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Select item 101932401.

eIF2α incites photoreceptor cell and retina damage by all-trans-retinal

Danxue He, Lei Tao, Binxiang Cai, Xiangjun Chen, Yan Wang, Shiying Li, Chunyan Liao, Yuling Chen, Jingmeng Chen, Zuguo Liu, Yalin Wu

J Biol Chem. 2023 May; 299(5): 104686. Published online 2023 Apr 7. doi: 10.1016/j.jbc.2023.104686

PMCID:: PMC10193240

Abstract Article PDF–4.6M

Select item 74950452.

Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation

Kim Schneider, Geoffrey Michael Nelson, Joseph Luke Watson, Jörg Morf, Maximillian Dalglish, Laura Martina Luh, Annika Weber, Anne Bertolotti

Cell Rep. 2020 Sep 15; 32(11): 108154. Published online 2020 Sep 15. doi: 10.1016/j.celrep.2020.108154

PMCID:: PMC7495045

Abstract Article

Select item 72937393.

Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury

Yong-Jing Tang, Huan Chen, Yu Yi, Gui-Mei Chen, Fang-Wan Yang, Ying Li, Ren-Dong Tian, Wen-Ge Huang, Qi-Jiao Cheng, Yi-Huai He

Biomed Res Int. 2020; 2020: 2626090. Published online 2020 Jun 5. doi: 10.1155/2020/2626090

PMCID:: PMC7293739

Abstract Article PDF–3.2M

Select item 55379424.

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman, Sung Hoon Back

Nutr Metab (Lond) 2017; 14: 48. Published online 2017 Aug 1. doi: 10.1186/s12986-017-0202-6

PMCID:: PMC5537942

Abstract Article PDF–6.5M

Select item 51547595.

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Martina Sgritta, Wei Huang, Krešimir Krnjević, Randal J Kaufman, John A Dani, Peter Walter, Mauro Costa-Mattioli

eLife. 2016; 5: e17517. Published online 2016 Dec 13. doi: 10.7554/eLife.17517

PMCID:: PMC5154759

Abstract Article PDF–1.9M

Select item 43913196.

Limited Effects of an eIF2α^S51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer's Disease

Katharina Paesler, Kan Xie, Moritz M. Hettich, Magdalena E. Siwek, Devon P. Ryan, Susanne Schröder, Anna Papazoglou, Karl Broich, Ralf Müller, Astrid Trog, Alexander Garthe, Gerd Kempermann, Marco Weiergräber, Dan Ehninger

Neural Plast. 2015; 2015: 825157. Published online 2015 Mar 26. doi: 10.1155/2015/825157

PMCID:: PMC4391319

Abstract Article PDF–1.5M

Select item 43405917.

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a

Gonzalo Viana Di Prisco, Wei Huang, Shelly A Buffington, Chih-Chun Hsu, Penelope E Bonnen, Andon N Placzek, Carmela Sidrauski, Krešimir Krnjevic, Randal J Kaufman, Peter Walter, Mauro Costa-Mattioli

Nat Neurosci. Author manuscript; available in PMC 2015 Feb 25.

Published in final edited form as: Nat Neurosci. 2014 Aug; 17(8): 1073–1082. Published online 2014 Jun 29. doi: 10.1038/nn.3754

PMCID:: PMC4340591

Abstract Article PDF–2.2M

Select item 40074508.

Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

Bo-Jhih Guan, Dawid Krokowski, Mithu Majumder, Christine L. Schmotzer, Scot R. Kimball, William C. Merrick, Antonis E. Koromilas, Maria Hatzoglou

J Biol Chem. 2014 May 2; 289(18): 12593–12611. Published online 2014 Mar 19. doi: 10.1074/jbc.M113.543215

PMCID:: PMC4007450

Abstract Article PDF–2.2M

Select item 31660959.

Eukaryotic initiation factor 2α phosphorylation is required for B-cell maturation and function in mice

Nina Mielke, Rolf Schwarzer, Cornelis F. Calkhoven, Randal J. Kaufman, Bernd Dörken, Achim Leutz, Franziska Jundt

Haematologica. 2011 Sep; 96(9): 1261–1268. Published online 2011 May 12. doi: 10.3324/haematol.2011.042853

PMCID:: PMC3166095

Abstract Article PDF–904K

Select item 278674710.

Dephosphorylation of eIF2α Mediated by the γ₁34.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion

Dustin Verpooten, Zongdi Feng, Tibor Valyi-Nagy, Yijie Ma, Huali Jin, Zhipeng Yan, Cuizhu Zhang, Youjia Cao, Bin He

J Virol. 2009 Dec; 83(23): 12626–12630. Published online 2009 Sep 16. doi: 10.1128/JVI.01431-09

PMCID:: PMC2786747

Abstract Article PDF–1.1M

Select item 242328811.

Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response

Lawrence B. Gardner

Mol Cell Biol. 2008 Jun; 28(11): 3729–3741. Published online 2008 Mar 24. doi: 10.1128/MCB.02284-07

PMCID:: PMC2423288

Abstract Article PDF–1.1M

Select item 147974812.

Phosphorylation of the α subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus

Larissa S. Carnevalli, Catia M. Pereira, Carolina B. Jaqueta, Viviane S. Alves, Vanessa N. Paiva, Krishna M. Vattem, Ronald C. Wek, Luiz Eugênio A. M. Mello, Beatriz A. Castilho

Biochem J. 2006 Jul 1; 397(Pt 1): 187–194. Prepublished online 2006 Feb 22. Published online 2006 Jun 14. doi: 10.1042/BJ20051643

PMCID:: PMC1479748

Abstract Article PDF–440K

Select item 118231313.

Importance of eIF2α Phosphorylation and Stress Granule Assembly in Alphavirus Translation Regulation

Gerald M. McInerney, Nancy L. Kedersha, Randal J. Kaufman, Paul Anderson, Peter Liljeström

Mol Biol Cell. 2005 Aug; 16(8): 3753–3763. doi: 10.1091/mbc.E05-02-0124

PMCID:: PMC1182313

Abstract Article PDF–529K

Select item 984344314.

Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism

Hong Wa Yung, Xiaohui Zhao, Luke Glover, Charlotte Burrin, Poh-Choo Pang, Carolyn J.P. Jones, Carolyn Gill, Kate Duhig, Matts Olovsson, Lucy C. Chappell, Stuart M. Haslam, Anne Dell, Graham J. Burton, D. Stephen Charnock-Jones

iScience. 2023 Jan 20; 26(1): 105911. Published online 2022 Dec 30. doi: 10.1016/j.isci.2022.105911

PMCID:: PMC9843443

Abstract Article PDF–4.3M

Select item 972262615.

Stress-mediated attenuation of translation undermines T-cell activity in cancer

Brian P. Riesenberg, Elizabeth G. Hunt, Megan D. Tennant, Katie E. Hurst, Alex M. Andrews, Lee R. Leddy, David M. Neskey, Elizabeth G. Hill, Guillermo O. Rangel Rivera, Chrystal M. Paulos, Peng Gao, Jessica E. Thaxton

Cancer Res. Author manuscript; available in PMC 2023 Jun 2.

Published in final edited form as: Cancer Res. 2022 Dec 2; 82(23): 4386–4399. doi: 10.1158/0008-5472.CAN-22-1744

PMCID:: PMC9722626

Abstract Article PDF–2.3M

Select item 852665316.

Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function

Francesco Longo, Maria Mancini, Pierre L. Ibraheem, Sameer Aryal, Caterina Mesini, Jyoti C. Patel, Elena Penhos, Nazia Rahman, Maggie Mamcarz, Emanuela Santini, Margaret E. Rice, Eric Klann

Mol Psychiatry. Author manuscript; available in PMC 2022 Jan 16.

Published in final edited form as: Mol Psychiatry. 2021 Nov; 26(11): 6427–6450. Published online 2021 Apr 20. doi: 10.1038/s41380-021-01099-w

PMCID:: PMC8526653

Abstract Article PDF–2.5M

Select item 757465317.

Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR

Cristina Scapin, Cinzia Ferri, Emanuela Pettinato, Francesca Bianchi, Ubaldo Del Carro, M. Laura Feltri, Randal J. Kaufman, Lawrence Wrabetz, Maurizio D'Antonio

J Neurosci. 2020 Oct 14; 40(42): 8174–8187. doi: 10.1523/JNEUROSCI.0957-20.2020