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Select item 109961081.

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring

Alzheimers Res Ther. 2024; 16: 70. Published online 2024 Apr 4. doi: 10.1186/s13195-024-01443-6

PMCID:: PMC10996108

Abstract Article PDF–3.7M

Select item 92704532.

Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins

Chigure Suzuki, Junji Yamaguchi, Takahito Sanada, Juan Alejandro Oliva Trejo, Souichirou Kakuta, Masahiro Shibata, Isei Tanida, Yasuo Uchiyama

Sci Rep. 2022; 12: 11662. Published online 2022 Jul 8. doi: 10.1038/s41598-022-15805-3

PMCID:: PMC9270453

Abstract Article PDF–7.1M

Select item 91966563.

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

Susy Prieto Huarcaya, Alice Drobny, André R. A. Marques, Alessandro Di Spiezio, Jan Philipp Dobert, Denise Balta, Christian Werner, Tania Rizo, Lisa Gallwitz, Simon Bub, Iva Stojkovska, Nandkishore R. Belur, Jens Fogh, Joseph R Mazzulli, Wei Xiang, Amitkumar Fulzele, Mario Dejung, Markus Sauer, Beate Winner, Stefan Rose-John, Philipp Arnold, Paul Saftig, Friederike Zunke

Autophagy. 2022; 18(5): 1127–1151. Published online 2022 Apr 28. doi: 10.1080/15548627.2022.2045534

PMCID:: PMC9196656

Abstract Article PDF–5.4M

Select item 90656274.

Cathepsin D interacts with adenosine A_2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling

Adrienn Skopál, Tamás Kéki, Péter Á. Tóth, Balázs Csóka, Balázs Koscsó, Zoltán H. Németh, Luca Antonioli, Andreas Ivessa, Francisco Ciruela, László Virág, György Haskó, Endre Kókai

J Biol Chem. 2022 May; 298(5): 101888. Published online 2022 Mar 31. doi: 10.1016/j.jbc.2022.101888

PMCID:: PMC9065627

Abstract Article PDF–3.7M

Select item 83230515.

Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice

Tulasi Yadati, Tom Houben, Albert Bitorina, Yvonne Oligschlaeger, Marion J. Gijbels, Ronny Mohren, Dieter Lütjohann, Princy Khurana, Sandeep Goyal, Aditya Kulkarni, Jan Theys, Berta Cillero-Pastor, Ronit Shiri-Sverdlov

Front Immunol. 2021; 12: 675535. Published online 2021 Jul 16. doi: 10.3389/fimmu.2021.675535

PMCID:: PMC8323051

Abstract Article PDF–1.9M

Select item 80038506.

Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease

Mahmoud Bassal, Junling Liu, Wanda Jankowiak, Paul Saftig, Udo Bartsch

Cells. 2021 Mar; 10(3): 696. Published online 2021 Mar 21. doi: 10.3390/cells10030696

PMCID:: PMC8003850

Abstract Article PDF–5.0M

Select item 73395837.

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring

Alzheimers Res Ther. 2020; 12: 80. Published online 2020 Jul 6. doi: 10.1186/s13195-020-00649-8

PMCID:: PMC7339583

Abstract Article PDF–1.4M

Select item 71589228.

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

André R. A. Marques, Alessandro Di Spiezio, Niklas Thießen, Lina Schmidt, Joachim Grötzinger, Renate Lüllmann-Rauch, Markus Damme, Steffen E. Storck, Claus U. Pietrzik, Jens Fogh, Julia Bär, Marina Mikhaylova, Markus Glatzel, Mahmoud Bassal, Udo Bartsch, Paul Saftig

Autophagy. 2020; 16(5): 811–825. Published online 2019 Jul 16. doi: 10.1080/15548627.2019.1637200

PMCID:: PMC7158922

Abstract Article PDF–6.3M

Select item 67728239.

Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons

Masato Koike, Hiroshi Nakanishi, Paul Saftig, Junji Ezaki, Kyoko Isahara, Yoshiyuki Ohsawa, Walter Schulz-Schaeffer, Tsuyoshi Watanabe, Satoshi Waguri, Satoshi Kametaka, Masahiro Shibata, Kenji Yamamoto, Eiki Kominami, Christoph Peters, Kurt von Figura, Yasuo Uchiyama

J Neurosci. 2000 Sep 15; 20(18): 6898–6906. doi: 10.1523/JNEUROSCI.20-18-06898.2000

PMCID:: PMC6772823

Abstract Article PDF–1.4M

Select item 549966010.

Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice

Shaowu Cheng, Willayat Y. Wani, David A. Hottman, Angela Jeong, Dongfeng Cao, Kyle J. LeBlanc, Paul Saftig, Jianhua Zhang, Ling Li

J Neurochem. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: J Neurochem. 2017 Jul; 142(2): 297–304. Published online 2017 May 26. doi: 10.1111/jnc.14048

PMCID:: PMC5499660

Abstract Article PDF–962K

Select item 500464111.

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD

Kanae Yamamoto-Nonaka, Masato Koike, Katsuhiko Asanuma, Miyuki Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Teruo Hidaka, Koichiro Ichimura, Tatsuo Sakai, Norihiro Tada, Takashi Ueno, Yasuo Uchiyama, Yasuhiko Tomino

J Am Soc Nephrol. 2016 Sep; 27(9): 2685–2700. Published online 2016 Jan 28. doi: 10.1681/ASN.2015040366

PMCID:: PMC5004641

Abstract Article

Select item 473571512.

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease

Christopher Fox, Pasquale Cocchiaro, Fiona Oakley, Rachel Howarth, Krystena Callaghan, Jack Leslie, Saimir Luli, Katrina M. Wood, Federica Genovese, Neil S. Sheerin, Anna Moles

Sci Rep. 2016; 6: 20101. Published online 2016 Feb 2. doi: 10.1038/srep20101

PMCID:: PMC4735715

Abstract Article PDF–2.7M

Select item 410839013.

Cleavage of Histone 3 by Cathepsin D in the Involuting Mammary Gland

Zhila Khalkhali-Ellis, William Goossens, Naira V. Margaryan, Mary J. C. Hendrix

PLoS One. 2014; 9(7): e103230. Published online 2014 Jul 23. doi: 10.1371/journal.pone.0103230

PMCID:: PMC4108390

Abstract Article PDF–966K

Select item 364589314.

Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration

Donna Crabtree, Michaël Boyer-Guittaut, Xiaosen Ouyang, Naomi Fineberg, Jianhua Zhang

Neurosci Lett. Author manuscript; available in PMC 2014 Mar 22.

Published in final edited form as: Neurosci Lett. 2013 Mar 22; 538: 3–8. Published online 2013 Feb 4. doi: 10.1016/j.neulet.2013.01.035

PMCID:: PMC3645893

Abstract Article PDF–607K

Select item 310884215.

Proteomic Evaluation and Validation of Cathepsin D Regulated Proteins in Macrophages Exposed to Streptococcus pneumoniae

Martin A. Bewley, Trong K. Pham, Helen M. Marriott, Josselin Noirel, Hseuh-Ping Chu, Saw Y. Ow, Alexey G. Ryazanov, Robert C. Read, Moira K. B. Whyte, Benny Chain, Phillip C. Wright, David H. Dockrell

Mol Cell Proteomics. 2011 Jun; 10(6): M111.008193. Published online 2011 Apr 7. doi: 10.1074/mcp.M111.008193