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Select item 112037231.

Unique Splicing of Lrp5 in the Brain: A New Player in Neurodevelopment and Brain Maturation

Aureli Luquero, Noelia Pimentel, Gemma Vilahur, Lina Badimon, Maria Borrell-Pages

Int J Mol Sci. 2024 Jun; 25(12): 6763. Published online 2024 Jun 20. doi: 10.3390/ijms25126763

PMCID:: PMC11203723

Abstract Article PDF–1.7M

Select item 110041782.

Wenwen Tang, Yi Luan, Qianying Yuan, Ao Li, Song Chen, Stanley Menacherry, Lawrence Young, Dianqing Wu

Nat Commun. 2024; 15: 3068. Published online 2024 Apr 9. doi: 10.1038/s41467-024-47262-z

PMCID:: PMC11004178

Abstract Article PDF–14M

Select item 103303843.

The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration

Hakan Turkkahraman, Shannan Flanagan, Tianli Zhu, Teresita M. Bellido, Xue Yuan

J Periodontal Res. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Periodontal Res. 2023 Aug; 58(4): 723–732. Published online 2023 May 2. doi: 10.1111/jre.13130

PMCID:: PMC10330384

Abstract Article PDF–1.9M

Select item 90978344.

LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway

Huixing Zhou, Fulei Zhang, Yahan Wu, Hongyu Liu, Ran Duan, Yuanyuan Liu, Yan Wang, Xiaoyu He, Yuemei Zhang, Xiue Ma, Yi Guan, Yi Liu, Dandan Liang, Liping Zhou, Yi‐Han Chen

J Cell Mol Med. 2022 May; 26(10): 2981–2994. Published online 2022 Apr 16. doi: 10.1111/jcmm.17311

PMCID:: PMC9097834

Abstract Article PDF–6.3M

Select item 88048545.

The Effect of Overexpression of Lrp5 on the Temporomandibular Joint

Achint Utreja, Hengameh Motevasel, Carol Bain, Robert Holland, Alexander Robling

Cartilage. 2021 Dec; 13(2 Suppl): 419S–426S. Published online 2020 Oct 30. doi: 10.1177/1947603520968875

PMCID:: PMC8804854

Abstract Article PDF–5.9M

Select item 73766976.

HBM MICE HAVE ALTERED BONE MATRIX COMPOSITION AND IMPROVED MATERIAL TOUGHNESS

Ryan D. Ross, Maleeha Mashiatulla, Alvin S. Acerbo, Jonathan D. Almer, Lisa M. Miller, Mark L. Johnson, D. Rick Sumner

Calcif Tissue Int. Author manuscript; available in PMC 2020 Jul 23.

Published in final edited form as: Calcif Tissue Int. 2016 Oct; 99(4): 384–395. Published online 2016 May 26. doi: 10.1007/s00223-016-0154-2

PMCID:: PMC7376697

Abstract Article PDF–966K

Select item 63601257.

Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism.

Kyung Shin Kang, Jung Min Hong, Daniel J. Horan, Kyung-Eun Lim, Whitney A. Bullock, Angela Bruzzaniti, Steven Hann, Matthew L. Warman, Alexander G. Robling

Bone. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Bone. 2019 Mar; 120: 166–175. Published online 2018 Oct 25. doi: 10.1016/j.bone.2018.10.007

PMCID:: PMC6360125

Abstract Article PDF–1.9M

Select item 53604548.

A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density

Jeremy R. Charette, Sarah E. Earp, Brent A. Bell, Cheryl L. Ackert-Bicknell, Dana A. Godfrey, Sujata Rao, Bela Anand-Apte, Patsy M. Nishina, Neal S. Peachey

Mol Vis. 2017; 23: 140–148. Published online 2017 Mar 18.

PMCID:: PMC5360454

Abstract Article PDF–1.3M

Select item 52229849.

Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy

Zhongxiao Wang, Chi-Hsiu Liu, Ye Sun, Yan Gong, Tara L. Favazza, Peyton C. Morss, Nicholas J. Saba, Thomas W. Fredrick, Xi He, James D. Akula, Jing Chen

Am J Pathol. 2016 Oct; 186(10): 2588–2600. doi: 10.1016/j.ajpath.2016.06.015

PMCID:: PMC5222984

Abstract Article PDF–2.6M

Select item 439519110.

LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice

Maria Borrell-Pagès, July Carolina Romero, Lina Badimon

J Cell Mol Med. 2015 Apr; 19(4): 770–777. Published online 2015 Feb 5. doi: 10.1111/jcmm.12396

PMCID:: PMC4395191

Abstract Article PDF–687K

Select item 401414611.

Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines

Chunfang Zhang, Jinyong Peng, Shan Wu, Yue Jin, Fan Xia, Changyuan Wang, Kexin Liu, Huijun Sun, Mozhen Liu

J Biomed Sci. 2014; 21(1): 30. Published online 2014 Apr 17. doi: 10.1186/1423-0127-21-30

PMCID:: PMC4014146

Abstract Article PDF–1.8M

Select item 378426212.

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner

Paul J. Niziolek, Matthew L. Warman, Alexander G. Robling

Bone. Author manuscript; available in PMC 2013 Sep 26.

Published in final edited form as: Bone. 2012 Sep; 51(3): 459–465. Published online 2012 Jun 28. doi: 10.1016/j.bone.2012.05.023

PMCID:: PMC3784262

Abstract Article PDF–683K

Select item 374309913.

An RNA-seq Protocol to Identify mRNA Expression Changes in Mouse Diaphyseal Bone: Applications in Mice with Bone Property Altering Lrp5 Mutations

Ugur M. Ayturk, Christina M. Jacobsen, Danos C. Christodoulou, Joshua Gorham, Jonathan G. Seidman, Christine E. Seidman, Alexander G. Robling, Matthew L. Warman

J Bone Miner Res. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: J Bone Miner Res. 2013 Oct; 28(10): 2081–2093. doi: 10.1002/jbmr.1946

PMCID:: PMC3743099

Abstract Article PDF–2.1M

Select item 360222614.

Inactivation of Lrp5 in Osteocytes Reduces Young’s Modulus and Responsiveness to the Mechanical Loading

Liming Zhao, Joon W. Shim, Todd R. Dodge, Alexander G. Robling, Hiroki Yokota

Bone. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Bone. 2013 May; 54(1): 35–43. Published online 2013 Jan 26. doi: 10.1016/j.bone.2013.01.033

PMCID:: PMC3602226

Abstract Article PDF–4.0M

Select item 334232215.

Lrp5 Is Not Required for the Proliferative Response of Osteoblasts to Strain but Regulates Proliferation and Apoptosis in a Cell Autonomous Manner

Behzad Javaheri, Andrew Sunters, Gul Zaman, Rosemary F. L. Suswillo, Leanne K. Saxon, Lance E. Lanyon, Joanna S. Price

PLoS One. 2012; 7(5): e35726. Published online 2012 May 2. doi: 10.1371/journal.pone.0035726

PMCID:: PMC3342322

Abstract Article PDF–1.0M

Select item 332094816.

Cross-talk between Insulin and Wnt Signaling in Preadipocytes: ROLE OF WNT CO-RECEPTOR LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5 (LRP5)

Jane Palsgaard, Brice Emanuelli, Jonathon N. Winnay, Grzegorz Sumara, Gerard Karsenty, C. Ronald Kahn

J Biol Chem. 2012 Apr 6; 287(15): 12016–12026. Published online 2012 Feb 15. doi: 10.1074/jbc.M111.337048

Correction in:: J Biol Chem. 2016 Aug 5; 291(32): 16878.

PMCID:: PMC3320948

Abstract Article PDF–2.7M

Select item 312195117.

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

Leanne K. Saxon, Brendan F. Jackson, Toshihiro Sugiyama, Lance E. Lanyon, Joanna S. Price

Bone. 2011 Aug; 49(2): 184–193. doi: 10.1016/j.bone.2011.03.683

PMCID:: PMC3121951

Abstract Article

Select item 290739218.

LRP5 Is Required for Vascular Development in Deeper Layers of the Retina

Chun-hong Xia, Zipora Yablonka-Reuveni, Xiaohua Gong

PLoS One. 2010; 5(7): e11676. Published online 2010 Jul 20. doi: 10.1371/journal.pone.0011676

PMCID:: PMC2907392

Abstract Article PDF–3.1M

Select item 249300319.

Dominant Negative LRP5 Decreases Tumorigenicity and Metastasis of Osteosarcoma in an Animal Model

Yi Guo, Elyssa M. Rubin, Jun Xie, Xiaolin Zi, Bang H. Hoang

Clin Orthop Relat Res. 2008 Sep; 466(9): 2039–2045. Published online 2008 Jun 20. doi: 10.1007/s11999-008-0344-y

PMCID:: PMC2493003

Abstract Article PDF–450K

Select item 129765920.

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

Philippe Clément-Lacroix, Minrong Ai, Frederic Morvan, Sergio Roman-Roman, Béatrice Vayssière, Cecille Belleville, Kenneth Estrera, Matthew L. Warman, Roland Baron, Georges Rawadi

Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48): 17406–17411. Published online 2005 Nov 17. doi: 10.1073/pnas.0505259102