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Select item 70642011.

Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation

Yoshimasa Hamada, Yuji Furumoto, Akira Izutani, Shusuke Taniuchi, Masato Miyake, Miho Oyadomari, Kenji Teranishi, Naoyuki Shimomura, Seiichi Oyadomari

PLoS One. 2020; 15(3): e0229948. Published online 2020 Mar 10. doi: 10.1371/journal.pone.0229948

PMCID:: PMC7064201

Abstract Article PDF–1.6M

Select item 58209652.

The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking

Wael Bahnan, Justin C. Boucher, Petoria Gayle, Niraj Shrestha, Mark Rosen, Bertal Aktas, Becky Adkins, Arba Ager, Wasif N. Khan, Kurt Schesser

Infect Immun. 2018 Mar; 86(3): e00707-17. Prepublished online 2018 Jan 8. Published online 2018 Feb 20. doi: 10.1128/IAI.00707-17

PMCID:: PMC5820965

Abstract Article PDF–2.3M

Select item 57901263.

HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

Shuping Zhang, Alejandra Macias-Garcia, Jason Velazquez, Elena Paltrinieri, Randal J. Kaufman, Jane-Jane Chen

Blood. 2018 Jan 25; 131(4): 450–461. Prepublished online 2017 Nov 3. doi: 10.1182/blood-2017-08-799908

PMCID:: PMC5790126

Abstract Article

Select item 50722814.

Haem-regulated eIF2α kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency

Sijin Liu, Sanchita Bhattacharya, Anping Han, Rajasekhar N. V. S. Suragani, Wanting Zhao, Rebecca C. Fry, Jane-Jane Chen

Br J Haematol. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Br J Haematol. 2008 Oct; 143(1): 129–137. Published online 2008 Jul 28. doi: 10.1111/j.1365-2141.2008.07293.x

PMCID:: PMC5072281

Abstract Article PDF–1.3M

Select item 79489855.

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Tapas Mukherjee, Valeria Ramaglia, Mena Abdel-Nour, Athanasia A. Bianchi, Jessica Tsalikis, Hien N. Chau, Suneil K. Kalia, Lorraine V. Kalia, Jane-Jane Chen, Damien Arnoult, Jennifer L. Gommerman, Dana J. Philpott, Stephen E. Girardin

J Biol Chem. 2021 Jan-Jun; 296: 100050. Published online 2020 Dec 2. doi: 10.1074/jbc.RA120.014415

PMCID:: PMC7948985

Abstract Article PDF–2.9M

Select item 36210766.

Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE^−/− mice

Sijin Liu, Rajasekhar N.V.S. Suragani, Anping Han, Wanting Zhao, Nancy C. Andrews, Jane-Jane Chen

Haematologica. Author manuscript; available in PMC 2013 Apr 9.

Published in final edited form as: Haematologica. 2008 May; 93(5): 753–756. Published online 2008 Mar 26. doi: 10.3324/haematol.12175

PMCID:: PMC3621076

Abstract Article PDF–1.1M

Select item 1257537.

Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

An-Ping Han, Channing Yu, Linrong Lu, Yuko Fujiwara, Carol Browne, Gregory Chin, Mark Fleming, Philippe Leboulch, Stuart H. Orkin, Jane-Jane Chen

EMBO J. 2001 Dec 3; 20(23): 6909–6918. doi: 10.1093/emboj/20.23.6909

PMCID:: PMC125753

Abstract Article PDF–326K

Select item 80168978.

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase

Eva Ramos-Fernández, Macarena S. Arrázola, Carolina A. Oliva, Sebastián B. Arredondo, Lorena Varela-Nallar, Nibaldo C. Inestrosa

Sci Rep. 2021; 11: 7395. Published online 2021 Apr 1. doi: 10.1038/s41598-021-86708-y

PMCID:: PMC8016897

Abstract Article PDF–6.1M

Select item 72246989.

The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

Beatriz Alvarez-Castelao, Susanne tom Dieck, Claudia M Fusco, Paul Donlin-Asp, Julio D Perez, Erin M Schuman

eLife. 2020; 9: e52714. Published online 2020 Apr 24. doi: 10.7554/eLife.52714

PMCID:: PMC7224698

Abstract Article PDF–2.8M

Select item 336961610.

Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

Rajasekhar N. V. S. Suragani, Roshini S. Zachariah, Jason G. Velazquez, Sijin Liu, Chiao-Wang Sun, Tim M. Townes, Jane-Jane Chen

Blood. 2012 May 31; 119(22): 5276–5284. Prepublished online 2012 Apr 12. doi: 10.1182/blood-2011-10-388132

PMCID:: PMC3369616

Abstract Article

Select item 1043372911.

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

Mena Abdel-Nour, Leticia A. M. Carneiro, Jeffrey Downey, Jessica Tsalikis, Ahmed Outlioua, Dave Prescott, Leandro Silva Da Costa, Elise S. Hovingh, Armin Farahvash, Ryan G. Gaudet, Raphael Molinaro, Rob van Dalen, Charles C. Y. Lau, Farshad C. Azimi, Nichole K. Escalante, Aaron Trotman-Grant, Jeffrey E. Lee, Scott D. Gray-Owen, Maziar Divangahi, Jane-Jane Chen, Dana J. Philpott, Damien Arnoult, Stephen E. Girardin

Science. Author manuscript; available in PMC 2023 Aug 17.

Published in final edited form as: Science. 2019 Jul 5; 365(6448): eaaw4144. doi: 10.1126/science.aaw4144

PMCID:: PMC10433729

Abstract Article PDF–2.2M

Select item 729009712.

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood. 2020 Jun 11; 135(24): 2121–2132. Prepublished online 2020 Apr 16. doi: 10.1182/blood.2020005301

PMCID:: PMC7290097

Abstract Article

Select item 502575413.

Integrated stress response of vertebrates is regulated by four eIF2α kinases

Shusuke Taniuchi, Masato Miyake, Kazue Tsugawa, Miho Oyadomari, Seiichi Oyadomari

Sci Rep. 2016; 6: 32886. Published online 2016 Sep 16. doi: 10.1038/srep32886

PMCID:: PMC5025754

Abstract Article PDF–3.5M

Select item 200081114.

The function of heme-regulated eIF2α kinase in murine iron homeostasis and macrophage maturation

Sijin Liu, Rajasekhar N.V.S. Suragani, Fudi Wang, Anping Han, Wanting Zhao, Nancy C. Andrews, Jane-Jane Chen

J Clin Invest. 2007 Nov 1; 117(11): 3296–3305. Published online 2007 Oct 11. doi: 10.1172/JCI32084

PMCID:: PMC2000811

Abstract Article PDF–1.0M

Select item 685698515.

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Jane-Jane Chen, Shuping Zhang

Blood. 2019 Nov 14; 134(20): 1697–1707. Prepublished online 2019 Sep 25. doi: 10.1182/blood.2019001915

PMCID:: PMC6856985

Abstract Article

Select item 605142016.

ATF4 Regulates CD4⁺ T Cell Immune Responses through Metabolic Reprogramming

Xi Yang, Rui Xia, Cuihua Yue, Wensi Zhai, Wenwen Du, Qianting Yang, Huiling Cao, Xiaojuan Chen, Danielle Obando, Yibei Zhu, Xinchun Chen, Jane-Jane Chen, Jon Piganelli, Peter Wipf, Yu Jiang, Guozhi Xiao, Changping Wu, Jingting Jiang, Binfeng Lu

Cell Rep. Author manuscript; available in PMC 2018 Jul 18.

Published in final edited form as: Cell Rep. 2018 May 8; 23(6): 1754–1766. doi: 10.1016/j.celrep.2018.04.032

PMCID:: PMC6051420

Abstract Article PDF–960K

Select item 581272917.

UBE2O remodels the proteome during terminal erythroid differentiation

Anthony T. Nguyen, Miguel A. Prado, Paul J. Schmidt, Anoop T. Sendamarai, Joshua T. Wilson-Grady, Mingwei Min, Dean R. Campagna, Geng Tian, Yuan Shi, Verena Dederer, Mona Kawan, Nathalie Kuehnle, Joao A. Paulo, Yu Yao, Mitchell J. Weiss, Monica J. Justice, Steven P. Gygi, Mark D. Fleming, Daniel Finley

Science. Author manuscript; available in PMC 2018 Feb 14.

Published in final edited form as: Science. 2017 Aug 4; 357(6350): eaan0218. doi: 10.1126/science.aan0218

PMCID:: PMC5812729

Abstract Article PDF–1.2M

Select item 264412318.

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

Heather P. Harding, Yuhong Zhang, Donalyn Scheuner, Jane-Jane Chen, Randal J. Kaufman, David Ron

Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6): 1832–1837. Published online 2009 Jan 30. doi: 10.1073/pnas.0809632106

PMCID:: PMC2644123

Abstract Article PDF–2.0M

Select item 113699819.

Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia

An-Ping Han, Mark D. Fleming, Jane-Jane Chen

J Clin Invest. 2005 Jun 1; 115(6): 1562–1570. doi: 10.1172/JCI24141

PMCID:: PMC1136998

Abstract Article PDF–715K

Select item 347942920.

Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner

Tatiana Nedelko, Heike Kollmus, Frank Klawonn, Sabine Spijker, Lu Lu, Manuela Heßman, Rudi Alberts, Robert W Williams, Klaus Schughart

BMC Genomics. 2012; 13: 411. Published online 2012 Aug 20. doi: 10.1186/1471-2164-13-411

PMCID:: PMC3479429

Abstract Article PDF–1.9M

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