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Items: 1 to 20 of 45

1.
The Ras family of GTPases in cancer cell invasion
R. Hernández-Alcoceba, L. del Peso, J. C. Lacal*
Cell Mol Life Sci. 2000 Jan; 57(1): 65–76. doi: 10.1007/s000180050499
PMCID:
PMC11146990
AbstractPDF–138K
2.
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling
Katarzyna Mleczko-Sanecka, Franziska Roche, Ana Rita da Silva, Debora Call, Flavia D’Alessio, Anan Ragab, Philip E. Lapinski, Ramesh Ummanni, Ulrike Korf, Christopher Oakes, Georg Damm, Lorenza A. D’Alessandro, Ursula Klingmüller, Philip D. King, Michael Boutros, Matthias W. Hentze, Martina U. Muckenthaler
Blood. 2014 Mar 6; 123(10): 1574–1585. Prepublished online 2014 Jan 2. doi: 10.1182/blood-2013-07-515957
PMCID:
PMC3945866
AbstractArticle
3.
Expression of the NH2-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes
Jiang-Yan Yang, Jöel Walicki, Evrim Jaccard, Gilles Dubuis, Natasa Bulat, Jean-Pierre Hornung, Bernard Thorens, Christian Widmann
Diabetes. 2009 Nov; 58(11): 2596–2606. Published online 2009 Aug 20. doi: 10.2337/db09-0104
PMCID:
PMC2768177
AbstractArticlePDF–797K
4.
RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice
Di Chen, Xin Geng, Philip E. Lapinski, Michael J. Davis, R. Sathish Srinivasan, Philip D. King
Development. 2020 Dec 1; 147(23): dev192351. Published online 2020 Dec 7. doi: 10.1242/dev.192351
PMCID:
PMC7746672
AbstractArticle
5.
RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development
Di Chen, Joyce M. Teng, Paula E. North, Philip E. Lapinski, Philip D. King
J Clin Invest. 2019 Sep 3; 129(9): 3545–3561. Published online 2019 Aug 5. doi: 10.1172/JCI124917
PMCID:
PMC6715364
AbstractArticlePDF–38M
6.
Caspase-3 Protects Stressed Organs against Cell Death
Hadi Khalil, Nieves Peltzer, Joël Walicki, Jiang-Yan Yang, Gilles Dubuis, Noémie Gardiol, Werner Held, Paul Bigliardi, Benjamin Marsland, Lucas Liaudet, Christian Widmann
Mol Cell Biol. 2012 Nov; 32(22): 4523–4533. doi: 10.1128/MCB.00774-12
PMCID:
PMC3486191
AbstractArticlePDF–4.4M
7.
A role for p120 RasGAP (RASA1) in thymocyte positive selection and survival of naïve T cells
Philip E. Lapinski, Yu Qiao, Cheong-Hee Chang, Philip D. King
J Immunol. Author manuscript; available in PMC 2012 Jul 1.
Published in final edited form as: J Immunol. 2011 Jul 1; 187(1): 151–163. Published online 2011 Jun 6. doi: 10.4049/jimmunol.1100178
PMCID:
PMC3119767
AbstractArticlePDF–2.1M
8.
Impaired Akt Activity Down-Modulation, Caspase-3 Activation, and Apoptosis in Cells Expressing a Caspase-resistant Mutant of RasGAP at Position 157
Jiang-Yan Yang, Joël Walicki, David Michod, Gilles Dubuis, Christian Widmann
Mol Biol Cell. 2005 Aug; 16(8): 3511–3520. doi: 10.1091/mbc.E05-01-0080
PMCID:
PMC1182293
AbstractArticlePDF–569K
9.
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.
P van der Geer, M Henkemeyer, T Jacks, T Pawson
Mol Cell Biol. 1997 Apr; 17(4): 1840–1847. doi: 10.1128/mcb.17.4.1840
PMCID:
PMC232031
SummaryPDF–906K
10.
RASA1 regulates the function of lymphatic vessel valves in mice
Philip E. Lapinski, Beth A. Lubeck, Di Chen, Abbas Doosti, Scott D. Zawieja, Michael J. Davis, Philip D. King
J Clin Invest. 2017 Jun 30; 127(7): 2569–2585. Published online 2017 May 22. doi: 10.1172/JCI89607
PMCID:
PMC5490778
AbstractArticlePDF–4.1M
11.
Co-deletion of the Ras GTPase-activating proteins Neurofibromin 1 (NF1) and p120 RasGAP (RASA1) in T cells results in the development of T cell acute lymphoblastic leukemia
Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, Olga Ksionda, Luis F. Parada, Yuan Zhu, Ivan Maillard, Mark Chiang, Jeroen Roose, Philip D. King
J Immunol. Author manuscript; available in PMC 2016 Jul 1.
Published in final edited form as: J Immunol. 2015 Jul 1; 195(1): 31–35. Published online 2015 May 22. doi: 10.4049/jimmunol.1402639
PMCID:
PMC4475412
AbstractArticlePDF–388K
12.
Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man
Patricia E. Burrows, Manuel L. Gonzalez-Garay, John C. Rasmussen, Melissa B. Aldrich, Renie Guilliod, Erik A. Maus, Caroline E. Fife, Sunkuk Kwon, Philip E. Lapinski, Philip D. King, Eva M. Sevick-Muraca
Proc Natl Acad Sci U S A. 2013 May 21; 110(21): 8621–8626. Published online 2013 May 6. doi: 10.1073/pnas.1222722110
PMCID:
PMC3666675
AbstractArticlePDF–1.0M
13.
RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice
Philip E. Lapinski, Sunkuk Kwon, Beth A. Lubeck, John E. Wilkinson, R. Sathish Srinivasan, Eva Sevick-Muraca, Philip D. King
J Clin Invest. 2012 Feb 1; 122(2): 733–747. Published online 2012 Jan 9. doi: 10.1172/JCI46116
PMCID:
PMC3266774
AbstractArticlePDF–1.8M
14.
A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation.
P M Irusta, D DiMaio
EMBO J. 1998 Dec 1; 17(23): 6912–6923. doi: 10.1093/emboj/17.23.6912
PMCID:
PMC1171039
SummaryPDF–575K
15.
Partial Cleavage of RasGAP by Caspases Is Required for Cell Survival in Mild Stress Conditions
Jiang-Yan Yang, David Michod, Joël Walicki, Brona M. Murphy, Shailaja Kasibhatla, Seamus J. Martin, Christian Widmann
Mol Cell Biol. 2004 Dec; 24(23): 10425–10436. doi: 10.1128/MCB.24.23.10425-10436.2004
PMCID:
PMC529026
AbstractArticlePDF–817K
16.
Blood Vascular Abnormalities in Rasa1R780Q Knockin Mice: Implications for the Pathogenesis of Capillary Malformation–Arteriovenous Malformation
Beth A. Lubeck, Philip E. Lapinski, Timothy J. Bauler, Jennifer A. Oliver, Elizabeth D. Hughes, Thomas L. Saunders, Philip D. King
Am J Pathol. 2014 Dec; 184(12): 3163–3169. doi: 10.1016/j.ajpath.2014.08.018
PMCID:
PMC4258499
AbstractArticlePDF–1.6M
17.
Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection
Nieves Peltzer, Güliz Vanli, Jiang-Yan Yang, Christian Widmann
PLoS One. 2013; 8(6): e68123. Published online 2013 Jun 27. doi: 10.1371/journal.pone.0068123
PMCID:
PMC3694949
AbstractArticlePDF–1.2M
18.
EphrinA/EphA signal facilitates insulin-like growth factor-I–induced myogenic differentiation through suppression of the Ras/extracellular signal–regulated kinase 1/2 cascade in myoblast cell lines
Masayoshi Minami, Tatsuya Koyama, Yuki Wakayama, Shigetomo Fukuhara, Naoki Mochizuki
Mol Biol Cell. 2011 Sep 15; 22(18): 3508–3519. doi: 10.1091/mbc.E11-03-0183
PMCID:
PMC3172274
AbstractArticlePDF–5.4M
19.
Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration
Anja Mai, Stefan Veltel, Teijo Pellinen, Artur Padzik, Eleanor Coffey, Varpu Marjomäki, Johanna Ivaska
J Cell Biol. 2011 Jul 25; 194(2): 291–306. doi: 10.1083/jcb.201012126
PMCID:
PMC3144408
AbstractArticlePDF–4.0M
20.
A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells
Christopher J. Benwell, Robert T. Johnson, James A. G. E. Taylor, Jordi Lambert, Stephen D. Robinson
Commun Biol. 2024; 7: 629. Published online 2024 May 24. doi: 10.1038/s42003-024-06320-4
PMCID:
PMC11126613
AbstractArticlePDF–8.0M

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