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Select item 71709031.

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao

Nat Commun. 2020; 11: 1869. Published online 2020 Apr 20. doi: 10.1038/s41467-020-15795-8

PMCID:: PMC7170903

Abstract Article PDF–7.8M

Select item 108509592.

Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase

Dönem Avci, Ronny Heidasch, Martina Costa, Christian Lüchtenborg, Dipali Kale, Britta Brügger, Marius K. Lemberg

J Biol Chem. 2024 Feb; 300(2): 105644. Published online 2024 Jan 11. doi: 10.1016/j.jbc.2024.105644

PMCID:: PMC10850959

Abstract Article PDF–2.5M

Select item 88987043.

Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression

Huihong Jiang, Erjiang Tang, Ying Chen, Hailong Liu, Yun Zhao, Moubin Lin, Luwei He

Cancer Sci. 2022 Mar; 113(3): 971–985. Published online 2022 Jan 6. doi: 10.1111/cas.15248

PMCID:: PMC8898704

Abstract Article PDF–2.6M

Select item 25465364.

Regulation of Cholesterologenesis by the Oxysterol Receptor, LXRα

Yongjun Wang, Pamela M. Rogers, Chen Su, Gabor Varga, Keith R. Stayrook, Thomas P. Burris

J Biol Chem. 2008 Sep 26; 283(39): 26332–26339. doi: 10.1074/jbc.M804808200

PMCID:: PMC2546536

Abstract Article PDF–728K

Select item 14725305.

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

Kathryn L. Kavanagh, Kunde Guo, James E. Dunford, Xiaoqiu Wu, Stefan Knapp, Frank H. Ebetino, Michael J. Rogers, R. Graham G. Russell, Udo Oppermann

Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7829–7834. Published online 2006 May 9. doi: 10.1073/pnas.0601643103

PMCID:: PMC1472530

Abstract Article PDF–1.4M

Select item 3596456.

Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.

G W Robinson, Y H Tsay, B K Kienzle, C A Smith-Monroy, R W Bishop

Mol Cell Biol. 1993 May; 13(5): 2706–2717. doi: 10.1128/mcb.13.5.2706

PMCID:: PMC359645

Summary Page Browse PDF–2.6M

Select item 26690747.

Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

Camilla Helene Andreasen, Mette Sloth Mogensen, Knut Borch-Johnsen, Annelli Sandbæk, Torsten Lauritzen, Katrine Almind, Lars Hansen, Torben Jørgensen, Oluf Pedersen, Torben Hansen

BMC Med Genet. 2009; 10: 17. Published online 2009 Feb 26. doi: 10.1186/1471-2350-10-17

PMCID:: PMC2669074

Abstract Article PDF–271K

Select item 28541068.

Louise K Sjöholm, Leena Kovanen, Sirkku T Saarikoski, Martin Schalling, Catharina Lavebratt, Timo Partonen

J Circadian Rhythms. 2010; 8: 1. Published online 2010 Jan 21. doi: 10.1186/1740-3391-8-1

PMCID:: PMC2854106

Abstract Article PDF–288K

Select item 26971419.

NPAS2 and PER2 are linked to risk factors of the metabolic syndrome

Ani Englund, Leena Kovanen, Sirkku T Saarikoski, Jari Haukka, Antti Reunanen, Arpo Aromaa, Jouko Lönnqvist, Timo Partonen

J Circadian Rhythms. 2009; 7: 5. Published online 2009 May 26. doi: 10.1186/1740-3391-7-5

PMCID:: PMC2697141

Abstract Article PDF–679K

Select item 296757610.

Genome-Wide Association Study Identifies Variants Associated with Histologic Features of Nonalcoholic Fatty Liver Disease

Naga Chalasani, Xiuqing Guo, Rohit Loomba, Mark O. Goodarzi, Talin Haritunians, Soonil Kwon, Jinrui Cui, Kent D. Taylor, Laura Wilson, Oscar W. Cummings, Yii-Der Ida Chen, Jerome I. Rotter

Gastroenterology. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Gastroenterology. 2010 Nov; 139(5): 1567–1576.e6. Published online 2010 Aug 11. doi: 10.1053/j.gastro.2010.07.057

PMCID:: PMC2967576

Abstract Article PDF–563K

Select item 299529511.

Pharmacogenetic Predictors of Statin-Mediated Low-Density Lipoprotein Cholesterol Reduction and Dose Response

Deepak Voora, Svati H. Shah, Carol R. Reed, Jun Zhai, David R. Crosslin, Chad Messer, Benjamin A. Salisbury, Geoffrey S. Ginsburg

Circ Cardiovasc Genet. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Circ Cardiovasc Genet. 2008 Dec; 1(2): 100–106. Published online 2008 Dec 9. doi: 10.1161/CIRCGENETICS.108.795013

PMCID:: PMC2995295

Abstract Article PDF–491K

Select item 541523512.

The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity

X. Huang, F. F. Dai, G. Gaisano, K. Giglou, J. Han, M. Zhang, S. Kittanakom, V. Wong, L. Wei, A. D. Showalter, K. W. Sloop, I. Stagljar, M. B. Wheeler

Mol Endocrinol. September 1, 2013; 27(9): 1550–1563. Published online 2013 Jul 17. doi: 10.1210/me.2013-1047

PMCID:: PMC5415235

Abstract Article

Select item 848332113.

Proteomic analysis identifies novel binding partners of BAP1

Roy Baas, Fenna J. van der Wal, Onno B. Bleijerveld, Haico van Attikum, Titia K. Sixma

PLoS One. 2021; 16(9): e0257688. Published online 2021 Sep 30. doi: 10.1371/journal.pone.0257688

PMCID:: PMC8483321

Abstract Article PDF–2.6M

Select item 676379114.

Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome

Ahmed Sharaf, Leonore Mensching, Christina Keller, Sebastian Rading, Marina Scheffold, Lysann Palkowitsch, Nevena Djogo, Meriem Rezgaoui, Hans A. Kestler, Barbara Moepps, Antonio Virgilio Failla, Meliha Karsak

Front Mol Neurosci. 2019; 12: 224. Published online 2019 Sep 20. doi: 10.3389/fnmol.2019.00224

PMCID:: PMC6763791

Abstract Article PDF–3.6M

Select item 385466915.

Genome Wide Association Study (GWAS) of Chagas Cardiomyopathy in Trypanosoma cruzi Seropositive Subjects

Xutao Deng, Ester C. Sabino, Edecio Cunha-Neto, Antonio L. Ribeiro, Barbara Ianni, Charles Mady, Michael P. Busch, Mark Seielstad, the REDSII Chagas study group from the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component

PLoS One. 2013; 8(11): e79629. Published online 2013 Nov 20. doi: 10.1371/journal.pone.0079629

PMCID:: PMC3854669

Abstract Article PDF–408K

Select item 432443916.

Proteomic Analysis and Identification of Cellular Interactors of the Giant Ubiquitin Ligase HERC2

Jeffrey T. Galligan, Gustavo Martinez-Noël, Verena Arndt, Sebastian Hayes, Thomas W. Chittenden, J. Wade Harper, Peter M. Howley

J Proteome Res. 2015 Feb 6; 14(2): 953–966. Published online 2014 Dec 4. doi: 10.1021/pr501005v

PMCID:: PMC4324439

Abstract Article PDF–7.5M

Select item 247469617.

Polymorphisms in the Estrogen Receptor 1 and Vitamin C and Matrix Metalloproteinase Gene Families Are Associated with Susceptibility to Lymphoma

Christine F. Skibola, Paige M. Bracci, Eran Halperin, Alexandra Nieters, Alan Hubbard, Randi A. Paynter, Danica R. Skibola, Luz Agana, Nikolaus Becker, Patrick Tressler, Matthew S. Forrest, Sriram Sankararaman, Lucia Conde, Elizabeth A. Holly, Martyn T. Smith

PLoS One. 2008; 3(7): e2816. Published online 2008 Jul 30. doi: 10.1371/journal.pone.0002816

PMCID:: PMC2474696

Abstract Article PDF–172K

Select item 723200918.

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress

Jiaojiao Yu, Tao Li, Yu Liu, Xi Wang, Jianchao Zhang, Xi'e Wang, Guizhi Shi, Jizhong Lou, Likun Wang, Chih‐chen Wang, Lei Wang

EMBO J. 2020 May 18; 39(10): e103841. Published online 2020 Mar 9. doi: 10.15252/embj.2019103841

PMCID:: PMC7232009

Abstract Article PDF–5.5M

Select item 325047919.

Defining human ERAD networks through an integrative mapping strategy

John C. Christianson, James A. Olzmann, Thomas A. Shaler, Mathew E. Sowa, Eric J. Bennett, Caleb M. Richter, Ryan E. Tyler, Ethan J. Greenblatt, J. Wade Harper, Ron R. Kopito

Nat Cell Biol. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: Nat Cell Biol. 2012 Jan; 14(1): 93–105. Published online 2011 Nov 27. doi: 10.1038/ncb2383