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Select item 99324611.

Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1

Yudai Iino, Tatsuro Naganuma, Makoto Arita

J Lipid Res. 2023 Feb; 64(2): 100329. Published online 2023 Jan 11. doi: 10.1016/j.jlr.2023.100329

PMCID:: PMC9932461

Abstract Article PDF–2.1M

Select item 87618582.

Autoinflammatory Keratinization Disease With Hepatitis and Autism Reveals Roles for JAK1 Kinase Hyperactivity in Autoinflammation

Takuya Takeichi, John Y. W. Lee, Yusuke Okuno, Yuki Miyasaka, Yuya Murase, Takenori Yoshikawa, Kana Tanahashi, Emi Nishida, Tatsuya Okamoto, Komei Ito, Yoshinao Muro, Kazumitsu Sugiura, Tamio Ohno, John A. McGrath, Masashi Akiyama

Front Immunol. 2021; 12: 737747. Published online 2022 Jan 3. doi: 10.3389/fimmu.2021.737747

PMCID:: PMC8761858

Abstract Article PDF–4.0M

Select item 85888003.

Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes

John D. Nowery, Rylee N. Cisney, Jacob W. Feldmann, Gordon P. Meares

ASN Neuro. 2021 Jan-Dec; 13: 17590914211033650. Published online 2021 Sep 9. doi: 10.1177/17590914211033650

PMCID:: PMC8588800

Abstract Article PDF–2.7M

Select item 65766904.

Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system

X Yang, D Chung, CL Cepko

J Neurosci. 1993 Jul 1; 13(7): 3006–3017. doi: 10.1523/JNEUROSCI.13-07-03006.1993

PMCID:: PMC6576690

Abstract PDF–2.3M

Select item 63896275.

Genome-Wide CRISPR Screening Identifies JAK1 Deficiency as a Mechanism of T-Cell Resistance

Ping Han, Qiang Dai, Lilv Fan, Hao Lin, Xiaoqing Zhang, Fanlin Li, Xuanming Yang

Front Immunol. 2019; 10: 251. Published online 2019 Feb 19. doi: 10.3389/fimmu.2019.00251

PMCID:: PMC6389627

Abstract Article PDF–4.8M

Select item 89819416.

Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2

Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong, Aimin Li

J Transl Med. 2022; 20: 157. Published online 2022 Apr 5. doi: 10.1186/s12967-022-03366-y

PMCID:: PMC8981941

Abstract Article PDF–16M

Select item 72489727.

Banhahubak-Tang Tablet, a Standardized Medicine Attenuates Allergic Asthma via Inhibition of Janus Kinase 1 (JAK1)/ Signal Transducer and Activator of Transcription 6 (STAT6) Signal Pathway

Yeon Kyung Nam, Seong Chul Jin, Mi Hye Kim, La Yoon Choi, Yong-Bok Lee, Woong Mo Yang

Molecules. 2020 May; 25(9): 2206. Published online 2020 May 8. doi: 10.3390/molecules25092206

PMCID:: PMC7248972

Abstract Article PDF–6.6M

Select item 69881318.

Generation of Janus kinase 1 (JAK1) conditional knockout mice

Kazuhito Sakamoto, Barbara L. Wehde, Patrick D. Rädler, Aleata A. Triplett, Kay-Uwe Wagner

Genesis. Author manuscript; available in PMC 2020 Jan 29.

Published in final edited form as: Genesis. 2016 Nov; 54(11): 582–588. Published online 2016 Oct 19. doi: 10.1002/dvg.22982

PMCID:: PMC6988131

Abstract Article PDF–722K

Select item 64310849.

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

Barbara L. Wehde, Patrick D. Rädler, Hridaya Shrestha, Stevi J. Johnson, Aleata A. Triplett, Kay-Uwe Wagner

Cell Rep. Author manuscript; available in PMC 2019 Mar 23.

Published in final edited form as: Cell Rep. 2018 Nov 20; 25(8): 2192–2207.e5. doi: 10.1016/j.celrep.2018.10.063

PMCID:: PMC6431084

Abstract Article PDF–3.9M

Select item 488716510.

Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis

Takuwa Yasuda, Toshiyuki Fukada, Keigo Nishida, Manabu Nakayama, Masashi Matsuda, Ikuo Miura, Teruki Dainichi, Shinji Fukuda, Kenji Kabashima, Shinji Nakaoka, Bum-Ho Bin, Masato Kubo, Hiroshi Ohno, Takanori Hasegawa, Osamu Ohara, Haruhiko Koseki, Shigeharu Wakana, Hisahiro Yoshida

J Clin Invest. 2016 Jun 1; 126(6): 2064–2076. Published online 2016 Apr 25. doi: 10.1172/JCI82887

PMCID:: PMC4887165

Abstract Article PDF–5.7M

Select item 486741611.

Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice

Ira J. Smith, Brandon Roberts, Adam Beharry, Guillermo L. Godinez, Donald G. Payan, Todd M. Kinsella, Andrew R. Judge, Leonardo F. Ferreira

Am J Physiol Regul Integr Comp Physiol. 2016 Apr 15; 310(8): R707–R710. Published online 2016 Feb 10. doi: 10.1152/ajpregu.00550.2015

PMCID:: PMC4867416

Abstract Article

Select item 397227712.

JAK1/3 signaling pathways are key initiators of T_H2 differentiation and lung allergic responses

Shigeru Ashino, Katsuyuki Takeda, Hui Li, Vanessa Taylor, Anthony Joetham, Polly R. Pine, Erwin W. Gelfand

J Allergy Clin Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: J Allergy Clin Immunol. 2014 Apr; 133(4): 1162–1174.e4. Published online 2013 Dec 22. doi: 10.1016/j.jaci.2013.10.036

PMCID:: PMC3972277

Abstract Article PDF–1.4M

Select item 310564613.

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors

Tekla Hornakova, Lorraine Springuel, Julien Devreux, Alexandra Dusa, Stefan N. Constantinescu, Laurent Knoops, Jean-Christophe Renauld

Haematologica. 2011 Jun; 96(6): 845–853. Published online 2011 Mar 10. doi: 10.3324/haematol.2010.036350

PMCID:: PMC3105646

Abstract Article PDF–753K

Select item 229221514.

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

Elisabetta Flex, Valentina Petrangeli, Lorenzo Stella, Sabina Chiaretti, Tekla Hornakova, Laurent Knoops, Cristina Ariola, Valentina Fodale, Emmanuelle Clappier, Francesca Paoloni, Simone Martinelli, Alessandra Fragale, Massimo Sanchez, Simona Tavolaro, Monica Messina, Giovanni Cazzaniga, Andrea Camera, Giovanni Pizzolo, Assunta Tornesello, Marco Vignetti, Angela Battistini, Hélène Cavé, Bruce D. Gelb, Jean-Christophe Renauld, Andrea Biondi, Stefan N. Constantinescu, Robin Foà, Marco Tartaglia

J Exp Med. 2008 Apr 14; 205(4): 751–758. doi: 10.1084/jem.20072182

PMCID:: PMC2292215

Abstract Article PDF–2.1M

Select item 39840315.

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

C Pallard, F Gouilleux, L Bénit, L Cocault, M Souyri, D Levy, B Groner, S Gisselbrecht, I Dusanter-Fourt

EMBO J. 1995 Jun 15; 14(12): 2847–2856. doi: 10.1002/j.1460-2075.1995.tb07284.x

PMCID:: PMC398403

Summary Page Browse PDF–2.4M

Select item 1114696016.

The Janus kinase family of protein tyrosine kinases and their role in signaling

T. C. Yeh, S. Pellegrini

Cell Mol Life Sci. 1999 Sep; 55(12): 1523–1534. doi: 10.1007/s000180050392

PMCID:: PMC11146960

Abstract PDF–790K

Select item 1107223717.

Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling

Jishou Zhang, Yao Xu, Cheng Wei, Zheng Yin, Wei Pan, Mengmeng Zhao, Wen Ding, Shuwan Xu, Jianfang Liu, Junping Yu, Jing Ye, Di Ye, Juan-Juan Qin, Jun Wan, Menglong Wang

Cell Mol Life Sci. 2023 Nov; 80(11): 324. Published online 2023 Oct 12. doi: 10.1007/s00018-023-04974-7

PMCID:: PMC11072237

Abstract Article PDF–17M

Select item 610888818.

Aloin suppresses lipopolysaccharide-induced inflammation by inhibiting JAK1-STAT1/3 activation and ROS production in RAW264.7 cells

Yunfei Ma, Tuo Tang, Lili Sheng, Ziqian Wang, Hong Tao, Qing Zhang, Yao Zhang, Zhilin Qi

Int J Mol Med. 2018 Oct; 42(4): 1925–1934. Published online 2018 Jul 31. doi: 10.3892/ijmm.2018.3796

PMCID:: PMC6108888

Abstract Article PDF–1.0M

Select item 600813519.

Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair

Huiyan Jin, Andrzej K. Ciechanowicz, Alanna R. Kaplan, Lin Wang, Ping-Xia Zhang, Yi-Chien Lu, Rachel E. Tobin, Brooke A. Tobin, Lauren Cohn, Caroline J. Zeiss, Patty J. Lee, Emanuela M. Bruscia, Diane S. Krause

Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314(5): L882–L892. Published online 2018 Jan 18. doi: 10.1152/ajplung.00418.2017

PMCID:: PMC6008135

Abstract Article

Select item 535447720.

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

Liu-Ya Tang, Mary Heller, Zhaojing Meng, Li-Rong Yu, Yi Tang, Ming Zhou, Ying E. Zhang

J Biol Chem. 2017 Mar 10; 292(10): 4302–4312. Published online 2017 Jan 31. doi: 10.1074/jbc.M116.773085

PMCID:: PMC5354477

Abstract Article PDF–2.5M

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