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Select item 108323841.

STAT1 Employs Myeloid Cell–Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection

Shekina Gonzalez-Ferrer, Hernán F. Peñaloza, Rick van der Geest, Zeyu Xiong, Atish Gheware, Mohammadreza Tabary, Megan Kochin, Kathryn Dalton, Henry Zou, Dequan Lou, Karina Lockwood, Yingze Zhang, William G. Bain, Rama K. Mallampalli, Anuradha Ray, Prabir Ray, Daria Van Tyne, Kong Chen, Janet S. Lee

Immunohorizons. 2024 Jan 1; 8(1): 122–135. Published online 2024 Jan 30. doi: 10.4049/immunohorizons.2300104

PMCID:: PMC10832384

Article PDF–2.2M

Select item 104694892.

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation

Jaime Imitola, Ethan W. Hollingsworth, Fumihiro Watanabe, Marta Olah, Wassim Elyaman, Sarah Starossom, Pia Kivisäkk, Samia J. Khoury

Front Cell Neurosci. 2023; 17: 1156802. Published online 2023 Aug 16. doi: 10.3389/fncel.2023.1156802

PMCID:: PMC10469489

Article PDF–10M

Select item 104073013.

T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis

Aaron B. Schultz, David G. Kugler, Luis Nivelo, Nicolas Vitari, Laura P. Doyle, Svetlana Ristin, Lothar Hennighausen, John J. O’Shea, Dragana Jankovic, Alejandro V. Villarino

Front Immunol. 2023; 14: 1212190. Published online 2023 Jul 25. doi: 10.3389/fimmu.2023.1212190

PMCID:: PMC10407301

Article PDF–2.9M

Select item 102728144.

Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

Juan E. Tichauer, Gabriel Arellano, Eric Acuña, Luis F. González, Nirmal R. Kannaiyan, Paola Murgas, Concepción Panadero-Medianero, Jorge Ibañez-Vega, Paula I. Burgos, Eileah Loda, Stephen D. Miller, Moritz J. Rossner, Peter J. Gebicke-Haerter, Rodrigo Naves

Front Immunol. 2023; 14: 1191838. Published online 2023 Jun 2. doi: 10.3389/fimmu.2023.1191838

PMCID:: PMC10272814

Article PDF–13M

Select item 102604025.

Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model

Katherine A. Waugh, Ross Minter, Jessica Baxter, Congwu Chi, Matthew D. Galbraith, Kathryn D. Tuttle, Neetha P. Eduthan, Kohl T. Kinning, Zdenek Andrysik, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael Ludwig, Kyndal A. Schade, Dayna Tracy, Keith P. Smith, Ross E. Granrath, Nicolas Busquet, Santosh Khanal, Ryan D. Anderson, Liza L. Cox, Belinda Enriquez Estrada, Angela L. Rachubinski, Hannah R. Lyford, Eleanor C. Britton, Katherine A. Fantauzzo, David J. Orlicky, Jennifer L. Matsuda, Kunhua Song, Timothy C. Cox, Kelly D. Sullivan, Joaquin M. Espinosa

Nat Genet. 2023; 55(6): 1034–1047. Published online 2023 Jun 5. doi: 10.1038/s41588-023-01399-7

PMCID:: PMC10260402

Article PDF–9.4M

Select item 102355316.

The human Stat1 gain-of-function T385M mutation causes expansion of activated T-follicular helper/T-helper 1-like CD4 T cells and sex-biased autoimmunity in specific pathogen-free mice

Ori Scott, Shagana Visuvanathan, Emily Reddy, Deeqa Mahamed, Bin Gu, Chaim M. Roifman, Ronald D. Cohn, Cynthia J. Guidos, Evgueni A. Ivakine

Front Immunol. 2023; 14: 1183273. Published online 2023 May 19. doi: 10.3389/fimmu.2023.1183273

PMCID:: PMC10235531

Article PDF–19M

Select item 101348757.

Type I Interferon Orchestrates Demand-Adapted Monopoiesis during Influenza A Virus Infection via STAT1-Mediated Upregulation of Macrophage Colony-Stimulating Factor Receptor Expression

Sue-Jane Lin, Kai-Min Lin, Shi-Yo Jill Chen, Chia-Chi Ku, Chen-Wei Huang, Chi-Hsiang Huang, Michael Gale, Jr., Ching-Hwa Tsai

J Virol. 2023 Apr; 97(4): e00102-23. Published online 2023 Apr 6. doi: 10.1128/jvi.00102-23

PMCID:: PMC10134875

Article PDF–1.6M

Select item 101218838.

STAT1 controls the functionality of influenza-primed CD4 T cells but therapeutic STAT4 engagement maximizes their antiviral impact

Caroline M. Finn, Kunal Dhume, Emily Prokop, Tara M. Strutt, K. Kai McKinstry

J Immunol. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: J Immunol. 2023 May 1; 210(9): 1292–1304. doi: 10.4049/jimmunol.2200407

PMCID:: PMC10121883

Article PDF–1.3M

Select item 100089429.

Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction

Asmma Doudin, Theresa Riebeling, Julia Staab, Priyanka Rajeev Menon, Fred Lühder, Oliver Wirths, Uwe Vinkemeier, Aleksandar Ivetic, Thomas Meyer

Front Cardiovasc Med. 2023; 10: 975012. Published online 2023 Feb 27. doi: 10.3389/fcvm.2023.975012

PMCID:: PMC10008942

Article PDF–15M

Select item 998761710.

Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma

Michael W. Knitz, Laurel B. Darragh, Thomas E. Bickett, Shilpa Bhatia, Sanjana Bukkapatnam, Jacob Gadwa, Miles Piper, Sophia Corbo, Diemmy Nguyen, Benjamin Van Court, Ayman Oweida, Sana D. Karam

Cancer Immunol Immunother. 2022 May; 71(5): 1049–1061. Published online 2021 Sep 24. doi: 10.1007/s00262-021-03059-3

PMCID:: PMC9987617

Article PDF–8.5M

Select item 943088011.

T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells

P. A. Sylvester, C. N. Jondle, D. L. Schmalzriedt, B. N. Dittel, V. L. Tarakanova

mBio. 2022 Jul-Aug; 13(4): e02107-22. Published online 2022 Aug 15. doi: 10.1128/mbio.02107-22

PMCID:: PMC9430880

Article PDF–1.6M

Select item 916644812.

CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model

Junki Maruyama, Rachel A. Reyna, Megumi Kishimoto-Urata, Shinji Urata, John T. Manning, Nantian Harsell, Rebecca Cook, Cheng Huang, Janko Nikolich-Zugich, Tomoko Makishima, Slobodan Paessler

PLoS Pathog. 2022 May; 18(5): e1010557. Published online 2022 May 23. doi: 10.1371/journal.ppat.1010557

PMCID:: PMC9166448

Article PDF–2.6M

Select item 891225713.

Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling

Callum Talbot-Cooper, Teodors Pantelejevs, John P. Shannon, Christian R. Cherry, Marcus T. Au, Marko Hyvönen, Heather D. Hickman, Geoffrey L. Smith

Cell Host Microbe. 2022 Mar 9; 30(3): 357–372.e11. doi: 10.1016/j.chom.2022.01.014

PMCID:: PMC8912257

Article

Select item 871576714.

Antibody Production Remains Intact Despite Loss of Bone Marrow B cells in Murine Norovirus Infected Stat1^−/− Mice

Daniel E Eldridge, Charlie C Hsu

Comp Med. 2021 Dec; 71(6): 1–10. Published online 2021 Dec. doi: 10.30802/AALAS-CM-21-000054

PMCID:: PMC8715767

Article PDF–1.9M

Select item 871502715.

Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation

Brandon W. Lewis, Devine Jackson, Stephanie A. Amici, Joshua Walum, Manel Guessas, Sonia Guessas, Elise Coneglio, Akhila V. Boda, Mireia Guerau-de-Arellano, Mitchell H. Grayson, Rodney D. Britt, Jr.

Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321(6): L1194–L1205. Published online 2021 Nov 10. doi: 10.1152/ajplung.00244.2021

PMCID:: PMC8715027

Article

Select item 862483116.

Microglia Reduce Herpes Simplex Virus 1 Lethality of Mice with Decreased T Cell and Interferon Responses in Brains

Meng-Shan Tsai, Li-Chiu Wang, Hsien-Yang Tsai, Yu-Jheng Lin, Hua-Lin Wu, Shun-Fen Tzeng, Sheng-Min Hsu, Shun-Hua Chen

Int J Mol Sci. 2021 Nov; 22(22): 12457. Published online 2021 Nov 18. doi: 10.3390/ijms222212457

PMCID:: PMC8624831

Article PDF–4.3M

Select item 842865617.

Infecting mosquitoes alters DENV-2 characteristics and enhances hemorrhage-induction potential in Stat1^-/- mice

Ka Wan Cheang, Wen-Yu Chen, Betty A. Wu-Hsieh, Shin-Hong Shiao

PLoS Negl Trop Dis. 2021 Aug; 15(8): e0009728. Published online 2021 Aug 27. doi: 10.1371/journal.pntd.0009728

PMCID:: PMC8428656

Article PDF–2.2M

Select item 835288018.

Tunable heat shock protein-mediated NK cell responses are orchestrated by STAT1 in Antigen Presenting Cells

Abigail L. Sedlacek, Lauren B. Kinner-Bibeau, Yifei Wang, Alicia P. Mizes, Robert J. Binder

Sci Rep. 2021; 11: 16106. Published online 2021 Aug 9. doi: 10.1038/s41598-021-95578-3

PMCID:: PMC8352880

Article PDF–15M

Select item 834697319.

Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Jinjoo Kang, Soyoung Lee, Namkyung Kim, Hima Dhakal, Taeg-Kyu Kwon, Eun-Nam Kim, Gil-Saeng Jeong, Sang-Hyun Kim

Molecules. 2021 Aug; 26(15): 4409. Published online 2021 Jul 21. doi: 10.3390/molecules26154409

PMCID:: PMC8346973

Article PDF–2.8M

Select item 793122120.

Periodontitis aggravates kidney injury by upregulating STAT1 expression in a mouse model of hypertension

Qin Yang, Handong Ding, Wei Wei, Jie Liu, Jiajia Wang, Jie Ren, Weicheng Chan, Min Wang, Liang Hao, Jinle Li, Yuan Yue

FEBS Open Bio. 2021 Mar; 11(3): 880–889. Published online 2021 Feb 19. doi: 10.1002/2211-5463.13081

PMCID:: PMC7931221

Article PDF–9.0M

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