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Select item 89867561.

Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence

Samatha Bhat, Divya Adiga, Vaibhav Shukla, Kanive Parashiva Guruprasad, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy

Cell Biol Toxicol. 2022; 38(2): 237–258. Published online 2021 Mar 24. doi: 10.1007/s10565-021-09598-w

PMCID:: PMC8986756

Abstract Article PDF–17M

Select item 71903542.

Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions

Mehak M Khan, Wade G Regehr

eLife. 2020; 9: e55165. Published online 2020 Apr 29. doi: 10.7554/eLife.55165

PMCID:: PMC7190354

Abstract Article PDF–2.2M

Select item 60145583.

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function

Arianne Aslamy, Eunjin Oh, Erika M. Olson, Jing Zhang, Miwon Ahn, Abu Saleh Md Moin, Ragadeepthi Tunduguru, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Debbie C. Thurmond

Diabetes. 2018 Jul; 67(7): 1332–1344. Published online 2018 Apr 16. doi: 10.2337/db17-1352

PMCID:: PMC6014558

Abstract Article PDF–2.0M

Select item 40555004.

Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivity

Latha Ramalingam, Eunjin Oh, Debbie C. Thurmond

Diabetologia. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Diabetologia. 2014 Jul; 57(7): 1476–1484. Published online 2014 Apr 6. doi: 10.1007/s00125-014-3227-7

PMCID:: PMC4055500

Abstract Article PDF–608K

Select item 34478985.

Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity

Latha Ramalingam, Eunjin Oh, Stephanie M. Yoder, Joseph T. Brozinick, Michael A. Kalwat, Alexander J. Groffen, Matthijs Verhage, Debbie C. Thurmond

Diabetes. 2012 Oct; 61(10): 2424–2432. Published online 2012 Sep 13. doi: 10.2337/db11-1525

PMCID:: PMC3447898

Abstract Article PDF–1.3M

Select item 67834746.

Doc2b Ca²⁺ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength

Quentin Bourgeois-Jaarsma, Matthijs Verhage, Alexander J. Groffen

Sci Rep. 2019; 9: 14408. Published online 2019 Oct 8. doi: 10.1038/s41598-019-50684-1

PMCID:: PMC6783474

Abstract Article PDF–2.7M

Select item 66185277.

Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release

Paulo S. Pinheiro, Heidi de Wit, Alexander M. Walter, Alexander J. Groffen, Matthijs Verhage, Jakob B. Sørensen

J Neurosci. 2013 Oct 16; 33(42): 16459–16470. doi: 10.1523/JNEUROSCI.2656-13.2013

PMCID:: PMC6618527

Abstract Article PDF–1.2M

Select item 62766818.

Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes

Arianne Aslamy, Eunjin Oh, Miwon Ahn, Abu Saleh Md Moin, Mariann Chang, Molly Duncan, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Fouad Kandeel, Linda A DiMeglio, Debbie C Thurmond

J Clin Endocrinol Metab. 2018 May; 103(5): 1966–1976. Published online 2018 Mar 1. doi: 10.1210/jc.2017-02492

PMCID:: PMC6276681

Abstract Article

Select item 41287019.

DOC2B and Munc13-1 Differentially Regulate Neuronal Network Activity

Ayal Lavi, Anton Sheinin, Ronit Shapira, Daniel Zelmanoff, Uri Ashery

Cereb Cortex. 2014 Sep; 24(9): 2309–2323. Published online 2013 Mar 28. doi: 10.1093/cercor/bht081

PMCID:: PMC4128701

Abstract Article PDF–1.0M

Select item 392364010.

Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission

Jon D. Gaffaney, Renhao Xue, Edwin R. Chapman

Mol Biol Cell. 2014 Feb 15; 25(4): 481–494. doi: 10.1091/mbc.E13-10-0571

PMCID:: PMC3923640

Abstract Article PDF–3.1M

Select item 267351111.

DOC2B Acts as a Calcium Switch and Enhances Vesicle Fusion

Reut Friedrich, Alexander J. Groffen, Emma Connell, Jan R. T. van Weering, Orit Gutman, Yoav I. Henis, Bazbek Davletov, Uri Ashery

J Neurosci. 2008 Jul 2; 28(27): 6794–6806. doi: 10.1523/JNEUROSCI.0538-08.2008

PMCID:: PMC2673511

Abstract Article PDF–10M

Select item 1114642812.

Disease-linked mutations in Munc18-1 deplete synaptic Doc2

Noah Guy Lewis Guiberson, Luca S Black, Jillian E Haller, Aniv Brukner, Debra Abramov, Saad Ahmad, Yan Xin Xie, Manu Sharma, Jacqueline Burré

Brain. 2024 Jun; 147(6): 2185–2202. Published online 2024 Jan 18. doi: 10.1093/brain/awae019

PMCID:: PMC11146428

Abstract Article PDF–2.4M

Select item 709613813.

Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons

Rocío Díez-Arazola, Marieke Meijer, Quentin Bourgeois-Jaarsma, L. Niels Cornelisse, Matthijs Verhage, Alexander J. Groffen

J Neurosci. 2020 Mar 25; 40(13): 2606–2617. doi: 10.1523/JNEUROSCI.0309-19.2020

PMCID:: PMC7096138

Abstract Article PDF–3.1M

Select item 645167014.

DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle

Jing Zhang, Eunjin Oh, Karla E. Merz, Arianne Aslamy, Rajakrishnan Veluthakal, Vishal A. Salunkhe, Miwon Ahn, Ragadeepthi Tunduguru, Debbie C. Thurmond

Diabetologia. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Diabetologia. 2019 May; 62(5): 845–859. Published online 2019 Feb 1. doi: 10.1007/s00125-019-4824-2

PMCID:: PMC6451670

Abstract Article PDF–1.4M

Select item 609056115.

Excitatory and inhibitory neurons utilize different Ca²⁺ sensors and sources to regulate spontaneous release

Nicholas A. Courtney, Joseph S. Briguglio, Mazdak M. Bradberry, Christina Greer, Edwin R. Chapman

Neuron. Author manuscript; available in PMC 2019 Jun 6.

Published in final edited form as: Neuron. 2018 Jun 6; 98(5): 977–991.e5. Published online 2018 May 10. doi: 10.1016/j.neuron.2018.04.022

PMCID:: PMC6090561

Abstract Article PDF–4.2M

Select item 453424316.

Structural elements that underlie Doc2β function during asynchronous synaptic transmission

Renhao Xue, Jon D. Gaffaney, Edwin R. Chapman

Proc Natl Acad Sci U S A. 2015 Aug 4; 112(31): E4316–E4325. Published online 2015 Jul 20. doi: 10.1073/pnas.1502288112

PMCID:: PMC4534243

Abstract Article PDF–1.9M

Select item 441844817.

Doc2b Serves as a Scaffolding Platform for Concurrent Binding of Multiple Munc18 Isoforms in Pancreatic Islet Beta Cells

Latha Ramalingam, Jingping Lu, Andy Hudmon, Debbie C. Thurmond

Biochem J. Author manuscript; available in PMC 2015 May 4.

Published in final edited form as: Biochem J. 2014 Dec 1; 464(2): 251–258. doi: 10.1042/BJ20140845

PMCID:: PMC4418448

Abstract Article PDF–576K

Select item 284632018.

Doc2b is a High Affinity Ca²⁺ Sensor for Spontaneous Neurotransmitter Release

Alexander J. Groffen, Sascha Martens, Rocío Díez Arazola, L. Niels Cornelisse, Natalia Lozovaya, Arthur P. H. de Jong, Natalia A. Goriounova, Ron L. P. Habets, Yoshimi Takai, J. Gerard Borst, Nils Brose, Harvey T. McMahon, Matthijs Verhage

Science. Author manuscript; available in PMC 2010 Sep 26.

Published in final edited form as: Science. 2010 Mar 26; 327(5973): 1614–1618. Published online 2010 Feb 11. doi: 10.1126/science.1183765