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Select item 111785401.

HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma

Zachary A. Bacigalupa, Emily N. Arner, Logan M. Vlach, Melissa M. Wolf, Whitney A. Brown, Evan S. Krystofiak, Xiang Ye, Rachel A. Hongo, Madelyn Landis, Edith K. Amason, Kathryn E. Beckermann, W. Kimryn Rathmell, Jeffrey C. Rathmell

J Clin Invest. 2024 Jun 17; 134(12): e164249. Published online 2024 Jun 17. doi: 10.1172/JCI164249

PMCID:: PMC11178540

Abstract Article PDF–4.7M

Select item 111107092.

HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis

Muyuan You, Minjie Fu, Zhewei Shen, Yuan Feng, Licheng Zhang, Xianmin Zhu, Zhengping Zhuang, Ying Mao, Wei Hua

Oncoimmunology. 2024; 13(1): 2356942. Published online 2024 May 20. doi: 10.1080/2162402X.2024.2356942

PMCID:: PMC11110709

Abstract Article PDF–9.7M

Select item 109521963.

Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2

William D. Figg, Jr., Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A. McDonough, Christopher J. Schofield

Proteins. 2023 Nov; 91(11): 1510–1524. Published online 2023 Jul 14. doi: 10.1002/prot.26541

PMCID:: PMC10952196

Abstract Article PDF–4.1M

Select item 108573714.

Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders

Elijah S. Lawrence, Wanjun Gu, Ryan J. Bohlender, Cecilia Anza-Ramirez, Amy M. Cole, James J. Yu, Hao Hu, Erica C. Heinrich, Katie A. O’Brien, Carlos A. Vasquez, Quinn T. Cowan, Patrick T. Bruck, Kysha Mercader, Mona Alotaibi, Tao Long, James E. Hall, Esteban A. Moya, Marco A. Bauk, Jennifer J. Reeves, Mitchell C. Kong, Rany M. Salem, Gustavo Vizcardo-Galindo, Jose-Luis Macarlupu, Rómulo Figueroa-Mujíca, Daniela Bermudez, Noemi Corante, Eduardo Gaio, Keolu P. Fox, Veikko Salomaa, Aki S. Havulinna, Andrew J. Murray, Atul Malhotra, Frank L. Powel, Mohit Jain, Alexis C. Komor, Gianpiero L. Cavalleri, Chad D. Huff, Francisco C. Villafuerte, Tatum S. Simonson

Sci Adv. 2024 Feb 9; 10(6): eadj5661. Published online 2024 Feb 9. doi: 10.1126/sciadv.adj5661

PMCID:: PMC10857371

Abstract Article PDF–2.6M

Select item 107351725.

A novel HIF2A mutation causes dyslipidemia and promotes hepatic lipid accumulation

Feiqiong Gao, Qigu Yao, Jiaqi Zhu, Wenyi Chen, Xudong Feng, Bing Feng, Jian Wu, Karel Pacak, Jared Rosenblum, Jiong Yu, Zhengping Zhuang, Hongcui Cao, Lanjuan Li

Pharmacol Res. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Pharmacol Res. 2023 Aug; 194: 106851. Published online 2023 Jul 13. doi: 10.1016/j.phrs.2023.106851

Correction in:: Pharmacol Res. 2024 Mar 8 : 107135.

PMCID:: PMC10735172

Abstract Article PDF–2.9M

Select item 106555166.

Somatic EPAS1 Variants in Pheochromocytoma and Paraganglioma in Patients With Sickle Cell Disease

Gemma White, Daisuke Nonaka, Teng-Teng Chung, Rebecca J Oakey, Louise Izatt

J Clin Endocrinol Metab. 2023 Dec; 108(12): 3302–3310. Published online 2023 Jun 7. doi: 10.1210/clinem/dgad311

PMCID:: PMC10655516

Abstract Article

Select item 105428347.

On either side of homeostasis: EPAS1 gain- and loss-of-function mutations

Josef T. Prchal, Gregg L. Semenza

Haematologica. 2023 Oct 1; 108(10): 2564–2565. Published online 2023 Jun 8. doi: 10.3324/haematol.2023.283285

PMCID:: PMC10542834

Article PDF–238K

Select item 103704528.

High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele

Kelsey Jorgensen, Daisheng Song, Julien Weinstein, Obed A Garcia, Laurel N Pearson, María Inclán, Maria Rivera-Chira, Fabiola León-Velarde, Melisa Kiyamu, Tom D Brutsaert, Abigail W Bigham, Frank S Lee

Mol Biol Evol. 2023 Jul; 40(7): msad162. Published online 2023 Jul 18. doi: 10.1093/molbev/msad162

PMCID:: PMC10370452

Abstract Article PDF–5.0M

Select item 103541009.

Cytoplasmic HIF-2α as tissue biomarker to identify metastatic sympathetic paraganglioma

Sinan Karakaya, Lisa Gunnesson, Erik Elias, Paula Martos-Salvo, Mercedes Robledo, Ola Nilsson, Bo Wängberg, Frida Abel, Sven Påhlman, Andreas Muth, Sofie Mohlin

Sci Rep. 2023; 13: 11588. Published online 2023 Jul 18. doi: 10.1038/s41598-023-38606-8

PMCID:: PMC10354100

Abstract Article PDF–2.0M

Select item 987933110.

Endotyping COPD: hypoxia-inducible factor-2 as a molecular “switch” between the vascular and airway phenotypes?

Oleh Myronenko, Vasile Foris, Slaven Crnkovic, Andrea Olschewski, Sonia Rocha, Mark R. Nicolls, Horst Olschewski

Eur Respir Rev. 2023 Mar 31; 32(167): 220173. Published online 2023 Jan 11. doi: 10.1183/16000617.0173-2022

PMCID:: PMC9879331

Abstract Article PDF–1.2M

Select item 943223011.

Possible association between a polymorphism of EPAS1 gene and persistent pulmonary hypertension of the newborn: a case-control study

Narongsak Nakwan, Surakameth Mahasirimongkol, Nusara Satproedprai, Tassamonwan Chaiyasung, Punna Kunhapan, Cheep Charoenlap, Kamonnut Singkhamanan, Chariyawan Charalsawadi

J Pediatr (Rio J) 2022 Jul-Aug; 98(4): 383–389. Published online 2021 Oct 20. doi: 10.1016/j.jped.2021.09.003

PMCID:: PMC9432230

Abstract Article PDF–887K

Select item 922098712.

The hypoxia induced changes in miRNA-mRNA in RNA-induced silencing complexes and HIF-2 induced miRNAs in human endothelial cells

Adrianna Moszyńska, Maciej Jaśkiewicz, Marcin Serocki, Aleksandra Cabaj, David K. Crossman, Sylwia Bartoszewska, Magdalena Gebert, Michał Dąbrowski, James F. Collawn, Rafal Bartoszewski

FASEB J. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: FASEB J. 2022 Jul; 36(7): e22412. doi: 10.1096/fj.202101987R

PMCID:: PMC9220987

Abstract Article PDF–2.8M

Select item 836608313.

Identification of novel mutations and functional impacts of EPAS1 in colorectal cancer

Farhadul Islam, Vinod Gopalan, Cu Tai Lu, Suja Pillai, Alfred K. Lam

Cancer Med. 2021 Aug; 10(16): 5557–5573. Published online 2021 Jul 11. doi: 10.1002/cam4.4116

PMCID:: PMC8366083

Abstract Article PDF–1.6M

Select item 834414714.

Differential effects of HIF2α antagonist and HIF2α silencing in renal cancer and sensitivity to repurposed drugs

Esther Arnaiz, Ana Miar, Esther Bridges, Naveen Prasad, Stephanie B. Hatch, Daniel Ebner, Charles H. Lawrie, Adrian L. Harris

BMC Cancer. 2021; 21: 896. Published online 2021 Aug 5. doi: 10.1186/s12885-021-08616-8

PMCID:: PMC8344147

Abstract Article PDF–2.2M

Select item 832959615.

Upregulation of hypoxia-inducible factors and autophagy in von Hippel-Lindau-associated retinal hemangioblastoma

Yujuan Wang, Mones S. Abu-Asab, Defen Shen, Zhengping Zhuang, Emily Y. Chew, Chi-Chao Chan

Graefes Arch Clin Exp Ophthalmol. Author manuscript; available in PMC 2021 Aug 3.

Published in final edited form as: Graefes Arch Clin Exp Ophthalmol. 2014 Aug; 252(8): 1319–1327. Published online 2014 May 24. doi: 10.1007/s00417-014-2660-0

PMCID:: PMC8329596

Abstract Article PDF–915K

Select item 817918616.

The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans

Xinjun Zhang, Kelsey E. Witt, Mayra M. Bañuelos, Amy Ko, Kai Yuan, Shuhua Xu, Rasmus Nielsen, Emilia Huerta-Sanchez

Proc Natl Acad Sci U S A. 2021 Jun 1; 118(22): e2020803118. Published online 2021 May 28. doi: 10.1073/pnas.2020803118

PMCID:: PMC8179186

Abstract Article PDF–1.0M

Select item 809378217.

Hypoxia-Inducible Factor 2a Expression Is Positively Correlated With Gleason Score in Prostate Cancer

Dimitrios Pavlakis, Spyridon Kampantais, Konstantinos Gkagkalidis, Victoras Gourvas, Dimitrios Memmos, Aikaterini Tsionga, Georgios Dimitriadis, Ioannis Vakalopoulos

Technol Cancer Res Treat. 2021; 20: 1533033821990010. Published online 2021 Mar 23. doi: 10.1177/1533033821990010

PMCID:: PMC8093782

Abstract Article PDF–810K

Select item 798985718.

Functional significance of germline EPAS1 variants

Trisha Dwight, Edward Kim, Karine Bastard, Diana E Benn, Graeme Eisenhofer, Susan Richter, Massimo Mannelli, Elena Rapizzi, Aleksander Prejbisz, Mariola Pęczkowska, Karel Pacak, Roderick Clifton-Bligh

Endocr Relat Cancer. 2021 Feb; 28(2): 97–109. Published online 2020 Dec 7. doi: 10.1530/ERC-20-0280

PMCID:: PMC7989857

Abstract Article PDF–1.5M

Select item 784470119.

MicroRNA-519d-3p Inhibits Proliferation and Promotes Apoptosis by Targeting HIF-2α in Cervical Cancer Under Hypoxic Conditions

Lixia Jiang, Shaohua Shi, Qiaofa Shi, Huijuan Zhang, Yu Xia, Tianyu Zhong

Oncol Res. 2018; 26(7): 1055–1062. Published online 2018 Aug 23. doi: 10.3727/096504018X15152056890500

PMCID:: PMC7844701

Abstract Article PDF–5.9M

Select item 769338520.

Identification of Novel Mutations and Expressions of EPAS1 in Phaeochromocytomas and Paragangliomas

Farhadul Islam, Suja Pillai, Vinod Gopalan, Alfred King-Yin Lam

Genes (Basel) 2020 Nov; 11(11): 1254. Published online 2020 Oct 24. doi: 10.3390/genes11111254

PMCID:: PMC7693385

Abstract Article PDF–20M

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