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Select item 107770001.

Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice

Takahiro Arima, Kazuki Sugimoto, Takuya Taniwaki, Kazuya Maeda, Yuto Shibata, Makoto Tateyama, Tatsuki Karasugi, Takuya Tokunaga, Takanao Sueyoshi, Satoshi Hisanaga, Tetsuro Masuda, Yusuke Uehara, Masaki Yugami, Kozo Matsushita, Ryuji Yonemitsu, Junki Kawakami, Naoto Yoshimura, Shuntaro Tanimura, Hajime Kato, Nobuaki Ito, Kenichi Inoue, Kana Bando, Takayuki Nakamura, Takeshi Miyamoto

J Biol Chem. 2024 Jan; 300(1): 105512. Published online 2023 Nov 30. doi: 10.1016/j.jbc.2023.105512

PMCID:: PMC10777000

Abstract Article PDF–2.1M

Select item 102943762.

Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

Zhiqiang Gao, Qiang Wang, Kai Guo, Xinhua Li, Yufeng Huang

J Orthop Surg Res. 2023; 18: 462. Published online 2023 Jun 27. doi: 10.1186/s13018-023-03923-1

PMCID:: PMC10294376

Abstract Article PDF–5.6M

Select item 97293103.

Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity

Hwajung Choi, Liu Yang, Yudong Liu, Ju-Kyung Jeong, Eui-Sic Cho

Sci Rep. 2022; 12: 21158. Published online 2022 Dec 7. doi: 10.1038/s41598-022-25846-3

PMCID:: PMC9729310

Abstract Article PDF–6.2M

Select item 97095934.

Catalysis-independent ENPP1 protein signaling regulates mammalian bone mass

Kristin Zimmerman, Xiaochen Li, Simon von Kroge, Paul Stabach, Ethan R. Lester, Emily Y. Chu, Shivani Srivastava, Martha J. Somerman, Steven M. Tommasini, Björn Busse, Thorsten Schinke, Thomas O. Carpenter, Ralf Oheim, Demetrios T. Braddock

J Bone Miner Res. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: J Bone Miner Res. 2022 Sep; 37(9): 1733–1749. Published online 2022 Jul 29. doi: 10.1002/jbmr.4640

PMCID:: PMC9709593

Abstract Article PDF–3.1M

Select item 96653515.

Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice

Fiona L. Roberts, Nabil A. Rashdan, Kanchan Phadwal, Greg R. Markby, Scott Dillon, Janna Zoll, Julian Berger, Elspeth Milne, Isabel R. Orriss, Gerard Karsenty, Olivier Le Saux, Nicholas M. Morton, Colin Farquharson, Vicky E. MacRae

J Cell Physiol. Author manuscript; available in PMC 2022 Nov 15.

Published in final edited form as: J Cell Physiol. 2021 Jun; 236(6): 4614–4624. Published online 2020 Dec 10. doi: 10.1002/jcp.30194

PMCID:: PMC9665351

Abstract Article PDF–1.6M

Select item 95714256.

ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway

Qiang Wang, Zhiqiang Gao, Kai Guo, Jiawei Lu, Feng Wang, Yufeng Huang, Desheng Wu

J Orthop Surg Res. 2022; 17: 455. Published online 2022 Oct 15. doi: 10.1186/s13018-022-03349-1

PMCID:: PMC9571425

Abstract Article PDF–2.2M

Select item 77443307.

Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization

Nathan D. Maulding, Dillon Kavanagh, Kristin Zimmerman, Gianfilippo Coppola, Thomas O. Carpenter, Nathaniel K. Jue, Demetrios T. Braddock

Bone. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Bone. 2021 Jan; 142: 115656. Published online 2020 Sep 24. doi: 10.1016/j.bone.2020.115656

PMCID:: PMC7744330

Abstract Article PDF–1.1M

Select item 68219138.

Role of macrophages and activated microglia in neuropathic pain associated with chronic progressive spinal cord compression

Naoto Takeura, Hideaki Nakajima, Shuji Watanabe, Kazuya Honjoh, Ai Takahashi, Akihiko Matsumine

Sci Rep. 2019; 9: 15656. Published online 2019 Oct 30. doi: 10.1038/s41598-019-52234-1

PMCID:: PMC6821913

Abstract Article PDF–5.4M

Select item 67285539.

Reduced Orthodontic Tooth Movement in Enpp1 Mutant Mice with Hypercementosis

M. Wolf, M. Ao, M.B. Chavez, T.N. Kolli, V. Thumbigere-Math, K. Becker, E.Y. Chu, A. Jäger, M.J. Somerman, B.L. Foster

J Dent Res. 2018 Jul; 97(8): 937–945. Published online 2018 Mar 13. doi: 10.1177/0022034518759295

PMCID:: PMC6728553

Abstract Article PDF–1.3M

Select item 621542610.

ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy

Tayeba Khan, Kerstin W. Sinkevicius, Sylvia Vong, Arlen Avakian, Markley C. Leavitt, Hunter Malanson, Andre Marozsan, Kim L. Askew

Dis Model Mech. 2018 Oct 1; 11(10): dmm035691. Published online 2018 Oct 8. doi: 10.1242/dmm.035691

PMCID:: PMC6215426

Abstract Article

Select item 573656211.

ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells

Hongsheng Wang, Ines Gonzalez-Garcia, Javier Traba, Shweta Jain, Solomon Conteh, Dong-Mi Shin, Chenfeng Qi, Yuanyuan Gao, Jiafang Sun, Sungyun Kang, Sadia Abbasi, Zohreh Naghashfar, Jeongheon Yoon, Wendy DuBois, Alexander L. Kovalchuk, Michael N. Sack, Patrick Duffy, Herbert C. Morse, III

Sci Rep. 2017; 7: 17867. Published online 2017 Dec 19. doi: 10.1038/s41598-017-18028-z

PMCID:: PMC5736562

Abstract Article PDF–2.2M

Select item 550352212.

Elevated dietary magnesium during pregnancy and postnatal life prevents ectopic mineralization in Enpp1^asj mice, a model for generalized arterial calcification of infancy

Joshua Kingman, Jouni Uitto, Qiaoli Li

Oncotarget. 2017 Jun 13; 8(24): 38152–38160. Published online 2017 Mar 29. doi: 10.18632/oncotarget.16687

PMCID:: PMC5503522

Abstract Article PDF–1.5M

Select item 534129313.

Variable patterns of ectopic mineralization in Enpp1^asj-2J mice, a model for generalized arterial calcification of infancy

Sarah Y. Siu, Nathaniel A. Dyment, David W. Rowe, John P. Sundberg, Jouni Uitto, Qiaoli Li

Oncotarget. 2016 Dec 20; 7(51): 83837–83842. Published online 2016 Nov 14. doi: 10.18632/oncotarget.13335

PMCID:: PMC5341293

Abstract Article PDF–1.7M

Select item 515454814.

Ectopic Mineralization and Conductive Hearing Loss in Enpp1^asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis

Cong Tian, Belinda S. Harris, Kenneth R. Johnson

PLoS One. 2016; 11(12): e0168159. Published online 2016 Dec 13. doi: 10.1371/journal.pone.0168159

PMCID:: PMC5154548

Abstract Article PDF–3.6M

Select item 503015715.

ENPP1 processes protein ADP‐ribosylation in vitro

Luca Palazzo, Casey M. Daniels, Joanne E. Nettleship, Nahid Rahman, Robert Lyle McPherson, Shao‐En Ong, Kazuki Kato, Osamu Nureki, Anthony K. L. Leung, Ivan Ahel

FEBS J. 2016 Sep; 283(18): 3371–3388. Published online 2016 Aug 5. doi: 10.1111/febs.13811

PMCID:: PMC5030157

Abstract Article PDF–1.4M

Select item 473104916.

Dual Effects of Bisphosphonates on Ectopic Skin and Vascular Soft Tissue Mineralization versus Bone Microarchitecture in a Mouse Model of Generalized Arterial Calcification of Infancy

Qiaoli Li, Joshua Kingman, John P. Sundberg, Michael A. Levine, Jouni Uitto

J Invest Dermatol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: J Invest Dermatol. 2016 Jan; 136(1): 275–283. doi: 10.1038/JID.2015.377

PMCID:: PMC4731049

Abstract Article PDF–2.3M

Select item 468671417.

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy

Ronald A. Albright, Paul Stabach, Wenxiang Cao, Dillon Kavanagh, Isabelle Mullen, Alexander A. Braddock, Mariel S. Covo, Martin Tehan, Guangxiao Yang, Zhiliang Cheng, Keith Bouchard, Zhao-Xue Yu, Stephanie Thorn, Xiangning Wang, Ewa J. Folta-Stogniew, Alejandro Negrete, Albert J. Sinusas, Joseph Shiloach, George Zubal, Joseph A. Madri, Enrique M. De La Cruz, Demetrios T. Braddock

Nat Commun. 2015; 6: 10006. Published online 2015 Dec 1. doi: 10.1038/ncomms10006

PMCID:: PMC4686714

Abstract Article PDF–2.0M

Select item 425700318.

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

Carmen Huesa, Dongxing Zhu, James D. Glover, Mathieu Ferron, Gerard Karsenty, Elspeth M. Milne, José Luis Millan, S. Faisal Ahmed, Colin Farquharson, Nicholas M. Morton, Vicky E. MacRae

Dis Model Mech. 2014 Dec; 7(12): 1341–1350. Published online 2014 Oct 31. doi: 10.1242/dmm.017905

PMCID:: PMC4257003

Abstract Article

Select item 422808519.

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1^−/− mice

Mark O.R. Hajjawi, Vicky E. MacRae, Carmen Huesa, Alan Boyde, José Luis Millán, Timothy R. Arnett, Isabel R. Orriss

Bone. 2014 Dec; 69: 139–147. doi: 10.1016/j.bone.2014.09.016

PMCID:: PMC4228085

Abstract Article

Select item 416098020.

A New Enpp1 allele, Enpp1^ttw-Ham, Identified in an ICR Closed Colony

Shuji Takabayashi, Shintaro Seto, Hideki Katoh

Exp Anim. 2014; 63(2): 193–204. Published online 2014 Apr 26. doi: 10.1538/expanim.63.193

PMCID:: PMC4160980

Abstract Article PDF–2.0M

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