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Select item 82709431.

Attenuated asthma phenotype in mice with a fetal-like antigen receptor repertoire

Regine Stutz, Christopher Meyer, Elisabeth Kaiser, Sybelle Goedicke-Fritz, Harry W. Schroeder, Jr, Robert Bals, Christoph Haertel, Tobias Rogosch, Sebastian Kerzel, Michael Zemlin

Sci Rep. 2021; 11: 14199. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93553-6

PMCID:: PMC8270943

Abstract Article PDF–1.8M

Select item 49110492.

Molecular Dynamics Simulations and Structural Analysis to Decipher Functional Impact of a Twenty Residue Insert in the Ternary Complex of Mus musculus TdT Isoform

Eshita Mutt, Ramanathan Sowdhamini

PLoS One. 2016; 11(6): e0157286. Published online 2016 Jun 16. doi: 10.1371/journal.pone.0157286

PMCID:: PMC4911049

Abstract Article PDF–12M

Select item 36701013.

The CDR-H3 repertoire from TdT deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver

Robert Schelonka, Ivaylo Ivanov, Andre M. Vale, Ewa Szymanska, Michael Zemlin, G. Larry Gartland, Harry W. Schroeder, Jr.

J Immunol. Author manuscript; available in PMC 2013 Jun 3.

Published in final edited form as: J Immunol. 2010 Nov 15; 185(10): 6075–6084. Published online 2010 Oct 18. doi: 10.4049/jimmunol.1001419

PMCID:: PMC3670101

Abstract Article PDF–2.9M

Select item 25969834.

TdT is required for the establishment of private virus-specific CD8⁺ TCR repertoires and facilitates optimal CTL responses

Katherine Kedzierska, Paul G. Thomas, Vanessa Venturi, Miles P. Davenport, Peter C. Doherty, Stephen J. Turner, Nicole L. La Gruta

J Immunol. Author manuscript; available in PMC 2009 Aug 15.

Published in final edited form as: J Immunol. 2008 Aug 15; 181(4): 2556–2562. doi: 10.4049/jimmunol.181.4.2556

PMCID:: PMC2596983

Abstract Article PDF–1.1M

Select item 25873145.

Terminal Deoxynucleotidyl Transferase Establishes and Broadens Anti-Viral CD8⁺ T Cell Immunodominance Hierarchies

S.M. Mansour Haeryfar, Heather D. Hickman, Kari R. Irvine, David C. Tscharke, Jack R. Bennink, Jonathan W. Yewdell

J Immunol. Author manuscript; available in PMC 2009 Jul 1.

Published in final edited form as: J Immunol. 2008 Jul 1; 181(1): 649–659. doi: 10.4049/jimmunol.181.1.649

PMCID:: PMC2587314

Abstract Article PDF–2.0M

Select item 21959706.

Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase

Jean-Pierre Cabaniols, Nicolas Fazilleau, Armanda Casrouge, Philippe Kourilsky, Jean M. Kanellopoulos

J Exp Med. 2001 Nov 5; 194(9): 1385–1390. doi: 10.1084/jem.194.9.1385

PMCID:: PMC2195970

Abstract Article PDF–73K

Select item 21958807.

The Long Isoform of Terminal Deoxynucleotidyl Transferase Enters the Nucleus And, Rather than Catalyzing Nontemplated Nucleotide Addition, Modulates the Catalytic Activity of the Short Isoform

Cindy L. Benedict, Susan Gilfillan, John F. Kearney

J Exp Med. 2001 Jan 1; 193(1): 89–100. doi: 10.1084/jem.193.1.89

PMCID:: PMC2195880

Abstract Article PDF–327K

Select item 3945058.

The two isoforms of mouse terminal deoxynucleotidyl transferase differ in both the ability to add N regions and subcellular localization.

L A Bentolila, M Fanton d'Andon, Q T Nguyen, O Martinez, F Rougeon, N Doyen

EMBO J. 1995 Sep 1; 14(17): 4221–4229. doi: 10.1002/j.1460-2075.1995.tb00096.x

PMCID:: PMC394505

Summary Page Browse PDF–2.4M

Select item 1258429.

Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase

M. Delarue, J.B. Boulé, J. Lescar, N. Expert-Bezançon, N. Jourdan, N. Sukumar, F. Rougeon, C. Papanicolaou

EMBO J. 2002 Feb 1; 21(3): 427–439. doi: 10.1093/emboj/21.3.427

PMCID:: PMC125842

Abstract Article PDF–791K

Select item 920830710.

Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors

Fabian Klein, Julien Roux, Grozdan Cvijetic, Patrick Fernandes Rodrigues, Lilly von Muenchow, Ruth Lubin, Pawel Pelczar, Simon Yona, Panagiotis Tsapogas, Roxane Tussiwand

Nat Immunol. Author manuscript; available in PMC 2022 Sep 30.

Published in final edited form as: Nat Immunol. 2022 Apr; 23(4): 505–517. Published online 2022 Mar 30. doi: 10.1038/s41590-022-01167-5

PMCID:: PMC9208307

Abstract Article PDF–8.4M

Select item 471036311.

Terminal deoxynucleotidyl Transferase is required for an optimal response to the polysaccharide α-1,3 Dextran

Tamer I. Mahmoud, John F. Kearney

J Immunol. Author manuscript; available in PMC 2016 Jan 12.

Published in final edited form as: J Immunol. 2010 Jan 15; 184(2): 851–858. Published online 2009 Dec 16. doi: 10.4049/jimmunol.0902791

PMCID:: PMC4710363

Abstract Article PDF–1.3M

Select item 396610512.

B-1a Cell Diversity: N-addition in B-1a immunoglobulin is determined by progenitor population and developmental location

Nichol E. Holodick, Teresa Vizconde, Thomas L. Rothstein

J Immunol. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: J Immunol. 2014 Mar 1; 192(5): 2432–2441. Published online 2014 Jan 29. doi: 10.4049/jimmunol.1300247

PMCID:: PMC3966105

Abstract Article PDF–1.1M

Select item 318100813.

Absence of N addition facilitates B cell development, but impairs immune responses

Robert L. Schelonka, Ivaylo I. Ivanov, Andre M. Vale, Reed A. Dimmitt, Mahnaz Khaled, Harry W. Schroeder, Jr.

Immunogenetics. 2011; 63(9): 599–609. Published online 2011 Jun 10. doi: 10.1007/s00251-011-0543-7

PMCID:: PMC3181008

Abstract Article PDF–910K

Select item 195140914.

Heterosubtypic Immunity to Influenza A Virus Infection Requires a Properly Diversified Antibody Repertoire

Huan H. Nguyen, Michael Zemlin, Ivaylo I. Ivanov, Judit Andrasi, Cosima Zemlin, Huong L. Vu, Robert Schelonka, Harry W. Schroeder, Jr., Jiri Mestecky

J Virol. 2007 Sep; 81(17): 9331–9338. Published online 2007 Jun 13. doi: 10.1128/JVI.00751-07

PMCID:: PMC1951409

Abstract Article PDF–551K

Select item 39180615.

Cloning of terminal transferase cDNA by antibody screening.

N R Landau, T P St John, I L Weissman, S C Wolf, A E Silverstone, D Baltimore

Proc Natl Acad Sci U S A. 1984 Sep; 81(18): 5836–5840. doi: 10.1073/pnas.81.18.5836

PMCID:: PMC391806

Summary Page Browse PDF–1.5M

Select item 31159116.

Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells.

O Koiwai, T Yokota, T Kageyama, T Hirose, S Yoshida, K Arai

Nucleic Acids Res. 1986 Jul 25; 14(14): 5777–5792. doi: 10.1093/nar/14.14.5777

PMCID:: PMC311591

Summary Page Browse PDF–1.6M

Select item 30928017.

Differential splicing in mouse thymus generates two forms of terminal deoxynucleotidyl transferase.

N Doyen, M F d'Andon, L A Bentolila, Q T Nguyen, F Rougeon

Nucleic Acids Res. 1993 Mar 11; 21(5): 1187–1191. doi: 10.1093/nar/21.5.1187

PMCID:: PMC309280

Summary Page Browse PDF–1.0M

Select item 273862218.

Limited terminal transferase in human DNA polymerase μ defines the required balance between accuracy and efficiency in NHEJ

Paula Andrade, María José Martín, Raquel Juárez, Francisco López de Saro, Luis Blanco

Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38): 16203–16208. Published online 2009 Sep 4. doi: 10.1073/pnas.0908492106

PMCID:: PMC2738622

Abstract Article PDF–2.1M

Select item 31024119.

DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells

Orlando Domínguez, José F. Ruiz, Teresa Laín de Lera, Miguel García-Díaz, Manuel A. González, Tomas Kirchhoff, Carlos Martínez-A, Antonio Bernad, Luis Blanco

EMBO J. 2000 Apr 3; 19(7): 1731–1742. doi: 10.1093/emboj/19.7.1731