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Select item 32532571.

NEMO-LIKE KINASE INHIBITS OSTEOBLASTOGENESIS BY SUPPRESSING BONE MORPHOGENETIC PROTEIN AND WNT CANONICAL SIGNALING

Stefano Zanotti, Ernesto Canalis

J Cell Biochem. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: J Cell Biochem. 2012 Feb; 113(2): 449–456. doi: 10.1002/jcb.23365

PMCID:: PMC3253257

Abstract Article PDF–727K

Select item 104252132.

Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration

Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Changwoo Lee, Benjamin Sanders, Paul J. Lee, Yangfei Xiang, Kimberly Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah H. Ro, Hyoungseok Ju, Clara Liao, Sofia Massaro Tieze, Frank Rigo, Paymaan Jafar-Nejad, Janghoo Lim

J Clin Invest. 2023 Aug 15; 133(16): e138207. Published online 2023 Aug 15. doi: 10.1172/JCI138207

PMCID:: PMC10425213

Abstract Article PDF–19M

Select item 50725783.

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart

Ruijie Liu, Hadi Khalil, Suh-Chin J. Lin, Michelle A. Sargent, Allen J. York, Jeffery D. Molkentin

PLoS One. 2016; 11(10): e0164897. Published online 2016 Oct 20. doi: 10.1371/journal.pone.0164897

PMCID:: PMC5072578

Abstract Article PDF–2.2M

Select item 45779824.

Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy

Tiffany W Todd, Hiroshi Kokubu, Helen C Miranda, Constanza J Cortes, Albert R La Spada, Janghoo Lim

eLife. 2015; 4: e08493. Published online 2015 Aug 26. doi: 10.7554/eLife.08493

PMCID:: PMC4577982

Abstract Article PDF–5.9M

Select item 41178155.

NEMO-LIKE KINASE REGULATES POSTNATAL SKELETAL HOMEOSTASIS

Ernesto Canalis, Lauren Kranz, Stefano Zanotti

J Cell Physiol. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: J Cell Physiol. 2014 Nov; 229(11): 1736–1743. doi: 10.1002/jcp.24625

PMCID:: PMC4117815

Abstract Article PDF–645K

Select item 37104586.

Polyglutamine Disease Toxicity Is Regulated by Nemo-like Kinase in Spinocerebellar Ataxia Type 1

Hyoungseok Ju, Hiroshi Kokubu, Tiffany W. Todd, Juliette J. Kahle, Soeun Kim, Ronald Richman, Karthik Chirala, Harry T. Orr, Huda Y. Zoghbi, Janghoo Lim

J Neurosci. 2013 May 29; 33(22): 9328–9336. doi: 10.1523/JNEUROSCI.3465-12.2013

PMCID:: PMC3710458

Abstract Article PDF–2.4M

Select item 31456337.

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

Daniel P. Reay, Michele Yang, Jon F. Watchko, Molly Daood, Terrence L. O'Day, Khaleel K. Rehman, Denis C. Guttridge, Paul D. Robbins, Paula R. Clemens

Neurobiol Dis. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Neurobiol Dis. 2011 Sep; 43(3): 598–608. Published online 2011 May 23. doi: 10.1016/j.nbd.2011.05.008

PMCID:: PMC3145633

Abstract Article PDF–3.4M

Select item 186398.

Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus

Barbara K. Brott, Benjamin A. Pinsky, Raymond L. Erikson

Proc Natl Acad Sci U S A. 1998 Feb 3; 95(3): 963–968. doi: 10.1073/pnas.95.3.963

PMCID:: PMC18639

Abstract Article PDF–258K

Select item 86637789.

Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway

Tingting Dong, Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Kimberly Luttik, Terri M. Driessen, Janghoo Lim

JCI Insight. 2021 Nov 22; 6(22): e136147. Published online 2021 Nov 22. doi: 10.1172/jci.insight.136147

PMCID:: PMC8663778

Abstract Article PDF–2.1M

Select item 664220510.

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

Shang-Ze Li, Qi-Peng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bing-Xue Jin, Tian-Zi Liuyu, Chao Li, Xi-Chen Huang, Run-Lei Du, Wei Song, Bo Zhong, Xiao-Dong Zhang

Nat Commun. 2019; 10: 3233. Published online 2019 Jul 19. doi: 10.1038/s41467-019-11258-x

PMCID:: PMC6642205

Abstract Article PDF–2.9M

Select item 521767611.

Lijuan Xing, Yang An, Guangsen Shi, Jie Yan, Pancheng Xie, Zhipeng Qu, Zhihui Zhang, Zhiwei Liu, Dejing Pan, Ying Xu

J Biol Chem. 2017 Jan 6; 292(1): 161–171. Published online 2016 Nov 22. doi: 10.1074/jbc.M116.751214

PMCID:: PMC5217676

Abstract Article PDF–3.0M

Select item 725485012.

Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease

Mali Jiang, Xiaoyan Zhang, Hongshuai Liu, Jared LeBron, Athanasios Alexandris, Qi Peng, Hao Gu, Fanghan Yang, Yuchen Li, Ruiling Wang, Zhipeng Hou, Nicolas Arbez, Qianwei Ren, Jen-Li Dong, Emma Whela, Ronald Wang, Tamara Ratovitski, Juan C Troncoso, Susumu Mori, Christopher A Ross, Janghoo Lim, Wenzhen Duan

Hum Mol Genet. 2020 May 28; 29(8): 1340–1352. Published online 2020 Apr 2. doi: 10.1093/hmg/ddaa061

PMCID:: PMC7254850

Abstract Article PDF–1.3M

Select item 644400113.

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Veerle Fleskens, Carlos M. Minutti, Xingmei Wu, Ping Wei, Cornelieke E.G.M. Pals, James McCrae, Saskia Hemmers, Vincent Groenewold, Harm-Jan Vos, Alexander Rudensky, Fan Pan, Huabin Li, Dietmar M. Zaiss, Paul J. Coffer

Cell Rep. 2019 Mar 26; 26(13): 3600–3612.e6. Published online 2019 Mar 26. doi: 10.1016/j.celrep.2019.02.087

PMCID:: PMC6444001

Abstract Article

Select item 733422014.

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare, K. M. Sakamoto

Nat Commun. 2020; 11: 3344. Published online 2020 Jul 3. doi: 10.1038/s41467-020-17100-z

PMCID:: PMC7334220

Abstract Article PDF–2.4M

Select item 216905115.

Nemo-Like Kinase-Myocyte Enhancer Factor 2A Signaling Regulates Anterior Formation in Xenopus Development

Kiyotoshi Satoh, Junji Ohnishi, Atsushi Sato, Michio Takeyama, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya

Mol Cell Biol. 2007 Nov; 27(21): 7623–7630. Published online 2007 Sep 4. doi: 10.1128/MCB.01481-07

PMCID:: PMC2169051

Abstract Article PDF–576K

Select item 1115836816.

Nemo‐like kinase suppresses a wide range of transcription factors, including nuclear factor‐kB

Jun Yasuda, Hideki Yokoo, Tesshi Yamada, Issay Kitabayashi, Takao Sekiya, Hitoshi Ichikawa

Cancer Sci. 2004 Jan; 95(1): 52–57. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2004.tb03170.x

PMCID:: PMC11158368

Abstract Article PDF–509K

Select item 521012217.

Phosphorylation by NLK inhibits YAP‐14‐3‐3‐interactions and induces its nuclear localization

Sungho Moon, Wantae Kim, Soyoung Kim, Youngeun Kim, Yonghee Song, Oleksii Bilousov, Jiyoung Kim, Taebok Lee, Boksik Cha, Minseong Kim, Hanjun Kim, Vladimir L Katanaev, Eek‐hoon Jho

EMBO Rep. 2017 Jan; 18(1): 61–71. Published online 2016 Dec 15. doi: 10.15252/embr.201642683

PMCID:: PMC5210122

Abstract Article PDF–2.1M

Select item 38742118.

Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK

Chie Kanei-Ishii, Jun Ninomiya-Tsuji, Jun Tanikawa, Teruaki Nomura, Tohru Ishitani, Satoshi Kishida, Kenji Kokura, Toshihiro Kurahashi, Emi Ichikawa-Iwata, Yongsok Kim, Kunihiro Matsumoto, Shunsuke Ishii

Genes Dev. 2004 Apr 1; 18(7): 816–829. doi: 10.1101/gad.1170604