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Select item 109961561.

Common Mutation in the HFE Gene Modifies Recovery After Intracerebral Hemorrhage

Timothy B. Helmuth, Rashmi Kumari, Kondaiah Palsa, Elizabeth B. Neely, Becky Slagle-Webb, Scott D. Simon, James R. Connor

Stroke. Author manuscript; available in PMC 2024 Apr 5.

Published in final edited form as: Stroke. 2023 Nov; 54(11): 2886–2894. Published online 2023 Sep 26. doi: 10.1161/STROKEAHA.123.043799

PMCID:: PMC10996156

Abstract Article PDF–1.3M

Select item 102193402.

Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism

Paul Knoop, Dilay Yilmaz, Rossana Paganoni, Peter Steele-Perkins, Andreas Gruber, Banu Akdogan, Hans Zischka, Kerstin Leopold, Maja Vujić Spasić

Int J Mol Sci. 2023 May; 24(10): 8948. Published online 2023 May 18. doi: 10.3390/ijms24108948

PMCID:: PMC10219340

Abstract Article PDF–2.7M

Select item 99179163.

Protein Susceptibility to Peroxidation by 4-Hydroxynonenal in Hereditary Hemochromatosis

Sandra Sánchez-Jaut, Susana Pérez-Benavente, Paloma Abad, Darío Méndez-Cuadro, Antonio Puyet, Amalia Diez, Gonzalo Galicia-Poblet, Elena Gómez-Domínguez, María J. Moran-Jiménez, José M. Bautista, Isabel G. Azcárate

Int J Mol Sci. 2023 Feb; 24(3): 2922. Published online 2023 Feb 2. doi: 10.3390/ijms24032922

PMCID:: PMC9917916

Abstract Article PDF–2.4M

Select item 94450234.

In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice

Alice Rovai, BoMee Chung, Qingluan Hu, Sebastian Hook, Qinggong Yuan, Tibor Kempf, Florian Schmidt, Dirk Grimm, Steven R. Talbot, Lars Steinbrück, Jasper Götting, Jens Bohne, Simon A. Krooss, Michael Ott

Nat Commun. 2022; 13: 5215. Published online 2022 Sep 5. doi: 10.1038/s41467-022-32906-9

PMCID:: PMC9445023

Abstract Article PDF–1.8M

Select item 89632085.

Iron Promotes Cardiac Doxorubicin Retention and Toxicity Through Downregulation of the Mitochondrial Exporter ABCB8

Archita Venugopal Menon, Jonghan Kim

Front Pharmacol. 2022; 13: 817951. Published online 2022 Mar 11. doi: 10.3389/fphar.2022.817951

PMCID:: PMC8963208

Abstract Article PDF–2.6M

Select item 86341926.

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice

Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

Haematologica. 2021 Dec 1; 106(12): 3149–3161. Published online 2020 Oct 13. doi: 10.3324/haematol.2019.241745

PMCID:: PMC8634192

Abstract Article PDF–1.5M

Select item 63386607.

Brain iron loading impairs DNA methylation and alters GABAergic function in mice

Qi Ye, Malav Trivedi, Yiting Zhang, Mark Böhlke, Helal Alsulimani, JuOae Chang, Timothy Maher, Richard Deth, Jonghan Kim

FASEB J. 2019 Feb; 33(2): 2460–2471. Published online 2018 Oct 2. doi: 10.1096/fj.201801116RR

PMCID:: PMC6338660

Abstract Article

Select item 62411308.

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis

Márcio Simão, António Camacho, Agnès Ostertag, Martine Cohen-Solal, I. Jorge Pinto, Graça Porto, Ea Hang Korng, M. Leonor Cancela

PLoS One. 2018; 13(11): e0207441. Published online 2018 Nov 14. doi: 10.1371/journal.pone.0207441

Correction in:: PLoS One. 2019; 14(4): e0216377.

PMCID:: PMC6241130

Abstract Article PDF–5.9M

Select item 58511449.

A role for sex and a common HFE gene variant in brain iron uptake

Kari A Duck, Elizabeth B Neely, Ian A Simpson, James R Connor

J Cereb Blood Flow Metab. 2018 Mar; 38(3): 540–548. Published online 2017 Mar 28. doi: 10.1177/0271678X17701949

PMCID:: PMC5851144

Abstract Article PDF–457K

Select item 492323610.

Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high‐calorie diet

Laurence Britton, Lesley Jaskowski, Kim Bridle, Nishreen Santrampurwala, Janske Reiling, Nick Musgrave, V. Nathan Subramaniam, Darrell Crawford

Physiol Rep. 2016 Jun; 4(12): e12837. Published online 2016 Jun 28. doi: 10.14814/phy2.12837

PMCID:: PMC4923236

Abstract Article PDF–2.6M

Select item 491701411.

Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure

Qi Ye, Jonghan Kim

Metallomics. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Metallomics. 2016 Jun 1; 8(6): 618–627. doi: 10.1039/c6mt00080k

PMCID:: PMC4917014

Abstract Article PDF–2.1M

Select item 424540112.

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis

Seung-Min Lee, Alexandre Loguinov, Robert E. Fleming, Christopher D. Vulpe

Genes Nutr. 2015 Jan; 10(1): 443. Published online 2014 Nov 27. doi: 10.1007/s12263-014-0443-1

PMCID:: PMC4245401

Abstract Article PDF–440K

Select item 421965113.

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

Jia Shen, Xiangpeng Sheng, ZeNan Chang, Qian Wu, Sheng Wang, Zongliang Xuan, Dan Li, Yalan Wu, Yongjia Shang, Xiangtao Kong, Long Yu, Lin Li, Kangchen Ruan, Hongyu Hu, Ying Huang, Lijian Hui, Dong Xie, Fudi Wang, Ronggui Hu

Cell Rep. Author manuscript; available in PMC 2014 Nov 4.

Published in final edited form as: Cell Rep. 2014 Apr 10; 7(1): 180–193. Published online 2014 Mar 27. doi: 10.1016/j.celrep.2014.02.042

PMCID:: PMC4219651

Abstract Article PDF–1.8M

Select item 366033114.

Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis

Jonghan Kim, Peter D. Buckett, Marianne Wessling-Resnick

PLoS One. 2013; 8(5): e64944. Published online 2013 May 21. doi: 10.1371/journal.pone.0064944

PMCID:: PMC3660331

Abstract Article PDF–384K

Select item 301220015.

Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis

Jingyu Huang, Deborah Jones, Bai Luo, Michael Sanderson, Jamie Soto, E. Dale Abel, Robert C. Cooksey, Donald A. McClain

Diabetes. 2011 Jan; 60(1): 80–87. Published online 2010 Sep 28. doi: 10.2337/db10-0593

PMCID:: PMC3012200

Abstract Article PDF–238K

Select item 289100716.

Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation

Marco Constante, Wenlei Jiang, Dongmei Wang, Valérie-Ann Raymond, Marc Bilodeau, Manuela M. Santos

Am J Physiol Gastrointest Liver Physiol. Author manuscript; available in PMC 2010 Jun 24.

Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2006 Aug; 291(2): G229–G237. Published online 2006 Mar 24. doi: 10.1152/ajpgi.00092.2006