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Select item 106560771.

Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function

Julia M. Adams, Sanket V. Rege, Angela T. Liu, Ninh V. Vu, Sharda Raina, Douglas Y. Kirsher, Amy L. Nguyen, Reema Harish, Balazs Szoke, Dino P. Leone, Eva Czirr, Steven Braithwaite, Meghan Kerrisk Campbell

Sci Adv. 2023 Nov 17; 9(46): eadf8764. Published online 2023 Nov 17. doi: 10.1126/sciadv.adf8764

PMCID:: PMC10656077

Abstract Article PDF–2.5M

Select item 62483582.

LTA4H regulates cell cycle and skin carcinogenesis

Naomi Oi, Hiroyuki Yamamoto, Alyssa Langfald, Ruihua Bai, Mee-Hyun Lee, Ann M. Bode, Zigang Dong

Carcinogenesis. 2017 Jul; 38(7): 728–737. Published online 2017 May 31. doi: 10.1093/carcin/bgx049

PMCID:: PMC6248358

Abstract Article PDF–8.0M

Select item 40836823.

Role of leukotriene A₄ hydrolase aminopeptidase in the pathogenesis of emphysema

Mikell Paige, Kan Wang, Marie Burdick, Sunhye Park, Josiah Cha, Erin Jeffrey, Nicholas Sherman, Y. Michael Shim

J Immunol. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: J Immunol. 2014 Jun 1; 192(11): 5059–5068. Published online 2014 Apr 25. doi: 10.4049/jimmunol.1400452

PMCID:: PMC4083682

Abstract Article PDF–3.2M

Select item 30727524.

A critical role for LTA₄H in limiting chronic pulmonary neutrophilic inflammation

Robert J. Snelgrove, Patricia L. Jackson, Matthew T. Hardison, Brett D. Noerager, Andrew Kinloch, Amit Gaggar, Suresh Shastry, Steven M. Rowe, Yun M. Shim, Tracy Hussell, J. Edwin Blalock

Science. Author manuscript; available in PMC 2011 Apr 8.

Published in final edited form as: Science. 2010 Oct 1; 330(6000): 90–94. Published online 2010 Sep 2. doi: 10.1126/science.1190594

PMCID:: PMC3072752

Abstract Article PDF–1021K

Select item 26899185.

Leukotriene B4 Release from Mast Cells in IgE-Mediated Airway Hyperresponsiveness and Inflammation

Nobuaki Miyahara, Hiroshi Ohnishi, Satoko Miyahara, Katsuyuki Takeda, Shigeki Matsubara, Hiroyuki Matsuda, Masakazu Okamoto, Joan E. Loader, Anthony Joetham, Mitsune Tanimoto, Azzeddine Dakhama, Erwin W. Gelfand

Am J Respir Cell Mol Biol. 2009 Jun; 40(6): 672–682. Published online 2008 Nov 21. doi: 10.1165/rcmb.2008-0095OC

PMCID:: PMC2689918

Abstract Article PDF–460K

Select item 95765606.

Transcellular biosynthesis of leukotriene B₄ orchestrates neutrophil swarming to fungi

Alex Hopke, Tian Lin, Allison K. Scherer, Ashley E. Shay, Kyle D. Timmer, Brittany Wilson-Mifsud, Michael K. Mansour, Charles N. Serhan, Daniel Irimia, Bryan P. Hurley

iScience. 2022 Oct 21; 25(10): 105226. Published online 2022 Sep 28. doi: 10.1016/j.isci.2022.105226

PMCID:: PMC9576560

Abstract Article PDF–2.7M

Select item 81671697.

Expression of leukotriene B₄ receptor 1 defines functionally distinct DCs that control allergic skin inflammation

Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, Mitsuyoshi Nakao, Takehiko Yokomizo

Cell Mol Immunol. 2021 Jun; 18(6): 1437–1449. Published online 2020 Oct 9. doi: 10.1038/s41423-020-00559-7

PMCID:: PMC8167169

Abstract Article PDF–3.8M

Select item 63424498.

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

Dhiren F. Patel, Teresa Peiró, Amelia Shoemark, Samia Akthar, Simone A. Walker, Aleksander M. Grabiec, Patricia L. Jackson, Tracy Hussell, Amit Gaggar, Xin Xu, Jennifer L. Trevor, Jindong Li, Chad Steele, Gael Tavernier, J. Edwin Blalock, Robert M. Niven, Lisa G. Gregory, Angela Simpson, Clare M. Lloyd, Robert J. Snelgrove

Sci Transl Med. Author manuscript; available in PMC 2019 Jan 22.

Published in final edited form as: Sci Transl Med. 2018 Aug 22; 10(455): eaaq0693. doi: 10.1126/scitranslmed.aaq0693

PMCID:: PMC6342449

Abstract Article PDF–2.0M

Select item 56488299.

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

Shin Numao, Franziska Hasler, Claire Laguerre, Honnappa Srinivas, Nathalie Wack, Petra Jäger, Andres Schmid, Arnaud Osmont, Patrik Röthlisberger, Jeremy Houguenade, Christian Bergsdorf, Janet Dawson, Nathalie Carte, Andreas Hofmann, Christian Markert, Liz Hardaker, Andreas Billich, Romain M. Wolf, Carlos A. Penno, Birgit Bollbuck, Wolfgang Miltz, Till A. Röhn

Sci Rep. 2017; 7: 13591. Published online 2017 Oct 19. doi: 10.1038/s41598-017-13490-1

PMCID:: PMC5648829

Abstract Article PDF–1.9M

Select item 459599710.

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection

Samia Akthar, Dhiren F. Patel, Rebecca C. Beale, Teresa Peiró, Xin Xu, Amit Gaggar, Patricia L. Jackson, J. Edwin Blalock, Clare M. Lloyd, Robert J. Snelgrove

Nat Commun. 2015; 6: 8423. Published online 2015 Sep 24. doi: 10.1038/ncomms9423

PMCID:: PMC4595997

Abstract Article PDF–713K

Select item 422602811.

An Aberrant Leukotriene A₄ Hydrolase–Proline-Glycine-Proline Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease

J. Michael Wells, Philip J. O’Reilly, Tomasz Szul, Daniel I. Sullivan, Guy Handley, Chris Garrett, Carmel M. McNicholas, Mojtaba Abdul Roda, Bruce E. Miller, Ruth Tal-Singer, Amit Gaggar, Stephen I. Rennard, Patricia L. Jackson, J. Edwin Blalock

Am J Respir Crit Care Med. 2014 Jul 1; 190(1): 51–61. Published online 2014 Jul 1. doi: 10.1164/rccm.201401-0145OC

PMCID:: PMC4226028

Abstract Article PDF–1.0M

Select item 347839912.

Leukotriene B₄ driven neutrophil recruitment to the skin is essential for allergic skin inflammation

Michiko K. Oyoshi, Rui He, Yitang Li, Subhanjan Mondal, Juhan Yoon, Roshi Afshar, Mei Chen, David M. Lee, Hongbo R. Luo, Andrew D. Luster, John S. Cho, Lloyd S. Miller, Allison Larson, George F. Murphy, Raif S. Geha

Immunity. Author manuscript; available in PMC 2013 Oct 19.

Published in final edited form as: Immunity. 2012 Oct 19; 37(4): 747–758. Published online 2012 Oct 11. doi: 10.1016/j.immuni.2012.06.018

PMCID:: PMC3478399

Abstract Article PDF–1.3M

Select item 648303113.

Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease

John R. Montford, Colin Bauer, Evgenia Dobrinskikh, Katharina Hopp, Moshe Levi, Mary Weiser-Evans, Raphael Nemenoff, Seth B. Furgeson

Am J Physiol Renal Physiol. 2019 Apr 1; 316(4): F732–F742. Published online 2019 Jan 16. doi: 10.1152/ajprenal.00262.2018

PMCID:: PMC6483031

Abstract Article

Select item 470559414.

Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment

Joanna M. Poczobutt, Teresa T. Nguyen, Dwight Hanson, Howard Li, Trisha R. Sippel, Mary C. M. Weiser-Evans, Miguel Gijon, Robert C. Murphy, Raphael A. Nemenoff

J Immunol. 2016 Jan 15; 196(2): 891–901. Published online 2015 Dec 11. doi: 10.4049/jimmunol.1501648

PMCID:: PMC4705594

Abstract Article PDF–1.3M

Select item 369031015.

Joint Tissues Amplify Inflammation and Alter Their Invasive Behavior via Leukotriene B₄ in Experimental Inflammatory Arthritis

Mei Chen, Bing K. Lam, Andrew D. Luster, Simona Zarini, Robert C. Murphy, Angela M. Bair, Roy J. Soberman, David M. Lee

J Immunol. Author manuscript; available in PMC 2013 Jun 23.

Published in final edited form as: J Immunol. 2010 Nov 1; 185(9): 5503–5511. Published online 2010 Sep 27. doi: 10.4049/jimmunol.1001258

PMCID:: PMC3690310

Abstract Article PDF–2.1M

Select item 268889316.

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

Simona Zarini, Miguel A. Gijón, Aaron E. Ransome, Robert C. Murphy, Angelo Sala

Proc Natl Acad Sci U S A. 2009 May 19; 106(20): 8296–8301. Published online 2009 May 4. doi: 10.1073/pnas.0903851106

PMCID:: PMC2688893

Abstract Article PDF–374K

Select item 211829217.

Neutrophil-derived leukotriene B₄ is required for inflammatory arthritis

Mei Chen, Bing K. Lam, Yoshihide Kanaoka, Peter A. Nigrovic, Laurent P. Audoly, K. Frank Austen, David M. Lee

J Exp Med. 2006 Apr 17; 203(4): 837–842. doi: 10.1084/jem.20052371

PMCID:: PMC2118292

Abstract Article PDF–1.7M

Select item 15097818.

Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo

Jean-Etienne Fabre, Jennifer L. Goulet, Estelle Riche, MyTrang Nguyen, Kenneth Coggins, Steven Offenbacher, Beverly H. Koller

J Clin Invest. 2002 May 15; 109(10): 1373–1380. doi: 10.1172/JCI14869

PMCID:: PMC150978

Abstract Article PDF–604K

Select item 145962819.

Expression of 5-lipoxygenase and leukotriene A₄ hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability

Hong Qiu, Anders Gabrielsen, Hanna E. Agardh, Min Wan, Anders Wetterholm, Chi-Huey Wong, Ulf Hedin, Jesper Swedenborg, Göran K. Hansson, Bengt Samuelsson, Gabrielle Paulsson-Berne, Jesper Z. Haeggström

Proc Natl Acad Sci U S A. 2006 May 23; 103(21): 8161–8166. Published online 2006 May 12. doi: 10.1073/pnas.0602414103

PMCID:: PMC1459628

Abstract Article PDF–1.7M

Select item 5235320.

Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

J F Medina, A Wetterholm, O Rådmark, R Shapiro, J Z Haeggström, B L Vallee, B Samuelsson

Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17): 7620–7624. doi: 10.1073/pnas.88.17.7620

PMCID:: PMC52353

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