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Select item 106946051.

Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

Lizhi Pang, Songlin Guo, Fatima Khan, Madeline Dunterman, Heba Ali, Yang Liu, Yuyun Huang, Peiwen Chen

Cell Rep Med. 2023 Nov 21; 4(11): 101238. Published online 2023 Oct 18. doi: 10.1016/j.xcrm.2023.101238

PMCID:: PMC10694605

Abstract Article PDF–8.1M

Select item 88815812.

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Chuntao Lei, Mengran Li, Yang Qiu, Yaru Xie, Zhe Hao, Xingjie Yin, Zhentao Zhang, Hua Su, Linlin Yang, Jihong Lin, Hans-Peter Hammes, Chun Zhang

Cell Death Dis. 2022 Feb; 13(2): 184. Published online 2022 Feb 25. doi: 10.1038/s41419-022-04621-2

PMCID:: PMC8881581

Abstract Article PDF–12M

Select item 50759993.

Legumain is activated in macrophages during pancreatitis

Laura E. Edgington-Mitchell, Thomas Wartmann, Alicia K. Fleming, Vasilena Gocheva, Wouter A. van der Linden, Nimali P. Withana, Martijn Verdoes, Luigi Aurelio, Daniel Edgington-Mitchell, TinaMarie Lieu, Belinda S. Parker, Bim Graham, Thomas Reinheckel, John B. Furness, Johanna A. Joyce, Peter Storz, Walter Halangk, Matthew Bogyo, Nigel W. Bunnett

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1; 311(3): G548–G560. Published online 2016 Aug 11. doi: 10.1152/ajpgi.00047.2016

PMCID:: PMC5075999

Abstract Article

Select item 26267264.

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

Chi-Bun Chan, Michiyo Abe, Noriyoshi Hashimoto, Chunhai Hao, Ifor R. Williams, Xia Liu, Shinji Nakao, Akitsugu Yamamoto, Chengyun Zheng, Jan-Inge Henter, Marie Meeths, Magnus Nordenskjold, Shi-Yong Li, Ikuko Hara-Nishimura, Masahide Asano, Keqiang Ye

Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2): 468–473. Published online 2008 Dec 23. doi: 10.1073/pnas.0809824105

Correction in:: Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14): 6023.

PMCID:: PMC2626726

Abstract Article PDF–1.5M

Select item 93815955.

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

Jing Xiong, Jianming Liao, Xia Liu, Zhaohui Zhang, Jonathan Adams, Roberto Pacifici, Keqiang Ye

Nat Commun. 2022; 13: 4820. Published online 2022 Aug 16. doi: 10.1038/s41467-022-32435-5

PMCID:: PMC9381595

Abstract Article PDF–4.9M

Select item 84086106.

Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease

Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, Keqiang Ye

EMBO J. 2021 Sep 1; 40(17): e106320. Published online 2021 Jul 14. doi: 10.15252/embj.2020106320

PMCID:: PMC8408610

Abstract Article PDF–5.0M

Select item 77862167.

Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2

Nguyen Huu Tu, Dane D. Jensen, Bethany M. Anderson, Elyssa Chen, Nestor N. Jimenez-Vargas, Nicole N. Scheff, Kenji Inoue, Hung D. Tran, John C. Dolan, Tamaryn A. Meek, Morley D. Hollenberg, Cheng Z. Liu, Stephen J. Vanner, Malvin N. Janal, Nigel W. Bunnett, Laura E. Edgington-Mitchell, Brian L. Schmidt

J Neurosci. 2021 Jan 6; 41(1): 193–210. doi: 10.1523/JNEUROSCI.1211-20.2020

PMCID:: PMC7786216

Abstract Article PDF–5.4M

Select item 62972268.

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts

Nat Commun. 2018; 9: 5343. Published online 2018 Dec 17. doi: 10.1038/s41467-018-07741-6

PMCID:: PMC6297226

Abstract Article PDF–3.4M

Select item 62794019.

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

Zhi-Hao Wang, Pai Liu, Xia Liu, Shan Ping Yu, Jian-Zhi Wang, Keqiang Ye

J Exp Med. 2018 Dec 3; 215(12): 3038–3056. doi: 10.1084/jem.20180539

PMCID:: PMC6279401

Abstract Article PDF–4.0M

Select item 465994010.

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Duc M. Duong, Nicholas T. Seyfried, Xuebing Cao, Liming Cheng, Yi E. Sun, Shan Ping Yu, Jianping Jia, Allan I. Levey, Keqiang Ye

Nat Commun. 2015; 6: 8762. Published online 2015 Nov 9. doi: 10.1038/ncomms9762

PMCID:: PMC4659940

Abstract Article PDF–4.9M

Select item 302340511.

The asparaginyl endopeptidase legumain after experimental stroke

Taku Ishizaki, Agnes Erickson, Enida Kuric, Mehrdad Shamloo, Ikuko Hara-Nishimura, Ana Rita Lourenço Inácio, Tadeusz Wieloch, Karsten Ruscher

J Cereb Blood Flow Metab. 2010 Oct; 30(10): 1756–1766. Published online 2010 Mar 17. doi: 10.1038/jcbfm.2010.39

PMCID:: PMC3023405

Abstract Article PDF–647K

Select item 631085512.

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease

Hualong Wang, Xia Liu, Shengdi Chen, Keqiang Ye

Proc Natl Acad Sci U S A. 2018 Dec 26; 115(52): E12427–E12434. Published online 2018 Dec 10. doi: 10.1073/pnas.1815915115

Correction in:: Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 26090.

PMCID:: PMC6310855

Abstract Article PDF–1.5M

Select item 600365013.

α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Susov Dhakal, P Michael Iuvone, Xuebing Cao, Keqiang Ye

EMBO J. 2018 Jun 15; 37(12): e98878. Published online 2018 May 16. doi: 10.15252/embj.201798878

PMCID:: PMC6003650

Abstract Article PDF–2.9M

Select item 121975814.

Cloning and expression of mouse legumain, a lysosomal endopeptidase.

J M Chen, P M Dando, R A Stevens, M Fortunato, A J Barrett

Biochem J. 1998 Oct 1; 335(Pt 1): 111–117. doi: 10.1042/bj3350111

PMCID:: PMC1219758

Summary PDF–717K

Select item 614117815.

BDNF inhibits neurodegenerative disease–associated asparaginyl endopeptidase activity via phosphorylation by AKT

Zhi-Hao Wang, Wanqiang Wu, Seong Su Kang, Xia Liu, Zhiping Wu, Junmin Peng, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Xuebo Liu, Jian-Zhi Wang, Keqiang Ye

JCI Insight. 2018 Aug 23; 3(16): e99007. Published online 2018 Aug 23. doi: 10.1172/jci.insight.99007

PMCID:: PMC6141178

Abstract Article PDF–4.3M

Select item 761477916.

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, Alexandra K. Davies, Julia P. Schessner, Reejuana Parveen, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik

Science. Author manuscript; available in PMC 2023 Jul 19.

Published in final edited form as: Science. 2023 Jun 23; 380(6651): 1258–1265. Published online 2023 Jun 22. doi: 10.1126/science.adg8802

PMCID:: PMC7614779

Abstract Article PDF–1.8M

Select item 422459517.

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease

Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Il-Sun Kwon, Duc M. Duong, Nicholas T. Seyfried, William T. Hu, Zhixue Liu, Jian-zhi Wang, Liming Cheng, Yi E. Sun, Shan Ping Yu, Allan I. Levey, Keqiang Ye

Nat Med. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Nat Med. 2014 Nov; 20(11): 1254–1262. Published online 2014 Oct 19. doi: 10.1038/nm.3700

PMCID:: PMC4224595

Abstract Article PDF–1.6M

Select item 378769618.

Asparaginyl endopeptidase cleaves TDP-43 in brain

Jeremy H. Herskowitz, Yair M. Gozal, Duc M. Duong, Eric B. Dammer, Marla Gearing, Keqiang Ye, James J. Lah, Junmin Peng, Allan I. Levey, Nicholas T. Seyfried

Proteomics. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Proteomics. 2012 Aug; 12(0): 2455–2463. doi: 10.1002/pmic.201200006

PMCID:: PMC3787696

Abstract Article PDF–1.1M

Select item 601507919.

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N. Trawick, Richard M. Ransohoff, François Tronche, Bénédicte Manoury, Sheela Vyas

Nat Commun. 2018; 9: 2450. Published online 2018 Jun 22. doi: 10.1038/s41467-018-04569-y

Correction in:: Nat Commun. 2018; 9: 3109.

PMCID:: PMC6015079

Abstract Article PDF–4.4M

Select item 342094620.

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

Sophia Maschalidi, Signe Hässler, Fany Blanc, Fernando E. Sepulveda, Mira Tohme, Michel Chignard, Peter van Endert, Mustapha Si-Tahar, Delphyne Descamps, Bénédicte Manoury

PLoS Pathog. 2012 Aug; 8(8): e1002841. Published online 2012 Aug 16. doi: 10.1371/journal.ppat.1002841