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Select item 100980391.

4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis

Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, Jing Qu

Protein Cell. 2023 Mar; 14(3): 202–216. Published online 2022 Aug 23. doi: 10.1093/procel/pwac037

PMCID:: PMC10098039

Abstract Article PDF–5.5M

Select item 92233692.

Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection

Yaoxiang Tang, Jiadi Luo, Yang Yang, Sile Liu, Hongmei Zheng, Yuting Zhan, Songqing Fan, Qiuyuan Wen

PLoS One. 2022; 17(6): e0265465. Published online 2022 Jun 23. doi: 10.1371/journal.pone.0265465

PMCID:: PMC9223369

Abstract Article PDF–1.3M

Select item 76590043.

4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs

Khawla Alasad, Kai Voeltzke, Liron Levin, Guido Reifenberger, Gabriel Leprivier, Barak Rotblat

Cell Death Dis. 2020 Nov; 11(11): 968. Published online 2020 Nov 11. doi: 10.1038/s41419-020-03182-6

PMCID:: PMC7659004

Article PDF–542K

Select item 65337684.

Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer

Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson, Stephen P. Ethier

BMC Cancer. 2019; 19: 491. Published online 2019 May 23. doi: 10.1186/s12885-019-5667-4

PMCID:: PMC6533768

Abstract Article PDF–3.0M

Select item 48459175.

4E-BP1, a multifactor regulated multifunctional protein

Xiaoyu Qin, Bin Jiang, Yanjie Zhang

Cell Cycle. 2016; 15(6): 781–786. Published online 2016 Feb 22. doi: 10.1080/15384101.2016.1151581

PMCID:: PMC4845917

Abstract Article PDF–452K

Select item 48123076.

Phosphorylated 4EBP1 is associated with tumor progression and poor prognosis in Xp11.2 translocation renal cell carcinoma

Yuanyuan Qu, Rui Zhao, Hongkai Wang, Kun Chang, Xiaoqun Yang, Xiaoyan Zhou, Bo Dai, Yao Zhu, Guohai Shi, Hailiang Zhang, Dingwei Ye

Sci Rep. 2016; 6: 23594. Published online 2016 Mar 30. doi: 10.1038/srep23594

PMCID:: PMC4812307

Abstract Article PDF–1.2M

Select item 46951727.

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

Min-Wu Chao, Li-Ting Wang, Chin-Yu Lai, Xiao-Ming Yang, Ya-Wen Cheng, Kuo-Hsiung Lee, Shiow-Lin Pan, Che-Ming Teng

Oncotarget. 2015 Sep 15; 6(27): 24092–24104. Published online 2015 Jun 29. doi: 10.18632/oncotarget.4483

PMCID:: PMC4695172

Abstract Article PDF–5.8M

Select item 45464938.

RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia

Austin Y. Shull, Satish K. Noonepalle, Farrukh T. Awan, Jimei Liu, Lirong Pei, Roni J. Bollag, Huda Salman, Zhiyong Ding, Huidong Shi

Oncotarget. 2015 Jun 10; 6(16): 14632–14645. Published online 2015 May 12. doi: 10.18632/oncotarget.4104

PMCID:: PMC4546493

Abstract Article PDF–4.0M

Select item 44669689.

Prognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer

Hyoun Wook Lee, Eun Hee Lee, Ji Hyun Lee, Jeong-Eun Kim, Seok-Hyun Kim, Tae Gyu Kim, Sang Won Hwang, Kyung Woo Kang

Int J Clin Exp Pathol. 2015; 8(4): 3955–3962. Published online 2015 Apr 1.

PMCID:: PMC4466968

Abstract Article PDF–1.1M

Select item 399554010.

Phosphorylated 4E-BP1 is Associated with Poor Survival in Melanoma

Kathryn E. O’Reilly, Melanie Warycha, Michael A. Davies, Vanessa Rodrik, Xi K. Zhou, Herman Yee, David Polsky, Anna C. Pavlick, Neal Rosen, Nina Bhardwaj, Gordon Mills, Iman Osman

Clin Cancer Res. Author manuscript; available in PMC 2014 Apr 22.

Published in final edited form as: Clin Cancer Res. 2009 Apr 15; 15(8): 2872–2878. Published online 2009 Mar 31. doi: 10.1158/1078-0432.CCR-08-2336

PMCID:: PMC3995540

Abstract Article PDF–1.9M

Select item 328665011.

4E-BP1 Is A Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways That Integrates Their Function in Tumors

Qing-Bai She, Ensar Halilovic, Qing Ye, Wei Zhen, Senji Shirasawa, Takehiko Sasazuki, David B. Solit, Neal Rosen

Cancer Cell. Author manuscript; available in PMC 2012 Feb 26.

Published in final edited form as: Cancer Cell. 2010 Jul 13; 18(1): 39–51. doi: 10.1016/j.ccr.2010.05.023

PMCID:: PMC3286650

Abstract Article PDF–4.3M

Select item 328160812.

Hepatitis C Virus NS5A Binds to the mRNA Cap-binding Eukaryotic Translation Initiation 4F (eIF4F) Complex and Up-regulates Host Translation Initiation Machinery through eIF4E-binding Protein 1 Inactivation

Anju George, Swarupa Panda, Devika Kudmulwar, Salma Pathan Chhatbar, Sanjeev Chavan Nayak, Harinivas Harshan Krishnan

J Biol Chem. 2012 Feb 10; 287(7): 5042–5058. Published online 2011 Dec 19. doi: 10.1074/jbc.M111.308916

PMCID:: PMC3281608

Abstract Article PDF–2.5M

Select item 313339213.

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

Beat Nyfeler, Philip Bergman, Ellen Triantafellow, Christopher J. Wilson, Yanyi Zhu, Branko Radetich, Peter M. Finan, Daniel J. Klionsky, Leon O. Murphy

Mol Cell Biol. 2011 Jul; 31(14): 2867–2876. doi: 10.1128/MCB.05430-11

PMCID:: PMC3133392

Abstract Article PDF–2.1M

Select item 257507014.

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival

Bryan C. Barnhart, Jennifer C. Lam, Regina M. Young, Peter J. Houghton, Brian Keith, M. Celeste Simon

Cancer Biol Ther. Author manuscript; available in PMC 2008 Oct 29.

Published in final edited form as: Cancer Biol Ther. 2008 Sep; 7(9): 1441–1449. Published online 2008 Sep 11. doi: 10.4161/cbt.7.9.6426

PMCID:: PMC2575070

Abstract Article PDF–4.9M

Select item 13371915.

Translational Control of Cell Fate: Availability of Phosphorylation Sites on Translational Repressor 4E-BP1 Governs Its Proapoptotic Potency

Shunan Li, Nahum Sonenberg, Anne-Claude Gingras, Mark Peterson, Svetlana Avdulov, Vitaly A. Polunovsky, Peter B. Bitterman

Mol Cell Biol. 2002 Apr; 22(8): 2853–2861. doi: 10.1128/MCB.22.8.2853-2861.2002

PMCID:: PMC133719

Abstract Article PDF–307K

Select item 1113169816.

Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1

R. Azar, S. Najib, H. Lahlou, C. Susini, S. Pyronnet

Cell Mol Life Sci. 2008 Oct; 65(19): 3110–3117. Published online 2008 Sep 23. doi: 10.1007/s00018-008-8418-2

PMCID:: PMC11131698

Abstract Article PDF–755K

Select item 1109413617.

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier

Nat Commun. 2024; 15: 4083. Published online 2024 May 14. doi: 10.1038/s41467-024-48386-y

PMCID:: PMC11094136

Abstract Article PDF–2.0M

Select item 857279718.

Targeting of EIF4EBP1 by miR‐99a‐3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression

Meng Yang, Binbin Yang, Danqi Deng

J Cell Mol Med. 2021 Nov; 25(21): 10291–10305. Published online 2021 Oct 20. doi: 10.1111/jcmm.16991

PMCID:: PMC8572797

Abstract Article PDF–2.5M

Select item 785603119.

The translational repressor 4E-BP1regulates RRM2 levels and functions as a tumor suppressor in Ewing Sarcoma Tumors

Kelli L. Goss, Stacia L. Koppenhafer, Torin Waters, William W. Terry, Kuo-Kuang Wen, Meng Wu, Jason Ostergaard, Peter M. Gordon, David J. Gordon

Oncogene. Author manuscript; available in PMC 2021 May 15.

Published in final edited form as: Oncogene. 2021 Jan; 40(3): 564–577. Published online 2020 Nov 15. doi: 10.1038/s41388-020-01552-0

PMCID:: PMC7856031

Abstract Article PDF–896K

Select item 761032820.

BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma

Pei Wan, Zhilin Chen, Weifeng Zhong, Huiming Jiang, Zhicheng Huang, Dong Peng, Qiang He, Nanhui Chen

Oncol Rep. 2020 Dec; 44(6): 2475–2486. Published online 2020 Oct 8. doi: 10.3892/or.2020.7796

PMCID:: PMC7610328

Abstract Article PDF–982K

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