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Items: 1 to 20 of 90

1.
The MK2 cascade mediates transient alteration in mGluR‐LTD and spatial learning in a murine model of Alzheimer's disease
Lucia Privitera, Ellen L. Hogg, Marcia Lopes, Luana B. Domingos, Matthias Gaestel, Jürgen Müller, Mark J. Wall, Sonia A. L. Corrêa
Aging Cell. 2022 Oct; 21(10): e13717. Published online 2022 Sep 22. doi: 10.1111/acel.13717
PMCID:
PMC9577942
AbstractArticlePDF–1.4M
2.
Substrate-based kinase activity inference identifies MK2 as driver of colitis
Samantha Dale Strasser, Phaedra C. Ghazi, Alina Starchenko, Myriam Boukhali, Amanda Edwards, Lucia Suarez-Lopez, Jesse Lyons, Paul S. Changelian, Joseph B. Monahan, Jon Jacobsen, Douglas K. Brubaker, Brian A. Joughin, Michael B. Yaffe, Wilhelm Haas, Douglas A. Lauffenburger, Kevin M. Haigis
Integr Biol (Camb) Author manuscript; available in PMC 2020 May 8.
Published in final edited form as: Integr Biol (Camb). 2019 Nov 26; 11(7): 301–314. doi: 10.1093/intbio/zyz025
PMCID:
PMC7208439
AbstractArticlePDF–1.9M
3.
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Contributes to Secondary Damage after Spinal Cord Injury
Nader Ghasemlou, Ruben Lopez-Vales, Claude Lachance, Thusanth Thuraisingam, Matthias Gaestel, Danuta Radzioch, Samuel David
J Neurosci. 2010 Oct 13; 30(41): 13750–13759. doi: 10.1523/JNEUROSCI.2998-10.2010
PMCID:
PMC6633726
AbstractArticlePDF–1.4M
4.
Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration
Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng, Yi Ting Zhou
Mol Cell Biol. 2018 Dec 15; 38(24): e00211-18. Prepublished online 2018 Oct 1. Published online 2018 Nov 28. doi: 10.1128/MCB.00211-18
PMCID:
PMC6275188
AbstractArticlePDF–6.7M
5.
A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury
Lei Sun, Qiong Wu, Yunjuan Nie, Ni Cheng, Rui Wang, Gang Wang, Dan Zhang, Huiqiong He, Richard D. Ye, Feng Qian
Front Immunol. 2018; 9: 2610. Published online 2018 Nov 13. doi: 10.3389/fimmu.2018.02610
PMCID:
PMC6243022
AbstractArticlePDF–3.4M
6.
MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth
Brandon B. Phinney, Anita L. Ray, Amanda S. Peretti, Stephanie J. Jerman, Carl Grim, Irina V. Pinchuk, Ellen J. Beswick
Front Immunol. 2018; 9: 1857. Published online 2018 Sep 21. doi: 10.3389/fimmu.2018.01857
PMCID:
PMC6160543
AbstractArticlePDF–5.2M
7.
Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α dependent colorectal cancer growth
Anita L. Ray, Kiersten L. Berggren, Sebastian Restrepo Cruz, Gregory N. Gan, Ellen J. Beswick
Int J Cancer. Author manuscript; available in PMC 2019 Apr 15.
Published in final edited form as: Int J Cancer. 2018 Apr 15; 142(8): 1702–1711. Published online 2017 Dec 12. doi: 10.1002/ijc.31191
PMCID:
PMC5814350
AbstractArticlePDF–1.7M
8.
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response
Klara Soukup, Angela Halfmann, Barbara Dillinger, Fiona Poyer, Katharina Martin, Bernadette Blauensteiner, Maximilian Kauer, Mario Kuttke, Gernot Schabbauer, Alexander M. Dohnal
Sci Rep. 2017; 7: 11746. Published online 2017 Sep 18. doi: 10.1038/s41598-017-12208-7
PMCID:
PMC5603533
AbstractArticlePDF–5.1M
9.
Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss
Bethany A. Herbert, Heidi M. Steinkamp, Matthias Gaestel, Keith L. Kirkwood
Infect Immun. 2017 Jan; 85(1): e00552-16. Prepublished online 2016 Oct 17. Published online 2016 Dec 29. doi: 10.1128/IAI.00552-16
PMCID:
PMC5203644
AbstractArticlePDF–2.4M
10.
Blockade of MK2 is protective in inflammation-associated colorectal cancer development
Anita L. Ray, Eliseo F. Castillo, Katherine T. Morris, Robert A Nofchissey, Lea L Weston, Von G. Samedi, Joshua A. Hanson, Matthias Gaestel, Irina V. Pinchuk, Ellen J. Beswick
Int J Cancer. Author manuscript; available in PMC 2017 Feb 1.
Published in final edited form as: Int J Cancer. 2016 Feb 1; 138(3): 770–775. Published online 2015 Aug 21. doi: 10.1002/ijc.29716
PMCID:
PMC4715542
AbstractArticlePDF–740K
11.
MAP-Kinase Activated Protein Kinase 2 Links Endothelial Activation and Monocyte/macrophage Recruitment in Arteriogenesis
Anne Limbourg, Johann von Felden, Kumaravelu Jagavelu, Kashyap Krishnasamy, L. Christian Napp, Piyushkumar R. Kapopara, Matthias Gaestel, Bernhard Schieffer, Johann Bauersachs, Florian P. Limbourg, Udo Bavendiek
PLoS One. 2015; 10(10): e0138542. Published online 2015 Oct 2. doi: 10.1371/journal.pone.0138542
PMCID:
PMC4592267
AbstractArticlePDF–8.6M
12.
Anthrax lethal toxin-induced lung injury and treatment by activating MK2
Tiegang Liu, Rod R. Warburton, Nicholas S. Hill, Usamah S. Kayyali
J Appl Physiol (1985) 2015 Aug 15; 119(4): 412–419. Published online 2015 Jun 11. doi: 10.1152/japplphysiol.00335.2015
PMCID:
PMC4538279
AbstractArticle
13.
Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Angiotensin II–Induced Inflammation and Hypertension: Regulation of Oxidative Stress
Talin Ebrahimian, Melissa Wei Li, Catherine A. Lemarié, Stefania M.C. Simeone, Patrick J. Pagano, Matthias Gaestel, Pierre Paradis, Sven Wassmann, Ernesto L. Schiffrin
Hypertension. Author manuscript; available in PMC 2015 Jul 31.
Published in final edited form as: Hypertension. 2011 Feb; 57(2): 245–254. Published online 2010 Dec 20. doi: 10.1161/HYPERTENSIONAHA.110.159889
PMCID:
PMC4521212
AbstractArticlePDF–1.1M
14.
Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations
Bethany A. Herbert, Michael S. Valerio, Matthias Gaestel, Keith L. Kirkwood
PLoS One. 2015; 10(5): e0125387. Published online 2015 May 6. doi: 10.1371/journal.pone.0125387
PMCID:
PMC4422514
AbstractArticlePDF–4.9M
15.
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Deficiency Reduces Insulin Sensitivity in High-Fat Diet-Fed Mice
Jan Freark de Boer, Arne Dikkers, Angelika Jurdzinski, Johann von Felden, Matthias Gaestel, Udo Bavendiek, Uwe J. F. Tietge
PLoS One. 2014; 9(9): e106300. Published online 2014 Sep 18. doi: 10.1371/journal.pone.0106300
PMCID:
PMC4169416
AbstractArticlePDF–696K
16.
MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock
Benjamin Vandendriessche, An Goethals, Alba Simats, Evelien Van Hamme, Peter Brouckaert, Anje Cauwels
BMC Physiol. 2014; 14: 5. Published online 2014 Sep 4. doi: 10.1186/s12899-014-0005-1
PMCID:
PMC4160542
AbstractArticlePDF–1.7M
17.
MAPK-Activated Protein Kinase 2 Is Required for Mouse Meiotic Spindle Assembly and Kinetochore-Microtubule Attachment
Ju Yuan, Bao-Zeng Xu, Shu-Tao Qi, Jing-Shan Tong, Liang Wei, Mo Li, Ying-Chun Ouyang, Yi Hou, Heide Schatten, Qing-Yuan Sun
PLoS One. 2010; 5(6): e11247. Published online 2010 Jun 28. doi: 10.1371/journal.pone.0011247
PMCID:
PMC2893158
AbstractArticlePDF–5.5M
18.
Lack of MK2 Inhibits Myofibroblast Formation and Exacerbates Pulmonary Fibrosis
Tiegang Liu, Rod R. Warburton, Oscar E. Guevara, Nicholas S. Hill, Barry L. Fanburg, Matthias Gaestel, Usamah S. Kayyali
Am J Respir Cell Mol Biol. 2007 Nov; 37(5): 507–517. Published online 2007 Jun 28. doi: 10.1165/rcmb.2007-0077OC
PMCID:
PMC2048679
AbstractArticlePDF–2.6M
19.
MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target
Damian Jacenik, Eric J. Lebish, Ellen J. Beswick
Front Immunol. 2023; 14: 1212100. Published online 2023 Jun 21. doi: 10.3389/fimmu.2023.1212100
PMCID:
PMC10321668
AbstractArticlePDF–3.9M
20.
Gene Therapy with Pellino-1 Improves Perfusion and Decreases Tissue Loss in Flk-1 Heterozygous Mice but Fails in MAPKAP KINASE-2 Knockout Murine Hind Limb Ischemia Model
Mahesh Thirunavukkarasu, Seetur R. Pradeep, Gopi Ukani, Salim Abunnaja, Mark Youssef, Diego Accorsi, Santosh Swaminathan, Sue Ting Lim, Virginia Parker, Jacob Campbell, Muhammad Tipu Rishi, J. Alexander Palesty, Nilanjana Maulik
Microvasc Res. Author manuscript; available in PMC 2023 May 1.
Published in final edited form as: Microvasc Res. 2022 May; 141: 104311. Published online 2022 Jan 7. doi: 10.1016/j.mvr.2022.104311
PMCID:
PMC9250804
AbstractArticlePDF–4.8M

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