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Select item 89002701.

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production

Shen Y. Heazlewood, Tanveer Ahmad, Monika Mohenska, Belinda B. Guo, Pradnya Gangatirkar, Emma C. Josefsson, Sarah L. Ellis, Madara Ratnadiwakara, Huimin Cao, Benjamin Cao, Chad K. Heazlewood, Brenda Williams, Madeline Fulton, Jacinta F. White, Mirana Ramialison, Susan K. Nilsson, Minna-Liisa Änkö

Blood. 2022 Mar 3; 139(9): 1359–1373. doi: 10.1182/blood.2021013826

PMCID:: PMC8900270

Abstract Article

Select item 67632472.

Degradation of splicing factor SRSF3 contributes to progressive liver disease

Deepak Kumar, Manasi Das, Consuelo Sauceda, Lesley G. Ellies, Karina Kuo, Purva Parwal, Mehak Kaur, Lily Jih, Gautam K. Bandyopadhyay, Douglas Burton, Rohit Loomba, Olivia Osborn, Nicholas J.G. Webster

J Clin Invest. 2019 Oct 1; 129(10): 4477–4491. Published online 2019 Sep 16. doi: 10.1172/JCI127374

PMCID:: PMC6763247

Abstract Article PDF–14M

Select item 45821483.

Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates

Masahiko Ajiro, Rong Jia, Rui-Hong Wang, Chu-Xia Deng, Zhi-Ming Zheng

Int J Biol Sci. 2015; 11(11): 1248–1256. Published online 2015 Sep 3. doi: 10.7150/ijbs.13011

PMCID:: PMC4582148

Abstract Article PDF–2.0M

Select item 2321644.

Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle.

H Jumaa, J L Guénet, P J Nielsen

Mol Cell Biol. 1997 Jun; 17(6): 3116–3124. doi: 10.1128/mcb.17.6.3116

PMCID:: PMC232164

Summary PDF–993K

Select item 101021265.

High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production

Shen Y. Heazlewood, Tanveer Ahmad, Benjamin Cao, Huimin Cao, Melanie Domingues, Xuan Sun, Chad K. Heazlewood, Songhui Li, Brenda Williams, Madeline Fulton, Jacinta F. White, Tom Nebl, Christian M. Nefzger, Jose M. Polo, Benjamin T. Kile, Felix Kraus, Michael T. Ryan, Yu B. Sun, Peter F. M. Choong, Sarah L. Ellis, Minna-Liisa Anko, Susan K. Nilsson

Nat Commun. 2023; 14: 2099. Published online 2023 Apr 13. doi: 10.1038/s41467-023-37780-7

PMCID:: PMC10102126

Abstract Article PDF–4.4M

Select item 85915416.

Regulated splicing of large exons is linked to phase‐separation of vertebrate transcription factors

Toshihiko Kawachi, Akio Masuda, Yoshihiro Yamashita, Jun‐ichi Takeda, Bisei Ohkawara, Mikako Ito, Kinji Ohno

EMBO J. 2021 Nov 15; 40(22): e107485. Published online 2021 Oct 4. doi: 10.15252/embj.2020107485

PMCID:: PMC8591541

Abstract Article PDF–5.9M

Select item 83294577.

Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating Srsf3 During Mouse Cerebral Cortex Development

Meng Zhang, Junjie Zhou, Li Jiao, Longjiang Xu, Lin Hou, Bin Yin, Boqin Qiang, Shuaiyao Lu, Pengcheng Shu, Xiaozhong Peng

Front Neurosci. 2021; 15: 709684. Published online 2021 Jul 20. doi: 10.3389/fnins.2021.709684

PMCID:: PMC8329457

Abstract Article PDF–10M

Select item 79483618.

SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels

Oliver Daniel Schwich, Nicole Blümel, Mario Keller, Marius Wegener, Samarth Thonta Setty, Melinda Elaine Brunstein, Ina Poser, Igor Ruiz De Los Mozos, Beatrix Suess, Christian Münch, François McNicoll, Kathi Zarnack, Michaela Müller-McNicoll

Genome Biol. 2021; 22: 82. Published online 2021 Mar 11. doi: 10.1186/s13059-021-02298-y

PMCID:: PMC7948361

Abstract Article PDF–5.8M

Select item 64281089.

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence

Ting Shen, Huan Li, Yifang Song, Li Li, Jinzhong Lin, Gang Wei, Ting Ni

Aging (Albany NY) 2019 Mar 15; 11(5): 1356–1388. Published online 2019 Mar 4. doi: 10.18632/aging.101836

PMCID:: PMC6428108

Abstract Article PDF–5.7M

Select item 431421910.

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

Supriya Sen, Hassan Jumaa, Nicholas J.G. Webster

Nat Commun. Author manuscript; available in PMC 2015 Feb 2.

Published in final edited form as: Nat Commun. 2013; 4: 1336. doi: 10.1038/ncomms2342

PMCID:: PMC4314219

Abstract Article PDF–2.4M

Select item 343996811.

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes

Minna-Liisa Änkö, Michaela Müller-McNicoll, Holger Brandl, Tomaz Curk, Crtomir Gorup, Ian Henry, Jernej Ule, Karla M Neugebauer

Genome Biol. 2012; 13(3): R17. Published online 2012 Mar 21. doi: 10.1186/gb-2012-13-3-r17

PMCID:: PMC3439968

Abstract Article PDF–4.0M

Select item 300534712.

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

Rong Jia, Cuiling Li, J. Philip McCoy, Chu-Xia Deng, Zhi-Ming Zheng

Int J Biol Sci. 2010; 6(7): 806–826. Published online 2010 Dec 15. doi: 10.7150/ijbs.6.806

PMCID:: PMC3005347

Abstract Article PDF–3.6M

Select item 204456013.

Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation

Ana Antunes-Martins, Keiko Mizuno, Elaine E. Irvine, Eve M. Lepicard, K. Peter Giese

Learn Mem. 2007 Oct; 14(10): 693–702. doi: 10.1101/lm.640307

PMCID:: PMC2044560

Abstract Article PDF–641K

Select item 661593114.

Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction

Paula Ortiz-Sánchez, María Villalba-Orero, Marina M. López-Olañeta, Javier Larrasa-Alonso, Fátima Sánchez-Cabo, Carlos Martí-Gómez, Emilio Camafeita, Jesús M. Gómez-Salinero, Laura Ramos-Hernández, Peter J. Nielsen, Jesús Vázquez, Michaela Müller-McNicoll, Pablo García-Pavía, Enrique Lara-Pezzi

Circ Res. 2019 Jul 5; 125(2): 170–183. Published online 2019 May 30. doi: 10.1161/CIRCRESAHA.118.314515

PMCID:: PMC6615931

Abstract Article PDF–5.1M

Select item 428035015.

Deletion of Splicing Factor SRSF3 in Hepatocytes Predisposes to Hepatocellular Carcinoma in Mice

Supriya Sen, Magda Langiewicz, Hassan Jumaa, Nicholas J.G. Webster

Hepatology. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Hepatology. 2015 Jan; 61(1): 171–183. Published online 2014 Nov 25. doi: 10.1002/hep.27380

PMCID:: PMC4280350

Abstract Article PDF–4.6M

Select item 931354516.

Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma

Deepak Kumar, Manasi Das, Alexis Oberg, Debashis Sahoo, Panyisha Wu, Consuelo Sauceda, Lily Jih, Lesley G. Ellies, Magda T. Langiewicz, Supriya Sen, Nicholas J. G. Webster

Adv Sci (Weinh) 2022 Jul; 9(21): 2105120. Published online 2022 May 26. doi: 10.1002/advs.202105120

PMCID:: PMC9313545

Abstract Article PDF–7.7M

Select item 616330117.

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis

Hui-Yu Peng, Yu-Chih Liang, Tse-Hua Tan, Huai-Chia Chuang, Ying-Ju Lin, Jung-Chun Lin

Int J Mol Sci. 2018 Sep; 19(9): 2646. Published online 2018 Sep 6. doi: 10.3390/ijms19092646

PMCID:: PMC6163301

Abstract Article PDF–2.7M

Select item 596391718.

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

Madara Ratnadiwakara, Stuart K Archer, Craig I Dent, Igor Ruiz De Los Mozos, Traude H Beilharz, Anja S Knaupp, Christian M Nefzger, Jose M Polo, Minna-Liisa Anko

eLife. 2018; 7: e37419. Published online 2018 May 9. doi: 10.7554/eLife.37419

PMCID:: PMC5963917

Abstract Article PDF–5.5M

Select item 401903019.

Homer1 Alternative Splicing Is Regulated by Gonadotropin-Releasing Hormone and Modulates Gonadotropin Gene Expression

Qian Wang, Maria D. Chikina, Hanna Pincas, Stuart C. Sealfon

Mol Cell Biol. 2014 May; 34(10): 1747–1756. doi: 10.1128/MCB.01401-13

PMCID:: PMC4019030

Abstract Article PDF–2.0M

Select item 156421620.

Testing gene function early in the B cell lineage in mb1-cre mice

E. Hobeika, S. Thiemann, B. Storch, H. Jumaa, P. J. Nielsen, R. Pelanda, M. Reth

Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37): 13789–13794. Published online 2006 Aug 29. doi: 10.1073/pnas.0605944103

PMCID:: PMC1564216

Abstract Article PDF–1.6M

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