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Select item 110829771.

TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2

Nabil Ahmed, Christian Preisinger, Thomas Wilhelm, Michael Huber

Cells. 2024 May; 13(9): 747. Published online 2024 Apr 25. doi: 10.3390/cells13090747

PMCID:: PMC11082977

Abstract Article PDF–3.0M

Select item 107492202.

Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish

Byungseok Jin, Tokiro Ishikawa, Mai Taniguchi, Satoshi Ninagawa, Tetsuya Okada, Shigehide Kagaya, Kazutoshi Mori

Cell Struct Funct. 2020; 45(1): 23–31. Published online 2019 Dec 26. doi: 10.1247/csf.19032

PMCID:: PMC10749220

Abstract Article PDF–821K

Select item 104175263.

IRE1a-Induced FilaminA Phosphorylation Enhances Migration of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients

Francesco Da Ros, Kinga Kowal, Carla Vicinanza, Elisabetta Lombardi, Francesco Agostini, Rosanna Ciancia, Maurizio Rupolo, Cristina Durante, Mariagrazia Michieli, Mario Mazzucato

Cells. 2023 Aug; 12(15): 1935. Published online 2023 Jul 26. doi: 10.3390/cells12151935

PMCID:: PMC10417526

Abstract Article PDF–1.9M

Select item 98299014.

Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer

Michael J. P. Crowley, Bhavneet Bhinder, Geoffrey J. Markowitz, Mitchell Martin, Akanksha Verma, Tito A. Sandoval, Chang-Suk Chae, Shira Yomtoubian, Yang Hu, Sahil Chopra, Diamile A. Tavarez, Paolo Giovanelli, Dingcheng Gao, Timothy E. McGraw, Nasser K. Altorki, Olivier Elemento, Juan R. Cubillos-Ruiz, Vivek Mittal

Nat Commun. 2023; 14: 120. Published online 2023 Jan 9. doi: 10.1038/s41467-022-35584-9

PMCID:: PMC9829901

Abstract Article PDF–2.8M

Select item 96349715.

Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates

Donghwi Bae, Rachel Elizabeth Jones, Katherine M. Piscopo, Mitali Tyagi, Jason D. Shepherd, Julie Hollien

Mol Biol Cell. 2022 Nov 1; 33(13): ar125. Published online 2022 Nov 1. doi: 10.1091/mbc.E22-07-0281

PMCID:: PMC9634971

Abstract Article PDF–5.3M

Select item 95413856.

Human cDC1s display constitutive activation of the UPR sensor IRE1

Paulina García‐González, Dominique Fernández, Diane Gutiérrez, Mauro Parra‐Cordero, Fabiola Osorio

Eur J Immunol. 2022 Jul; 52(7): 1069–1076. Published online 2022 Apr 22. doi: 10.1002/eji.202149774

PMCID:: PMC9541385

Abstract Article PDF–1.2M

Select item 92652137.

Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells

Po-Chun Hsieh, Chung-Kan Peng, Guan-Ting Liu, Chan-Yen Kuo, I-Shiang Tzeng, Ming-Chieh Wang, Chou-Chin Lan, Kun-Lun Huang

Front Immunol. 2022; 13: 916102. Published online 2022 Jun 24. doi: 10.3389/fimmu.2022.916102

PMCID:: PMC9265213

Abstract Article PDF–10M

Select item 92171298.

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

Vladislav Belyy, Iratxe Zuazo-Gaztelu, Andrew Alamban, Avi Ashkenazi, Peter Walter

eLife. 2022; 11: e74342. Published online 2022 Jun 22. doi: 10.7554/eLife.74342

PMCID:: PMC9217129

Abstract Article PDF–4.7M

Select item 90768279.

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali

Nat Commun. 2022; 13: 2493. Published online 2022 May 6. doi: 10.1038/s41467-022-30159-0

PMCID:: PMC9076827

Abstract Article PDF–2.2M

Select item 904131610.

The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes

Ngoc-Han Tran, Stephen D. Carter, Ann De Mazière, Avi Ashkenazi, Judith Klumperman, Peter Walter, Grant J. Jensen

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): 52–57. Published online 2021 Sep 30. doi: 10.1126/science.abh2474

PMCID:: PMC9041316

Abstract Article PDF–2.7M

Select item 867435811.

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi

Nat Commun. 2021; 12: 7310. Published online 2021 Dec 15. doi: 10.1038/s41467-021-27597-7

PMCID:: PMC8674358

Abstract Article PDF–3.2M

Select item 861920512.

IRE1-Mediated Unfolded Protein Response Promotes the Replication of Tick-Borne Flaviviruses in a Virus and Cell-Type Dependent Manner

Veronika J. M. Breitkopf, Gerhard Dobler, Peter Claus, Hassan Y. Naim, Imke Steffen

Viruses. 2021 Nov; 13(11): 2164. Published online 2021 Oct 27. doi: 10.3390/v13112164

PMCID:: PMC8619205

Abstract Article PDF–2.5M

Select item 820384113.

An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation

Daniela Ricci, Stephen Tutton, Ilaria Marrocco, Mingjie Ying, Daniel Blumenthal, Daniela Eletto, Jade Vargas, Sarah Boyle, Hossein Fazelinia, Lei Qian, Krishna Suresh, Deanne Taylor, James C. Paton, Adrienne W. Paton, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Ravi Radhakrishnan, Tali Gidalevitz, Yair Argon

J Biol Chem. 2021 Jan-Jun; 296: 100781. Published online 2021 May 14. doi: 10.1016/j.jbc.2021.100781

PMCID:: PMC8203841

Abstract Article PDF–3.6M

Select item 800251214.

IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation

Emily A. Hull-Ryde, John T. Minges, Mary E. B. Martino, Takafumi Kato, Jacqueline L. Norris-Drouin, Carla M. P. Ribeiro

Int J Mol Sci. 2021 Mar; 22(6): 3063. Published online 2021 Mar 17. doi: 10.3390/ijms22063063

PMCID:: PMC8002512

Abstract Article PDF–2.1M

Select item 779267615.

Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes

Yingli Chen, Alexandra Griffiths, Jun Wang, Tingting Zhang, Qing Song, Zhenyuan Song

Am J Physiol Cell Physiol. 2020 Dec 1; 319(6): C1130–C1140. Published online 2020 Oct 14. doi: 10.1152/ajpcell.00165.2020

PMCID:: PMC7792676

Abstract Article

Select item 773658116.

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang

Nat Commun. 2020; 11: 6387. Published online 2020 Dec 14. doi: 10.1038/s41467-020-19974-5

PMCID:: PMC7736581

Abstract Article PDF–2.5M

Select item 772681017.

Inositol‐requiring enzyme‐1 regulates phosphoinositide signaling lipids and macrophage growth

Syed Muhammad Hamid, Mevlut Citir, Erdem Murat Terzi, Ismail Cimen, Zehra Yildirim, Asli Ekin Dogan, Begum Kocaturk, Umut Inci Onat, Moshe Arditi, Christian Weber, Alexis Traynor‐Kaplan, Carsten Schultz, Ebru Erbay

EMBO Rep. 2020 Dec 3; 21(12): e51462. Published online 2020 Nov 2. doi: 10.15252/embr.202051462