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Select item 106264521.

Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner

Front Immunol. 2023; 14: 1252874. Published online 2023 Oct 23. doi: 10.3389/fimmu.2023.1252874

PMCID:: PMC10626452

Abstract Article PDF–6.1M

Select item 103675502.

11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling

Hanwen Li, Sihan Hu, Runze Wu, Hongyou Zhou, Kai Zhang, Ke Li, Wenzheng Lin, Qin Shi, Hao Chen, Shan Lv

Int J Biol Sci. 2023; 19(11): 3628–3639. Published online 2023 Jul 15. doi: 10.7150/ijbs.82933

PMCID:: PMC10367550

Abstract Article PDF–8.3M

Select item 101724633.

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

Rahul Y. Mahida, Siân Lax, Christopher R. Bassford, Aaron Scott, Dhruv Parekh, Rowan S. Hardy, Babu Naidu, Michael A. Matthay, Paul M. Stewart, Mark C. Cooper, Gavin D. Perkins, David R. Thickett

Front Immunol. 2023; 14: 1159831. Published online 2023 Apr 27. doi: 10.3389/fimmu.2023.1159831

PMCID:: PMC10172463

Abstract Article PDF–3.5M

Select item 100270824.

11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

Justine M. Webster, Kelsy Waaijenberg, Wouter R. P. H. van de Worp, Marco C. J. M. Kelders, Sara Lambrichts, Claire Martin, Frank Verhaegen, Brent Van der Heyden, Charlotte Smith, Gareth G. Lavery, Annemie M. W. J. Schols, Rowan S. Hardy, Ramon C. J. Langen

Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1; 324(4): L400–L412. Published online 2023 Feb 21. doi: 10.1152/ajplung.00009.2022

PMCID:: PMC10027082

Abstract Article

Select item 95780885.

11β-HSD1 contributes to age-related metabolic decline in male mice

Stuart A Morgan, Laura L Gathercole, Zaki K Hassan-Smith, Jeremy Tomlinson, Paul M Stewart, Gareth G Lavery

J Endocrinol. 2022 Dec 1; 255(3): 117–129. Published online 2022 Oct 7. doi: 10.1530/JOE-22-0169

PMCID:: PMC9578088

Abstract Article PDF–1.0M

Select item 95568376.

Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

Elina Akalestou, Livia Lopez-Noriega, Ioannis Christakis, Ming Hu, Alexander D. Miras, Isabelle Leclerc, Guy A. Rutter

Front Endocrinol (Lausanne) 2022; 13: 1020576. Published online 2022 Sep 29. doi: 10.3389/fendo.2022.1020576

PMCID:: PMC9556837

Abstract Article PDF–6.7M

Select item 91349087.

The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1

Mengliang Hu, Tingting Han, Qiyu Pan, Dongsheng Ni, Fengyi Gao, Liying Wang, Hangjiang Ren, Xiaoyi Zhang, Haoyun Jiao, Yuefeng Wang, Dapeng Dai, Yong Man, Weiqing Tang, Yue Sun, Wei Li, Jian Li, Guoping Li

Int J Biol Sci. 2022; 18(8): 3107–3121. Published online 2022 Apr 30. doi: 10.7150/ijbs.42376

PMCID:: PMC9134908

Abstract Article PDF–3.2M

Select item 87900728.

Enhanced Angiogenesis by 11βHSD1 Blockage Is Insufficient to Improve Reperfusion Following Hindlimb Ischaemia

Junxi Wu, Eileen Miller, Callam Davidson, Brian R. Walker, Patrick W. F. Hadoke

Front Cardiovasc Med. 2021; 8: 795823. Published online 2022 Jan 12. doi: 10.3389/fcvm.2021.795823

PMCID:: PMC8790072

Abstract Article PDF–1.3M

Select item 66731519.

Enhanced Hippocampal Long-Term Potentiation and Spatial Learning in Aged 11β-Hydroxysteroid Dehydrogenase Type 1 Knock-Out Mice

Joyce L. W. Yau, Kara M. McNair, June Noble, David Brownstein, Carina Hibberd, Nik Morton, John J. Mullins, Richard G. M. Morris, Stuart Cobb, Jonathan R. Seckl

J Neurosci. 2007 Sep 26; 27(39): 10487–10496. doi: 10.1523/JNEUROSCI.2190-07.2007

PMCID:: PMC6673151

Abstract Article PDF–458K

Select item 644303910.

Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11βHydroxysteroid Dehydrogenase Type 1-Deficient Mice

Janice M. Paterson, Megan C. Holmes, Christopher J. Kenyon, Roderick Carter, John J. Mullins, Jonathan R. Seckl

Endocrinology. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Endocrinology. 2007 Mar; 148(3): 961–966. Published online 2006 Dec 14. doi: 10.1210/en.2006-0603

PMCID:: PMC6443039

Abstract Article PDF–1.2M

Select item 565382311.

11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner

L. Vandermosten, C. De Geest, S. Knoops, G. Thijs, K. E. Chapman, K. De Bosscher, G. Opdenakker, P. E. Van den Steen

Sci Rep. 2017; 7: 13835. Published online 2017 Oct 23. doi: 10.1038/s41598-017-14288-x

PMCID:: PMC5653823

Abstract Article PDF–1.6M

Select item 557430512.

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis

Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl, Karen E Chapman

J Endocrinol. 2017 Sep; 234(3): 291–299. Published online 2017 Jul 4. doi: 10.1530/JOE-17-0223

PMCID:: PMC5574305

Abstract Article PDF–2.5M

Select item 546093013.

11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice

Craig L. Doig, Rachel S. Fletcher, Stuart A. Morgan, Emma L. McCabe, Dean P. Larner, Jeremy W. Tomlinson, Paul M. Stewart, Andrew Philp, Gareth G. Lavery

Endocrinology. 2017 Jun 1; 158(6): 1964–1976. Published online 2017 Mar 27. doi: 10.1210/en.2016-1722

PMCID:: PMC5460930

Abstract Article

Select item 524468514.

Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice

S. Caughey, A. P. Harris, J. R. Seckl, M. C. Holmes, J. L. W. Yau

J Neuroendocrinol. 2017 Jan; 29(1): 10.1111/jne.12447. Published online 2017 Jan 9. doi: 10.1111/jne.12447

PMCID:: PMC5244685

Abstract Article PDF–533K

Select item 510791415.

11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes

Kesong Peng, Yong Pan, Jieli Li, Zia Khan, Mendi Fan, Haimin Yin, Chao Tong, Yunjie Zhao, Guang Liang, Chao Zheng

Sci Rep. 2016; 6: 37160. Published online 2016 Nov 14. doi: 10.1038/srep37160

PMCID:: PMC5107914

Abstract Article PDF–1.5M

Select item 486238016.

Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes: the role in narrow-band UVB-induced dermatitis

Saori Itoi-Ochi, Mika Terao, Hiroyuki Murota, Ichiro Katayama

Dermatoendocrinol. 2016 Jan-Dec; 8(1): e1119958. Published online 2016 Jan 5. doi: 10.1080/19381980.2015.1119958

PMCID:: PMC4862380

Abstract Article PDF–1.0M

Select item 481151517.

Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma

Xu Liu, Xiao-long Tan, Meng Xia, Chao Wu, Jia Song, Jing-jing Wu, Arian Laurence, Qing-guo Xie, Ming-zhi Zhang, Hui-fang Liang, Bi-xiang Zhang, Xiao-ping Chen

Oncotarget. 2016 Jan 12; 7(2): 2038–2053. Published online 2015 Dec 18. doi: 10.18632/oncotarget.6661