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Items: 1 to 20 of 41

1.
High endogenous activated protein C levels attenuates bleomycin‐induced pulmonary fibrosis
Cong Lin, Jan von der Thüsen, Berend Isermann, Hartmut Weiler, Tom van der Poll, Keren Borensztajn, Chris A. Spek
J Cell Mol Med. 2016 Nov; 20(11): 2029–2035. Published online 2016 Jun 14. doi: 10.1111/jcmm.12891
PMCID:
PMC5082406
AbstractArticlePDF–605K
2.
Polyphosphate elicits proinflammatory responses that are counteracted by activated protein C in both cellular and animal models
Jong-Sup Bae, Wonhwa Lee, Alireza R. Rezaie
J Thromb Haemost. Author manuscript; available in PMC 2013 Jun 1.
Published in final edited form as: J Thromb Haemost. 2012 Jun; 10(6): 1145–1151. doi: 10.1111/j.1538-7836.2012.04671.x
PMCID:
PMC3366017
AbstractArticlePDF–428K
3.
Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation
GL Van Sluis, LW Brüggemann, CT. Esmon, PW Kamphuisen, DJ Richel, HR Büller, CJF van Noorden, CA Spek
Cancer Lett. Author manuscript; available in PMC 2012 Jan 1.
Published in final edited form as: Cancer Lett. 2011 Jul 1; 306(1): 106–110. Published online 2011 Mar 21. doi: 10.1016/j.canlet.2011.02.038
PMCID:
PMC3159049
AbstractArticlePDF–129K
4.
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency
Angelina J. Lay, Deborah Donahue, Meng-Ju Tsai, Francis J. Castellino
Blood. 2007 Mar 1; 109(5): 1984–1991. Prepublished online 2006 Oct 17. doi: 10.1182/blood-2006-07-037945
PMCID:
PMC1801051
AbstractArticle
5.
A Protein C Deficiency Exacerbates Inflammatory and Hypotensive Responses in Mice During Polymicrobial Sepsis in a Cecal Ligation and Puncture Model
Jorge G. Ganopolsky, Francis J. Castellino
Am J Pathol. 2004 Oct; 165(4): 1433–1446. doi: 10.1016/S0002-9440(10)63401-3
PMCID:
PMC1618621
AbstractArticlePDF–621K
6.
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities
Angelina J. Lay, Zhong Liang, Elliot D. Rosen, Francis J. Castellino
J Clin Invest. 2005 Jun 1; 115(6): 1552–1561. Published online 2005 May 5. doi: 10.1172/JCI24030
PMCID:
PMC1089798
AbstractArticlePDF–1003K
7.
Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice
Marco Heestermans, Amber B. Ouweneel, Jasmin Hassan, Meander Kloosterman, Pieter H. Reitsma, Marion J. J. Gijbels, Bart J. M. van Vlijmen, Miranda van Eck
Sci Rep. 2018; 8: 15106. Published online 2018 Oct 10. doi: 10.1038/s41598-018-32584-y
PMCID:
PMC6180072
AbstractArticlePDF–5.3M
8.
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke
Ranjeet K. Sinha, Yaoming Wang, Zhen Zhao, Xiao Xu, Laurent Burnier, Naveen Gupta, José A. Fernández, Greg Martin, Sergey Kupriyanov, Laurent O. Mosnier, Berislav V. Zlokovic, John H. Griffin
Blood. 2018 Mar 15; 131(11): 1163–1171. Prepublished online 2018 Jan 17. doi: 10.1182/blood-2017-10-810895
PMCID:
PMC5855020
AbstractArticle
9.
Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis
Sanjana Dayal, Sean X Gu, Ryan D. Hutchins, Katina M. Wilson, Yi Wang, Xiaoyun Fu, Steven R. Lentz
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8): 1798–1804. Published online 2015 Jun 11. doi: 10.1161/ATVBAHA.115.305963
PMCID:
PMC4514539
AbstractArticlePDF–424K
10.
Low levels of Tissue Factor rescue Protein C-associated pregnancy failure in mice
Angelina J. Lay, Claire M. Northway, Deborah L. Donahue, Francis J. Castellino
J Thromb Haemost. Author manuscript; available in PMC 2013 Jun 5.
Published in final edited form as: J Thromb Haemost. 2008 Oct; 6(10): 1815–1817. Published online 2008 Jul 19. doi: 10.1111/j.1538-7836.2008.03085.x
PMCID:
PMC3673713
ArticlePDF–270K
11.
INCREASE IN ACTIVATED PROTEIN C MEDIATES ACUTE TRAUMATIC COAGULOPATHY IN MICE
Brian B. Chesebro, Pamela Rahn, Michel Carles, Charles T. Esmon, Jun Xu, Karim Brohi, Daniel Frith, Jean-François Pittet, Mitchell J. Cohen
Shock. Author manuscript; available in PMC 2013 Feb 16.
Published in final edited form as: Shock. 2009 Dec; 32(6): 659–665. doi: 10.1097/SHK.0b013e3181a5a632
PMCID:
PMC3574570
AbstractArticlePDF–972K
12.
Activated Protein C Inhibits Pancreatic Islet Inflammation, Stimulates T Regulatory Cells, and Prevents Diabetes in Non-obese Diabetic (NOD) Mice
Meilang Xue, Suat Dervish, Leonard C. Harrison, Gregory Fulcher, Christopher J. Jackson
J Biol Chem. 2012 May 11; 287(20): 16356–16364. Published online 2012 Mar 23. doi: 10.1074/jbc.M111.325951
PMCID:
PMC3351324
AbstractArticlePDF–2.7M
13.
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation
Stefania Vetrano, Victoria A. Ploplis, Emanuela Sala, Mayra Sandoval-Cooper, Deborah L. Donahue, Carmen Correale, Vincenzo Arena, Antonino Spinelli, Alessandro Repici, Alberto Malesci, Francis J. Castellino, Silvio Danese
Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49): 19830–19835. Published online 2011 Nov 22. doi: 10.1073/pnas.1107140108
PMCID:
PMC3241765
AbstractArticlePDF–1.1M
14.
Activated protein C protects against ventilator-induced pulmonary capillary leak
James H. Finigan, Adel Boueiz, Emily Wilkinson, Rachel Damico, Jarrett Skirball, Hyun Hae Pae, Mahendra Damarla, Emile Hasan, David B. Pearse, Sekhar P. Reddy, Dmitry N. Grigoryev, Christopher Cheadle, Charles T. Esmon, Joe G. N. Garcia, Paul M. Hassoun
Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6): L1002–L1011. Published online 2009 Apr 10. doi: 10.1152/ajplung.90555.2008
PMCID:
PMC2692806
AbstractArticle
15.
Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge
M. Anna Kowalska, Shawn A. Mahmud, Michele P. Lambert, Mortimer Poncz, Arne Slungaard
Blood. 2007 Sep 15; 110(6): 1903–1905. Prepublished online 2007 May 31. doi: 10.1182/blood-2007-03-081901
PMCID:
PMC1976343
AbstractArticle
16.
Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging
Di Ren, Julia Fedorova, Kayla Davitt, Tran Ngoc Van Le, John H. Griffin, Patricia C. Liaw, Charles T. Esmon, Alireza R. Rezaie, Ji Li
Circ Res. Author manuscript; available in PMC 2023 Jan 21.
Published in final edited form as: Circ Res. 2022 Jan 21; 130(2): 252–272. Published online 2021 Dec 21. doi: 10.1161/CIRCRESAHA.121.319044
Correction in:
Circ Res. 2022 Jun 24; 131(1): e1.
PMCID:
PMC8882057
AbstractArticlePDF–4.4M
17.
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc
Fabian Bock, Khurrum Shahzad, Hongjie Wang, Stoyan Stoyanov, Juliane Wolter, Wei Dong, Pier Giuseppe Pelicci, Muhammed Kashif, Satish Ranjan, Simone Schmidt, Robert Ritzel, Vedat Schwenger, Klaus G. Reymann, Charles T. Esmon, Thati Madhusudhan, Peter P. Nawroth, Berend Isermann
Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2): 648–653. Published online 2012 Dec 24. doi: 10.1073/pnas.1218667110
PMCID:
PMC3545757
AbstractArticlePDF–1.4M
18.
Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin
Marlene E. Starr, Junji Ueda, Hitoshi Takahashi, Hartmut Weiler, Charles T. Esmon, B. Mark Evers, Hiroshi Saito
Blood. 2010 Jun 10; 115(23): 4886–4893. Prepublished online 2010 Mar 26. doi: 10.1182/blood-2009-10-246678
PMCID:
PMC2890181
AbstractArticle
19.
Protection of Vascular Barrier Integrity by Activated Protein C in Murine Models Depends on Protease-Activated Receptor-1
Reto A. Schuepbach, Clemens Feistritzer, José A. Fernández, John H. Griffin, Matthias Riewald
Thromb Haemost. Author manuscript; available in PMC 2009 May 11.
Published in final edited form as: Thromb Haemost. 2009 Apr; 101(4): 724–733. doi: 10.1160/th08-10-0632
PMCID:
PMC2680237
AbstractArticlePDF–920K
20.
Activated protein C inhibits LPS-mediated acetylation and secretion of HMGB1 in endothelial cells
Xiaofeng Cai, Indranil Biswas, Sumith R. Panicker, Hemant Giri, Alireza R. Rezaie
J Thromb Haemost. Author manuscript; available in PMC 2020 May 1.
Published in final edited form as: J Thromb Haemost. 2019 May; 17(5): 803–817. Published online 2019 Apr 9. doi: 10.1111/jth.14425
PMCID:
PMC6494677
AbstractArticlePDF–1.6M

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