, Tami A. Martino

Sci Rep. 2019; 9: 4994. Published online 2019 Mar 21. doi: 10.1038/s41598-019-41469-7

PMCID:: PMC6428811

Abstract Article PDF–5.2M

Select item 557725610.

Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis

Ken-ichi Hashikawa, Chiharu Katamune, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

Sci Rep. 2017; 7: 9995. Published online 2017 Aug 30. doi: 10.1038/s41598-017-10599-1

PMCID:: PMC5577256

Abstract Article PDF–3.8M

Select item 544407511.

Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H. Tsang, Johanna L. Barclay, Henrik Oster

Mol Metab. 2017 Jun; 6(6): 512–523. Published online 2017 Mar 29. doi: 10.1016/j.molmet.2017.03.008

PMCID:: PMC5444075

Abstract Article PDF–2.5M

Select item 526424812.

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya Matsunaga, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Makoto Tsuda, Kazuhide Inoue, Akio Ojida, Satoru Koyanagi, Shigehiro Ohdo

EBioMedicine. 2016 Nov; 13: 262–273. Published online 2016 Oct 6. doi: 10.1016/j.ebiom.2016.10.008

PMCID:: PMC5264248

Abstract Article PDF–1.9M

Select item 525697713.

CLOCK regulates mammary epithelial cell growth and differentiation

Theresa Casey, Jennifer Crodian, Aridany Suárez-Trujillo, Emily Erickson, Bethany Weldon, Kristi Crow, Shelby Cummings, Yulu Chen, Avi Shamay, Sameer J. Mabjeesh, Karen Plaut

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1; 311(6): R1125–R1134. Published online 2016 Oct 5. doi: 10.1152/ajpregu.00032.2016

PMCID:: PMC5256977

Abstract Article

Select item 508415614.

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

Chao Lu, Yang Yang, Ran Zhao, Bingxuan Hua, Chen Xu, Zuoqin Yan, Ning Sun, Ruizhe Qian

Protein Cell. 2016 Nov; 7(11): 820–832. Published online 2016 Sep 23. doi: 10.1007/s13238-016-0319-9

PMCID:: PMC5084156

Abstract Article PDF–4.1M

Select item 491749215.

Altered Myocardial Metabolic Adaptation to Increased Fatty Acid Availability in Cardiomyocyte-Specific CLOCK Mutant Mice

Rodrigo A. Peliciari-Garcia, Mehak Goel, Jonathan A. Aristorenas, Krishna Shah, Lan He, Qinglin Yang, Anath Shalev, Shannon M. Bailey, Sumanth D. Prabhu, John C. Chatham, Karen L. Gamble, Martin E. Young

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Oct; 1860(10): 1579–1595. Published online 2015 Dec 22. doi: 10.1016/j.bbalip.2015.12.012

PMCID:: PMC4917492

Abstract Article PDF–5.1M

Select item 483256916.

The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

Baokun He, Kazunari Nohara, Noheon Park, Yong-Sung Park, Bobby Guillory, Zhaoyang Zhao, Jose M. Garcia, Nobuya Koike, Cheng Chi Lee, Joseph S. Takahashi, Seung-Hee Yoo, Zheng Chen

Cell Metab. Author manuscript; available in PMC 2017 Apr 12.

Published in final edited form as: Cell Metab. 2016 Apr 12; 23(4): 610–621. doi: 10.1016/j.cmet.2016.03.007

PMCID:: PMC4832569

Abstract Article PDF–2.2M

Select item 465331517.

Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice

Noriko Ando, Yuki Nakamura, Rui Aoki, Kayoko Ishimaru, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Shinji Shimada, Atsuhito Nakao

J Invest Dermatol. 2015 Dec; 135(12): 3001–3008. Prepublished online 2015 Aug 20. Published online 2015 Sep 10. doi: 10.1038/jid.2015.316

PMCID:: PMC4653315

Abstract Article PDF–2.4M

Select item 442497218.

Overexpression of the Circadian Clock Gene Rev-erbα Affects Murine Bone Mesenchymal Stem Cell Proliferation and Osteogenesis

Yao He, Fuwei Lin, Yaqun Chen, Zhen Tan, Ding Bai, Qing Zhao

Stem Cells Dev. 2015 May 15; 24(10): 1194–1204. Published online 2014 Dec 24. doi: 10.1089/scd.2014.0437

PMCID:: PMC4424972

Abstract Article PDF–725K

Select item 423168319.

The Mammalian Circadian Clock Protein Period Counteracts Cryptochrome in Phosphorylation Dynamics of Circadian Locomotor Output Cycles Kaput (CLOCK)

Ritsuko Matsumura, Yoshiki Tsuchiya, Isao Tokuda, Takahiro Matsuo, Miho Sato, Koichi Node, Eisuke Nishida, Makoto Akashi

J Biol Chem. 2014 Nov 14; 289(46): 32064–32072. Published online 2014 Sep 30. doi: 10.1074/jbc.M114.578278

PMCID:: PMC4231683

Abstract Article PDF–1.9M

Select item 401903320.

CLOCK-Controlled Polyphonic Regulation of Circadian Rhythms through Canonical and Noncanonical E-Boxes

Hikari Yoshitane, Haruka Ozaki, Hideki Terajima, Ngoc-Hien Du, Yutaka Suzuki, Taihei Fujimori, Naoki Kosaka, Shigeki Shimba, Sumio Sugano, Toshihisa Takagi, Wataru Iwasaki, Yoshitaka Fukada

Mol Cell Biol. 2014 May; 34(10): 1776–1787. doi: 10.1128/MCB.01465-13

PMCID:: PMC4019033

Abstract Article PDF–1.1M

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