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Select item 112696061.

Development and validation of a predictive model based on β-Klotho for head and neck squamous cell carcinoma

XiangXiu Wang, HongWei Liu, Gang Wu, Yan Lu, Ying Cui

Sci Rep. 2024; 14: 17081. Published online 2024 Jul 24. doi: 10.1038/s41598-024-68130-2

PMCID:: PMC11269606

Abstract Article PDF–11M

Select item 79214692.

The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

Nadia Panera, Marica Meroni, Miriam Longo, Annalisa Crudele, Luca Valenti, Emanuele Bellacchio, Luca Miele, Valentina D'Oria, Erika Paolini, Marco Maggioni, Anna Ludovica Fracanzani, Anna Alisi, Paola Dongiovanni

EBioMedicine. 2021 Mar; 65: 103249. Published online 2021 Feb 25. doi: 10.1016/j.ebiom.2021.103249

PMCID:: PMC7921469

Abstract Article PDF–2.2M

Select item 67819843.

KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese

Fang Ji, Ye Liu, Jun-Gui Hao, Li-Ping Wang, Ming-Jia Dai, Gui-Fang Shen, Xue-Bing Yan

Aging (Albany NY) 2019 Sep 30; 11(18): 7847–7858. Published online 2019 Sep 23. doi: 10.18632/aging.102293

PMCID:: PMC6781984

Abstract Article PDF–966K

Select item 35594764.

βKlotho Suppresses Tumor Growth in Hepatocellular Carcinoma by Regulating Akt/GSK-3β/Cyclin D1 Signaling Pathway

Xiaoming Ye, Yu Guo, Qi Zhang, Wenjie Chen, Xuefeng Hua, Wei Liu, Yang Yang, Guihua Chen

PLoS One. 2013; 8(1): e55615. Published online 2013 Jan 30. doi: 10.1371/journal.pone.0055615

PMCID:: PMC3559476

Abstract Article PDF–1.3M

Select item 31092065.

A Klothoβ Variant Mediates Protein Stability and Associates with Colon Transit in Irritable Bowel Syndrome with Diarrhea

Banny S. Wong, Michael Camilleri, Paula J. Carlson, Maria E. Guicciardi, Duane Burton, Sanna McKinzie, Archana S. Rao, Alan R. Zinsmeister, Gregory J. Gores

Gastroenterology. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Gastroenterology. 2011 Jun; 140(7): 1934–1942. Published online 2011 Mar 9. doi: 10.1053/j.gastro.2011.02.063

PMCID:: PMC3109206

Abstract Article PDF–1.1M

Select item 100743396.

KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children

Sebastià Galmés, Azahara I. Rupérez, Juana Sánchez, Luis A. Moreno, Ronja Foraita, Antje Hebestreit, Dénes Molnár, Andreu Palou, Catalina Picó

Sci Rep. 2023; 13: 5563. Published online 2023 Apr 5. doi: 10.1038/s41598-023-31537-4

PMCID:: PMC10074339

Abstract Article PDF–1.5M

Select item 69942317.

Effect of Increased Bile Acid Synthesis or Fecal Excretion in Irritable Bowel Syndrome-Diarrhea

Michael Camilleri, Irene Busciglio, Andres Acosta, Andrea Shin, Paula Carlson, Duane Burton, Michael Ryks, Deborah Rhoten, Jesse Lamsam, Alan Lueke, Leslie J. Donato, Alan R. Zinsmeister

Am J Gastroenterol. Author manuscript; available in PMC 2020 Jan 31.

Published in final edited form as: Am J Gastroenterol. 2014 Oct; 109(10): 1621–1630. Published online 2014 Jul 29. doi: 10.1038/ajg.2014.215

PMCID:: PMC6994231

Abstract Article PDF–801K

Select item 68909988.

Robust RBM3 and β-klotho expression in developing neurons in the human brain

Travis C Jackson, Keri Janesko-Feldman, Shaun W Carlson, Shawn E Kotermanski, Patrick M Kochanek

J Cereb Blood Flow Metab. 2019 Dec; 39(12): 2355–2367. Published online 2019 Sep 29. doi: 10.1177/0271678X19878889

PMCID:: PMC6890998

Abstract Article PDF–2.0M

Select item 65941749.

Structures of β-Klotho reveal a ‘zip code’-like mechanism for endocrine FGF signaling

Sangwon Lee, Jungyuen Choi, Jyotidarsini Mohanty, Leiliane P. Sousa, Francisco Tome, Els Pardon, Jan Steyaert, Mark A. Lemmon, Irit Lax, Joseph Schlessinger

Nature. Author manuscript; available in PMC 2019 Jun 26.

Published in final edited form as: Nature. 2018 Jan 25; 553(7689): 501–505. Published online 2018 Jan 17. doi: 10.1038/nature25010

PMCID:: PMC6594174

Abstract Article PDF–2.0M

Select item 647541910.

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

Ekaterina S. Kuzina, Peter Man-Un Ung, Jyotidarsini Mohanty, Francisco Tome, Jungyuen Choi, Els Pardon, Jan Steyaert, Irit Lax, Avner Schlessinger, Joseph Schlessinger, Sangwon Lee

Proc Natl Acad Sci U S A. 2019 Apr 16; 116(16): 7819–7824. Published online 2019 Apr 3. doi: 10.1073/pnas.1822055116

PMCID:: PMC6475419

Abstract Article PDF–2.8M

Select item 605974311.

βKlotho inhibits androgen/androgen receptor-associated epithelial-mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling

Zhao Liu, Hui Zhang, Sentai Ding, Shasha Qi, Shuai Liu, Dingqi Sun, Wei Dong, Lei Yin, Mingjiang Li, Xingbo Zhao, Jiaju Lu

Oncol Rep. 2018 Jul; 40(1): 217–225. Published online 2018 Apr 25. doi: 10.3892/or.2018.6399

PMCID:: PMC6059743

Abstract Article PDF–1.2M

Select item 516719812.

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Gunter Schumann, Chunyu Liu, Paul O’Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, Stefan Enroth, Krista Fischer, Jenni Hällfors, Sarah E. Harris, Saskia Hieber, Edith Hofer, Jouke-Jan Hottenga, Åsa Johansson, Peter K. Joshi, Niina Kaartinen, Jaana Laitinen, Rozenn Lemaitre, Anu Loukola, Jian’an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Hamdi Mbarek, Yuri Milaneschi, Alireza Moayyeri, Kenneth Mukamal, Christopher Nelson, Jennifer Nettleton, Eemil Partinen, Rajesh Rawal, Antonietta Robino, Lynda Rose, Cinzia Sala, Takashi Satoh, Reinhold Schmidt, Katharina Schraut, Robert Scott, Albert Vernon Smith, John M. Starr, Alexander Teumer, Stella Trompet, André G. Uitterlinden, Cristina Venturini, Anne-Claire Vergnaud, Niek Verweij, Veronique Vitart, Dragana Vuckovic, Juho Wedenoja, Loic Yengo, Bing Yu, Weihua Zhang, Jing Hua Zhao, Dorret I. Boomsma, John Chambers, Daniel I. Chasman, Toniolo Daniela, Eco de Geus, Ian Deary, Johan G. Eriksson, Tõnu Esko, Volker Eulenburg, Oscar H. Franco, Philippe Froguel, Christian Gieger, Hans J. Grabe, Vilmundur Gudnason, Ulf Gyllensten, Tamara B. Harris, Anna-Liisa Hartikainen, Andrew C. Heath, Lynne Hocking, Albert Hofman, Cornelia Huth, Marjo-Riitta Jarvelin, J. Wouter Jukema, Jaakko Kaprio, Jaspal S. Kooner, Zoltan Kutalik, Jari Lahti, Claudia Langenberg, Terho Lehtimäki, Yongmei Liu, Pamela A. F. Madden, Nicholas Martin, Alanna Morrison, Brenda Penninx, Nicola Pirastu, Bruce Psaty, Olli Raitakari, Paul Ridker, Richard Rose, Jerome I. Rotter, Nilesh J. Samani, Helena Schmidt, Tim D. Spector, David Stott, David Strachan, Ioanna Tzoulaki, Pim van der Harst, Cornelia M. van Duijn, Pedro Marques-Vidal, Peter Vollenweider, Nicholas J. Wareham, John B. Whitfield, James Wilson, Bruce Wolffenbuttel, Georgy Bakalkin, Evangelos Evangelou, Yun Liu, Kenneth M. Rice, Sylvane Desrivières, Steven A. Kliewer, David J. Mangelsdorf, Christian P. Müller, Daniel Levy, Paul Elliott

Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50): 14372–14377. Published online 2016 Nov 28. doi: 10.1073/pnas.1611243113

PMCID:: PMC5167198

Abstract Article PDF–829K

Select item 459180513.

Unliganded Fibroblast Growth Factor Receptor 1 Forms Density-independent Dimers

Laëtitia Comps-Agrar, Diana Ronai Dunshee, Dan L. Eaton, Junichiro Sonoda

J Biol Chem. 2015 Oct 2; 290(40): 24166–24177. Published online 2015 Aug 13. doi: 10.1074/jbc.M115.681395

PMCID:: PMC4591805

Abstract Article PDF–511K

Select item 392008514.

Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit

Michael Camilleri, Eric W. Klee, Andrea Shin, Paula Carlson, Ying Li, Madhusudan Grover, Alan R. Zinsmeister

Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1; 306(1): G13–G26. Published online 2013 Nov 7. doi: 10.1152/ajpgi.00294.2013

PMCID:: PMC3920085

Abstract Article

Select item 380982715.

Pharmacogenetics of the Effects of Colesevelam on Colonic Transit in Irritable Bowel Syndrome with Diarrhea

Banny S. Wong, Michael Camilleri, Paula J. Carlson, Suwebatu Odunsi-Shiyanbade, Sanna McKinzie, Irene Busciglio, Duane Burton, Alan R. Zinsmeister

Dig Dis Sci. Author manuscript; available in PMC 2013 Oct 28.

Published in final edited form as: Dig Dis Sci. 2012 May; 57(5): 10.1007/s10620-012-2035-5. Published online 2012 Jan 21. doi: 10.1007/s10620-012-2035-5

PMCID:: PMC3809827

Abstract Article PDF–593K

Select item 336149616.

Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma

Weijie Poh, Winnie Wong, Huimin Ong, Myat Oo Aung, Seng Gee Lim, Boon Tin Chua, Han Kiat Ho

Mol Cancer. 2012; 11: 14. Published online 2012 Mar 23. doi: 10.1186/1476-4598-11-14

PMCID:: PMC3361496

Abstract Article PDF–800K

Select item 323485517.

Short Hairpin RNA Screen Indicates That Klotho Beta/FGF19 Protein Overcomes Stasis in Human Colonic Epithelial Cells

Jinyong Kim, Ugur Eskiocak, Guido Stadler, Zhenjun Lou, Makoto Kuro-o, Jerry W. Shay, Woodring E. Wright

J Biol Chem. 2011 Dec 16; 286(50): 43294–43300. Published online 2011 Oct 21. doi: 10.1074/jbc.M111.267641

PMCID:: PMC3234855

Abstract Article PDF–1.4M

Select item 821970818.

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Rainer Malik, Michael Ewers

Nat Commun. 2021; 12: 3825. Published online 2021 Jun 22. doi: 10.1038/s41467-021-23755-z

PMCID:: PMC8219708

Abstract Article PDF–1.2M

Select item 1080566919.

Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2

Yonat Tzur, Katarzyna Winek, Nimrod Madrer, Serafima Dubnov, Estelle R. Bennett, David S. Greenberg, Geula Hanin, Asaad Gammal, Joseph Tam, Isaiah T. Arkin, Iddo Paldor, Hermona Soreq

Mol Metab. 2024 Jan; 79: 101856. Published online 2023 Dec 22. doi: 10.1016/j.molmet.2023.101856

PMCID:: PMC10805669

Abstract Article PDF–2.6M

Select item 562384220.

KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

Cheng Xu, Andrea Messina, Emmanuel Somm, Hichem Miraoui, Tarja Kinnunen, James Acierno, Jr, Nicolas J Niederländer, Justine Bouilly, Andrew A Dwyer, Yisrael Sidis, Daniele Cassatella, Gerasimos P Sykiotis, Richard Quinton, Christian De Geyter, Mirjam Dirlewanger, Valérie Schwitzgebel, Trevor R Cole, Andrew A Toogood, Jeremy MW Kirk, Lacey Plummer, Urs Albrecht, William F Crowley, Jr, Moosa Mohammadi, Manuel Tena‐Sempere, Vincent Prevot, Nelly Pitteloud

EMBO Mol Med. 2017 Oct; 9(10): 1379–1397. Published online 2017 Jul 28. doi: 10.15252/emmm.201607376

PMCID:: PMC5623842

Abstract Article PDF–2.4M

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