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Select item 111923841.

Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1

Christine W. Gao, WanYing Lin, Ryan C. Riddle, Sheetal Chopra, Jiyoung Kim, Leandros Boukas, Kasper D. Hansen, Hans T. Björnsson, Jill A. Fahrner

PLoS Genet. 2024 Jun; 20(6): e1011310. Published online 2024 Jun 10. doi: 10.1371/journal.pgen.1011310

PMCID:: PMC11192384

Abstract Article PDF–2.5M

Select item 111550982.

Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis

Dexiang Zhang, Xiaohong Zhao, Yu Gao, Meixing Wang, Mi Xiao, Kaihua Zhu, Wei Niu, Yuedi Dai

Eur J Med Res. 2024; 29: 310. Published online 2024 Jun 6. doi: 10.1186/s40001-024-01828-1

PMCID:: PMC11155098

Abstract Article PDF–7.5M

Select item 106387853.

Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway

Yong Xie, Zixiang Luo, Wei Peng, Yudong Liu, Feifei Yuan, Jiaqi Xu, Yi Sun, Hongbin Lu, Tianding Wu, Liyuan Jiang, Jianzhong Hu

J Neuroinflammation. 2023; 20: 259. Published online 2023 Nov 11. doi: 10.1186/s12974-023-02936-1

PMCID:: PMC10638785

Abstract Article PDF–21M

Select item 104820124.

Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice

Lisa Y. Q. Hong, Emily S. H. Yeung, Duc Tin Tran, Veera Ganesh Yerra, Harmandeep Kaur, M. D. Golam Kabir, Suzanne L. Advani, Youan Liu, Sri Nagarjun Batchu, Andrew Advani

Dis Model Mech. 2023 Sep 1; 16(9): dmm049991. Published online 2023 Sep 1. doi: 10.1242/dmm.049991

PMCID:: PMC10482012

Abstract Article

Select item 103391435.

Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibroblasts-to-Myofibroblasts Trans-Differentiation

Chao Li, Tiantian Lin, Delin Li, Daoyuan Si, Huan Sun, Sibao Yang, Zhongfan Zhang, Qian Zhang, Kaiyao Shi

Anatol J Cardiol. 2023 Jul; 27(7): 398–407. Published online 2023 Jul 1. doi: 10.14744/AnatolJCardiol.2023.2777

PMCID:: PMC10339143

Abstract Article PDF–9.1M

Select item 102351956.

X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain

Cayce K Shaw, Samira Abdulai-Saiku, Francesca Marino, Dan Wang, Emily J Davis, Barbara Panning, Dena B Dubal

J Gerontol A Biol Sci Med Sci. 2023 Jun; 78(6): 938–943. Published online 2023 Jan 9. doi: 10.1093/gerona/glad007

PMCID:: PMC10235195

Abstract Article PDF–317K

Select item 98512527.

UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation

Mingyu Pan, Yue Yin, Tongyu Hu, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai, Haiyang Hu, Chen Wang

Autophagy. 2023; 19(2): 440–456. Published online 2022 May 30. doi: 10.1080/15548627.2022.2076192

PMCID:: PMC9851252

Abstract Article PDF–3.3M

Select item 93083438.

Sex-biased and parental allele-specific gene regulation by KDM6A

Wenxiu Ma, He Fang, Nicolas Pease, Galina N. Filippova, Christine M. Disteche, Joel B. Berletch

Biol Sex Differ. 2022; 13: 40. Published online 2022 Jul 23. doi: 10.1186/s13293-022-00452-0

PMCID:: PMC9308343

Abstract Article PDF–3.2M

Select item 92798499.

Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M Gaida, Mathias Heikenwälder, Diego F Calvisi, Christoph Plass, Scott W Lowe, Darjus F Tschaharganeh

Gut. 2022 Aug; 71(8): 1613–1628. Published online 2021 Sep 11. doi: 10.1136/gutjnl-2021-325405

PMCID:: PMC9279849

Abstract Article PDF–7.5M

Select item 919481110.

Kdm6b Haploinsufficiency Causes ASD/ADHD-Like Behavioral Deficits in Mice

Yuen Gao, Mohammad B. Aljazi, Jin He

Front Behav Neurosci. 2022; 16: 905783. Published online 2022 May 31. doi: 10.3389/fnbeh.2022.905783

PMCID:: PMC9194811

Abstract Article PDF–3.1M

Select item 877370211.

Adipocyte Utx Deficiency Promotes High-Fat Diet-Induced Metabolic Dysfunction in Mice

Fenfen Li, Shirong Wang, Xin Cui, Jia Jing, Liqing Yu, Bingzhong Xue, Hang Shi

Cells. 2022 Jan; 11(2): 181. Published online 2022 Jan 6. doi: 10.3390/cells11020181

PMCID:: PMC8773702

Abstract Article PDF–2.7M

Select item 859244012.

Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype

Ling Tian, Monique Chavez, Gue Su Chang, Nichole M. Helton, Casey D. S. Katerndahl, Christopher A. Miller, Lukas D. Wartman

PLoS One. 2021; 16(11): e0255706. Published online 2021 Nov 15. doi: 10.1371/journal.pone.0255706

PMCID:: PMC8592440

Abstract Article PDF–3.9M

Select item 855815613.

X-linked histone H3K27 demethylase Kdm6a regulates sexually dimorphic differentiation of hypothalamic neurons

Lucas E. Cabrera Zapata, Carla D. Cisternas, Camila Sosa, Luis Miguel Garcia-Segura, Maria Angeles Arevalo, María Julia Cambiasso

Cell Mol Life Sci. 2021 Nov; 78(21-22): 7043–7060. Published online 2021 Oct 11. doi: 10.1007/s00018-021-03945-0

PMCID:: PMC8558156

Abstract Article PDF–3.7M

Select item 816708814.

Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity

Jun Chen, Xing Xu, Yan Li, Fan Li, Jianjun Zhang, Qin Xu, Wantao Chen, Yan Wei, Xu Wang

Cell Death Differ. 2021 May; 28(5): 1688–1704. Published online 2020 Dec 10. doi: 10.1038/s41418-020-00694-8

PMCID:: PMC8167088

Abstract Article PDF–6.9M

Select item 811261315.

UTX promotes CD8⁺ T cell-mediated antiviral defenses but reduces T cell durability

Joseph E. Mitchell, Makayla M. Lund, Josh Starmer, Kai Ge, Terry Magnuson, Karl B. Shpargel, Jason K. Whitmire

Cell Rep. Author manuscript; available in PMC 2021 May 11.

Published in final edited form as: Cell Rep. 2021 Apr 13; 35(2): 108966. doi: 10.1016/j.celrep.2021.108966

PMCID:: PMC8112613

Abstract Article PDF–1.4M

Select item 692052816.

Upregulation of H3K27 Demethylase KDM6 During RSV Infection Enhances Pro-Inflammatory Responses and Immunopathology

Carrie-Anne Malinczak, Andrew J. Rasky, Wendy Fonseca, Matthew A. Schaller, Ronald M. Allen, Catherine Ptaschinski, Susan Morris, Nicholas W Lukacs

J Immunol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Immunol. 2020 Jan 1; 204(1): 159–168. Published online 2019 Nov 20. doi: 10.4049/jimmunol.1900741

PMCID:: PMC6920528

Abstract Article PDF–2.4M

Select item 662426917.

High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase

Kazushige Ota, Akiyoshi Komuro, Hisayuki Amano, Akinori Kanai, Kai Ge, Takeshi Ueda, Hitoshi Okada

Sci Rep. 2019; 9: 10036. Published online 2019 Jul 11. doi: 10.1038/s41598-019-46445-9

PMCID:: PMC6624269

Abstract Article PDF–1.5M

Select item 602966118.

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J. Knights, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A. Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Bertie Göttgens, Lars Bullinger, Paul A. Northcott, David Adams, George S. Vassiliou, Brian J.P. Huntly

Nat Genet. Author manuscript; available in PMC 2018 Dec 1.

Published in final edited form as: Nat Genet. 2018 Jun; 50(6): 883–894. Published online 2018 May 7. doi: 10.1038/s41588-018-0114-z

Correction in:: Nat Genet. 2022 Jun 14

PMCID:: PMC6029661

Abstract Article PDF–2.7M

Select item 535884719.

The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner

Kazushige Ota, Kit I. Tong, Kouichiro Goto, Shuta Tomida, Akiyoshi Komuro, Zhong Wang, Kazuto Nishio, Hitoshi Okada

PLoS One. 2017; 12(3): e0173713. Published online 2017 Mar 20. doi: 10.1371/journal.pone.0173713

Correction in:: PLoS One. 2017; 12(4): e0176424.

PMCID:: PMC5358847

Abstract Article PDF–1.9M

Select item 524732120.

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

Semir Beyaz, Ji Hyung Kim, Luca Pinello, Michael E. Xifaras, Yu Hu, Jialiang Huang, Marc A. Kerenyi, Partha P. Das, R. Anthony Barnitz, Aurelie Herault, Rizkullah Dogum, W. Nicholas Haining, Ömer H. Yilmaz, Emmanuelle Passegue, Guo-Cheng Yuan, Stuart H. Orkin, Florian Winau

Nat Immunol. Author manuscript; available in PMC 2017 Jun 19.

Published in final edited form as: Nat Immunol. 2017 Feb; 18(2): 184–195. Published online 2016 Dec 19. doi: 10.1038/ni.3644

PMCID:: PMC5247321

Abstract Article PDF–4.0M

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