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Select item 109730621.

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse

Jin-Wen Kang, Jia-Peng He, Ying-Nan Liu, Yu Zhang, Shan-Shan Song, Qi-Xin Xu, Shu-Wen Wei, Lei Lu, Xiang-Qi Meng, Lin Xu, Bin Guo, Ren-Wei Su

Cell Mol Life Sci. 2024 Dec; 81(1): 155. Published online 2024 Mar 28. doi: 10.1007/s00018-024-05143-0

PMCID:: PMC10973062

Abstract Article PDF–23M

Select item 108664022.

Myeloid-specific knockout of Notch-1 inhibits MyD88- and TRIF-mediated TLR signaling pathways by regulating oxidative stress-SHP2 axis, thus restraining aneurysm progression

Yu Li, Ailin Guo, Jianlei Liu, Lijuan Tang, Lide Su, Zonghong Liu

Aging (Albany NY) 2024 Jan 31; 16(2): 1182–1191. Published online 2024 Jan 26. doi: 10.18632/aging.205392

PMCID:: PMC10866402

Abstract Article PDF–982K

Select item 105600833.

Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis

Rachel K LoPilato, Heike Kroeger, Sneha K Mohan, James D Lauderdale, Neil Grimsey, Robert S Haltiwanger

Glycobiology. 2023 Aug; 33(8): 661–672. Published online 2023 Jun 17. doi: 10.1093/glycob/cwad048

PMCID:: PMC10560083

Abstract Article PDF–1.5M

Select item 102633834.

Aberrant activation of Notch1 signaling in the mouse uterine epithelium promotes hyper-proliferation by increasing estrogen sensitivity

Qi-Xin Xu, Manoj Madhavan, Shu-Wen Wei, Wang-Qing Zhang, Lei Lu, Ke-Zhi Wang, Moldovan Genna, Yong Song, Yu Zhao, Huan-Ting Shao, Jin-Wen Kang, Asgerally T. Fazleabas, Ripla Arora, Ren-Wei Su

FASEB J. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: FASEB J. 2023 Jul; 37(7): e22983. doi: 10.1096/fj.202201868RR

PMCID:: PMC10263383

Abstract Article PDF–3.8M

Select item 101879835.

A double negative thymocyte specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection

Mariko Kashiwagi, Daniela Salgado Figueroa, Ferhat Ay, Bruce A Morgan, Katia Georgopoulos

Nat Immunol. Author manuscript; available in PMC 2023 May 16.

Published in final edited form as: Nat Immunol. 2022 Nov; 23(11): 1628–1643. Published online 2022 Oct 31. doi: 10.1038/s41590-022-01322-y

PMCID:: PMC10187983

Abstract Article PDF–7.3M

Select item 99253796.

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth

Emilie Abby, Stefan C. Dentro, Michael W. J. Hall, Joanna C. Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W. Siebel, Moritz Gerstung, Benjamin A. Hall, Philip H. Jones

Nat Genet. 2023; 55(2): 232–245. Published online 2023 Jan 19. doi: 10.1038/s41588-022-01280-z

PMCID:: PMC9925379

Abstract Article PDF–23M

Select item 98387157.

Deletion of Notch1 during Cochlear Maturation Leads to Rapid Supporting Cell Death and Profound Deafness

Alison Heffer, Felicia A. Gilels, Amy E. Kiernan

J Neurosci. 2023 Jan 11; 43(2): 199–210. doi: 10.1523/JNEUROSCI.1090-22.2022

PMCID:: PMC9838715

Abstract Article PDF–5.6M

Select item 92542568.

NOTCH1 signaling regulates the latent neurogenic program in adult reactive astrocytes after spinal cord injury

Zijian Tan, Shangyao Qin, Yimin Yuan, Xin Hu, Xiao Huang, Hong Liu, Yingyan Pu, Cheng He, Zhida Su

Theranostics. 2022; 12(10): 4548–4563. Published online 2022 May 27. doi: 10.7150/thno.71378

PMCID:: PMC9254256

Abstract Article PDF–5.2M

Select item 92342389.

Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells

Kenjiroo Matsumoto, Vivek Kumar, Shweta Varshney, Alison V. Nairn, Atsuko Ito, Florian Pennarubia, Kelley W. Moremen, Pamela Stanley, Robert S. Haltiwanger

J Biol Chem. 2022 Jul; 298(7): 102064. Published online 2022 May 25. doi: 10.1016/j.jbc.2022.102064

PMCID:: PMC9234238

Abstract Article PDF–2.9M

Select item 909025710.

A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion

Kilian Sottoriva, Na Yoon Paik, Zachary White, Thilinie Bandara, Lijian Shao, Teruyuki Sano, Kostandin V. Pajcini

JCI Insight. 2022 May 9; 7(9): e157015. Published online 2022 May 9. doi: 10.1172/jci.insight.157015

PMCID:: PMC9090257

Abstract Article PDF–3.9M

Select item 891363911.

Sex-specific involvement of the Notch–JAG pathway in social recognition

Hanna Jaaro-Peled, Melissa A. Landek-Salgado, Nicola G. Cascella, Frederick C. Nucifora, Jr, Jennifer M. Coughlin, Gerald Nestadt, Thomas W. Sedlak, Joelle Lavoie, Sarah De Silva, Somin Lee, Katsunori Tajinda, Hideki Hiyama, Koko Ishizuka, Kun Yang, Akira Sawa

Transl Psychiatry. 2022; 12: 99. Published online 2022 Mar 10. doi: 10.1038/s41398-022-01867-4

PMCID:: PMC8913639

Abstract Article PDF–687K

Select item 866628712.

Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling

Yueyi Yang, Demao Zhang, Daimo Guo, Jiachi Li, Siqun Xu, Jieya Wei, Jing Xie, Xuedong Zhou

Cell Prolif. 2021 Dec; 54(12): e13156. Published online 2021 Nov 2. doi: 10.1111/cpr.13156

PMCID:: PMC8666287

Abstract Article PDF–2.6M

Select item 837391913.

Notch1 haploinsufficiency in mice accelerates adipogenesis

Kazutoshi Yamaguchi, Motoharu Hayashi, Yasuhiro Uchida, Xian Wu Cheng, Takayuki Nakayama, Tadashi Matsushita, Toyoaki Murohara, Kyosuke Takeshita

Sci Rep. 2021; 11: 16761. Published online 2021 Aug 18. doi: 10.1038/s41598-021-96017-z

PMCID:: PMC8373919

Abstract Article PDF–2.0M

Select item 801651414.

Intracerebral hemorrhage influences hippocampal neurogenesis and neurological function recovery via Notch1 signaling

Jing Chen, Xing-Yun Yuan, Xu Zhang

Neuroreport. 2021 Apr 7; 32(6): 489–497. Published online 2021 Mar 1. doi: 10.1097/WNR.0000000000001614

PMCID:: PMC8016514

Abstract Article PDF–722K

Select item 748388215.

Modulation of Notch1 signaling regulates bone fracture healing

Sanja Novak, Emilie Roeder, Benjamin P. Sinder, Douglas J. Adams, Chris W. Siebel, Danka Grcevic, Kurt D. Hankenson, Brya G. Matthews, Ivo Kalajzic

J Orthop Res. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Orthop Res. 2020 Nov; 38(11): 2350–2361. Published online 2020 Mar 16. doi: 10.1002/jor.24650

PMCID:: PMC7483882

Abstract Article PDF–3.0M

Select item 736387816.

Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition

Natacha Bohin, Theresa M. Keeley, Alexis J. Carulli, Emily M. Walker, Elizabeth A. Carlson, Jie Gao, Iannis Aifantis, Christian W. Siebel, Michael W. Rajala, Martin G. Myers, Jr., Jennifer C. Jones, Constance D. Brindley, Peter J. Dempsey, Linda C. Samuelson

Stem Cell Reports. 2020 Jul 14; 15(1): 156–170. Published online 2020 Jun 11. doi: 10.1016/j.stemcr.2020.05.010

PMCID:: PMC7363878

Abstract Article PDF–8.6M

Select item 734813817.

Inhibition of the Notch1 pathway induces peripartum cardiomyopathy

Rong‐rong Zhu, Qian Chen, Zhi‐bo Liu, Han‐guang Ruan, Qi‐cai Wu, Xue‐liang Zhou

J Cell Mol Med. 2020 Jul; 24(14): 7907–7914. Published online 2020 Jun 11. doi: 10.1111/jcmm.15423

PMCID:: PMC7348138

Abstract Article PDF–1.2M

Select item 732420818.

Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress

Irma Tindemans, Anne van Schoonhoven, Alex KleinJan, Marjolein J.W. de Bruijn, Melanie Lukkes, Menno van Nimwegen, Anouk van den Branden, Ingrid M. Bergen, Odilia B.J. Corneth, Wilfred F.J. van IJcken, Ralph Stadhouders, Rudi W. Hendriks

J Clin Invest. 2020 Jul 1; 130(7): 3576–3591. Published online 2020 Jun 2. doi: 10.1172/JCI128310

PMCID:: PMC7324208

Abstract Article PDF–9.5M

Select item 718587119.

Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties

Hong Qiu, Patrick M. Zmina, Alex Y. Huang, David Askew, Barbara Bedogni

Cancer Lett. Author manuscript; available in PMC 2020 Apr 27.

Published in final edited form as: Cancer Lett. 2018 Oct 10; 434: 144–151. Published online 2018 Jul 21. doi: 10.1016/j.canlet.2018.07.024

PMCID:: PMC7185871

Abstract Article PDF–1.1M

Select item 698496420.

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland

Anna M. Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D. Simons, Silvia Fre

Nat Cell Biol. Author manuscript; available in PMC 2020 Jan 27.

Published in final edited form as: Nat Cell Biol. 2018 Jun 1; 20(6): 677–687. Published online 2018 May 21. doi: 10.1038/s41556-018-0108-1