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Select item 116158091.

The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation

Chenxi Li, Qiongliang Liu, Lianyong Han, Haiyun Zhang, Roland Immler, Birgit Rathkolb, Judith Secklehner, Martin Hrabe de Angelis, Ali Önder Yildirim, Dagmar Zeuschner, Annette Nicke, Leo M. Carlin, Markus Sperandio, Tobias Stoeger, Markus Rehberg

Adv Sci (Weinh) 2024 Dec; 11(45): 2404661. Published online 2024 Oct 4. doi: 10.1002/advs.202404661

PMCID:: PMC11615809

Article PDF–5.2M

Select item 113904602.

Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain of Toxoplasma gondii

Thuany Prado-Rangel, Aline Cristina Abreu Moreira-Souza, Sthefani Rodrigues Batista da Silva, Thais Barboza-Araujo, Archimedes Barbosa Castro-Junior, Isalira Peroba Rezende Ramos, Christina Maeda Takiya, Rossiane Claudia Vommaro, Robson Coutinho-Silva

Front Immunol. 2024; 15: 1452828. Published online 2024 Aug 29. doi: 10.3389/fimmu.2024.1452828

PMCID:: PMC11390460

Article PDF–7.0M

Select item 112322843.

New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling

Jiajia Lu, Xiaojian Shi, Qiang Fu, Yaguang Han, Lei Zhu, Zhibin Zhou, Yongchuan Li, Nan Lu

Cell Mol Biol Lett. 2024; 29: 100. Published online 2024 Jul 8. doi: 10.1186/s11658-024-00614-5

PMCID:: PMC11232284

Article PDF–2.7M

Select item 110704684.

The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation

Ylenia Longo, Sara Moreno Mascaraque, Giuseppe Andreacchio, Julia Werner, Ichiro Katahira, Elena De Marchi, Anna Pegoraro, Robert Jan Lebbink, Karl Köhrer, Patrick Petzsch, Ronny Tao, Francesco Di Virgilio, Elena Adinolfi, Ingo Drexler

Front Immunol. 2024; 15: 1360140. Published online 2024 Apr 22. doi: 10.3389/fimmu.2024.1360140

PMCID:: PMC11070468

Article PDF–3.0M

Select item 104628285.

P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse

Lumei Huang, Paula Mut-Arbona, Bernadett Varga, Bibiana Török, János Brunner, Antonia Arszovszki, András Iring, Máté Kisfali, E. Sylvester Vizi, Beáta Sperlágh

iScience. 2023 Sep 15; 26(9): 107560. Published online 2023 Aug 7. doi: 10.1016/j.isci.2023.107560

PMCID:: PMC10462828

Article PDF–7.4M

Select item 102911796.

Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control

Letícia Paula Trajano Noronha, Monique Daiane Andrade Martins, Archimedes Barbosa Castro-Junior, Maria Luiza Thorstenberg, Laís Costa-Soares, Thuany Prado Rangel, Felipe Carvalho-Gondim, Bartira Rossi-Bergmann, Luiz Eduardo Baggio Savio, Claudio de Azevedo Canetti, Robson Coutinho-Silva

Front Cell Infect Microbiol. 2023; 13: 1192800. Published online 2023 Jun 12. doi: 10.3389/fcimb.2023.1192800

PMCID:: PMC10291179

Article PDF–2.1M

Select item 102456107.

P2X7 receptor inhibition ameliorates ubiquitin–proteasome system dysfunction associated with Alzheimer’s disease

Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández

Alzheimers Res Ther. 2023; 15: 105. Published online 2023 Jun 7. doi: 10.1186/s13195-023-01258-x

PMCID:: PMC10245610

Article PDF–10M

Select item 102358578.

Upregulation of P2X7 Exacerbates Myocardial Ischemia–Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice

Fancan Wu, Hong Wei, Yingxin Hu, Jiahong Gao, Shiyuan Xu

J Immunol. 2023 Jun 15; 210(12): 1962–1973. Published online 2023 May 5. doi: 10.4049/jimmunol.2200838

PMCID:: PMC10235857

Article PDF–4.7M

Select item 101606269.

P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice

Vinícius Santos Alves, Joyce Pereira da Silva, Fabiana Cristina Rodrigues, Suzana Maria Bernardino Araújo, André Luiz Gouvêa, Raíssa Leite-Aguiar, Stephanie Alexia Cristina Silva Santos, Milla Souza Pessoa da Silva, Fernanda Silva Ferreira, Eduardo Peil Marques, Beatriz Amanda Barbosa Rangel dos Passos, Tatiana Maron-Gutierrez, Eleonora Kurtenbach, Robson da Costa, Cláudia Pinto Figueiredo, Angela T. S. Wyse, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio

Front Pharmacol. 2023; 14: 1179723. Published online 2023 Apr 21. doi: 10.3389/fphar.2023.1179723

PMCID:: PMC10160626

Article PDF–1.8M

Select item 1010801510.

Increased uptake of the P2X7 receptor radiotracer ¹⁸F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice

James Morgan, Oscar Moreno, Mariana Alves, Zuriñe Baz, Aida Menéndez Méndez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke, Anindya Bhattacharya, Marc Ceusters, David C. Henshall, Vanessa Gómez‐Vallejo, Jordi Llop, Tobias Engel

Epilepsia. 2023 Feb; 64(2): 511–523. Published online 2022 Dec 27. doi: 10.1111/epi.17484

PMCID:: PMC10108015

Article PDF–4.2M

Select item 996277911.

Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development

Paula Mut-Arbona, Lumei Huang, Mária Baranyi, Pál Tod, András Iring, Francesco Calzaferri, Cristobal de los Ríos, Beáta Sperlágh

J Neurosci. 2023 Feb 15; 43(7): 1125–1142. doi: 10.1523/JNEUROSCI.0805-22.2022

PMCID:: PMC9962779

Article PDF–4.0M

Select item 983218112.

P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons

Rachael Bartlett, Diane Ly, Neil R. Cashman, Ronald Sluyter, Justin J. Yerbury

Purinergic Signal. 2022 Dec; 18(4): 451–467. Published online 2022 Apr 28. doi: 10.1007/s11302-022-09863-5

PMCID:: PMC9832181

Article PDF–4.4M

Select item 935548013.

ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively

Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang

Front Pharmacol. 2022; 13: 944541. Published online 2022 Jul 22. doi: 10.3389/fphar.2022.944541

PMCID:: PMC9355480

Article PDF–3.1M

Select item 925064114.

P2RX7 enhances tumor control by CD8⁺ T cells in adoptive cell therapy

Kelsey M. Wanhainen, Changwei Peng, Maggie H. Zhou, Bruna de Gois Macedo, Stephen O’Flanagan, Tingyuan Yang, Ameeta Kelekar, Brandon J. Burbach, Henrique Borges da Silva, Stephen C. Jameson

Cancer Immunol Res. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Cancer Immunol Res. 2022 Jul 1; 10(7): 871–884. doi: 10.1158/2326-6066.CIR-21-0691

PMCID:: PMC9250641

Article PDF–2.2M

Select item 909955115.

The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome

Claudio Bernardazzi, Morgana Teixeira Lima Castelo-Branco, Beatriz Pêgo, Beatriz Elias Ribeiro, Siane Lopes Bittencourt Rosas, Patrícia Teixeira Santana, João Carlos Machado, Camille Leal, Fabiano Thompson, Robson Coutinho-Silva, Heitor Siffert Pereira de Souza

Int J Mol Sci. 2022 May; 23(9): 4616. Published online 2022 Apr 21. doi: 10.3390/ijms23094616

PMCID:: PMC9099551

Article PDF–4.5M

Select item 909763216.

Medullary astrocytes mediate irregular breathing patterns generation in chronic heart failure through purinergic P2X7 receptor signalling

Camilo Toledo, Esteban Díaz-Jara, Hugo S. Diaz, Karla G. Schwarz, Katherin V. Pereyra, Alexandra Las Heras, Angélica Rios-Gallardo, David C. Andrade, Thiago Moreira, Ana Takakura, Noah J. Marcus, Rodrigo Del Rio

eBioMedicine. 2022 Jun; 80: 104044. Published online 2022 May 9. doi: 10.1016/j.ebiom.2022.104044

PMCID:: PMC9097632

Article PDF–4.1M

Select item 901800917.

Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences

Alexandre A. da Silva, Sydney P. Moak, Xuemei Dai, Gisele C. Borges, Ana C. M. Omoto, Zhen Wang, Xuan Li, Alan J. Mouton, John E. Hall, Jussara M. do Carmo

Am J Physiol Regul Integr Comp Physiol. 2022 May 1; 322(5): R421–R433. Published online 2022 Mar 23. doi: 10.1152/ajpregu.00300.2021

PMCID:: PMC9018009

Article

Select item 897673918.

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8⁺ T Cells

Trupti Vardam-Kaur, Sarah van Dijk, Changwei Peng, Kelsey M. Wanhainen, Stephen C. Jameson, Henrique Borges da Silva

J Immunol. 2022 Apr 1; 208(7): 1686–1699. Published online 2022 Apr 1. doi: 10.4049/jimmunol.2100555

PMCID:: PMC8976739

Article PDF–2.9M

Select item 878877819.

Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance

Alba Clara Sarti, Valentina Vultaggio-Poma, Simonetta Falzoni, Sonia Missiroli, Anna Lisa Giuliani, Paola Boldrini, Massimo Bonora, Francesco Faita, Nicole Di Lascio, Claudia Kusmic, Anna Solini, Salvatore Novello, Michele Morari, Marco Rossato, Mariusz R Wieckowski, Carlotta Giorgi, Paolo Pinton, Francesco Di Virgilio

Function (Oxf) 2021; 2(2): zqab005. Published online 2021 Jan 28. doi: 10.1093/function/zqab005

Correction in:: Function (Oxf). 2021; 2(4): zqab025.

PMCID:: PMC8788778

Article PDF–1.1M

Select item 869542120.

Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice

Paola Fabbrizio, Jessica D’Agostino, Cassandra Margotta, Giulia Mella, Nicolò Panini, Laura Pasetto, Eliana Sammali, Flavia Raggi, Gianni Sorarù, Valentina Bonetto, Caterina Bendotti, Giovanni Nardo

Cell Mol Life Sci. 2022 Jan; 79(1): 7. Published online 2021 Dec 22. doi: 10.1007/s00018-021-04070-8

PMCID:: PMC8695421

Article PDF–13M

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