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Select item 110409881.

Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression

Yan Qi, Xiangchao Meng, Jing Li, Aoyue He, Jie Hao, Xu Zhao, Ruonan Zhao, Rongrong Chen, Rongqiang Zhang

Clin Epigenetics. 2024; 16: 57. Published online 2024 Apr 24. doi: 10.1186/s13148-024-01668-0

PMCID:: PMC11040988

Abstract Article PDF–4.9M

Select item 74314182.

Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer

Iuri Martin Goemann, Vicente Rodrigues Marczyk, Mariana Recamonde-Mendoza, Simone Magagnin Wajner, Marcia Silveira Graudenz, Ana Luiza Maia

Sci Rep. 2020; 10: 13914. Published online 2020 Aug 17. doi: 10.1038/s41598-020-70892-4

PMCID:: PMC7431418

Abstract Article PDF–1.7M

Select item 24228293.

The Thyroid Hormone-Inactivating Deiodinase Functions as a Homodimer

G. D. Vivek Sagar, Balázs Gereben, Isabelle Callebaut, Jean-Paul Mornon, Anikó Zeöld, Cyntia Curcio-Morelli, John W. Harney, Cristina Luongo, Michelle A. Mulcahey, P. Reed Larsen, Stephen A. Huang, Antonio C. Bianco

Mol Endocrinol. 2008 Jun; 22(6): 1382–1393. Published online 2008 Mar 20. doi: 10.1210/me.2007-0490

PMCID:: PMC2422829

Abstract Article

Select item 1858944.

Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.

D Salvatore, S C Low, M Berry, A L Maia, J W Harney, W Croteau, D L St Germain, P R Larsen

J Clin Invest. 1995 Nov; 96(5): 2421–2430. doi: 10.1172/JCI118299

PMCID:: PMC185894

Summary Page Browse PDF–2.1M

Select item 111140455.

The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis

Leonidas Benetatos, Eleftheria Hatzimichael, Eric Londin, George Vartholomatos, Phillipe Loher, Isidore Rigoutsos, Evangelos Briasoulis

Cell Mol Life Sci. 2013 Mar; 70(5): 795–814. Published online 2012 Jul 24. doi: 10.1007/s00018-012-1080-8

PMCID:: PMC11114045

Abstract Article PDF–474K

Select item 82987166.

Human placental piwi-interacting RNA transcriptome is characterized by expression from the DLK1-DIO3 imprinted region

Victor D. Martinez, Adam P. Sage, Brenda C. Minatel, Erin A. Marshall, E. Magda Price, Daiana D. Becker-Santos, Wendy P. Robinson, Wan L. Lam

Sci Rep. 2021; 11: 14981. Published online 2021 Jul 22. doi: 10.1038/s41598-021-93885-3

PMCID:: PMC8298716

Abstract Article PDF–1.4M

Select item 82379947.

Deiodinases and the Metabolic Code for Thyroid Hormone Action

Samuel C Russo, Federico Salas-Lucia, Antonio C Bianco

Endocrinology. 2021 Aug; 162(8): bqab059. Published online 2021 Mar 15. doi: 10.1210/endocr/bqab059

PMCID:: PMC8237994

Abstract Article

Select item 76854828.

High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus

Sebastián Gutiérrez-Vega, Axel Armella, Daniela Mennickent, Marco Loyola, Ambart Covarrubias, Bernel Ortega-Contreras, Carlos Escudero, Marcelo Gonzalez, Martín Alcalá, María del Pilar Ramos, Marta Viana, Erica Castro, Andrea Leiva, Enrique Guzmán-Gutiérrez

PLoS One. 2020; 15(11): e0242743. Published online 2020 Nov 24. doi: 10.1371/journal.pone.0242743

PMCID:: PMC7685482

Abstract Article PDF–1.4M

Select item 62180469.

Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells

Silvia García-López, Carmen Albo-Castellanos, Rocio G. Urdinguio, Susana Cañón, Fátima Sánchez-Cabo, Alberto Martínez-Serrano, Mario F. Fraga, Antonio Bernad

PLoS One. 2018; 13(11): e0206534. Published online 2018 Nov 5. doi: 10.1371/journal.pone.0206534

PMCID:: PMC6218046

Abstract Article PDF–2.1M

Select item 534836810.

Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome

Katey S.S. Enfield, Victor D. Martinez, Erin A. Marshall, Greg L. Stewart, Sonia H.Y. Kung, Jhon R. Enterina, Wan L. Lam

Oncotarget. 2016 Dec 6; 7(49): 80957–80966. Published online 2016 Nov 5. doi: 10.18632/oncotarget.13133

PMCID:: PMC5348368

Abstract Article PDF–8.4M

Select item 511006311.

Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14

Maria Elena Martinez, David F Cox, Brian P Youth, Arturo Hernandez

Eur J Hum Genet. 2016 Nov; 24(11): 1617–1621. Published online 2016 Jun 22. doi: 10.1038/ejhg.2016.66

PMCID:: PMC5110063

Abstract Article PDF–1.0M

Select item 316243112.

DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival

John M. Luk, Julja Burchard, Chunsheng Zhang, Angela M. Liu, Kwong F. Wong, Felix H. Shek, Nikki P. Lee, Sheung Tat Fan, Ronnie T. Poon, Irena Ivanovska, Ulrike Philippar, Michele A. Cleary, Carolyn A. Buser, Peter M. Shaw, Chuen-Neng Lee, Daniel G. Tenen, Hongyue Dai, Mao Mao

J Biol Chem. 2011 Sep 2; 286(35): 30706–30713. Published online 2011 Jul 7. doi: 10.1074/jbc.M111.229831

PMCID:: PMC3162431

Abstract Article PDF–3.5M

Select item 277598813.

Knockdown of the Type 3 Iodothyronine Deiodinase (D3) Interacting Protein Peroxiredoxin 3 Decreases D3-Mediated Deiodination in Intact Cells

Goele Aerts, Rafael Arrojo e Drigo, Stijn L. J. Van Herck, Eva Sammels, Delphine Mirebeau-Prunier, Balázs Gereben, Anikó Zeöld, John W. Harney, Stephen A. Huang, Michelle A. Mulcahey, Serge Van der Geyten, Gert Van den Bergh, Lut Arckens, Veerle M. Darras, Ann Marie Zavacki

Endocrinology. 2009 Nov; 150(11): 5171–5180. Published online 2009 Oct 9. doi: 10.1210/en.2009-0702

PMCID:: PMC2775988

Abstract Article

Select item 1116320114.

DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis

Julie Sanceau, Lucie Poupel, Camille Joubel, Isabelle Lagoutte, Stefano Caruso, Sandra Pinto, Christèle Desbois-Mouthon, Cécile Godard, Akila Hamimi, Enzo Montmory, Cécile Dulary, Sophie Chantalat, Amélie Roehrig, Kevin Muret, Benjamin Saint-Pierre, Jean-François Deleuze, Sophie Mouillet-Richard, Thierry Forné, Christophe F. Grosset, Jessica Zucman-Rossi, Sabine Colnot, Angélique Gougelet

Mol Ther. 2024 Apr 3; 32(4): 1125–1143. Published online 2024 Feb 3. doi: 10.1016/j.ymthe.2024.01.036

PMCID:: PMC11163201

Abstract Article PDF–6.9M

Select item 577425315.

The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species

Anne H. van der Spek, Kin Ki Jim, Aldona Karaczyn, Hermina C. van Beeren, Mariëtte T. Ackermans, Veerle M. Darras, Christina M. J. E. Vandenbroucke-Grauls, Arturo Hernandez, Matthijs C. Brouwer, Eric Fliers, Diederik van de Beek, Anita Boelen

Endocrinology. 2018 Feb; 159(2): 826–835. Published online 2017 Nov 24. doi: 10.1210/en.2017-00666

PMCID:: PMC5774253

Abstract Article

Select item 555823816.

Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Old AβPP/PS1 Double Transgenic Mice

Thomas van Groen, Inga Kadish, Susanne Aileen Funke, Dirk Bartnik, Dieter Willbold

J Alzheimers Dis. Author manuscript; available in PMC 2017 Aug 16.

Published in final edited form as: J Alzheimers Dis. 2013; 34(3): 609–620. doi: 10.3233/JAD-121792

PMCID:: PMC5558238

Abstract Article PDF–713K

Select item 406584217.

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma

Paul N. Valdmanis, Biswajoy Roy-Chaudhuri, Hak Kyun Kim, Leanne C. Sayles, Yanyan Zheng, Chen-Hua Chuang, Deborah R. Caswell, Kirk Chu, Monte M. Winslow, E. Alejandro Sweet-Cordero, Mark A. Kay

Oncogene. Author manuscript; available in PMC 2015 Jul 2.

Published in final edited form as: Oncogene. 2015 Jan 2; 34(1): 94–103. Published online 2013 Dec 9. doi: 10.1038/onc.2013.523

PMCID:: PMC4065842

Abstract Article PDF–1.3M

Select item 251508018.

A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine

Vijay Panicker, Christie Cluett, Beverley Shields, Anna Murray, Kirstie S. Parnell, John R. B. Perry, Michael N. Weedon, Andrew Singleton, Dena Hernandez, Jonathan Evans, Claire Durant, Luigi Ferrucci, David Melzer, Ponnusamy Saravanan, Theo J. Visser, Graziano Ceresini, Andrew T. Hattersley, Bijay Vaidya, Colin M. Dayan, Timothy M. Frayling

J Clin Endocrinol Metab. 2008 Aug; 93(8): 3075–3081. Published online 2008 May 20. doi: 10.1210/jc.2008-0397

PMCID:: PMC2515080

Abstract Article

Select item 1101490719.

MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster contribute to glioblastoma tumor heterogeneity

Christopher M. Smith, Daniel Catchpoole, Gyorgy Hutvagner

Sci Rep. 2024; 14: 8570. Published online 2024 Apr 13. doi: 10.1038/s41598-024-58870-6

PMCID:: PMC11014907

Abstract Article PDF–4.2M

Select item 476936420.

The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis

M. Elena Martinez, Aldona Karaczyn, J. Patrizia Stohn, William T. Donnelly, Walburga Croteau, Robin P. Peeters, Valerie A. Galton, Douglas Forrest, Donald St. Germain, Arturo Hernandez

Endocrinology. 2016 Mar; 157(3): 1276–1288. Published online 2016 Jan 4. doi: 10.1210/en.2015-1910

PMCID:: PMC4769364

Abstract Article

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