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Select item 112854471.

Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults

D. Ryan King, Mustafa Demirtas, Mikhail Tarasov, Heather L. Struckman, Xiaolei Meng, Drew Nassal, Nicolae Moise, Alec Miller, Dennison Min, Andrew M. Soltisz, Midhun N.K. Anne, Patrícia A. Alves Dias, Jacy L. Wagnon, Seth H. Weinberg, Thomas J. Hund, Rengasayee Veeraraghavan, Przemysław B. Radwański

JACC Clin Electrophysiol. Author manuscript; available in PMC 2024 Jul 29.

Published in final edited form as: JACC Clin Electrophysiol. 2024 May; 10(5): 829–842. Published online 2024 Feb 28. doi: 10.1016/j.jacep.2024.01.003

PMCID:: PMC11285447

Abstract Article PDF–3.3M

Select item 106283462.

Clinical and electrophysiological features of SCN8A variants causing episodic or chronic ataxia

Hang Lyu, Christian M. Boßelmann, Katrine M. Johannesen, Mahmoud Koko, Juan Dario Ortigoza-Escobar, Sergio Aguilera-Albesa, Deyanira Garcia-Navas Núñez, Tarja Linnankivi, Eija Gaily, Henriette J.A. van Ruiten, Ruth Richardson, Cornelia Betzler, Gabriella Horvath, Eva Brilstra, Niels Geerdink, Daniele Orsucci, Alessandra Tessa, Elena Gardella, Zofia Fleszar, Ludger Schöls, Holger Lerche, Rikke S. Møller, Yuanyuan Liu

eBioMedicine. 2023 Dec; 98: 104855. Published online 2023 Oct 28. doi: 10.1016/j.ebiom.2023.104855

PMCID:: PMC10628346

Abstract Article PDF–2.8M

Select item 90877413.

Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice

Xiaofan Yang, Hongqiang Yin, Xiaojing Wang, Yueqing Sun, Xianli Bian, Gaorui Zhang, Anning Li, Aihua Cao, Baomin Li, Darius Ebrahimi-Fakhari, Zhuo Yang, Miriam H. Meisler, Qiji Liu

Front Mol Neurosci. 2022; 15: 822129. Published online 2022 Apr 26. doi: 10.3389/fnmol.2022.822129

PMCID:: PMC9087741

Abstract Article PDF–3.8M

Select item 89038294.

NBI-921352, a first-in-class, Na_V1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield

eLife. 2022; 11: e72468. Published online 2022 Mar 2. doi: 10.7554/eLife.72468

PMCID:: PMC8903829

Abstract Article PDF–2.4M

Select item 88139805.

Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death

Ian C. Wenker, Elizabeth A. Blizzard, Pravin K. Wagley, Manoj K. Patel

Front Neurosci. 2021; 15: 795145. Published online 2022 Jan 21. doi: 10.3389/fnins.2021.795145

PMCID:: PMC8813980

Abstract Article PDF–3.6M

Select item 86357676.

Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease

Jennifer C. Wong, Kameryn M. Butler, Lindsey Shapiro, Jacquelyn T. Thelin, Kari A. Mattison, Kathryn B. Garber, Paula C. Goldenberg, Shobana Kubendran, G. Bradley Schaefer, Andrew Escayg

Front Pharmacol. 2021; 12: 748415. Published online 2021 Nov 17. doi: 10.3389/fphar.2021.748415

PMCID:: PMC8635767

Abstract Article PDF–2.3M

Select item 84297507.

Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model

Jennifer C. Wong, Steven F. Grieco, Karoni Dutt, Lujia Chen, Jacquelyn T. Thelin, George Andrew S. Inglis, Shangrila Parvin, Sandra M. Garraway, Xiangmin Xu, Alan L. Goldin, Andrew Escayg

Neuropsychopharmacology. 2021 Oct; 46(11): 2011–2020. Published online 2021 Mar 3. doi: 10.1038/s41386-021-00985-9

PMCID:: PMC8429750

Abstract Article PDF–2.2M

Select item 80171648.

Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge

Barakat Alrashdi, Bassel Dawod, Sabine Tacke, Stefanie Kuerten, Patrice D. Côté, Jean S. Marshall

Front Immunol. 2021; 12: 533423. Published online 2021 Mar 19. doi: 10.3389/fimmu.2021.533423

PMCID:: PMC8017164

Abstract Article PDF–2.6M

Select item 79828909.

Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy

Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel

Front Neurosci. 2021; 15: 581048. Published online 2021 Mar 4. doi: 10.3389/fnins.2021.581048

PMCID:: PMC7982890

Abstract Article PDF–3.6M

Select item 685290210.

Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis

Barakat Alrashdi, Bassel Dawod, Andrea Schampel, Sabine Tacke, Stefanie Kuerten, Jean S. Marshall, Patrice D. Côté

J Neuroinflammation. 2019; 16: 215. Published online 2019 Nov 13. doi: 10.1186/s12974-019-1622-1

PMCID:: PMC6852902

Abstract Article PDF–2.1M

Select item 679349111.

The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons

Kelly D. García, Leslie K. Sprunger, Miriam H. Meisler, Kurt G. Beam

J Neurosci. 1998 Jul 15; 18(14): 5234–5239. doi: 10.1523/JNEUROSCI.18-14-05234.1998

PMCID:: PMC6793491

Abstract Article PDF–136K

Select item 679318712.

Functional Analysis of the Mouse Scn8a Sodium Channel

Marianne R. Smith, Raymond D. Smith, Nicholas W. Plummer, Miriam H. Meisler, Alan L. Goldin

J Neurosci. 1998 Aug 15; 18(16): 6093–6102. doi: 10.1523/JNEUROSCI.18-16-06093.1998

PMCID:: PMC6793187

Abstract Article PDF–211K

Select item 675752513.

A Role for Phosphorylation in the Maintenance of Resurgent Sodium Current in Cerebellar Purkinje Neurons

Tina M. Grieco, Fatemeh S. Afshari, Indira M. Raman

J Neurosci. 2002 Apr 15; 22(8): 3100–3107. doi: 10.1523/JNEUROSCI.22-08-03100.2002

PMCID:: PMC6757525

Abstract Article PDF–268K

Select item 675321214.

Amyloid β-Induced Upregulation of Na_v1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model

Roselia Ciccone, Cristina Franco, Ilaria Piccialli, Francesca Boscia, Antonella Casamassa, Valeria de Rosa, Pasquale Cepparulo, Mauro Cataldi, Lucio Annunziato, Anna Pannaccione

Sci Rep. 2019; 9: 13592. Published online 2019 Sep 19. doi: 10.1038/s41598-019-50018-1