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Select item 87052991.

Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation

Stephan Kohrt, Sarah Strobel, Melanie C. Mann, Heinrich Sticht, Bernhard Fleckenstein, Andrea K. Thoma-Kress

Int J Mol Sci. 2021 Dec; 22(24): 13597. Published online 2021 Dec 18. doi: 10.3390/ijms222413597

PMCID:: PMC8705299

Abstract Article PDF–4.6M

Select item 59170262.

The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression

Mina Ali, Ram Ajore, Anna-Karin Wihlborg, Abhishek Niroula, Bhairavi Swaminathan, Ellinor Johnsson, Owen W Stephens, Gareth Morgan, Tobias Meissner, Ingemar Turesson, Hartmut Goldschmidt, Ulf-Henrik Mellqvist, Urban Gullberg, Markus Hansson, Kari Hemminki, Hareth Nahi, Anders Waage, Niels Weinhold, Björn Nilsson

Nat Commun. 2018; 9: 1649. Published online 2018 Apr 25. doi: 10.1038/s41467-018-04082-2

PMCID:: PMC5917026

Abstract Article PDF–1.4M

Select item 57613403.

ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells

Yachen Zang, Laura E. Pascal, Yibin Zhou, Xiaonan Qiu, Leizhen Wei, Junkui Ai, Joel B. Nelson, Mingming Zhong, Boxin Xue, Shaoxiong Wang, Dongrong Yang, Li Lan, Yuxi Shan, Zhou Wang

Cancer Lett. Author manuscript; available in PMC 2019 Feb 28.

Published in final edited form as: Cancer Lett. 2018 Feb 28; 415: 198–207. Published online 2017 Nov 26. doi: 10.1016/j.canlet.2017.11.028

PMCID:: PMC5761340

Abstract Article PDF–2.4M

Select item 56089694.

Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism

Ni Li, David C. Johnson, Niels Weinhold, Scott Kimber, Sara E. Dobbins, Jonathan S. Mitchell, Ben Kinnersley, Amit Sud, Philip J. Law, Giulia Orlando, Matthew Scales, Christopher P. Wardell, Asta Försti, Phuc H. Hoang, Molly Went, Amy Holroyd, Fadi Hariri, Tomi Pastinen, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan, Martin Kaiser, Richard S. Houlston

Cell Rep. 2017 Sep 12; 20(11): 2556–2564. Published online 2017 Sep 12. doi: 10.1016/j.celrep.2017.08.062

PMCID:: PMC5608969

Abstract Article

Select item 204935.

ELL2, a new member of an ELL family of RNA polymerase II elongation factors

Ali Shilatifard, D. Roxanne Duan, Dewan Haque, Charles Florence, William H. Schubach, Joan Weliky Conaway, Ronald C. Conaway

Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8): 3639–3643. doi: 10.1073/pnas.94.8.3639

PMCID:: PMC20493

Abstract Article PDF–502K

Select item 65375866.

Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells

Tiejun Yang, Yifeng Jing, Jun Dong, Xinpei Yu, Mingming Zhong, Laura E. Pascal, Dan Wang, Zhongxian Zhang, Baoping Qiao, Zhou Wang

Prostate. Author manuscript; available in PMC 2019 May 28.

Published in final edited form as: Prostate. 2018 Nov; 78(15): 1201–1212. Published online 2018 Jul 15. doi: 10.1002/pros.23695

Correction in:: Prostate. 2020 Feb; 80(2): 238.

PMCID:: PMC6537586

Abstract Article PDF–1.5M

Select item 56790847.

Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia

Laura E. Pascal, Khalid Z. Masoodi, June Liu, Xiaonan Qiu, Qiong Song, Yujuan Wang, Yachen Zang, Tiejun Yang, Yao Wang, Lora H. Rigatti, Uma Chandran, Leandro M. Colli, Ricardo Z.N. Vencio, Yi Lu, Jian Zhang, Zhou Wang

J Endocrinol. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: J Endocrinol. 2017 Nov; 235(2): 123–136. doi: 10.1530/JOE-17-0112

PMCID:: PMC5679084

Abstract Article PDF–1.1M

Select item 56534408.

Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival

Lou-Ella M.M Alexander, January Watters, Jessica A. Reusch, Michelle Maurin, Brook S. Nepon-Sixt, Katerina Vrzalikova, Mark G. Alexandrow, Paul G. Murray, Kenneth L. Wright

Mol Immunol. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Mol Immunol. 2017 Nov; 91: 8–16. Published online 2017 Aug 31. doi: 10.1016/j.molimm.2017.08.016

PMCID:: PMC5653440

Abstract Article PDF–711K

Select item 52902739.

Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

Shiqian Qi, Zichong Li, Ursula Schulze-Gahmen, Goran Stjepanovic, Qiang Zhou, James H. Hurley

Nat Commun. 2017; 8: 14076. Published online 2017 Jan 30. doi: 10.1038/ncomms14076

PMCID:: PMC5290273

Abstract Article PDF–1.5M

Select item 445511010.

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma

Bhairavi Swaminathan, Guðmar Thorleifsson, Magnus Jöud, Mina Ali, Ellinor Johnsson, Ram Ajore, Patrick Sulem, Britt-Marie Halvarsson, Guðmundur Eyjolfsson, Vilhelmina Haraldsdottir, Christina Hultman, Erik Ingelsson, Sigurður Y. Kristinsson, Anna K. Kähler, Stig Lenhoff, Gisli Masson, Ulf-Henrik Mellqvist, Robert Månsson, Sven Nelander, Isleifur Olafsson, Olof Sigurðardottir, Hlif Steingrimsdóttir, Annette Vangsted, Ulla Vogel, Anders Waage, Hareth Nahi, Daniel F. Gudbjartsson, Thorunn Rafnar, Ingemar Turesson, Urban Gullberg, Kári Stefánsson, Markus Hansson, Unnur Thorsteinsdóttir, Björn Nilsson

Nat Commun. 2015; 6: 7213. Published online 2015 May 26. doi: 10.1038/ncomms8213

PMCID:: PMC4455110

Abstract Article PDF–1.0M

Select item 420198211.

Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response

Kyung Soo Park, Ian Bayles, Alec Szlachta-McGinn, Joshua Paul, Julie Boiko, Patricia Santos, June Liu, Zhou Wang, Lisa Borghesi, Christine Milcarek

J Immunol. 2014 Nov 1; 193(9): 4663–4674. Published online 2014 Sep 19. doi: 10.4049/jimmunol.1401608

PMCID:: PMC4201982

Abstract Article PDF–1.0M

Select item 303205712.

The molecular biology of HIV latency: Breaking and restoring the Tat-dependent transcriptional circuit

Jonathan Karn

Curr Opin HIV AIDS. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Curr Opin HIV AIDS. 2011 Jan; 6(1): 4–11. doi: 10.1097/COH.0b013e328340ffbb

PMCID:: PMC3032057

Abstract Article PDF–277K

Select item 277155613.

Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

Kathleen Martincic, Serkan A. Alkan, Alys Cheatle, Lisa Borghesi, Christine Milcarek

Nat Immunol. Author manuscript; available in PMC 2010 Apr 1.

Published in final edited form as: Nat Immunol. 2009 Oct; 10(10): 1102–1109. Published online 2009 Sep 13. doi: 10.1038/ni.1786

PMCID:: PMC2771556

Abstract Article PDF–4.3M

Select item 504539314.

Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells

Xinpei Yu, Junkui Ai, Liquan Cai, Yifeng Jing, Dan Wang, Jun Dong, Laura E. Pascal, Jian Zhang, Rongcheng Luo, Zhou Wang

Oncotarget. 2016 May 17; 7(20): 29245–29254. Published online 2016 Apr 5. doi: 10.18632/oncotarget.8588

Correction in:: Oncotarget. 2019 Dec 24; 10(67): 7181–7182.

PMCID:: PMC5045393

Abstract Article PDF–5.3M

Select item 480079115.

A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency

Zichong Li, Huasong Lu, Qiang Zhou

Mol Cell Biol. 2016 Apr 1; 36(7): 1194–1205. Prepublished online 2016 Feb 1. Published online 2016 Mar 18. doi: 10.1128/MCB.00994-15

PMCID:: PMC4800791

Abstract Article PDF–2.2M

Select item 736718416.

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

Jun Wu, Yuhua Xue, Xiang Gao, Qiang Zhou

Nucleic Acids Res. 2020 Jul 27; 48(13): 7321–7332. Published online 2020 Jun 1. doi: 10.1093/nar/gkaa461

PMCID:: PMC7367184

Abstract Article PDF–3.8M

Select item 336096417.

The ubiquitin ligase Siah1 controls ELL2 stability and formation of Super Elongation Complexes (SECs) to modulate gene transcription

Min Liu, Joanne Hsu, Caleb Chan, Zichong Li, Qiang Zhou

Mol Cell. Author manuscript; available in PMC 2013 May 11.

Published in final edited form as: Mol Cell. 2012 May 11; 46(3): 325–334. Published online 2012 Apr 5. doi: 10.1016/j.molcel.2012.03.007

PMCID:: PMC3360964

Abstract Article PDF–4.1M

Select item 316913518.

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

Nanhai He, Caleb K. Chan, Bijan Sobhian, Seemay Chou, Yuhua Xue, Min Liu, Tom Alber, Monsef Benkirane, Qiang Zhou

Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36): E636-E645. Published online 2011 Aug 22. doi: 10.1073/pnas.1107107108

PMCID:: PMC3169135

Abstract Article PDF–1.1M

Select item 401058319.

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

Uri Mbonye, Jonathan Karn

Virology. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Virology. 2014 Apr; 0: 328–339. Published online 2014 Feb 22. doi: 10.1016/j.virol.2014.02.008

PMCID:: PMC4010583

Abstract Article PDF–818K

Select item 389089020.

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

Huasong Lu, Zichong Li, Yuhua Xue, Ursula Schulze-Gahmen, Jeffrey R. Johnson, Nevan J. Krogan, Tom Alber, Qiang Zhou

Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1): E15–E24. Published online 2013 Dec 23. doi: 10.1073/pnas.1318503111

PMCID:: PMC3890890

Abstract Article PDF–1.3M

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