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Select item 107607221.

Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-κB / NLRP3 signaling pathway

Hui Li, Quanwei Zhao, Danan Liu, Bo Zhou, Fujun Liao, Long Chen

PLoS One. 2024; 19(1): e0294514. Published online 2024 Jan 2. doi: 10.1371/journal.pone.0294514

PMCID:: PMC10760722

Abstract Article PDF–2.8M

Select item 104416112.

Trypsin activity in secretagogue-induced murine pancreatitis is solely elicited by cathepsin B and does not mediate key pathologic responses

Andrea Geisz, Thanh Tran, Anna Orekhova, Miklós Sahin-Tóth

Gastroenterology. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Gastroenterology. 2023 Apr; 164(4): 684–687.e4. Published online 2023 Jan 11. doi: 10.1053/j.gastro.2023.01.004

PMCID:: PMC10441611

Article PDF–411K

Select item 101854323.

Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition

Gregory Hook, Mark Kindy, Vivian Hook

J Alzheimers Dis. 2023; 93(1): 33–46. Prepublished online 2023 Mar 21. Published online 2023 May 2. doi: 10.3233/JAD-221005

PMCID:: PMC10185432

Abstract Article PDF–467K

Select item 97441624.

Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice

Zongzhuang Wen, Haixia Zhu, Bin Wu, Aizhen Zhang, Hongxiang Wang, Yin Cheng, Hui Zhao, Jianyuan Li, Min Liu, Jiangang Gao

PeerJ. 2022; 10: e14472. Published online 2022 Dec 2. doi: 10.7717/peerj.14472

PMCID:: PMC9744162

Abstract Article PDF–31M

Select item 96137565.

S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders

Ki-Ryeong Kim, Eun-Jung Cho, Jae-Won Eom, Sang-Seok Oh, Tomohiro Nakamura, Chang-ki Oh, Stuart A. Lipton, Yang-Hee Kim

Cell Death Differ. 2022 Nov; 29(11): 2137–2150. Published online 2022 Apr 24. doi: 10.1038/s41418-022-01004-0

PMCID:: PMC9613756

Abstract Article PDF–4.7M

Select item 95531146.

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark Kindy, Christoph Peters, Vivian Hook

Pharmacol Rev. 2022 Jul; 74(3): 600–629. Published online 2022 Jul. doi: 10.1124/pharmrev.121.000527

PMCID:: PMC9553114

Abstract Article PDF–1.8M

Select item 90978407.

Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis

Carolina Duarte, Chiaki Yamada, Christopher Garcia, Juliet Akkaoui, Anny Ho, Frank Nichols, Alexandru Movila

J Cell Mol Med. 2022 May; 26(10): 2841–2851. Published online 2022 Apr 16. doi: 10.1111/jcmm.17299

PMCID:: PMC9097840

Abstract Article PDF–5.0M

Select item 85843948.

Cathepsin B Regulates Mice Granulosa Cells’ Apoptosis and Proliferation In Vitro

Chao Chen, Muhammad Jamil Ahmad, Tingzhu Ye, Chao Du, Xinxin Zhang, Aixin Liang, Liguo Yang

Int J Mol Sci. 2021 Nov; 22(21): 11827. Published online 2021 Oct 31. doi: 10.3390/ijms222111827

PMCID:: PMC8584394

Abstract Article PDF–2.2M

Select item 75816269.

Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling

Muzhou Jiang, Jie Meng, Fan Zeng, Hong Qing, Gregory Hook, Vivian Hook, Zhou Wu, Junjun Ni

J Neurochem. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Neurochem. 2020 Nov; 155(3): 300–312. Published online 2020 Jun 15. doi: 10.1111/jnc.15032

PMCID:: PMC7581626

Abstract Article PDF–2.4M

Select item 731130710.

Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis

Wenqian Fang, Zhiyong Deng, Feriel Benadjaoud, Chongzhe Yang, Guo-Ping Shi

Transl Res. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Transl Res. 2020 Aug; 222: 28–40. Published online 2020 May 11. doi: 10.1016/j.trsl.2020.04.011

PMCID:: PMC7311307

Abstract Article PDF–2.3M

Select item 666307411.

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

Matthias Sendler, Frank-Ulrich Weiss, Janine Golchert, Georg Homuth, Cindy van den Brandt, Ujjwal M. Mahajan, Lars-Ivo Partecke, Paula Döring, Ilya Gukovsky, Anna S. Gukovskaya, Preshit R. Wagh, Markus M. Lerch, Julia Mayerle

Gastroenterology. Author manuscript; available in PMC 2019 Jul 29.

Published in final edited form as: Gastroenterology. 2018 Feb; 154(3): 704–718.e10. Published online 2018 Jan 10. doi: 10.1053/j.gastro.2017.10.018

PMCID:: PMC6663074

Abstract Article PDF–1.8M

Select item 662118512.

Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain

Li Sun, Zhou Wu, Yoshinori Hayashi, Christoph Peters, Makoto Tsuda, Kazuhide Inoue, Hiroshi Nakanishi

J Neurosci. 2012 Aug 15; 32(33): 11330–11342. doi: 10.1523/JNEUROSCI.0677-12.2012

PMCID:: PMC6621185

Abstract Article PDF–4.0M

Select item 580910013.

Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

Yaping Wang, Liangliang Jia, Jian Shen, Yidong Wang, Zurong Fu, Sheng-an Su, Zhejun Cai, Jian-an Wang, Meixiang Xiang

PLoS Pathog. 2018 Jan; 14(1): e1006872. Published online 2018 Jan 23. doi: 10.1371/journal.ppat.1006872

PMCID:: PMC5809100

Abstract Article PDF–8.3M

Select item 493819014.

Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis

Matthias Sendler, Sandrina Maertin, Daniel John, Maria Persike, F. Ulrich Weiss, Burkhard Krüger, Thomas Wartmann, Preshit Wagh, Walter Halangk, Norbert Schaschke, Julia Mayerle, Markus M. Lerch

J Biol Chem. 2016 Jul 8; 291(28): 14717–14731. Published online 2016 May 12. doi: 10.1074/jbc.M116.718999

PMCID:: PMC4938190

Abstract Article PDF–3.3M

Select item 486832215.

Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner

Orhan Rasid, Véronique Mériaux, Erin M. Khan, Chloé Borde, Ioana S. Ciulean, Catherine Fitting, Bénédicte Manoury, Jean-Marc Cavaillon, Noëlle Doyen

PLoS Negl Trop Dis. 2016 May; 10(5): e0004716. Published online 2016 May 16. doi: 10.1371/journal.pntd.0004716

PMCID:: PMC4868322

Abstract Article PDF–2.2M

Select item 449660516.

Chlamydia muridarum Infection of Macrophages Elicits Bactericidal Nitric Oxide Production via Reactive Oxygen Species and Cathepsin B

Krithika Rajaram, David E. Nelson

Infect Immun. 2015 Aug; 83(8): 3164–3175. Prepublished online 2015 May 26. Published online 2015 Jul 8. doi: 10.1128/IAI.00382-15

PMCID:: PMC4496605

Abstract Article PDF–2.6M

Select item 430928917.

Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer’s Disease Mouse Model Expressing AβPP Containing the Wild-Type β-Secretase Site Sequence

Mark S. Kindy, Jin Yu, Hong Zhu, Salim S. El-Amouri, Vivian Hook, Gregory R. Hook

J Alzheimers Dis. Author manuscript; available in PMC 2015 Jan 28.

Published in final edited form as: J Alzheimers Dis. 2012; 29(4): 827–840. doi: 10.3233/JAD-2012-111604

PMCID:: PMC4309289

Abstract Article PDF–2.5M

Select item 417785418.

Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection

Iris J. Gonzalez-Leal, Bianca Röger, Angela Schwarz, Tanja Schirmeister, Thomas Reinheckel, Manfred B. Lutz, Heidrun Moll

PLoS Negl Trop Dis. 2014 Sep; 8(9): e3194. Published online 2014 Sep 25. doi: 10.1371/journal.pntd.0003194

PMCID:: PMC4177854

Abstract Article PDF–1.4M

Select item 346851019.

Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation

Agnieszka Gornicka, Jade Fettig, Akiko Eguchi, Michael P. Berk, Samjhana Thapaliya, Laura J. Dixon, Ariel E. Feldstein

Am J Physiol Endocrinol Metab. 2012 Sep 1; 303(5): E597–E606. Published online 2012 Jun 26. doi: 10.1152/ajpendo.00022.2012

PMCID:: PMC3468510

Abstract Article

Select item 316365020.

Profiling Trait Anxiety: Transcriptome Analysis Reveals Cathepsin B (Ctsb) as a Novel Candidate Gene for Emotionality in Mice

Ludwig Czibere, Laura A. Baur, Anke Wittmann, Katja Gemmeke, Andrea Steiner, Peter Weber, Benno Pütz, Nafees Ahmad, Mirjam Bunck, Cornelia Graf, Regina Widner, Claudia Kühne, Markus Panhuysen, Boris Hambsch, Gabriele Rieder, Thomas Reinheckel, Christoph Peters, Florian Holsboer, Rainer Landgraf, Jan M. Deussing

PLoS One. 2011; 6(8): e23604. Published online 2011 Aug 29. doi: 10.1371/journal.pone.0023604