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Select item 80406031.

CD11c⁺CD88⁺CD317⁺ myeloid cells are critical mediators of persistent CNS autoimmunity

Navid Manouchehri, Rehana Z. Hussain, Petra D. Cravens, Ekaterina Esaulova, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Anne H. Cross, Richard Doelger, Nicolas Loof, Todd N. Eagar, Thomas G. Forsthuber, Laurent Calvier, Joachim Herz, Olaf Stüve

Proc Natl Acad Sci U S A. 2021 Apr 6; 118(14): e2014492118. Published online 2021 Mar 30. doi: 10.1073/pnas.2014492118

PMCID:: PMC8040603

Abstract Article PDF–1.2M

Select item 77618352.

Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4–Integrin Deficient NOD Mouse

Salim Oulghazi, Sarah K. Wegner, Gabriele Spohn, Nina Müller, Sabine Harenkamp, Albrecht Stenzinger, Thalia Papayannopoulou, Halvard Bonig

Cells. 2020 Dec; 9(12): 2597. Published online 2020 Dec 4. doi: 10.3390/cells9122597

PMCID:: PMC7761835

Abstract Article PDF–3.1M

Select item 71086293.

The role of α4 integrin in Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS)

Yuta Hirano, Kunitoshi Kobayashi, Hiroki Tomiki, Yuhji Inaba, Motoki Ichikawa, Byung S. Kim, Chang-Sung Koh

Int Immunol. 2016 Nov 1 : dxw045. Published online 2016 Nov 1. doi: 10.1093/intimm/dxw045

PMCID:: PMC7108629

Abstract PDF–1.6M

Select item 50796334.

Enhanced Integrin α4β1–Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes

Wesley T. Abplanalp, Daniel J. Conklin, Joseph M. Cantor, Mark H. Ginsberg, Marcin Wysoczynski, Aruni Bhatnagar, Timothy E. O’Toole

Diabetes. 2016 Nov; 65(11): 3505–3515. Published online 2016 Aug 5. doi: 10.2337/db16-0634

PMCID:: PMC5079633

Abstract Article PDF–1.5M

Select item 48686625.

Integrin alpha-4 is required for regulatory B cell control of experimental autoimmune encephalomyelitis

Simon Glatigny, Catriona A. Wagner, Estelle Bettelli

J Immunol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: J Immunol. 2016 May 1; 196(9): 3542–3546. Published online 2016 Mar 25. doi: 10.4049/jimmunol.1502614

Correction in:: J Immunol. 2017 May 1; 198(9): 3756.

PMCID:: PMC4868662

Abstract Article PDF–775K

Select item 40474066.

The Novel α4B Murine α4 Integrin Protein Splicing Variant Inhibits α4 Protein-dependent Cell Adhesion

Hitomi Kouro, Shigeyuki Kon, Naoki Matsumoto, Tomoe Miyashita, Ayaka Kakuchi, Dai Ashitomi, Kodai Saitoh, Takuya Nakatsuru, Sumihito Togi, Ryuta Muromoto, Tadashi Matsuda

J Biol Chem. 2014 Jun 6; 289(23): 16389–16398. Published online 2014 Apr 22. doi: 10.1074/jbc.M114.553610

PMCID:: PMC4047406

Abstract Article PDF–2.1M

Select item 37606087.

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces

Wei-Chien Hung, Shih-Hsun Chen, Colin D. Paul, Kimberly M. Stroka, Ying-Chun Lo, Joy T. Yang, Konstantinos Konstantopoulos

J Cell Biol. 2013 Sep 2; 202(5): 807–824. doi: 10.1083/jcb.201302132

PMCID:: PMC3760608

Abstract Article PDF–5.1M

Select item 37059058.

Distinct changes in adult lymphopoiesis in Rag2^−/− mice fully reconstituted by α4-deficient adult bone marrow cells

Ena R. Banerjee, Yvette E. Latchman, Yi Jiang, Greg V. Priestley, Thalia Papayannopoulou

Exp Hematol. Author manuscript; available in PMC 2013 Jul 9.

Published in final edited form as: Exp Hematol. 2008 Aug; 36(8): 1004–1013. Published online 2008 May 12. doi: 10.1016/j.exphem.2008.03.008

PMCID:: PMC3705905

Abstract Article PDF–588K

Select item 35918009.

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

Yao-Te Hsieh, Eun Ji Gang, Huimin Geng, Eugene Park, Sandra Huantes, Doreen Chudziak, Katrin Dauber, Paul Schaefer, Carlton Scharman, Hiroyuki Shimada, Seyedmehdi Shojaee, Lars Klemm, Reshmi Parameswaran, Mignon Loh, Eun-Suk Kang, Hong Hoe Koo, Wolf-Karsten Hofmann, Jacob Andrade, Gay M. Crooks, Cheryl L. Willman, Markus Müschen, Thalia Papayannopoulou, Nora Heisterkamp, Halvard Bönig, Yong-Mi Kim

Blood. 2013 Mar 7; 121(10): 1814–1818. Prepublished online 2013 Jan 14. doi: 10.1182/blood-2012-01-406272

PMCID:: PMC3591800

Abstract Article

Select item 324944610.

Combined blockade of integrin α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth

Michael C. Schmid, Christie J. Avraamides, Philippe Foubert, Yuval Shaked, Sang-Won Kang, Robert S. Kerbel, Judith A. Varner

Cancer Res. Author manuscript; available in PMC 2012 Nov 15.

Published in final edited form as: Cancer Res. 2011 Nov 15; 71(22): 6965–6975. Published online 2011 Sep 23. doi: 10.1158/0008-5472.CAN-11-0588

PMCID:: PMC3249446

Abstract Article PDF–7.4M

Select item 281435511.

Constitutive Expression of the α₄ Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma

Robert B Rebhun, Hua Cheng, Jeffrey E Gershenwald, Dominic Fan, Isaiah J Fidler, Robert R Langley

Neoplasia. 2010 Feb; 12(2): 173–182. doi: 10.1593/neo.91604

PMCID:: PMC2814355

Abstract Article PDF–3.5M

Select item 272741812.

BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells

Pablo Ramirez, Michael P. Rettig, Geoffrey L. Uy, Elena Deych, Matthew S. Holt, Julie K. Ritchey, John F. DiPersio

Blood. 2009 Aug 13; 114(7): 1340–1343. Prepublished online 2009 Jul 1. doi: 10.1182/blood-2008-10-184721

PMCID:: PMC2727418

Abstract Article

Select item 259760613.

Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates α₄ integrins

Yoichi Imai, Eun Jeong Park, Dan Peer, António Peixoto, Guiying Cheng, Ulrich H. von Andrian, Christopher V. Carman, Motomu Shimaoka

Blood. 2008 Dec 15; 112(13): 5007–5015. Prepublished online 2008 Sep 22. doi: 10.1182/blood-2008-03-144543

PMCID:: PMC2597606

Abstract Article

Select item 252555814.

Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties

Eric T. Clambey, Janice White, John W. Kappler, Philippa Marrack

Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35): 12997–13002. Published online 2008 Aug 26. doi: 10.1073/pnas.0805465105

PMCID:: PMC2525558

Abstract Article PDF–825K

Select item 227609315.

Activated α4 Integrins are Preferentially Expressed on Immature Thymocytes and Activated T Cells

Fengyu Shu, Bernhard Holzmann, Frank Seibold, David Erle, John F. Kearney

Dev Immunol. 2002 Jun; 9(2): 73–84. doi: 10.1080/1044667021000024229

PMCID:: PMC2276093

Summary PDF–568K

Select item 223406716.

Enucleation of primitive erythroid cells generates a transient population of “pyrenocytes” in the mammalian fetus

Kathleen E. McGrath, Paul D. Kingsley, Anne D. Koniski, Rebecca L. Porter, Timothy P. Bushnell, James Palis

Blood. 2008 Feb 15; 111(4): 2409–2417. Prepublished online 2007 Nov 21. doi: 10.1182/blood-2007-08-107581

PMCID:: PMC2234067

Abstract Article

Select item 211806517.

Functional disruption of α4 integrin mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization

Gangjian Qin, Masaaki Ii, Marcy Silver, Andrea Wecker, Evelyn Bord, Hong Ma, Mary Gavin, David A. Goukassian, Young-sup Yoon, Thalia Papayannopoulou, Takayuki Asahara, Marianne Kearney, Tina Thorne, Cynthia Curry, Liz Eaton, Lindsay Heyd, Deepika Dinesh, Raj Kishore, Yan Zhu, Douglas W. Losordo

J Exp Med. 2006 Jan 23; 203(1): 153–163. doi: 10.1084/jem.20050459

PMCID:: PMC2118065

Abstract Article PDF–4.9M

Select item 195548118.

Role of Very-late Antigen-4 (VLA-4) in Myelin Basic Protein-primed T Cell Contact-induced Expression of Proinflammatory Cytokines in Microglial Cells

Subhajit Dasgupta, Malabendu Jana, Xiaojuan Liu, Kalipada Pahan

J Biol Chem. Author manuscript; available in PMC 2007 Aug 28.

Published in final edited form as: J Biol Chem. 2003 Jun 20; 278(25): 22424–22431. Published online 2003 Apr 10. doi: 10.1074/jbc.M301789200

PMCID:: PMC1955481

Abstract Article PDF–484K

Select item 189539219.

Lack of α4 integrin expression in stem cells restricts competitive function and self-renewal activity

Gregory V. Priestley, Linda M. Scott, Tatiana Ulyanova, Thalia Papayannopoulou

Blood. 2006 Apr 1; 107(7): 2959–2967. Prepublished online 2005 Dec 15. doi: 10.1182/blood-2005-07-2670

PMCID:: PMC1895392

Abstract Article

Select item 136134820.

Blocking the α4 integrinαpaxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

Chloé C. Féral, David M. Rose, Jaewon Han, Norma Fox, Gregg J. Silverman, Kenneth Kaushansky, Mark H. Ginsberg

J Clin Invest. 2006 Mar 1; 116(3): 715–723. Published online 2006 Feb 9. doi: 10.1172/JCI26091

PMCID:: PMC1361348

Abstract Article PDF–1.0M

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