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Select item 76055241.

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami

JCI Insight. 2020 Oct 15; 5(20): e142446. Published online 2020 Oct 15. doi: 10.1172/jci.insight.142446

PMCID:: PMC7605524

Abstract Article PDF–2.5M

Select item 70811042.

Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy

Karissa M. Dieseldorff Jones, Cynthia Vied, Isela C. Valera, P. Bryant Chase, Michelle S. Parvatiyar, Jose R. Pinto

Physiol Rep. 2020 Mar; 8(6): e14396. Published online 2020 Mar 19. doi: 10.14814/phy2.14396

PMCID:: PMC7081104

Abstract Article PDF–1.7M

Select item 62827433.

Structural and functional impact of troponin C-mediated Ca²⁺ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle

David Gonzalez-Martinez, Jamie R. Johnston, Maicon Landim-Vieira, Weikang Ma, Olga Antipova, Omar Awan, Thomas C. Irving, P. Bryant Chase, J. Renato Pinto

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Mol Cell Cardiol. 2018 Oct; 123: 26–37. Published online 2018 Aug 21. doi: 10.1016/j.yjmcc.2018.08.015

PMCID:: PMC6282743

Abstract Article PDF–1.7M

Select item 54346484.

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy

Amanda M. Dossat, Marcos A. Sanchez-Gonzalez, Andrew P. Koutnik, Stefano Leitner, Edda L. Ruiz, Brittany Griffin, Jens T. Rosenberg, Samuel C. Grant, Francis D. Fincham, Jose R. Pinto, Mohamed Kabbaj

FASEB J. 2017 Jun; 31(6): 2492–2506. Published online 2017 Feb 24. doi: 10.1096/fj.201600955RR

PMCID:: PMC5434648

Abstract Article

Select item 54063735.

Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model

Masataka Kawai, Jamie R. Johnston, Tarek Karam, Li Wang, Rakesh K. Singh, Jose R. Pinto

Biophys J. 2017 Apr 25; 112(8): 1726–1736. Published online 2017 Apr 25. doi: 10.1016/j.bpj.2017.02.045

PMCID:: PMC5406373

Abstract Article PDF–1.2M

Select item 45507776.

Knock-in mice harboring a Ca²⁺ desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy

Bradley K. McConnell, Sonal Singh, Qiying Fan, Adriana Hernandez, Jesus P. Portillo, Peter J. Reiser, Svetlana B. Tikunova

Front Physiol. 2015; 6: 242. Published online 2015 Aug 27. doi: 10.3389/fphys.2015.00242

PMCID:: PMC4550777

Abstract Article PDF–2.8M

Select item 30185407.

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

Kareen L. Kreutziger, Nicoletta Piroddi, Jonathan T. McMichael, Chiara Tesi, Corrado Poggesi, Michael Regnier

J Mol Cell Cardiol. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: J Mol Cell Cardiol. 2011 Jan; 50(1): 165–174. Published online 2010 Oct 28. doi: 10.1016/j.yjmcc.2010.10.025

PMCID:: PMC3018540

Abstract Article PDF–1.2M

Select item 23974838.

Increased Cross-bridge Cycling Kinetics after Exchange of C-terminal Truncated Troponin I in Skinned Rat Cardiac Muscle

Kittipong Tachampa, Tomoyoshi Kobayashi, Helen Wang, Anne F. Martin, Brandon J. Biesiadecki, R. John Solaro, Pieter P. de Tombe

J Biol Chem. 2008 May 30; 283(22): 15114–15121. doi: 10.1074/jbc.M801636200

PMCID:: PMC2397483

Abstract Article PDF–371K

Select item 23624009.

Role of the Acidic N′-Region of Cardiac Troponin I In Regulating Myocardial Function*

Sakthivel Sadayappan, Natosha Finley, Jack W Howarth, Hanna Osinska, Raisa Klevitsky, John N Lorenz, Paul R Rosevear, Jeffrey Robbins

FASEB J. Author manuscript; available in PMC 2009 Apr 1.

Published in final edited form as: FASEB J. 2008 Apr; 22(4): 1246–1257. Published online 2007 Nov 5. doi: 10.1096/fj.07-9458com

PMCID:: PMC2362400

Abstract Article PDF–2.8M

Select item 36436710.

Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene.

M S Parmacek, A J Vora, T Shen, E Barr, F Jung, J M Leiden

Mol Cell Biol. 1992 May; 12(5): 1967–1976. doi: 10.1128/mcb.12.5.1967

PMCID:: PMC364367

Summary Page Browse PDF–2.3M

Select item 461810411.

In vivo Analysis of Troponin C Knock-in (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Adriano S. Martins, Michelle S. Parvatiyar, Han-Zhong Feng, J. Martijn Bos, David Gonzalez-Martinez, Milica Vukmirovic, Rajdeep S. Turna, Marcos A. Sanchez-Gonzalez, Crystal-Dawn Badger, Diego A. R. Zorio, Rakesh K. Singh, Yingcai Wang, J.-P. Jin, Michael J. Ackerman, Jose R. Pinto

Circ Cardiovasc Genet. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Circ Cardiovasc Genet. 2015 Oct; 8(5): 653–664. Published online 2015 Aug 24. doi: 10.1161/CIRCGENETICS.114.000957

PMCID:: PMC4618104

Abstract Article PDF–2.4M

Select item 293464612.

Predicting Cardiomyopathic Phenotypes by Altering Ca²⁺ Affinity of Cardiac Troponin C

Michelle S. Parvatiyar, Jose Renato Pinto, Jingsheng Liang, James D. Potter

J Biol Chem. 2010 Sep 3; 285(36): 27785–27797. Published online 2010 Jun 21. doi: 10.1074/jbc.M110.112326

PMCID:: PMC2934646

Abstract Article PDF–1.4M

Select item 276949813.

Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI

Jianfeng Du, Jing Liu, Han-Zhong Feng, M. M. Hossain, Nariman Gobara, Chi Zhang, Yuejin Li, Pierre-Yves Jean-Charles, Jian-Ping Jin, Xu-Pei Huang

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC 2009 Oct 28.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6): H2604–H2613. Published online 2008 Apr 11. doi: 10.1152/ajpheart.91506.2007

PMCID:: PMC2769498

Abstract Article PDF–1.5M

Select item 122507114.

Effects of cardiac thin filament Ca2+: statistical mechanical analysis of a troponin C site II mutant.

Q Huynh, C A Butters, J M Leiden, L S Tobacman

Biophys J. 1996 Mar; 70(3): 1447–1455. doi: 10.1016/S0006-3495(96)79704-7

PMCID:: PMC1225071

Summary Page Browse PDF–1.8M

Select item 244144015.

The Role of Cardiac Troponin T Quantity and Function in Cardiac Development and Dilated Cardiomyopathy

Ferhaan Ahmad, Sanjay K. Banerjee, Michele L. Lage, Xueyin N. Huang, Stephen H. Smith, Samir Saba, Jennifer Rager, David A. Conner, Andrzej M. Janczewski, Kimimasa Tobita, Joseph P. Tinney, Ivan P. Moskowitz, Antonio R. Perez-Atayde, Bradley B. Keller, Michael A. Mathier, Sanjeev G. Shroff, Christine E. Seidman, J. G. Seidman

PLoS One. 2008; 3(7): e2642. Published online 2008 Jul 9. doi: 10.1371/journal.pone.0002642

PMCID:: PMC2441440

Abstract Article PDF–915K

Select item 226986316.

Regulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calcium

Earl Homsher, David M Lee, Carl Morris, Dmitry Pavlov, Larry S Tobacman

J Physiol. 2000 Apr 1; 524(Pt 1): 233–243. doi: 10.1111/j.1469-7793.2000.00233.x

PMCID:: PMC2269863

Abstract Article PDF–224K

Select item 296432817.

Oxytocin-Gly-Lys-Arg: A Novel Cardiomyogenic Peptide

Bogdan A. Danalache, Jolanta Gutkowska, Magdalena J. Ślusarz, Irena Berezowska, Marek Jankowski

PLoS One. 2010; 5(10): e13643. Published online 2010 Oct 26. doi: 10.1371/journal.pone.0013643

PMCID:: PMC2964328

Abstract Article PDF–7.7M

Select item 643485118.

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development

Kai Wang, Hua Shen, Peiheng Gan, Susana Cavallero, S. Ram Kumar, Ching-Ling Lien, Henry M. Sucov

BMC Dev Biol. 2019; 19: 5. Published online 2019 Mar 25. doi: 10.1186/s12861-019-0186-8

PMCID:: PMC6434851

Abstract Article PDF–5.1M

Select item 38098819.

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart

Jian-Hua Ding, Xiangdong Xu, Dongmei Yang, Pao-Hsien Chu, Nancy D Dalton, Zhen Ye, Joanne M Yeakley, Heping Cheng, Rui-Ping Xiao, John Ross, Jr, Ju Chen, Xiang-Dong Fu

EMBO J. 2004 Feb 25; 23(4): 885–896. Published online 2004 Feb 12. doi: 10.1038/sj.emboj.7600054

PMCID:: PMC380988

Abstract Article PDF–432K

Select item 1093203520.

Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway

Taha Rehmani, Ana Paula Dias, Marsel Kamal, Maysoon Salih, Balwant S. Tuana

Int J Mol Sci. 2024 Mar; 25(5): 2888. Published online 2024 Mar 1. doi: 10.3390/ijms25052888

PMCID:: PMC10932035

Abstract Article PDF–4.4M

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