PMC Links for Gene (Select 22808) - PMC

Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu

Nature. 2022; 609(7926): 400–407. Published online 2022 Jun 29. doi: 10.1038/s41586-022-04838-3

PMCID:: PMC9452301

Abstract Article PDF–21M

Select item 63773384.

Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males

Shad B. Smith, Marc Parisien, Eric Bair, Inna Belfer, Anne-Julie Chabot-Doré, Pavel Gris, Samar Khoury, Shannon Tansley, Yelizaveta Torosyan, Dmitri V. Zaykin, Olaf Bernhardt, Priscila de Oliveira Serrano, Richard H. Gracely, Deepti Jain, Marjo-Riitta Järvelin, Linda M. Kaste, Kathleen F. Kerr, Thomas Kocher, Raija Lähdesmäki, Nadia Laniado, Cathy C. Laurie, Cecelia A. Laurie, Minna Männikkö, Carolina B. Meloto, Andrea G. Nackley, Sarah C. Nelson, Paula Pesonen, Margarete C. Ribeiro-Dasilva, Celia M. Rizzatti-Barbosa, Anne E. Sanders, Christian Schwahn, Kirsi Sipilä, Tamar Sofer, Alexander Teumer, Jeffrey S. Mogil, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, Gary D. Slade, William Maixner, Luda Diatchenko

Pain. 2019 Mar; 160(3): 579–591. Published online 2018 Nov 13. doi: 10.1097/j.pain.0000000000001438

PMCID:: PMC6377338

Abstract Article PDF–1013K

Select item 53339625.

Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy

Erin M. Higgins, J. Martijn Bos, Heather Mason-Suares, David J. Tester, Jaeger P. Ackerman, Calum A. MacRae, Katia Sol-Church, Karen W. Gripp, Raul Urrutia, Michael J. Ackerman

JCI Insight. 2017 Mar 9; 2(5): e91225. Published online 2017 Mar 9. doi: 10.1172/jci.insight.91225

PMCID:: PMC5333962

Abstract Article PDF–1.6M

Select item 52696926.

Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer

Makiko Yasumoto, Etsuko Sakamoto, Sachiko Ogasawara, Taro Isobe, Junya Kizaki, Akiko Sumi, Hironori Kusano, Jun Akiba, Takuji Torimura, Yoshito Akagi, Hiraku Itadani, Tsutomu Kobayashi, Shinichi Hasako, Masafumi Kumazaki, Shinji Mizuarai, Shinji Oie, Hirohisa Yano

Cancer Med. 2017 Jan; 6(1): 235–244. Published online 2016 Nov 28. doi: 10.1002/cam4.959

PMCID:: PMC5269692

Abstract Article PDF–391K

Select item 103650137.

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Daniel A. Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I. Finci, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G. Stephen, Dhirendra K. Simanshu

Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2022 Oct; 29(10): 966–977. Published online 2022 Sep 29. doi: 10.1038/s41594-022-00841-4

PMCID:: PMC10365013

Abstract Article PDF–6.2M

Select item 96943388.

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex

Jason J. Kwon, Behnoush Hajian, Yuemin Bian, Lucy C. Young, Alvaro J. Amor, James R. Fuller, Cara V. Fraley, Abbey M. Sykes, Jonathan So, Joshua Pan, Laura Baker, Sun Joo Lee, Douglas B. Wheeler, David L. Mayhew, Nicole S. Persky, Xiaoping Yang, David E. Root, Anthony M. Barsotti, Andrew W. Stamford, Charles K. Perry, Alex Burgin, Frank McCormick, Christopher T. Lemke, William C. Hahn, Andrew J. Aguirre

Nature. Author manuscript; available in PMC 2022 Nov 25.

Published in final edited form as: Nature. 2022 Sep; 609(7926): 408–415. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04928-2

PMCID:: PMC9694338

Abstract Article PDF–5.8M

Select item 94522959.

Structure of the MRAS–SHOC2–PP1C phosphatase complex

Zachary J. Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A. Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S. Beyer, Giorgio G. Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J. Eck, Luca Tordella, Claudio R. Thoma, Daniel A. King

Nature. 2022; 609(7926): 416–423. Published online 2022 Jul 13. doi: 10.1038/s41586-022-05086-1

PMCID:: PMC9452295

Abstract Article PDF–21M

Select item 269554310.

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann, Anika Großhennig, Peter S Braund, Inke R König, Christian Hengstenberg, Alistair S Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K Wagner, Klaus Stark, Stephen M Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F Voight, Christopher J O'Donnell, Leena Peltonen, David S Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried Maärz, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G Ball, Anthony J Balmforth, H-Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H Ouwehand, Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert

Nat Genet. Author manuscript; available in PMC 2009 Sep 1.

Published in final edited form as: Nat Genet. 2009 Mar; 41(3): 280–282. Published online 2009 Feb 8. doi: 10.1038/ng.307

PMCID:: PMC2695543

Abstract Article PDF–489K

Select item 13398611.

R-Ras3/M-Ras Induces Neuronal Differentiation of PC12 Cells through Cell-Type-Specific Activation of the Mitogen-Activated Protein Kinase Cascade

Alec C. Kimmelman, Nelson Nuñez Rodriguez, Andrew M.-L. Chan

Mol Cell Biol. 2002 Aug; 22(16): 5946–5961. doi: 10.1128/MCB.22.16.5946-5961.2002

PMCID:: PMC133986

Abstract Article PDF–967K

Select item 421326512.

A novel SHOC2 variant in Rasopathy

Vickie Hannig, Myoungkun Jeoung, Eun Ryoung Jang, John A. Phillips, III, Emilia Galperin

Hum Mutat. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Hum Mutat. 2014 Nov; 35(11): 1290–1294. Published online 2014 Sep 11. doi: 10.1002/humu.22634

PMCID:: PMC4213265

Abstract Article PDF–950K

Select item 418773613.

HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold

Eun Ryoung Jang, Ping Shi, Jamal Bryant, Jing Chen, Vikas Dukhande, Matthew S. Gentry, HyeIn Jang, Myoungkun Jeoung, Emilia Galperin

Mol Cell Biol. 2014 Oct; 34(19): 3579–3593. doi: 10.1128/MCB.00811-14

PMCID:: PMC4187736

Abstract Article PDF–3.3M

Select item 194936114.

The M-Ras-RA-GEF-2-Rap1 Pathway Mediates Tumor Necrosis Factor-α–dependent Regulation of Integrin Activation in Splenocytes

Yoko Yoshikawa, Takaya Satoh, Takashi Tamura, Ping Wei, Shymaa E. Bilasy, Hironori Edamatsu, Atsu Aiba, Koko Katagiri, Tatsuo Kinashi, Kazuki Nakao, Tohru Kataoka

Mol Biol Cell. 2007 Aug; 18(8): 2949–2959. doi: 10.1091/mbc.E07-03-0250

PMCID:: PMC1949361

Abstract Article PDF–1.6M

Select item 720601115.

LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases

Taiki Abe, Ikumi Umeki, Shin-ichiro Kanno, Shin-ichi Inoue, Tetsuya Niihori, Yoko Aoki

Cell Death Differ. 2020 Mar; 27(3): 1023–1035. Published online 2019 Jul 23. doi: 10.1038/s41418-019-0395-5

PMCID:: PMC7206011

Abstract Article PDF–3.4M

Select item 471281916.

Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5

Eun Ryoung Jang, HyeIn Jang, Ping Shi, Gabriel Popa, Myoungkun Jeoung, Emilia Galperin

J Cell Sci. 2015 Dec 1; 128(23): 4428–4441. doi: 10.1242/jcs.177543

PMCID:: PMC4712819

Abstract Article

Select item 698668217.

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Pau Castel, Alice Cheng, Antonio Cuevas-Navarro, David B. Everman, Alex G. Papageorge, Dhirendra K. Simanshu, Alexandra Tankka, Jacqueline Galeas, Anatoly Urisman, Frank McCormick

Science. Author manuscript; available in PMC 2020 Jan 28.

Published in final edited form as: Science. 2019 Mar 15; 363(6432): 1226–1230. doi: 10.1126/science.aav1444

PMCID:: PMC6986682

Abstract Article PDF–1.1M

Select item 296535118.

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

Samuli Ripatti, Emmi Tikkanen, Marju Orho-Melander, Aki S Havulinna, Kaisa Silander, Amitabh Sharma, Candace Guiducci, Markus Perola, Antti Jula, Juha Sinisalo, Marja-Liisa Lokki, Markku S Nieminen, Olle Melander, Veikko Salomaa, Leena Peltonen, Sekar Kathiresan

Lancet. 2010 Oct 23; 376(9750): 1393–1400. doi: 10.1016/S0140-6736(10)61267-6

PMCID:: PMC2965351

Abstract Article

Select item 244265319.

Neither Replication nor Simulation Supports a Role for the Axon Guidance Pathway in the Genetics of Parkinson's Disease

Yonghong Li, Charles Rowland, Georgia Xiromerisiou, Robert J. Lagier, Steven J. Schrodi, Efthimios Dradiotis, David Ross, Nam Bui, Joseph Catanese, Konstantinos Aggelakis, Andrew Grupe, Georgios Hadjigeorgiou

PLoS One. 2008; 3(7): e2707. Published online 2008 Jul 16. doi: 10.1371/journal.pone.0002707

PMCID:: PMC2442653

Abstract Article PDF–245K

Select item 311926120.

Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert, Inke R. König, Sekar Kathiresan, Muredach P. Reilly, Themistocles L. Assimes, Hilma Holm, Michael Preuss, Alexandre F. R. Stewart, Maja Barbalic, Christian Gieger, Devin Absher, Zouhair Aherrahrou, Hooman Allayee, David Altshuler, Sonia S. Anand, Karl Andersen, Jeffrey L. Anderson, Diego Ardissino, Stephen G. Ball, Anthony J. Balmforth, Timothy A. Barnes, Diane M. Becker, Lewis C. Becker, Klaus Berger, Joshua C. Bis, S. Matthijs Boekholdt, Eric Boerwinkle, Peter S. Braund, Morris J. Brown, Mary Susan Burnett, Ian Buysschaert, Cardiogenics, John F. Carlquist, Li Chen, Sven Cichon, Veryan Codd, Robert W. Davies, George Dedoussis, Abbas Dehghan, Serkalem Demissie, Joseph M. Devaney, Ron Do, Angela Doering, Sandra Eifert, Nour Eddine El Mokhtari, Stephen G. Ellis, Roberto Elosua, James C. Engert, Stephen E. Epstein, Ulf de Faire, Marcus Fischer, Aaron R. Folsom, Jennifer Freyer, Bruna Gigante, Domenico Girelli, Solveig Gretarsdottir, Vilmundur Gudnason, Jeffrey R. Gulcher, Eran Halperin, Naomi Hammond, Stanley L. Hazen, Albert Hofman, Benjamin D. Horne, Thomas Illig, Carlos Iribarren, Gregory T. Jones, J.Wouter Jukema, Michael A. Kaiser, Lee M. Kaplan, John J.P. Kastelein, Kay-Tee Khaw, Joshua W. Knowles, Genovefa Kolovou, Augustine Kong, Reijo Laaksonen, Diether Lambrechts, Karin Leander, Guillaume Lettre, Mingyao Li, Wolfgang Lieb, Patrick Linsel-Nitschke, Christina Loley, Andrew J. Lotery, Pier M. Mannucci, Seraya Maouche, Nicola Martinelli, Pascal P. McKeown, Christa Meisinger, Thomas Meitinger, Olle Melander, Pier Angelica Merlini, Vincent Mooser, Thomas Morgan, Thomas W. Mühleisen, Joseph B. Muhlestein, Thomas Münzel, Kiran Musunuru, Janja Nahrstaedt, Christopher P. Nelson, Markus M. Nöthen, Oliviero Olivieri, Riyaz S. Patel, Chris C. Patterson, Annette Peters, Flora Peyvandi, Liming Qu, Arshed A. Quyyumi, Daniel J. Rader, Loukianos S. Rallidis, Catherine Rice, Frits R. Rosendaal, Diana Rubin, Veikko Salomaa, M. Lourdes Sampietro, Manj S. Sandhu, Eric Schadt, Arne Schäfer, Arne Schillert, Stefan Schreiber, Jürgen Schrezenmeir, Stephen M. Schwartz, David S. Siscovick, Mohan Sivananthan, Suthesh Sivapalaratnam, Albert Smith, Tamara B. Smith, Jaapjan D. Snoep, Nicole Soranzo, John A. Spertus, Klaus Stark, Kathy Stirrups, Monika Stoll, W. H. Wilson Tang, Stephanie Tennstedt, Gudmundur Thorgeirsson, Gudmar Thorleifsson, Maciej Tomaszewski, Andre G. Uitterlinden, Andre M. van Rij, Benjamin F. Voight, Nick J. Wareham, George A. Wells, H.-Erich Wichmann, Philipp S. Wild, Christina Willenborg, Jaqueline C. M. Witteman, Benjamin J. Wright, Shu Ye, Tanja Zeller, Andreas Ziegler, Francois Cambien, Alison H. Goodall, L. Adrienne Cupples, Thomas Quertermous, Winfried März, Christian Hengstenberg, Stefan Blankenberg, Willem H. Ouwehand, Alistair S. Hall, Panos Deloukas, John R. Thompson, Kari Stefansson, Robert Roberts, Unnur Thorsteinsdottir, Christopher J. O’Donnell, Ruth McPherson, Jeanette Erdmann, Nilesh J. Samani

Nat Genet. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Nat Genet. 2011 Mar 6; 43(4): 333–338. Published online 2011 Mar 6. doi: 10.1038/ng.784

PMCID:: PMC3119261

Abstract Article PDF–405K

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