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Items: 1 to 20 of 29

1.
Expression of Mutated Mouse Myocilin Induces Open-Angle Glaucoma in Transgenic Mice
Vladimir Senatorov, Irina Malyukova, Robert Fariss, Eric F. Wawrousek, Srividya Swaminathan, Shyam K. Sharan, Stanislav Tomarev
J Neurosci. 2006 Nov 15; 26(46): 11903–11914. doi: 10.1523/JNEUROSCI.3020-06.2006
PMCID:
PMC6674879
AbstractArticlePDF–1.6M
2.
Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3
Myung Kuk Joe, Raquel L. Lieberman, Naoki Nakaya, Stanislav I. Tomarev
Invest Ophthalmol Vis Sci. 2017 Oct; 58(12): 5308–5318. doi: 10.1167/iovs.16-20336
PMCID:
PMC5644706
AbstractArticlePDF–1.1M
3.
Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration
Gaurang C. Patel, Tien N. Phan, Prabhavathi Maddineni, Ramesh B. Kasetti, J. Cameron Millar, Abbot F. Clark, Gulab S. Zode
Am J Pathol. 2017 Apr; 187(4): 713–723. doi: 10.1016/j.ajpath.2016.12.003
PMCID:
PMC5397678
AbstractArticlePDF–1.5M
4.
Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
Ramesh B. Kasetti, Tien N. Phan, J. Cameron Millar, Gulab S. Zode
Invest Ophthalmol Vis Sci. 2016 Nov; 57(14): 6058–6069. doi: 10.1167/iovs.16-19610
PMCID:
PMC5102566
AbstractArticlePDF–3.4M
5.
Expression of Myocilin Mutants Sensitizes Cells to Oxidative Stress-Induced Apoptosis : Implication for Glaucoma Pathogenesis
Myung Kuk Joe, Stanislav I. Tomarev
Am J Pathol. 2010 Jun; 176(6): 2880–2890. doi: 10.2353/ajpath.2010.090853
PMCID:
PMC2877849
AbstractArticlePDF–971K
6.
Mutant Myocilin Nonsecretion In Vivo Is Not Sufficient To Cause Glaucoma
Douglas B. Gould, Mark Reedy, Lawriston A. Wilson, Richard S. Smith, Randy L. Johnson, Simon W. M. John
Mol Cell Biol. 2006 Nov; 26(22): 8427–8436. Published online 2006 Sep 5. doi: 10.1128/MCB.01127-06
PMCID:
PMC1636791
AbstractArticlePDF–1.2M
7.
Genetically Increasing Myoc Expression Supports a Necessary Pathologic Role of Abnormal Proteins in Glaucoma
Douglas B. Gould, Laura Miceli-Libby, Olga V. Savinova, Mario Torrado, Stanislav I. Tomarev, Richard S. Smith, Simon W. M. John
Mol Cell Biol. 2004 Oct; 24(20): 9019–9025. doi: 10.1128/MCB.24.20.9019-9025.2004
PMCID:
PMC517885
AbstractArticlePDF–575K
8.
Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function
Byong Su Kim, Olga V. Savinova, Mark V. Reedy, Janice Martin, Yi Lun, Lin Gan, Richard S. Smith, Stanislav I. Tomarev, Simon W. M. John, Randy L. Johnson
Mol Cell Biol. 2001 Nov; 21(22): 7707–7713. doi: 10.1128/MCB.21.22.7707-7713.2001
PMCID:
PMC99941
AbstractArticlePDF–1.4M
9.
MEF2c-dependent downregulation of Myocilin mediates cancer-induced muscle wasting and associates with cachexia in cancer patients
Sarah M. Judge, Michael R. Deyhle, Daria Neyroud, Rachel L. Nosacka, Andrew C. D’Lugos, Miles E. Cameron, Ravneet S. Vohra, Ashley J. Smuder, Brandon M. Roberts, Chandler S. Callaway, Patrick W. Underwood, Stephen M. Chrzanowski, Abhinandan Batra, Meghan E. Murphy, Jonathan D. Heaven, Glenn A. Walter, Jose G. Trevino, Andrew R. Judge
Cancer Res. Author manuscript; available in PMC 2020 Nov 1.
Published in final edited form as: Cancer Res. 2020 May 1; 80(9): 1861–1874. Published online 2020 Mar 4. doi: 10.1158/0008-5472.CAN-19-1558
PMCID:
PMC7250164
AbstractArticlePDF–2.3M
10.
Differential misfolding properties of glaucoma-associated olfactomedin domains from human and mouse
Athéna C. Patterson-Orazem, Shannon E. Hill, Yiming Wang, Iramofu M. Dominic, Carol K. Hall, Raquel L. Lieberman
Biochemistry. Author manuscript; available in PMC 2020 Apr 2.
Published in final edited form as: Biochemistry. 2019 Apr 2; 58(13): 1718–1727. Published online 2019 Mar 12. doi: 10.1021/acs.biochem.8b01309
PMCID:
PMC6815101
AbstractArticlePDF–1.7M
11.
Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle
Jeffrey M. Lynch, Andrew J. Dolman, Chenying Guo, Katie Dolan, Chuanxi Xiang, Samir Reda, Bing Li, Ganesh Prasanna
PLoS One. 2018; 13(11): e0206801. Published online 2018 Nov 5. doi: 10.1371/journal.pone.0206801
PMCID:
PMC6218065
AbstractArticlePDF–2.4M
12.
Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma
Myung Kuk Joe, Naoki Nakaya, Mones Abu-Asab, Stanislav I. Tomarev
Hum Mol Genet. 2015 Jun 15; 24(12): 3322–3334. Published online 2015 Mar 3. doi: 10.1093/hmg/ddv082
PMCID:
PMC4447889
AbstractArticlePDF–2.0M
13.
Myocilin Regulates Cell Proliferation and Survival
Myung Kuk Joe, Heung Sun Kwon, Radu Cojocaru, Stanislav I. Tomarev
J Biol Chem. 2014 Apr 4; 289(14): 10155–10167. Published online 2014 Feb 22. doi: 10.1074/jbc.M113.547091
PMCID:
PMC3974985
AbstractArticlePDF–2.8M
14.
Efficient In Vivo Doxycycline and Cre Recombinase–Mediated Inducible Transgene Activation in the Murine Trabecular Meshwork
Pu Liu, Xueyao Fu, Randy L. Johnson
Invest Ophthalmol Vis Sci. 2011 Feb; 52(2): 969–974. Published online 2011 Feb 23. doi: 10.1167/iovs.09-5052
PMCID:
PMC3053115
AbstractArticlePDF–3.1M
15.
Transgenic Mice Expressing the Tyr437His Mutant of Human Myocilin Protein Develop Glaucoma
Yu Zhou, Oleg Grinchuk, Stanislav I. Tomarev
Invest Ophthalmol Vis Sci. Author manuscript; available in PMC 2010 Jan 21.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 May; 49(5): 1932–1939. doi: 10.1167/iovs.07-1339
PMCID:
PMC2809368
AbstractArticlePDF–1.9M
16.
Characterization and Comparison of the Human and Mouse GLC1A Glaucoma Genes
John H. Fingert, Lihua Ying, Ruth E. Swiderski, Arne M. Nystuen, Nancy C. Arbour, Wallace L.M. Alward, Val C. Sheffield, Edwin M. Stone
Genome Res. 1998 Apr; 8(4): 377–384. doi: 10.1101/gr.8.4.377
PMCID:
PMC310708
AbstractArticlePDF–481K
17.
Myocilin Stimulates Osteogenic Differentiation of Mesenchymal Stem Cells through Mitogen-activated Protein Kinase Signaling
Heung Sun Kwon, Thomas V. Johnson, Stanislav I. Tomarev
J Biol Chem. 2013 Jun 7; 288(23): 16882–16894. Published online 2013 Apr 29. doi: 10.1074/jbc.M112.422972
PMCID:
PMC3675621
AbstractArticlePDF–3.3M
18.
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells
Jeffrey M. Lynch, Bing Li, Parvaneh Katoli, Chuanxi Xiang, Barrett Leehy, Nalini Rangaswamy, Veronica Saenz-Vash, Y. Karen Wang, Hong Lei, Thomas B. Nicholson, Erik Meredith, Dennis S. Rice, Ganesh Prasanna, Amy Chen
J Biol Chem. 2018 Dec 28; 293(52): 20137–20156. Published online 2018 Nov 2. doi: 10.1074/jbc.RA118.004325
PMCID:
PMC6311499
AbstractArticlePDF–4.6M
19.
Myocilin Is Involved in NgR1/Lingo-1-Mediated Oligodendrocyte Differentiation and Myelination of the Optic Nerve
Heung Sun Kwon, Naoki Nakaya, Mones Abu-Asab, Hong Sug Kim, Stanislav I. Tomarev
J Neurosci. 2014 Apr 16; 34(16): 5539–5551. doi: 10.1523/JNEUROSCI.4731-13.2014
PMCID:
PMC3988410
AbstractArticlePDF–5.9M
20.
Myocilin Interacts with Syntrophins and Is Member of Dystrophin-associated Protein Complex
Myung Kuk Joe, Changwon Kee, Stanislav I. Tomarev
J Biol Chem. 2012 Apr 13; 287(16): 13216–13227. Published online 2012 Feb 25. doi: 10.1074/jbc.M111.224063
PMCID:
PMC3339941
AbstractArticlePDF–2.6M

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