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Select item 87705931.

Crystal structure of the α_1B-adrenergic receptor reveals molecular determinants of selective ligand recognition

Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R. Cridge, Lazarus A. de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M. Vaid, Peer R. E. Mittl, Pascal Egloff, Stefanie A. Eberle, Oliver Zerbe, David K. Chalmers, Daniel J. Scott, Andreas Plückthun

Nat Commun. 2022; 13: 382. Published online 2022 Jan 19. doi: 10.1038/s41467-021-27911-3

PMCID:: PMC8770593

Abstract Article PDF–2.8M

Select item 71161372.

Functional Impact of the G279S Substitution in the Adenosine A₁-Receptor (A₁R-G279S^7.44), a Mutation Associated with Parkinson’s Disease

Shahrooz Nasrollahi-Shirazi, Daniel Szöllösi, Qiong Yang, Edin Muratspahic, Ali El-Kasaby, Sonja Sucic, Thomas Stockner, Christian Nanoff, Michael Freissmuth

Mol Pharmacol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Mol Pharmacol. 2020 Sep 1; 98(3): 250–266. doi: 10.1124/molpharm.120.000003

PMCID:: PMC7116137

Abstract Article PDF–3.1M

Select item 69747743.

NanoBiT Complementation to Monitor Agonist-Induced Adenosine A₁ Receptor Internalization

Mark Soave, Barrie Kellam, Jeanette Woolard, Stephen J. Briddon, Stephen J. Hill

SLAS Discov. 2020 Feb; 25(2): 186–194. Published online 2019 Oct 4. doi: 10.1177/2472555219880475

PMCID:: PMC6974774

Abstract Article PDF–788K

Select item 60776994.

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A₁ receptors

Eva-Maria Elmenhorst, David Elmenhorst, Sibylle Benderoth, Tina Kroll, Andreas Bauer, Daniel Aeschbach

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 8009–8014. Published online 2018 Jul 16. doi: 10.1073/pnas.1803770115

PMCID:: PMC6077699

Abstract Article PDF–1.0M

Select item 54024425.

Recovery sleep after extended wakefulness restores elevated A₁ adenosine receptor availability in the human brain

David Elmenhorst, Eva-Maria Elmenhorst, Eva Hennecke, Tina Kroll, Andreas Matusch, Daniel Aeschbach, Andreas Bauer

Proc Natl Acad Sci U S A. 2017 Apr 18; 114(16): 4243–4248. Published online 2017 Apr 3. doi: 10.1073/pnas.1614677114

PMCID:: PMC5402442

Abstract Article PDF–1.0M

Select item 53182916.

ADORA1 mutations are not a common cause of Parkinson's disease and dementia with Lewy bodies

Cornelis Blauwendraat, Mike A. Nalls, Monica Federoff, Olga Pletnikova, Jinhui Ding, Christopher Letson, Joshua T. Geiger, J. Raphael Gibbs, Dena G. Hernandez, Juan C. Troncoso, Javier Simón-Sánchez, Sonja W. Scholz, the International Parkinson's Disease Genomics Consortium

Mov Disord. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Mov Disord. 2017 Feb; 32(2): 298–299. Published online 2016 Dec 17. doi: 10.1002/mds.26886

PMCID:: PMC5318291

Article PDF–268K

Select item 50050067.

Hibernation, Hypothermia and a Possible Therapeutic “Shifted Homeostasis” Induced by Central Activation of A1 Adenosine Receptor (A1AR)

Domenico Tupone, Justin S. Cetas, Shaun F. Morrison

Nihon Shinkei Seishin Yakurigaku Zasshi. Author manuscript; available in PMC 2016 Aug 30.

Published in final edited form as: Nihon Shinkei Seishin Yakurigaku Zasshi. 2016 Apr; 36(2): 51–54.

PMCID:: PMC5005006

Abstract Article PDF–302K

Select item 45136398.

Chaperoning of the A₁-Adenosine Receptor by Endogenous Adenosine—An Extension of the Retaliatory Metabolite Concept

Justyna Kusek, Qiong Yang, Martin Witek, Christian W. Gruber, Christian Nanoff, Michael Freissmuth

Mol Pharmacol. Author manuscript; available in PMC 2015 Jul 24.

Published in final edited form as: Mol Pharmacol. 2015 Jan; 87(1): 39–51. Published online 2014 Oct 29. doi: 10.1124/mol.114.094045

PMCID:: PMC4513639

Abstract Article PDF–2.0M

Select item 31407109.

Probing the Binding Site of the A₁ Adenosine Receptor Reengineered for Orthogonal Recognition by Tailored Nucleosides

Krishnan K. Palaniappan, Zhan-Guo Gao, Andrei A. Ivanov, Rebecca Greaves, Hayamitsu Adachi, Pedro Besada, Hea Ok Kim, Ae Yil Kim, Seung Ah Choe, Lak Shin Jeong, Kenneth A. Jacobson

Biochemistry. Author manuscript; available in PMC 2011 Jul 21.

Published in final edited form as: Biochemistry. 2007 Jun 26; 46(25): 7437–7448. Published online 2007 Jun 2. doi: 10.1021/bi7001828

PMCID:: PMC3140710

Abstract Article PDF–1.0M

Select item 293356410.

Adenosine A1 Receptor Gene Variants Associated with Post-traumatic Seizures after Severe TBI

Amy K. Wagner, Megan A. Miller, Joelle Scanlon, Dianxu Ren, Patrick M. Kochanek, Yvette P. Conley

Epilepsy Res. Author manuscript; available in PMC 2011 Aug 1.

Published in final edited form as: Epilepsy Res. 2010 Aug; 90(3): 259–272. Published online 2010 Jul 6. doi: 10.1016/j.eplepsyres.2010.06.001

PMCID:: PMC2933564

Abstract Article PDF–222K

Select item 282920311.

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A₁ receptor ligands

Jillian G Baker, Richard Middleton, Luke Adams, Lauren T May, Stephen J Briddon, Barrie Kellam, Stephen J Hill

Br J Pharmacol. 2010 Feb; 159(4): 772–786. doi: 10.1111/j.1476-5381.2009.00488.x

PMCID:: PMC2829203

Abstract Article PDF–690K

Select item 206584912.

Adenosine A₁ Receptors Mediate Mobilization of Calcium in Human Bronchial Smooth Muscle Cells

Michael F. Ethier, J. Mark Madison

Am J Respir Cell Mol Biol. 2006 Oct; 35(4): 496–502. Published online 2006 May 18. doi: 10.1165/rcmb.2005-0290OC

PMCID:: PMC2065849

Abstract Article PDF–175K

Select item 157389013.

A role of protein kinase Cμ in signalling from the human adenosine A₁ receptor to the nucleus

Kathryn J Hill, Anne C Webber, Stephen J Hill

Br J Pharmacol. 2003 Jun; 139(4): 721–732. Published online 2003 Jun 20. doi: 10.1038/sj.bjp.0705294

PMCID:: PMC1573890

Abstract Article PDF–469K

Select item 122047614.

Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors.

Z Gao, Y Ni, G Szabo, J Linden

Biochem J. 1999 Sep 1; 342(Pt 2): 387–395.

PMCID:: PMC1220476

Summary PDF–240K

Select item 1098310915.

Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation

Weize Zhu, Ying Hong, Zhaowei Tong, Xiaofang He, Yan Li, Hao Wang, Xinxin Gao, Pengtao Song, Xianshan Zhang, Xiaochang Wu, Zhenhua Tan, Wenjin Huang, Zekun Liu, Yiyang Bao, Junli Ma, Ningning Zheng, Cen Xie, Xisong Ke, Wen Zhou, Wei Jia, Mingxiao Li, Jing Zhong, Lili Sheng, Houkai Li

Cell Rep Med. 2024 Mar 19; 5(3): 101477. Published online 2024 Mar 21. doi: 10.1016/j.xcrm.2024.101477

Correction in:: Cell Rep Med. 2024 May 21; 5(5): 101563.

PMCID:: PMC10983109

Abstract Article PDF–10M

Select item 852329316.

Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment

Dongli Tian, Jiaying Li, Linfeng Zou, Min Lin, Xiaoxiao Shi, Yuting Hu, Jiaxin Lang, Lubin Xu, Wenling Ye, Xuemei Li, Limeng Chen

J Diabetes Res. 2021; 2021: 5584871. Published online 2021 Oct 11. doi: 10.1155/2021/5584871

PMCID:: PMC8523293

Abstract Article PDF–3.8M

Select item 768648817.

ADORA2A variation and adenosine A₁ receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation

Christa Hohoff, Tina Kroll, Baoyuan Zhao, Nicole Kerkenberg, Ilona Lang, Kathrin Schwarte, David Elmenhorst, Eva-Maria Elmenhorst, Daniel Aeschbach, Weiqi Zhang, Bernhard T. Baune, Bernd Neumaier, Andreas Bauer, Jürgen Deckert

Transl Psychiatry. 2020; 10: 406. Published online 2020 Nov 24. doi: 10.1038/s41398-020-01085-w

PMCID:: PMC7686488

Abstract Article PDF–1.0M

Select item 765973018.

Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels

Antoine A. Khalil, Olga Ilina, Angela Vasaturo, Jan-Hendrik Venhuizen, Manon Vullings, Victor Venhuizen, Ab Bilos, Carl G. Figdor, Paul N. Span, Peter Friedl

J Cell Biol. 2020 Oct 5; 219(10): e201911120. Published online 2020 Aug 10. doi: 10.1083/jcb.201911120