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Select item 110309461.

Topoisomerase II alpha as a universal tumor antigen: antitumor immunity in murine tumor models and H-2K^b-restricted T cell epitope

Jung-Sun Park, Hye-Sung Kim, Mi-Young Park, Chang-Hyun Kim, Yeun-Jun Chung, Yong-Kil Hong, Tai-Gyu Kim

Cancer Immunol Immunother. 2010 May; 59(5): 747–757. Published online 2009 Nov 20. doi: 10.1007/s00262-009-0795-3

PMCID:: PMC11030946

Abstract Article PDF–567K

Select item 53953022.

TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin

Erik L. Miller, Diana C. Hargreaves, Cigall Kadoch, Chiung-Ying Chang, Joseph P. Calarco, Courtney Hodges, Jason D. Buenrostro, Kairong Cui, William J. Greenleaf, Keji Zhao, Gerald R. Crabtree

Nat Struct Mol Biol. Author manuscript; available in PMC 2017 Aug 27.

Published in final edited form as: Nat Struct Mol Biol. 2017 Apr; 24(4): 344–352. Published online 2017 Feb 27. doi: 10.1038/nsmb.3384

PMCID:: PMC5395302

Abstract Article PDF–1.8M

Select item 41725593.

Inhibition of DNA Topoisomerase II Selectively Reduces the Threat of Tumorigenicity Following Induced Pluripotent Stem Cell-Based Myocardial Therapy

Saranya P. Wyles, Satsuki Yamada, Saji Oommen, Joseph J. Maleszewski, Rosanna Beraldi, Almudena Martinez-Fernandez, Andre Terzic, Timothy J. Nelson

Stem Cells Dev. 2014 Oct 1; 23(19): 2274–2282. Published online 2014 Jul 18. doi: 10.1089/scd.2014.0259

PMCID:: PMC4172559

Abstract Article PDF–895K

Select item 109366594.

TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation

Kaiwen Zhang, Xingyu Zheng, Yiqing Sun, Xinyu Feng, Xirong Wu, Wenlu Liu, Chao Gao, Ye Yan, Wenyan Tian, Yingmei Wang

Cancer Biol Ther. 2024; 25(1): 2325126. Published online 2024 Mar 6. doi: 10.1080/15384047.2024.2325126

PMCID:: PMC10936659

Abstract Article PDF–7.9M

Select item 57573715.

Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole(Hx) polyamide

Luke Pett, Konstantinos Kiakos, Vijay Satam, Pravin Patil, Sarah Laughlin-Toth, Matthew Gregory, Michael Bowerman, Kevin Olson, Mia Savagian, Megan Lee, Moses Lee, W. David Wilson, Daniel Hochhauser, John A. Hartley

Biochim Biophys Acta. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Biochim Biophys Acta. 2017 May; 1860(5): 617–629. Published online 2016 Oct 24. doi: 10.1016/j.bbagrm.2016.10.005

PMCID:: PMC5757371

Abstract Article PDF–1.0M

Select item 35929266.

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

Fernando Gómez-Herreros, Rocío Romero-Granados, Zhihong Zeng, Alejandro Álvarez-Quilón, Cristina Quintero, Limei Ju, Lieve Umans, Liesbeth Vermeire, Danny Huylebroeck, Keith W. Caldecott, Felipe Cortés-Ledesma

PLoS Genet. 2013 Mar; 9(3): e1003226. Published online 2013 Mar 7. doi: 10.1371/journal.pgen.1003226

PMCID:: PMC3592926

Abstract Article PDF–2.8M

Select item 27992507.

The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped Topoisomerase II-DNA cleavable complexes

Hai Xiao, David W. Goodrich

Oncogene. Author manuscript; available in PMC 2009 Dec 29.

Published in final edited form as: Oncogene. 2005 Dec 8; 24(55): 8105–8113. doi: 10.1038/sj.onc.1208958

PMCID:: PMC2799250

Abstract Article PDF–1.4M

Select item 19041558.

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

Anna M. Azarova, Yi Lisa Lyu, Chao-Po Lin, Yuan-Chin Tsai, Johnson Yiu-Nam Lau, James C. Wang, Leroy F. Liu

Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26): 11014–11019. Published online 2007 Jun 19. doi: 10.1073/pnas.0704002104

PMCID:: PMC1904155

Abstract Article PDF–502K

Select item 3319309.

Mutant isolation of mouse DNA topoisomerase II alpha in yeast.

N Adachi, H Ikeda, A Kikuchi

Nucleic Acids Res. 1994 Oct 11; 22(20): 4229–4233. doi: 10.1093/nar/22.20.4229

PMCID:: PMC331930

Summary Page Browse PDF–1.0M

Select item 1011296410.

Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components

Gabriel Muciño-Hernández, Pilar Sarah Acevo-Rodríguez, Sandra Cabrera-Benitez, Adán Oswaldo Guerrero, Horacio Merchant-Larios, Susana Castro-Obregón

J Cell Sci. 2023 Jan 1; 136(1): jcs260563. Published online 2023 Jan 12. doi: 10.1242/jcs.260563

PMCID:: PMC10112964

Abstract Article

Select item 292990811.

Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53–Mediated Mouse Mammary Tumors

Norazizah Shafee, Christopher R. Smith, Shuanzeng Wei, Yoon Kim, Gordon B. Mills, Gabriel N. Hortobagyi, Eric J. Stanbridge, Eva Y-H. P. Lee

Cancer Res. Author manuscript; available in PMC 2010 Aug 30.

Published in final edited form as: Cancer Res. 2008 May 1; 68(9): 3243–3250. doi: 10.1158/0008-5472.CAN-07-5480

PMCID:: PMC2929908

Abstract Article PDF–1.3M

Select item 32909412.

Possible role of DNA topoisomerase II on transcription of the homeobox gene Hox-2.1 in F9 embryonal carcinoma cells.

K Ura, S Hirose

Nucleic Acids Res. 1991 Nov 25; 19(22): 6087–6092. doi: 10.1093/nar/19.22.6087

PMCID:: PMC329094

Summary Page Browse PDF–1.2M

Select item 702167213.

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma

Nat Commun. 2020; 11: 910. Published online 2020 Feb 14. doi: 10.1038/s41467-020-14638-w