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Select item 101713591.

Na_v 1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation

Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf

Exp Neurol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Neurol. 2023 Jun; 364: 114393. Published online 2023 Mar 30. doi: 10.1016/j.expneurol.2023.114393

PMCID:: PMC10171359

Abstract Article PDF–1.9M

Select item 84974392.

Dissecting the precise nature of itch-evoked scratching

Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong, Zihe Zhang, Diana M. Bautista, Clifford J. Woolf

Neuron. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3075–3087.e2. Published online 2021 Aug 18. doi: 10.1016/j.neuron.2021.07.020

PMCID:: PMC8497439

Abstract Article PDF–1.4M

Select item 81193013.

Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype

Lubin Chen, Nivanthika K. Wimalasena, Jaehoon Shim, Chongyang Han, Seong-il Lee, Rafael Gonzalez-Cano, Mark Estacion, Catharina G. Faber, Giuseppe Lauria, Sulayman D. Dib-Hajj, Clifford J. Woolf, Stephen G. Waxman

Pain. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Pain. 2021 Jun 1; 162(6): 1758–1770. doi: 10.1097/j.pain.0000000000002171

PMCID:: PMC8119301

Article PDF–1.3M

Select item 70309264.

Sensory neuron–derived Na_V1.7 contributes to dorsal horn neuron excitability

Sascha R. A. Alles, Filipe Nascimento, Rafael Luján, Ana P. Luiz, Queensta Millet, M. Ali Bangash, Sonia Santana-Varela, Xuelong Zhou, James J. Cox, Andrei L. Okorokov, Marco Beato, Jing Zhao, John N. Wood

Sci Adv. 2020 Feb; 6(8): eaax4568. Published online 2020 Feb 19. doi: 10.1126/sciadv.aax4568

PMCID:: PMC7030926

Abstract Article PDF–3.0M

Select item 69287435.

3’-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model

Fan Zhang, Ying Wu, Shuwen Xue, Shuangyan Wang, Chunlei Zhang, Zhengyu Cao

Int J Mol Sci. 2019 Dec; 20(23): 6058. Published online 2019 Dec 1. doi: 10.3390/ijms20236058

PMCID:: PMC6928743

Abstract Article PDF–3.4M

Select item 65962016.

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

Shannon D. Shields, Lunbin Deng, Rebecca M. Reese, Michelle Dourado, Janet Tao, Oded Foreman, Jae H. Chang, David H. Hackos

J Neurosci. 2018 Nov 21; 38(47): 10180–10201. doi: 10.1523/JNEUROSCI.1049-18.2018

PMCID:: PMC6596201

Abstract Article PDF–2.7M

Select item 57937987.

Mapping protein interactions of sodium channel Na_V1.7 using epitope‐tagged gene‐targeted mice

Alexandros H Kanellopoulos, Jennifer Koenig, Honglei Huang, Martina Pyrski, Queensta Millet, Stéphane Lolignier, Toru Morohashi, Samuel J Gossage, Maude Jay, John E Linley, Georgios Baskozos, Benedikt M Kessler, James J Cox, Annette C Dolphin, Frank Zufall, John N Wood, Jing Zhao

EMBO J. 2018 Feb 1; 37(3): 427–445. Published online 2018 Jan 15. doi: 10.15252/embj.201796692

PMCID:: PMC5793798

Abstract Article PDF–1.6M

Select item 41548978.

Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

Jacinthe Gingras, Sarah Smith, David J. Matson, Danielle Johnson, Kim Nye, Lauren Couture, Elma Feric, Ruoyuan Yin, Bryan D. Moyer, Matthew L. Peterson, James B. Rottman, Rudolph J. Beiler, Annika B. Malmberg, Stefan I. McDonough

PLoS One. 2014; 9(9): e105895. Published online 2014 Sep 4. doi: 10.1371/journal.pone.0105895

PMCID:: PMC4154897

Abstract Article PDF–3.1M

Select item 37181549.

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Ken McCormack, Sonia Santos, Mark L. Chapman, Douglas S. Krafte, Brian E. Marron, Christopher W. West, Michael J. Krambis, Brett M. Antonio, Shannon G. Zellmer, David Printzenhoff, Karen M. Padilla, Zhixin Lin, P. Kay Wagoner, Nigel A. Swain, Paul A. Stupple, Marcel de Groot, Richard P. Butt, Neil A. Castle

Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29): E2724–E2732. Published online 2013 Jul 1. doi: 10.1073/pnas.1220844110

PMCID:: PMC3718154

Abstract Article PDF–1.1M

Select item 211957910.

Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways

J Cell Biol. 1993 Aug 2; 122(4): 915–921. doi: 10.1083/jcb.122.4.915

PMCID:: PMC2119579

Summary PDF–1.1M

Select item 958654711.

Na_v1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett

Brain. 2022 Oct; 145(10): 3637–3653. Published online 2021 Dec 27. doi: 10.1093/brain/awab482

PMCID:: PMC9586547

Abstract Article PDF–1.9M

Select item 661550012.

Depolarized Inactivation Overcomes Impaired Activation to Produce DRG Neuron Hyperexcitability in a Na_v1.7 Mutation in a Patient with Distal Limb Pain

Jianying Huang, Yang Yang, Sulayman D. Dib-Hajj, Michael van Es, Peng Zhao, Jody Salomon, Joost P.H. Drenth, Stephen G. Waxman

J Neurosci. 2014 Sep 10; 34(37): 12328–12340. doi: 10.1523/JNEUROSCI.2773-14.2014

PMCID:: PMC6615500

Abstract Article PDF–2.8M

Select item 491268813.

Near-Perfect Synaptic Integration by Na_v1.7 in Hypothalamic Neurons Regulates Body Weight

Tiago Branco, Adam Tozer, Christopher J. Magnus, Ken Sugino, Shinsuke Tanaka, Albert K. Lee, John N. Wood, Scott M. Sternson

Cell. 2016 Jun 16; 165(7): 1749–1761. doi: 10.1016/j.cell.2016.05.019

PMCID:: PMC4912688

Abstract Article

Select item 425347014.

Na⁺ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression

Quan Zhang, Margarita V Chibalina, Martin Bengtsson, Lukas N Groschner, Reshma Ramracheya, Nils J G Rorsman, Veronika Leiss, Mohammed A Nassar, Andrea Welling, Fiona M Gribble, Frank Reimann, Franz Hofmann, John N Wood, Frances M Ashcroft, Patrik Rorsman

J Physiol. 2014 Nov 1; 592(Pt 21): 4677–4696. Published online 2014 Oct 31. doi: 10.1113/jphysiol.2014.274209

PMCID:: PMC4253470

Abstract Article PDF–1.8M

Select item 380861315.

Discovery of a selective Na_V1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

Shilong Yang, Yao Xiao, Di Kang, Jie Liu, Yuan Li, Eivind A. B. Undheim, Julie K. Klint, Mingqiang Rong, Ren Lai, Glenn F. King

Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43): 17534–17539. Published online 2013 Sep 30. doi: 10.1073/pnas.1306285110

PMCID:: PMC3808613

Abstract Article PDF–1.0M

Select item 310113016.

Na_v1.7 is the predominant sodium channel in rodent olfactory sensory neurons

Hye-Sook Ahn, Joel A Black, Peng Zhao, Lynda Tyrrell, Stephen G Waxman, Sulayman D Dib-Hajj

Mol Pain. 2011; 7: 32. Published online 2011 May 10. doi: 10.1186/1744-8069-7-32

PMCID:: PMC3101130

Abstract Article PDF–14M

Select item 273053317.

A Role of SCN9A in Human Epilepsies, As a Cause of Febrile Seizures and As a Potential Modifier of Dravet Syndrome

Nanda A. Singh, Chris Pappas, E. Jill Dahle, Lieve R. F. Claes, Timothy H. Pruess, Peter De Jonghe, Joel Thompson, Missy Dixon, Christina Gurnett, Andy Peiffer, H. Steve White, Francis Filloux, Mark F. Leppert

PLoS Genet. 2009 Sep; 5(9): e1000649. Published online 2009 Sep 18. doi: 10.1371/journal.pgen.1000649

PMCID:: PMC2730533

Abstract Article PDF–894K

Select item 121551318.

Neuropathic pain develops normally in mice lacking both Na_v1.7 and Na_v1.8

Mohammed A Nassar, Alessandra Levato, L Caroline Stirling, John N Wood

Mol Pain. 2005; 1: 24. Published online 2005 Aug 22. doi: 10.1186/1744-8069-1-24

PMCID:: PMC1215513

Abstract Article PDF–312K

Select item 953684219.

Selective optogenetic activation of Na_V1.7–expressing afferents in Na_V1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

Toyoaki Maruta, Kotaro Hidaka, Satoshi Kouroki, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Seiya Mizuno, Tetsuro Shirasaka, Toshihiko Yanagita, Satoru Takahashi, Ryu Takeya, Isao Tsuneyoshi

PLoS One. 2022; 17(10): e0275751. Published online 2022 Oct 6. doi: 10.1371/journal.pone.0275751

PMCID:: PMC9536842

Abstract Article PDF–1.4M

Select item 671140420.

Synergistic regulation of serotonin and opioid signaling contribute to pain insensitivity in Na_v1.7 knockout mice

Jörg Isensee, Leonhardt Krahé, Katharina Moeller, Vanessa Pereira, Jane E. Sexton, Xiaohui Sun, Edward Emery, John N. Wood, Tim Hucho

Sci Signal. Author manuscript; available in PMC 2019 Aug 14.

Published in final edited form as: Sci Signal. 2017 Jan 10; 10(461): eaah4874. Published online 2017 Jan 10. doi: 10.1126/scisignal.aah4874

PMCID:: PMC6711404

Abstract Article PDF–3.1M

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