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Select item 63152941.

SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation

Roland Steinacher, Zeinab Barekati, Petar Botev, Anna Kuśnierczyk, Geir Slupphaug, Primo Schär

EMBO J. 2019 Jan 3; 38(1): e99242. Published online 2018 Dec 6. doi: 10.15252/embj.201899242

PMCID:: PMC6315294

Abstract Article PDF–1.3M

Select item 82184152.

Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

Atsushi Onodera, Edahí González-Avalos, Chan-Wang Jerry Lio, Romain O. Georges, Alfonso Bellacosa, Toshinori Nakayama, Anjana Rao

Genome Biol. 2021; 22: 186. Published online 2021 Jun 22. doi: 10.1186/s13059-021-02384-1

PMCID:: PMC8218415

Abstract Article PDF–3.4M

Select item 75278623.

Inducible TDG knockout models to study epigenetic regulation

Simon D. Schwarz, Eliane Grundbacher, Alexandra M. Hrovat, Jianming Xu, Anna Kuśnierczyk, Cathrine B. Vågbø, Primo Schär, David Schuermann

Version 2. F1000Res. 2020; 9: 1112. Published online 2020 Oct 19. doi: 10.12688/f1000research.25637.2

PMCID:: PMC7527862

Abstract Article PDF–3.4M

Select item 26715604.

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

Christophe Kunz, Frauke Focke, Yusuke Saito, David Schuermann, Teresa Lettieri, Jim Selfridge, Primo Schär

PLoS Biol. 2009 Apr; 7(4): e1000091. Published online 2009 Apr 28. doi: 10.1371/journal.pbio.1000091

PMCID:: PMC2671560

Abstract Article

Select item 105865165.

TET1 and TDG suppress inflammatory response in intestinal tumorigenesis: implications for colorectal tumors with the CpG Island Methylator Phenotype

Rossella Tricarico, Jozef Madzo, Gabrielle Scher, Maya Cohen, Jaroslav Jelinek, Shinji Maegawa, Rajeswari Nagarathinam, Carly Scher, Wen-Chi Chang, Emmanuelle Nicolas, Michael Slifker, Yan Zhou, Karthik Devarajan, Kathy Q. Cai, Tim Kwok, Pamela Nakajima, Jinfei Xu, Pietro Mancuso, Valentina Doneddu, Luigi Bagella, Riley Williams, Siddharth Balachandran, Nicholas Maskalenko, Kerry Campbell, Xueying Ma, Israel Cañadas, Julen Viana, Victor Moreno, Laura Valle, Sergei Grivennikov, Iuliia Peshkova, Natalia Kurilenko, Aleksandra Mazitova, Ekaterina Koltsova, Hayan Lee, Martin Walsh, Reuben Duttweiler, Johnathan R. Whetstine, Timothy J. Yen, Jean-Pierre Issa, Alfonso Bellacosa

Gastroenterology. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Gastroenterology. 2023 May; 164(6): 921–936.e1. Published online 2023 Feb 8. doi: 10.1053/j.gastro.2023.01.039

PMCID:: PMC10586516

Abstract Article PDF–3.0M

Select item 60079976.

An intrinsic epigenetic barrier for functional axon regeneration

Yi-Lan Weng, Ran An, Jessica Cassin, Jessica Joseph, Ruifa Mi, Chen Wang, Chun Zhong, Seung-Gi Jin, Gerd P. Pfeifer, Alfonso Bellacosa, Xinzhong Dong, Ahmet Hoke, Zhigang He, Hongjun Song, Guo-li Ming

Neuron. Author manuscript; available in PMC 2018 Jun 19.

Published in final edited form as: Neuron. 2017 Apr 19; 94(2): 337–346.e6. doi: 10.1016/j.neuron.2017.03.034

PMCID:: PMC6007997

Abstract Article PDF–2.5M

Select item 56857267.

Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression

Jinfei Xu, Salvatore Cortellino, Rossella Tricarico, Wen-Chi Chang, Gabrielle Scher, Karthik Devarajan, Michael Slifker, Robert Moore, Maria Rosaria Bassi, Elena Caretti, Margie Clapper, Harry Cooper, Alfonso Bellacosa

Oncotarget. 2017 Oct 27; 8(52): 89988–89997. Published online 2017 Sep 23. doi: 10.18632/oncotarget.21219

PMCID:: PMC5685726

Abstract Article PDF–3.3M

Select item 32018778.

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Henrik Sahlin Pettersen, Torkild Visnes, Cathrine Broberg Vågbø, Eva. K. Svaasand, Berit Doseth, Geir Slupphaug, Bodil Kavli, Hans E. Krokan

Nucleic Acids Res. 2011 Oct; 39(19): 8430–8444. Published online 2011 Jul 9. doi: 10.1093/nar/gkr563

PMCID:: PMC3201877

Abstract Article PDF–1.5M

Select item 28313179.

Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase

Ryan D. Mohan, David W. Litchfield, Joseph Torchia, Marc Tini

Nucleic Acids Res. 2010 Mar; 38(4): 1135–1148. Published online 2009 Dec 4. doi: 10.1093/nar/gkp1097

PMCID:: PMC2831317

Abstract Article PDF–5.8M

Select item 180259910.

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair

Ya-Qiang Li, Ping-Zhu Zhou, Xiu-Dan Zheng, Colum P. Walsh, Guo-Liang Xu

Nucleic Acids Res. 2007 Jan; 35(2): 390–400. Published online 2006 Dec 14. doi: 10.1093/nar/gkl1052

PMCID:: PMC1802599

Abstract Article PDF–3.3M

Select item 346223111.

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He, Guo-Liang Xu

Science. Author manuscript; available in PMC 2012 Oct 2.

Published in final edited form as: Science. 2011 Sep 2; 333(6047): 1303–1307. Published online 2011 Aug 4. doi: 10.1126/science.1210944

PMCID:: PMC3462231

Abstract Article PDF–846K

Select item 128352512.

T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif

Marie J. Lucey, Dongsheng Chen, Jorge Lopez-Garcia, Stephen M. Hart, Fladia Phoenix, Rajai Al-Jehani, John P. Alao, Roger White, Karin B. Kindle, Régine Losson, Pierre Chambon, Malcolm G. Parker, Primo Schär, David M. Heery, Lakjaya Buluwela, Simak Ali

Nucleic Acids Res. 2005; 33(19): 6393–6404. Published online 2005 Nov 10. doi: 10.1093/nar/gki940

PMCID:: PMC1283525

Abstract Article PDF–587K

Select item 386371513.

Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway

Petra Hajkova, Sean J. Jeffries, Caroline Lee, Nigel Miller, Stephen P. Jackson, M. Azim Surani

Science. Author manuscript; available in PMC 2013 Dec 16.

Published in final edited form as: Science. 2010 Jul 2; 329(5987): 10.1126/science.1187945. doi: 10.1126/science.1187945

PMCID:: PMC3863715

Abstract Article PDF–2.1M

Select item 270544114.

Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA

Michael J. Boland, Judith K. Christman

J Mol Biol. Author manuscript; available in PMC 2009 Jul 2.

Published in final edited form as: J Mol Biol. 2008 Jun 6; 379(3): 492–504. Published online 2008 Feb 29. doi: 10.1016/j.jmb.2008.02.049

PMCID:: PMC2705441

Abstract Article PDF–1.0M

Select item 180065815.

SUMO-1-Dependent Allosteric Regulation of Thymine DNA Glycosylase Alters Subnuclear Localization and CBP/p300 Recruitment

Ryan D. Mohan, Anita Rao, Jason Gagliardi, Marc Tini

Mol Cell Biol. 2007 Jan; 27(1): 229–243. Published online 2006 Oct 23. doi: 10.1128/MCB.00323-06

PMCID:: PMC1800658

Abstract Article PDF–1.1M

Select item 260290116.

Thymine DNA Glycosylase Represses Myocardin-induced Smooth Muscle Cell Differentiation by Competing with Serum Response Factor for Myocardin Binding

Jiliang Zhou, Emily K. Blue, Guoqing Hu, B. Paul Herring

J Biol Chem. 2008 Dec 19; 283(51): 35383–35392. doi: 10.1074/jbc.M805489200

PMCID:: PMC2602901

Abstract Article PDF–834K

Select item 323022317.

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

Salvatore Cortellino, Jinfei Xu, Mara Sannai, Robert Moore, Elena Caretti, Antonio Cigliano, Madeleine Le Coz, Karthik Devarajan, Andy Wessels, Dianne Soprano, Lara K. Abramowitz, Marisa S. Bartolomei, Florian Rambow, Maria Rosaria Bassi, Tiziana Bruno, Maurizio Fanciulli, Catherine Renner, Andres J. Klein-Szanto, Yoshihiro Matsumoto, Dominique Kobi, Irwin Davidson, Christophe Alberti, Lionel Larue, Alfonso Bellacosa

Cell. Author manuscript; available in PMC 2012 Jul 8.

Published in final edited form as: Cell. 2011 Jul 8; 146(1): 67–79. Published online 2011 Jun 30. doi: 10.1016/j.cell.2011.06.020

PMCID:: PMC3230223

Abstract Article PDF–3.1M

Select item 40210318.

Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

P M Chevray, D Nathans

Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13): 5789–5793. doi: 10.1073/pnas.89.13.5789

PMCID:: PMC402103

Summary Page Browse PDF–1.3M

Select item 382575119.

Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract

Kimberly P. Keil, Helene M. Altmann, Vatsal Mehta, Lisa L. Abler, Erik A. Elton, Chad M. Vezina

Gene Expr Patterns. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Gene Expr Patterns. 2013 Dec; 13(8): 10.1016/j.gep.2013.07.008. Published online 2013 Aug 3. doi: 10.1016/j.gep.2013.07.008

PMCID:: PMC3825751

Abstract Article PDF–7.2M

Select item 18788520.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

Jens Hansen, Thomas Floss, Petra Van Sloun, Ernst-Martin Füchtbauer, Franz Vauti, Hans-Hennig Arnold, Frank Schnütgen, Wolfgang Wurst, Harald von Melchner, Patricia Ruiz

Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 9918–9922. Published online 2003 Aug 6. doi: 10.1073/pnas.1633296100

PMCID:: PMC187885

Abstract Article PDF–287K

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