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Select item 104099111.

脂质纳米粒递送靶向Cyp2e1基因的小干扰RNA可减轻小鼠亚急性酒精性肝损伤

吴爽, 陈秋冰, 王亚兰, 殷昊, 魏渊

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2023 Jun 25; 52(3): 306–317. Chinese. doi: 10.3724/zdxbyxb-2022-0729

PMCID:: PMC10409911

Abstract Article PDF–5.1M

Select item 103435252.

Chronotoxicity of Acrylamide in Mice Fed a High-Fat Diet: The Involvement of Liver CYP2E1 Upregulation and Gut Leakage

Luanfeng Wang, Yanhong Liu, Huajing Gao, Shuqi Ge, Xinru Yao, Chang Liu, Xintong Tan

Molecules. 2023 Jul; 28(13): 5132. Published online 2023 Jun 30. doi: 10.3390/molecules28135132

PMCID:: PMC10343525

Abstract Article PDF–3.2M

Select item 87596673.

Alcohol induced hepatic retinoid depletion is associated with the induction of multiple retinoid catabolizing cytochrome P450 enzymes

Afroza Ferdouse, Rishi R. Agrawal, Madeleine A. Gao, Hongfeng Jiang, William S. Blaner, Robin D. Clugston

PLoS One. 2022; 17(1): e0261675. Published online 2022 Jan 14. doi: 10.1371/journal.pone.0261675

PMCID:: PMC8759667

Abstract Article PDF–1.6M

Select item 72870024.

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver

Mohamad M. Kronfol, Fay M. Jahr, Mikhail G. Dozmorov, Palak S. Phansalkar, Lin Y. Xie, Karolina A. Aberg, MaryPeace McRae, Elvin T. Price, Patricia W. Slattum, Philip M. Gerk, Joseph L. McClay

GeroScience. 2020 Jun; 42(3): 819–832. Published online 2020 Mar 27. doi: 10.1007/s11357-020-00181-5

PMCID:: PMC7287002

Abstract Article PDF–1.0M

Select item 52096745.

Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis

Mohamed A. Abdelmegeed, Youngshim Choi, Grzegorz Godlewski, Seung-Kwon Ha, Atrayee Banerjee, Sehwan Jang, Byoung-Joon Song

Sci Rep. 2017; 7: 39764. Published online 2017 Jan 4. doi: 10.1038/srep39764

Correction in:: Sci Rep. 2017; 7: 42566.

PMCID:: PMC5209674

Abstract Article PDF–2.5M

Select item 38596916.

Sulforaphane Induces Nrf2 and Protects Against CYP2E1-dependent Binge Alcohol –induced Liver Steatosis

Richard Zhou, Jianjun Lin, Defeng Wu

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Jan; 1840(1): 10.1016/j.bbagen.2013.09.018. Published online 2013 Sep 21. doi: 10.1016/j.bbagen.2013.09.018

PMCID:: PMC3859691

Abstract Article PDF–8.0M

Select item 37487677.

Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping

Jie Cheng, Chi Chen, Krausz W. Kristopher, Soumen K. Manna, Mike Scerba, Fred K. Friedman, Hans Luecke, Jeffrey R. Idle, Frank J. Gonzalez

Toxicol Sci. 2013 Sep; 135(1): 37–47. Published online 2013 Jun 28. doi: 10.1093/toxsci/kft143

PMCID:: PMC3748767

Abstract Article PDF–4.6M

Select item 37298588.

CYP2E1 Potentiates Ethanol-induction of Hypoxia and HIF-1α in vivo

Xiaodong Wang, Defeng Wu, Lili Yang, Lixia Gan, Arthur I Cederbaum

Free Radic Biol Med. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2013 Oct; 63: 175–186. Published online 2013 May 10. doi: 10.1016/j.freeradbiomed.2013.05.009

PMCID:: PMC3729858

Abstract Article PDF–3.7M

Select item 36614169.

CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid

Jie Cheng, Kristopher W. Krausz, Feng Li, Xiaochao Ma, Frank J. Gonzalez

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2014 Jan 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2013 Jan 15; 266(2): 245–253. Published online 2012 Nov 8. doi: 10.1016/j.taap.2012.10.024

PMCID:: PMC3661416

Abstract Article PDF–4.2M

Select item 365161810.

Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver

Maria Konstandi, Jie Cheng, Frank J. Gonzalez

Am J Physiol Endocrinol Metab. 2013 May 15; 304(10): E1118–E1128. Published online 2013 Apr 2. doi: 10.1152/ajpendo.00585.2012

PMCID:: PMC3651618

Abstract Article

Select item 351873811.

Inhibition of CYP2E1 Attenuates Chronic Alcohol Intake-Induced Myocardial Contractile Dysfunction and Apoptosis

Rong-Huai Zhang, Jian-Yuan Gao, Hai-Tao Guo, Glenda I. Scott, Anna R. Eason, Xiao-Ming Wang, Jun Ren

Biochim Biophys Acta. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Biochim Biophys Acta. 2013 Jan; 1832(1): 128–141. Published online 2012 Sep 2. doi: 10.1016/j.bbadis.2012.08.014

Correction in:: Biochim Biophys Acta. 2014 Dec; 1842(12A): 2528.

PMCID:: PMC3518738

Abstract Article PDF–4.3M

Select item 344566412.

Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced nonalcoholic steatohepatitis

Mohamed A. Abdelmegeed, Atrayee Banerjee, Seong-Ho Yoo, Sehwan Jang, Frank J. Gonzalez, Byoung-Joon Song

J Hepatol. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: J Hepatol. 2012 Oct; 57(4): 860–866. Published online 2012 Jun 2. doi: 10.1016/j.jhep.2012.05.019

PMCID:: PMC3445664

Abstract Article PDF–1.7M

Select item 343696213.

Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy

Defeng Wu, Xiaodong Wang, Richard Zhou, Lili Yang, Arthur I. Cederbaum

Free Radic Biol Med. Author manuscript; available in PMC 2013 Sep 15.

Published in final edited form as: Free Radic Biol Med. 2012 Sep 15; 53(6): 1346–1357. Published online 2012 Jul 20. doi: 10.1016/j.freeradbiomed.2012.07.005

PMCID:: PMC3436962

Abstract Article PDF–7.4M

Select item 331128814.

Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance

Haihong Zong, Michal Armoni, Chava Harel, Eddy Karnieli, Jeffrey E. Pessin

Am J Physiol Endocrinol Metab. 2012 Mar 1; 302(5): E532–E539. Published online 2011 Dec 20. doi: 10.1152/ajpendo.00258.2011

PMCID:: PMC3311288

Abstract Article

Select item 330727815.

Identification of N-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-guided Biochemical Analysis

Xiaolei Shi, Dan Yao, Chi Chen

J Biol Chem. 2012 Feb 24; 287(9): 6336–6349. Published online 2012 Jan 6. doi: 10.1074/jbc.M111.312199

PMCID:: PMC3307278

Abstract Article PDF–4.2M

Select item 321151916.

Role of CYP2E1 in Ethanol-Induced Oxidant Stress, Fatty Liver and Hepatotoxicity

Arthur I. Cederbaum

Dig Dis. 2011 Apr; 28(6): 802–811. doi: 10.1159/000324289

PMCID:: PMC3211519

Abstract Article PDF–207K

Select item 290040817.

ACTIVATION OF ASK-1 AND DOWNSTREAM MAP KINASES IN CYTOCHROME P4502E1 POTENTIATED TUMOR NECROSIS FACTOR ALPHA LIVER INJURY

Defeng Wu, Arthur Cederbaum

Free Radic Biol Med. Author manuscript; available in PMC 2011 Aug 1.

Published in final edited form as: Free Radic Biol Med. 2010 Aug 1; 49(3): 348–360. Published online 2010 May 14. doi: 10.1016/j.freeradbiomed.2010.04.021

PMCID:: PMC2900408

Abstract Article PDF–5.2M

Select item 278415018.

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity

Mohamed A. Abdelmegeed, Kwan-Hoon Moon, Chi Chen, Frank J. Gonzalez, Byoung-Joon Song

Biochem Pharmacol. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Biochem Pharmacol. 2010 Jan 1; 79(1): 57–66. Published online 2009 Aug 4. doi: 10.1016/j.bcp.2009.07.016

PMCID:: PMC2784150

Abstract Article PDF–3.4M

Select item 226824719.

IDENTIFICATION OF NOVEL TOXICITY-ASSOCIATED METABOLITES BY METABOLOMICS AND MASS ISOTOPOMER ANALYSIS OF ACETAMINOPHEN METABOLISM IN WILD-TYPE AND CYP2E1-NULL MICE

Chi Chen, Kristopher W. Krausz, Jeffrey R. Idle, Frank J. Gonzalez

J Biol Chem. Author manuscript; available in PMC 2008 Mar 17.

Published in final edited form as: J Biol Chem. 2008 Feb 22; 283(8): 4543–4559. Published online 2007 Dec 19. doi: 10.1074/jbc.M706299200

PMCID:: PMC2268247

Abstract Article PDF–1.4M

Select item 191403820.

Acute Ethanol Pretreatment Increases FAS-Mediated Liver Injury in Mice: Role of Oxidative Stress and CYP2E1-Dependent and Independent Pathways

Xiaodong Wang, Arthur I. Cederbaum

Free Radic Biol Med. Author manuscript; available in PMC 2008 Apr 1.

Published in final edited form as: Free Radic Biol Med. 2007 Apr 1; 42(7): 971–984. Published online 2006 Dec 22. doi: 10.1016/j.freeradbiomed.2006.12.023