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Select item 64453561.

The Mother or the Fetus? 11β-Hydroxysteroid Dehydrogenase Type 2 Null Mice Provide Evidence for Direct Fetal Programming of Behavior by Endogenous Glucocorticoids

Megan C. Holmes, Christian T. Abrahamsen, Karen L. French, Janice M. Paterson, John J. Mullins, Jonathan R. Seckl

J Neurosci. 2006 Apr 5; 26(14): 3840–3844. doi: 10.1523/JNEUROSCI.4464-05.2006

PMCID:: PMC6445356

Abstract Article PDF–234K

Select item 64430402.

11ß-Hydroxysteroid Dehydrogenase Type 2 Protects the Neonatal Cerebellum From Deleterious Effects of Glucocorticoids

M. C. Holmes, M. Sangra, K. L. French, I. R. Whittle, J. Paterson, J. J. Mullins, J. R. Seckl

Neuroscience. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Neuroscience. 2006 Feb; 137(3): 865–873. Published online 2005 Nov 14. doi: 10.1016/j.neuroscience.2005.09.037

PMCID:: PMC6443040

Abstract Article PDF–1.9M

Select item 48303993.

Hsd11b2 HAPLOINSUFFICIENCY IN MICE CAUSES SALT-SENSITIVITY OF BLOOD PRESSURE

Matthew A. Bailey, Eilidh Craigie, Dawn E.W. Livingstone, Yuri V. Kotelevtsev, Emad A.S. Al-Dujaili, Christopher J. Kenyon, John J. Mullins

Hypertension. Author manuscript; available in PMC 2016 Apr 13.

Published in final edited form as: Hypertension. 2011 Mar; 57(3): 515–520. Published online 2011 Jan 31. doi: 10.1161/HYPERTENSIONAHA.110.163782

PMCID:: PMC4830399

Abstract Article PDF–589K

Select item 48197724.

Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension

Louise C. Evans, Jessica R. Ivy, Caitlin Wyrwoll, Julie A. McNairn, Robert I. Menzies, Thorbjørn H. Christensen, Emad A.S. Al-Dujaili, Christopher J. Kenyon, John J. Mullins, Jonathan R. Seckl, Megan C. Holmes, Matthew A. Bailey

Circulation. 2016 Apr 5; 133(14): 1360–1370. Published online 2016 Apr 4. doi: 10.1161/CIRCULATIONAHA.115.019341

PMCID:: PMC4819772

Abstract Article PDF–863K

Select item 34286285.

Failure to down-regulate the epithelial sodium channel causes salt-sensitivity in Hsd11b2 heterozygote mice

Eilidh Craigie, Louise C Evans, John J Mullins, Matthew A Bailey

Hypertension. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Hypertension. 2012 Sep; 60(3): 684–690. Published online 2012 Jul 9. doi: 10.1161/HYPERTENSIONAHA.112.196410

PMCID:: PMC3428628

Abstract Article PDF–621K

Select item 34231126.

A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice

Louise C. Evans, Dawn E. Livingstone, Christopher J. Kenyon, Maurits A. Jansen, James W. Dear, John J. Mullins, Matthew A. Bailey

Am J Physiol Renal Physiol. 2012 Aug 15; 303(4): F494–F502. Published online 2012 May 23. doi: 10.1152/ajprenal.00165.2012

PMCID:: PMC3423112

Abstract Article

Select item 33836837.

Epigenetic Effects of Prenatal Stress on 11β-Hydroxysteroid Dehydrogenase-2 in the Placenta and Fetal Brain

Catherine Jensen Peña, Catherine Monk, Frances A. Champagne

PLoS One. 2012; 7(6): e39791. Published online 2012 Jun 26. doi: 10.1371/journal.pone.0039791

PMCID:: PMC3383683

Abstract Article PDF–998K

Select item 31142798.

Glucocorticoid receptor stimulation and the regulation of neonatal cerebellar neural progenitor cell apoptosis

Kevin K. Noguchi, Karen Lau, Derek J. Smith, Brant S. Swiney, Nuri B. Farber

Neurobiol Dis. Author manuscript; available in PMC 2012 Aug 1.

Published in final edited form as: Neurobiol Dis. 2011 Aug; 43(2): 356–363. Published online 2011 Apr 20. doi: 10.1016/j.nbd.2011.04.004

PMCID:: PMC3114279

Abstract Article PDF–389K

Select item 4081189.

Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2

Yuri Kotelevtsev, Roger W. Brown, Stewart Fleming, Christopher Kenyon, Christopher R.W. Edwards, Jonathan R. Seckl, John J. Mullins

J Clin Invest. 1999 Mar 1; 103(5): 683–689. doi: 10.1172/JCI4445

PMCID:: PMC408118

Abstract Article PDF–381K

Select item 397704210.

11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes pro-inflammatory changes in the endothelium in Apoe^−/− mice

Graeme A Deuchar, Danielle McLean, Patrick W.F. Hadoke, David G Brownstein, David J Webb, John J Mullins, Karen Chapman, Jonathan R Seckl, Yuri V Kotelevtsev

Endocrinology. Author manuscript; available in PMC 2014 Apr 7.

Published in final edited form as: Endocrinology. 2011 Jan; 152(1): 236–246. Published online 2010 Nov 24. doi: 10.1210/en.2010-0925

PMCID:: PMC3977042

Abstract Article PDF–4.9M

Select item 377807311.

Epithelial 11β-hydroxysteroid dehydrogenase type II deletion inhibits Apc^+/min mouse tumorigenesis via COX-2 pathway inhibition and induction of G1 cell cycle arrest

Li Jiang, Shilin Yang, Huiyong Yin, Xiaofeng Fan, Suwan Wang, Bing Yao, Ambra Pozzi, Xiaoping Chen, Raymond C Harris, Ming-Zhi Zhang

Mol Cancer Res. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Mol Cancer Res. 2013 Sep; 11(9): 1040–1050. Published online 2013 Jun 5. doi: 10.1158/1541-7786.MCR-13-0084-T

PMCID:: PMC3778073

Abstract Article PDF–2.2M

Select item 328109612.

Lack of Renal 11 Beta-Hydroxysteroid Dehydrogenase Type 2 at Birth, a Targeted Temporal Window for Neonatal Glucocorticoid Action in Human and Mice

Laetitia Martinerie, Eric Pussard, Geri Meduri, Anne-Lise Delezoide, Pascal Boileau, Marc Lombès

PLoS One. 2012; 7(2): e31949. Published online 2012 Feb 16. doi: 10.1371/journal.pone.0031949

PMCID:: PMC3281096

Abstract Article PDF–773K

Select item 327973713.

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Agnes E. Coutinho, Mohini Gray, David G. Brownstein, Donald M. Salter, Deborah A. Sawatzky, Spike Clay, James S. Gilmour, Jonathan R. Seckl, John S. Savill, Karen E. Chapman

Endocrinology. 2012 Jan; 153(1): 234–240. Published online 2011 Nov 8. doi: 10.1210/en.2011-1398

PMCID:: PMC3279737

Abstract Article

Select item 319614214.

Ligand-receptor Interaction between Triterpenoids and the 11β-Hydroxysteroid dehydrogenase type 2 (11βHSD2) Enzyme Predicts Their Toxic Effects against Tumorigenic r/m HM-SFME-1 Cells

Hideaki Yamaguchi, Tao Yu, Toshiro Noshita, Yumi Kidachi, Katsuyoshi Kamiie, Kenji Yoshida, Tatsuo Akitaya, Hironori Umetsu, Kazuo Ryoyama

J Biol Chem. 2011 Oct 21; 286(42): 36888–36897. Published online 2011 Aug 31. doi: 10.1074/jbc.M111.265900

PMCID:: PMC3196142

Abstract Article PDF–2.1M

Select item 292614615.

Col3.6-HSD2 Transgenic Mice: A Glucocorticoid Loss-of-Function Model Spanning Early and Late Osteoblast Differentiation

Maobin Yang, Lorin B. Trettel, Douglas J. Adams, John R. Harrison, Ernesto Canalis, Barbara E. Kream

Bone. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Bone. 2010 Sep; 47(3): 573–582. Published online 2010 Jun 9. doi: 10.1016/j.bone.2010.06.002

PMCID:: PMC2926146

Abstract Article PDF–1.0M

Select item 239103116.

A Switch in the Mechanism of Hypertension in the Syndrome of Apparent Mineralocorticoid Excess

Matthew A. Bailey, Janice M. Paterson, Patrick W.F. Hadoke, Nicola Wrobel, Christopher O.C. Bellamy, David G. Brownstein, Jonathan R. Seckl, John J. Mullins

J Am Soc Nephrol. 2008 Jan; 19(1): 47–58. doi: 10.1681/ASN.2007040401

PMCID:: PMC2391031

Abstract Article

Select item 798877517.

Pre-locus coeruleus neurons in rat and mouse

Silvia Gasparini, Jon M. Resch, Anuradha M. Gore, Lila Peltekian, Joel C. Geerling

Am J Physiol Regul Integr Comp Physiol. 2021 Mar 1; 320(3): R342–R361. Published online 2020 Dec 9. doi: 10.1152/ajpregu.00261.2020

PMCID:: PMC7988775

Abstract Article

Select item 650385118.

Cilia-associated oxysterols activate Smoothened

David R. Raleigh, Navdar Sever, Pervinder K. Choksi, Monika Abedin Sigg, Kelly M. Hines, Bonne M. Thompson, Daniel Elnatan, Priyadarshini Jaishankar, Paola Bisignano, Francesc R. Garcia-Gonzalo, Alexis Leigh Krup, Markus Eberl, Sunny Y. Wong, Adam R. Renslo, Michael Grabe, Jeffrey G. McDonald, Libin Xu, Philip A. Beachy, Jeremy F. Reiter

Mol Cell. Author manuscript; available in PMC 2019 May 7.

Published in final edited form as: Mol Cell. 2018 Oct 18; 72(2): 316–327.e5. doi: 10.1016/j.molcel.2018.08.034