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Select item 105094611.

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development

Sarah Gruenbacher, Markus Jaritz, Louisa Hill, Markus Schäfer, Meinrad Busslinger

J Exp Med. 2023 Dec 4; 220(12): e20230260. Published online 2023 Sep 19. doi: 10.1084/jem.20230260

PMCID:: PMC10509461

Abstract Article PDF–7.6M

Select item 93597292.

Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice

Ana Casado-García, Marta Isidro-Hernández, Ninad Oak, Andrea Mayado, Christine Mann-Ran, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Alexandra Buhles, Dario Sterker, Elena G. Sánchez, Jorge Martínez-Cano, Oscar Blanco, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Thomas Radimerski, Manuel Ramírez-Orellana, César Cobaleda, Jun J. Yang, Carolina Vicente-Dueñas, Andreas Weiss, Kim E. Nichols, Isidro Sánchez-García

Cancer Res. 2022 Mar 15; 82(6): 1098–1109. Published online 2022 Mar 15. doi: 10.1158/0008-5472.CAN-21-3386

PMCID:: PMC9359729

Abstract Article PDF–1.2M

Select item 76114493.

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN downregulation

Lesly Calderón, Karina Schindler, Stephen G. Malin, Alexandra Schebesta, Qiong Sun, Tanja Schwickert, Chiara Alberti, Maria Fischer, Markus Jaritz, Hiromi Tagoh, Anja Ebert, Martina Minnich, Adrian Liston, Luisa Cochella, Meinrad Busslinger

Sci Immunol. Author manuscript; available in PMC 2022 Jan 23.

Published in final edited form as: Sci Immunol. 2021 Jul 23; 6(61): eabg5003. Published online 2021 Jul 23. doi: 10.1126/sciimmunol.abg5003

PMCID:: PMC7611449

Abstract Article PDF–4.1M

Select item 62455744.

Loss of Pax5 exploits Sca1-BCR-ABL^p190 susceptibility to confer the metabolic shift essential for pB-ALL

Alberto Martín-Lorenzo, Franziska Auer, Lai N. Chan, Idoia García-Ramírez, Inés González-Herrero, Guillermo Rodríguez-Hernández, Christoph Bartenhagen, Martin Dugas, Michael Gombert, Sebastian Ginzel, Oscar Blanco, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Maria B. García-Cenador, Francisco J. García-Criado, Markus Müschen, Isidro Sánchez-García, Arndt Borkhardt, Carolina Vicente-Dueñas, Julia Hauer

Cancer Res. Author manuscript; available in PMC 2019 May 15.

Published in final edited form as: Cancer Res. 2018 May 15; 78(10): 2669–2679. Published online 2018 Feb 28. doi: 10.1158/0008-5472.CAN-17-3262

PMCID:: PMC6245574

Abstract Article PDF–1.7M

Select item 44588005.

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia

Jinjun Dang, Lei Wei, Jeroen de Ridder, Xiaoping Su, Alistair G. Rust, Kathryn G. Roberts, Debbie Payne-Turner, Jinjun Cheng, Jing Ma, Chunxu Qu, Gang Wu, Guangchun Song, Robert G. Huether, Brenda Schulman, Laura Janke, Jinghui Zhang, James R. Downing, Louise van der Weyden, David J. Adams, Charles G. Mullighan

Blood. 2015 Jun 4; 125(23): 3609–3617. Prepublished online 2015 Apr 8. doi: 10.1182/blood-2015-02-626127

PMCID:: PMC4458800

Abstract Article

Select item 34000136.

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

Roger Revilla-i-Domingo, Ivan Bilic, Bojan Vilagos, Hiromi Tagoh, Anja Ebert, Ido M Tamir, Leonie Smeenk, Johanna Trupke, Andreas Sommer, Markus Jaritz, Meinrad Busslinger

EMBO J. 2012 Jul 18; 31(14): 3130–3146. Published online 2012 Jun 5. doi: 10.1038/emboj.2012.155

PMCID:: PMC3400013

Abstract Article PDF–1.5M

Select item 33936777.

Regulation of DNA Replication within the Immunoglobulin Heavy-Chain Locus During B Cell Commitment

Agnieszka Demczuk, Michel G. Gauthier, Ingrid Veras, Settapong Kosiyatrakul, Carl L. Schildkraut, Meinrad Busslinger, John Bechhoefer, Paolo Norio

PLoS Biol. 2012 Jul; 10(7): e1001360. Published online 2012 Jul 10. doi: 10.1371/journal.pbio.1001360

PMCID:: PMC3393677

Abstract Article PDF–1.3M

Select item 26604358.

Identifying Activated T Cells in Reconstituted RAG Deficient Mice Using Retrovirally Transduced Pax5 Deficient Pro-B Cells

Nadesan Gajendran, Dominique Vanhecke, Volker Brinkmann, Stefan H. E. Kaufmann

PLoS One. 2009; 4(4): e5115. Published online 2009 Apr 2. doi: 10.1371/journal.pone.0005115

PMCID:: PMC2660435

Abstract Article PDF–674K

Select item 22133509.

Early Function of Pax5 (BSAP) before the Pre-B Cell Receptor Stage of B Lymphopoiesis

Claire Thévenin, Stephen L. Nutt, Meinrad Busslinger

J Exp Med. 1998 Aug 17; 188(4): 735–744. doi: 10.1084/jem.188.4.735

PMCID:: PMC2213350

Abstract Article PDF–2.6M

Select item 221272710.

Pax5 Activates Immunoglobulin Heavy Chain V to DJ Rearrangement in Transgenic Thymocytes

Lih-Yun Hsu, Hong-Erh Liang, Kristen Johnson, Chulho Kang, Mark S. Schlissel

J Exp Med. 2004 Mar 15; 199(6): 825–830. doi: 10.1084/jem.20032249

PMCID:: PMC2212727

Abstract Article PDF–194K

Select item 183994311.

B-lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages

Suchita Hodawadekar, Duonan Yu, Diana Cozma, Bruce Freedman, Oriol Sunyer, Michael L. Atchison, Andrei Thomas-Tikhonenko

Exp Cell Res. Author manuscript; available in PMC 2008 Jan 15.

Published in final edited form as: Exp Cell Res. 2007 Jan 15; 313(2): 331–340. Published online 2006 Oct 25. doi: 10.1016/j.yexcr.2006.10.015

PMCID:: PMC1839943

Abstract Article PDF–639K

Select item 117057512.

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments.

S L Nutt, A M Morrison, P Dörfler, A Rolink, M Busslinger

EMBO J. 1998 Apr 15; 17(8): 2319–2333. doi: 10.1093/emboj/17.8.2319

PMCID:: PMC1170575

Summary PDF–552K

Select item 19596613.

Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments

David G.T. Hesslein, David L. Pflugh, Dipanjan Chowdhury, Alfred L. M. Bothwell, Ranjan Sen, David G. Schatz

Genes Dev. 2003 Jan 1; 17(1): 37–42. doi: 10.1101/gad.1031403

PMCID:: PMC195966

Abstract Article PDF–163K

Select item 16905314.

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPα and GATA factors

Barry Heavey, Christoforos Charalambous, Cesar Cobaleda, Meinrad Busslinger

EMBO J. 2003 Aug 1; 22(15): 3887–3897. doi: 10.1093/emboj/cdg380

PMCID:: PMC169053

Abstract Article PDF–581K

Select item 4168915.

Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription.

M F Neurath, E E Max, W Strober

Proc Natl Acad Sci U S A. 1995 Jun 6; 92(12): 5336–5340. doi: 10.1073/pnas.92.12.5336

PMCID:: PMC41689

Summary Page Browse PDF–1.7M

Select item 1044988716.

Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice

Marta Isidro-Hernández, Ana Casado-García, Ninad Oak, Silvia Alemán-Arteaga, Belén Ruiz-Corzo, Jorge Martínez-Cano, Andrea Mayado, Elena G. Sánchez, Oscar Blanco, Ma Luisa Gaspar, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Manuel Ramírez-Orellana, Belén de Andrés, Carolina Vicente-Dueñas, César Cobaleda, Kim E. Nichols, Isidro Sánchez-García

Nat Commun. 2023; 14: 5159. Published online 2023 Aug 24. doi: 10.1038/s41467-023-40961-z

PMCID:: PMC10449887

Abstract Article PDF–8.2M

Select item 992794117.

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling

J Clin Invest. 2023 Feb 15; 133(4): e163612. Published online 2023 Feb 15. doi: 10.1172/JCI163612

PMCID:: PMC9927941

Abstract Article PDF–3.0M

Select item 861691518.

Pax5 mediates the transcriptional activation of the CD81 gene

Kohei Hosokawa, Hanako Ishimaru, Tadashi Watanabe, Masahiro Fujimuro

Sci Rep. 2021; 11: 22919. Published online 2021 Nov 25. doi: 10.1038/s41598-021-02082-9

PMCID:: PMC8616915

Abstract Article PDF–2.7M

Select item 792375419.

Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1

Jiyeon Yu, Sumi Kim, Nari Lee, Hyoeun Jeon, Jun Lee, Masamichi Takami, Jaerang Rho

Int J Mol Sci. 2021 Feb; 22(4): 2097. Published online 2021 Feb 20. doi: 10.3390/ijms22042097

PMCID:: PMC7923754

Abstract Article PDF–2.5M

Select item 764472220.

Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

Marta Isidro-Hernández, Andrea Mayado, Ana Casado-García, Jorge Martínez-Cano, Chiara Palmi, Grazia Fazio, Alberto Orfao, Jordi Ribera, Josep Maria Ribera, Lurdes Zamora, Javier Raboso-Gallego, Oscar Blanco, Diego Alonso-López, Javier De Las Rivas, Rafael Jiménez, Francisco Javier García Criado, María Begoña García Cenador, Manuel Ramírez-Orellana, Giovanni Cazzaniga, César Cobaleda, Carolina Vicente-Dueñas, Isidro Sánchez-García

Sci Rep. 2020; 10: 19189. Published online 2020 Nov 5. doi: 10.1038/s41598-020-76206-y

PMCID:: PMC7644722

Abstract Article PDF–4.1M

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