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Select item 110146671.

Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL

Nicolas Dupré, Florian Gueniot, Valérie Domenga-Denier, Virginie Dubosclard, Christelle Nilles, David Hill-Eubanks, Christelle Morgenthaler-Roth, Mark T. Nelson, Céline Keime, Lydia Danglot, Anne Joutel

J Clin Invest. 2024 Apr 15; 134(8): e175789. Published online 2024 Feb 22. doi: 10.1172/JCI175789

PMCID:: PMC11014667

Abstract Article PDF–19M

Select item 108702282.

INDUCTION OF A NOTCH3 LEHMAN SYNDROME MUTATION IN OSTEOCYTES CAUSES OSTEOPENIA IN MALE C57BL/6J MICE

E. Canalis, S.P. Yee, A.N. Economides, L. Schilling, J. Yu

Bone. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Bone. 2022 Sep; 162: 116476. Published online 2022 Jun 26. doi: 10.1016/j.bone.2022.116476

PMCID:: PMC10870228

Abstract Article PDF–1.8M

Select item 107867013.

Milagros C. Romay, Russell H. Knutsen, Feiyang Ma, Ana Mompeón, Gloria E. Hernandez, Jocelynda Salvador, Snezana Mirkov, Ayush Batra, David P. Sullivan, Daniele Procissi, Samuel Buchanan, Elise Kronquist, Elisa A. Ferrante, William A. Muller, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Craig Horbinski, Elisabeth Tournier‑Lasserve, Adam M. Sonabend, Farzaneh A. Sorond, Michael M. Wang, Manfred Boehm, Beth A. Kozel, M. Luisa Iruela-Arispe

J Clin Invest. 2024 Jan 16; 134(2): e166134. Published online 2024 Jan 16. doi: 10.1172/JCI166134

PMCID:: PMC10786701

Abstract Article PDF–8.4M

Select item 104976274.

Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart

Francesca Del Gaudio, Dongli Liu, Maarja Andaloussi Mäe, Eike-Benjamin Braune, Emil M. Hansson, Qing-Dong Wang, Christer Betsholtz, Urban Lendahl

Sci Rep. 2023; 13: 15022. Published online 2023 Sep 12. doi: 10.1038/s41598-023-42010-7

PMCID:: PMC10497627

Abstract Article PDF–9.2M

Select item 97882315.

Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca²⁺ Entry

Frank Helle, Michael Hultström, Panagiotis Kavvadas, Bjarne Iversen, Christos E. Chadjichristos, Christos Chatziantoniou

Int J Mol Sci. 2022 Dec; 23(24): 16068. Published online 2022 Dec 16. doi: 10.3390/ijms232416068

PMCID:: PMC9788231

Abstract Article PDF–1.8M

Select item 90899116.

Use of antisense oligonucleotides to target Notch3 in skeletal cells

Ernesto Canalis, Michele Carrer, Tabitha Eller, Lauren Schilling, Jungeun Yu

PLoS One. 2022; 17(5): e0268225. Published online 2022 May 10. doi: 10.1371/journal.pone.0268225

PMCID:: PMC9089911

Abstract Article PDF–2.1M

Select item 88634787.

Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome

Kathryn Jespersen, Chenxin Li, Rishi Batra, Christopher A. Stephenson, Paul Harding, Kylie Sestak, Ryan T. Foley, Harrison Greene, Trevor Meisinger, Jason R. Cook, B. Timothy Baxter, Wanfen Xiong

J Immunol Res. 2022; 2022: 7538649. Published online 2022 Feb 15. doi: 10.1155/2022/7538649

PMCID:: PMC8863478

Abstract Article PDF–1.0M

Select item 87789058.

Activation of Notch3 in Renal Tubular Cells Leads to Progressive Cystic Kidney Disease

Sonja Djudjaj, Panagiotis Kavvadas, Niki Prakoura, Roman D. Bülow, Tiffany Migeon, Sandrine Placier, Christos E. Chadjichristos, Peter Boor, Christos Chatziantoniou

Int J Mol Sci. 2022 Jan; 23(2): 884. Published online 2022 Jan 14. doi: 10.3390/ijms23020884

PMCID:: PMC8778905

Abstract Article PDF–4.4M

Select item 76089759.

Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression

Sabine Brandt, Tobias M. Ballhause, Anja Bernhardt, Annika Becker, Delia Salaru, Hien Minh Le-Deffge, Alexander Fehr, Yan Fu, Lars Philipsen, Sonja Djudjaj, Andreas J. Müller, Rafael Kramann, Mahmoud Ibrahim, Robert Geffers, Chris Siebel, Berend Isermann, Florian H. Heidel, Jonathan A. Lindquist, Peter R. Mertens

J Am Soc Nephrol. 2020 Nov; 31(11): 2589–2608. Published online 2020 Aug 28. doi: 10.1681/ASN.2019121289

PMCID:: PMC7608975

Abstract Article

Select item 748179410.

NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages

Susana López-López, Eva María Monsalve, María José Romero de Ávila, Julia González-Gómez, Natalia Hernández de León, Francisco Ruiz-Marcos, Victoriano Baladrón, María Luisa Nueda, María Jesús García-León, Isabella Screpanti, María Pía Felli, Jorge Laborda, José Javier García-Ramírez, María José M. Díaz-Guerra

Sci Rep. 2020; 10: 14839. Published online 2020 Sep 9. doi: 10.1038/s41598-020-71810-4

PMCID:: PMC7481794

Abstract Article PDF–1.6M

Select item 728939411.

Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model

Jessica C. Price, Elham Azizi, L. A. Naiche, Jenny G. Parvani, Priyanka Shukla, Seoyeon Kim, Jill K. Slack-Davis, Dana Pe’er, Jan K. Kitajewski

PLoS One. 2020; 15(6): e0233962. Published online 2020 Jun 11. doi: 10.1371/journal.pone.0233962

PMCID:: PMC7289394

Abstract Article PDF–2.6M

Select item 677870212.

An Antibody to Notch3 Reverses the Skeletal Phenotype of Lateral Meningocele Syndrome in Male Mice

Jungeun Yu, Christian W. Siebel, Lauren Schilling, Ernesto Canalis

J Cell Physiol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Cell Physiol. 2020 Jan; 235(1): 210–220. Published online 2019 Jun 12. doi: 10.1002/jcp.28960

PMCID:: PMC6778702

Abstract Article PDF–2.1M

Select item 659683413.

Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone

Hiroki Kawai, Daichi Kawaguchi, Benjamin D. Kuebrich, Takeo Kitamoto, Masahiro Yamaguchi, Yukiko Gotoh, Shohei Furutachi

J Neurosci. 2017 Dec 6; 37(49): 11867–11880. doi: 10.1523/JNEUROSCI.0001-17.2017

PMCID:: PMC6596834

Abstract Article PDF–3.6M

Select item 650250514.

Notch3 as a novel therapeutic target in metastatic medullary thyroid cancer

Irene Lou, Scott Odorico, Xiao-Min Yu, April Harrison, Renata Jaskula-Sztul, Herbert Chen

Surgery. Author manuscript; available in PMC 2019 May 6.

Published in final edited form as: Surgery. 2018 Jan; 163(1): 104–111. Published online 2017 Nov 8. doi: 10.1016/j.surg.2017.07.039

PMCID:: PMC6502505

Abstract Article PDF–1.8M

Select item 613093215.

The lateral meningocele syndrome mutation causes marked osteopenia in mice

Ernesto Canalis, Jungeun Yu, Lauren Schilling, Siu-Pok Yee, Stefano Zanotti

J Biol Chem. 2018 Sep 7; 293(36): 14165–14177. Published online 2018 Jul 24. doi: 10.1074/jbc.RA118.004242

PMCID:: PMC6130932

Abstract Article PDF–4.4M

Select item 563970716.

Notch3 deficiency impairs coronary microvascular maturation and reduces cardiac recovery after myocardial ischemia

Yong-Kang Tao, Heng Zeng, Guo-Qiang Zhang, Sean T Chen, Xue-Jiao Xie, Xiaochen He, Shuo Wang, Hongyan Wen, Jian-Xiong Chen

Int J Cardiol. Author manuscript; available in PMC 2017 Oct 13.

Published in final edited form as: Int J Cardiol. 2017 Jun 1; 236: 413–422. Published online 2017 Jan 24. doi: 10.1016/j.ijcard.2017.01.096

PMCID:: PMC5639707

Abstract Article PDF–874K

Select item 448357417.

Activation of Notch3 in Glomeruli Promotes the Development of Rapidly Progressive Renal Disease

Fala El Machhour, Zela Keuylian, Panagiotis Kavvadas, Jean-Claude Dussaule, Christos Chatziantoniou

J Am Soc Nephrol. 2015 Jul; 26(7): 1561–1575. Published online 2014 Nov 24. doi: 10.1681/ASN.2013090968

PMCID:: PMC4483574

Abstract Article

Select item 424402418.

Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord

Gabriel Rusanescu, Jianren Mao

J Cell Mol Med. 2014 Oct; 18(10): 2103–2116. Published online 2014 Aug 28. doi: 10.1111/jcmm.12362

PMCID:: PMC4244024

Abstract Article PDF–2.0M

Select item 312141119.

Activation Dynamics and Signaling Properties of Notch3 Receptor in the Developing Pulmonary Artery

Shamik Ghosh, Jesus R. Paez-Cortez, Karthik Boppidi, Michelle Vasconcelos, Monideepa Roy, Wellington Cardoso, Xingbin Ai, Alan Fine

J Biol Chem. 2011 Jun 24; 286(25): 22678–22687. Published online 2011 May 2. doi: 10.1074/jbc.M111.241224

PMCID:: PMC3121411

Abstract Article PDF–3.4M

Select item 265874820.

Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries

E.J. Belin de Chantemèle, K. Retailleau, F. Pinaud, E. Vessières, A Bocquet, A.L. Guihot, B. Lemaire, V. Domenga, C. Baufreton, L. Loufrani, A. Joutel, D. Henrion

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2009 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12): 2216–2224. Published online 2008 Sep 25. doi: 10.1161/ATVBAHA.108.171751

PMCID:: PMC2658748

Abstract Article PDF–579K

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