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Select item 105980031.

Control of CD4⁺ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase

Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofang Xiong, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song

Signal Transduct Target Ther. 2023; 8: 415. Published online 2023 Oct 24. doi: 10.1038/s41392-023-01648-5

PMCID:: PMC10598003

Abstract Article PDF–4.5M

Select item 88095362.

Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8⁺ T cells

Jugal Kishore Das, Yijie Ren, Anil Kumar, Hao-Yun Peng, Liqing Wang, Xiaofang Xiong, Robert C. Alaniz, Paul de Figueiredo, Xingcong Ren, Xiaoqi Liu, Alexey G. Ryazonov, Jin-Ming Yang, Jianxun Song

Sci Adv. 2022 Feb; 8(5): eabl9783. Published online 2022 Feb 2. doi: 10.1126/sciadv.abl9783

PMCID:: PMC8809536

Abstract Article PDF–4.8M

Select item 81856583.

Eef2k is not required for fertility in male mice

Tianhao Feng, Shushu Zhou, Xiaodan Shi, Xin Zhang, Jintao Zhang, Shuqin Zhao, Xiaoyu Yang, Xuhui Meng, Mingxi Liu

Transl Androl Urol. 2021 May; 10(5): 1988–1999. doi: 10.21037/tau-21-18

PMCID:: PMC8185658

Abstract Article PDF–3.2M

Select item 72427904.

D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis

Orit David, Iliana Barrera, Nathaniel Gould, Shunit Gal-Ben-Ari, Kobi Rosenblum

Front Mol Neurosci. 2020; 13: 67. Published online 2020 May 15. doi: 10.3389/fnmol.2020.00067

PMCID:: PMC7242790

Abstract Article PDF–6.2M

Select item 53110595.

Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

Devon C. Crawford, Denise M. O. Ramirez, Brent Trauterman, Lisa M. Monteggia, Ege T. Kavalali

Nat Commun. 2017; 8: 14436. Published online 2017 Feb 10. doi: 10.1038/ncomms14436

PMCID:: PMC5311059

Abstract Article PDF–2.2M

Select item 50166906.

Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival

Yi Liao, Hsueh-Ping Chu, Zhixian Hu, Jason J. Merkin, Jianmin Chen, Zuguo Liu, Kurt Degenhardt, Eileen White, Alexey G. Ryazanov

J Biol Chem. 2016 Sep 9; 291(37): 19545–19557. Published online 2016 Jul 27. doi: 10.1074/jbc.M116.724856

PMCID:: PMC5016690

Abstract Article PDF–5.1M

Select item 48439537.

Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule‐related proteins in neurons

Justin W. Kenney, Maja Genheden, Kyung‐Mee Moon, Xuemin Wang, Leonard J. Foster, Christopher G. Proud

J Neurochem. 2016 Jan; 136(2): 276–284. Published online 2015 Nov 17. doi: 10.1111/jnc.13407

PMCID:: PMC4843953

Abstract Article PDF–393K

Select item 47602748.

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

Claire E.J. Moore, Xuemin Wang, Jianling Xie, Jo Pickford, John Barron, Sergio Regufe da Mota, Matthias Versele, Christopher G. Proud

Cell Signal. 2016 Apr; 28(4): 284–293. doi: 10.1016/j.cellsig.2016.01.005

PMCID:: PMC4760274

Abstract Article PDF–1.2M

Select item 47126489.

Germline quality control: eEF2K stands guard to eliminate defective oocytes

Hsueh-Ping Chu, Yi Liao, James S. Novak, Zhixian Hu, Jason J. Merkin, Yuriy Shymkiv, Bart P. Braeckman, Maxim V. Dorovkov, Alexandra Nguyen, Peter M. Clifford, Robert G. Nagele, David E. Harrison, Ronald E. Ellis, Alexey G. Ryazanov

Dev Cell. Author manuscript; available in PMC 2016 Jan 14.

Published in final edited form as: Dev Cell. 2014 Mar 10; 28(5): 561–572. Published online 2014 Feb 27. doi: 10.1016/j.devcel.2014.01.027

PMCID:: PMC4712648

Abstract Article PDF–2.2M

Select item 442497510.

Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation

Peng Zhang, Maziar Riazy, Matthew Gold, Shu-Huei Tsai, Kelly McNagny, Christopher Proud, Vincent Duronio

Can J Cardiol. 2014 Dec; 30(12): 1684–1688. doi: 10.1016/j.cjca.2014.09.019

PMCID:: PMC4424975

Abstract Article PDF–988K

Select item 329351811.

Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice

Iness Gildish, David Manor, Orit David, Vijendra Sharma, David Williams, Usha Agarwala, Xuemin Wang, Justin W. Kenney, Chris G. Proud, Kobi Rosenblum

Learn Mem. 2012 Mar; 19(3): 116–125. Published online 2012 Mar. doi: 10.1101/lm.023937.111

PMCID:: PMC3293518

Abstract Article PDF–849K

Select item 289369012.

Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase-Regulated Pathway

Aslam A. Khan, Dru S. Dace, Alexey G. Ryazanov, Jennifer Kelly, Rajendra S. Apte

Am J Pathol. 2010 Jul; 177(1): 481–492. doi: 10.2353/ajpath.2010.090836

PMCID:: PMC2893690

Abstract Article PDF–1.0M

Select item 970811613.

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24^Bst Mouse

John R.P. Knight, Christopher G. Proud, Giovanna Mallucci, Tobias von der Haar, C. Mark Smales, Anne E. Willis, Owen J. Sansom

J Invest Dermatol. 2022 Dec; 142(12): 3346–3348.e1. doi: 10.1016/j.jid.2022.06.019

PMCID:: PMC9708116

Article

Select item 896117514.

eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma

Xisha Chen, Kuansong Wang, Shilong Jiang, Hongyin Sun, Xuanling Che, Minghui Zhang, Jiaying He, Ying Wen, Mengting Liao, Xiangling Li, Xiaoming Zhou, Jianxun Song, Xingcong Ren, Wenjun Yi, Jinming Yang, Xiang Chen, Mingzhu Yin, Yan Cheng

J Immunother Cancer. 2022; 10(3): e004026. Published online 2022 Mar 28. doi: 10.1136/jitc-2021-004026