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Select item 89193391.

ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration

Kristiane Søreng, Serhiy Pankiv, Camilla Bergsmark, Ellen M. Haugsten, Anette K. Dahl, Laura R. de la Ballina, Ai Yamamoto, Alf H. Lystad, Anne Simonsen

J Cell Sci. 2022 Feb 15; 135(4): jcs259138. Published online 2022 Feb 18. doi: 10.1242/jcs.259138

PMCID:: PMC8919339

Abstract Article

Select item 79024752.

A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance

Erin F. Reinhart, Nicole A. Litt, Sarah Katzenell, Maria Pellegrini, Ai Yamamoto, Michael J. Ragusa

Traffic. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Traffic. 2021 Jan; 22(1-2): 23–37. Published online 2020 Dec 1. doi: 10.1111/tra.12771

PMCID:: PMC7902475

Abstract Article PDF–1.5M

Select item 67360923.

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size

Diana Le Duc, Cecilia Giulivi, Susan M Hiatt, Eleonora Napoli, Alexios Panoutsopoulos, Angelo Harlan De Crescenzo, Urania Kotzaeridou, Steffen Syrbe, Evdokia Anagnostou, Meron Azage, Renee Bend, Amber Begtrup, Natasha J Brown, Benjamin Büttner, Megan T Cho, Gregory M Cooper, Jan H Doering, Christèle Dubourg, David B Everman, Michael S Hildebrand, Francis Jeshira Reynoso Santos, Barbara Kellam, Jennifer Keller-Ramey, Johannes R Lemke, Shuxi Liu, Dmitriy Niyazov, Katelyn Payne, Richard Person, Chloé Quélin, Rhonda E Schnur, Brooke T Smith, Jonathan Strober, Susan Walker, Mathew Wallis, Laurence Walsh, Sandra Yang, Ryan K C Yuen, Andreas Ziegler, Heinrich Sticht, Michael C Pride, Lori Orosco, Verónica Martínez-Cerdeño, Jill L Silverman, Jacqueline N Crawley, Stephen W Scherer, Konstantinos S Zarbalis, Rami Jamra

Brain. 2019 Sep; 142(9): 2617–2630. Published online 2019 Jul 20. doi: 10.1093/brain/awz198

Correction in:: Brain. 2019 Nov; 142(11): e63.

PMCID:: PMC6736092

Abstract Article PDF–1.2M

Select item 56368804.

The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells

Anna M. Schläfli, Pauline Isakson, E. Garattini, Anne Simonsen, Mario P. Tschan

Sci Rep. 2017; 7: 12980. Published online 2017 Oct 11. doi: 10.1038/s41598-017-12734-4

PMCID:: PMC5636880

Abstract Article PDF–1.7M

Select item 30604155.

Alfy-dependent elimination of aggregated proteins by macroautophagy: Can there be too much of a good thing?

Ai Yamamoto, Anne Simonsen

Autophagy. 2011 Mar; 7(3): 346–350. Published online 2011 Mar 1. doi: 10.4161/auto.7.3.14234

PMCID:: PMC3060415

Abstract Article PDF–1.3M

Select item 29748996.

A Master Conductor for Aggregate Clearance by Autophagy

Vojo Deretic

Dev Cell. Author manuscript; available in PMC 2010 Nov 6.

Published in final edited form as: Dev Cell. 2010 May 18; 18(5): 694–696. doi: 10.1016/j.devcel.2010.04.009

PMCID:: PMC2974899

Abstract Article PDF–139K

Select item 70601237.

Huntington’s disease pathogenesis is modified in vivo by Alfy/Wdfy3 and selective macroautophagy

Leora M. Fox, Kiryung Kim, Christopher W. Johnson, Shawei Chen, Katherine R. Croce, Matheus B. Victor, Evelien Eenjes, Joan R. Bosco, Lisa K. Randolph, Ioannis Dragatsis, Joanna M. Dragich, Andrew S. Yoo, Ai Yamamoto

Neuron. Author manuscript; available in PMC 2021 Mar 4.

Published in final edited form as: Neuron. 2020 Mar 4; 105(5): 813–821.e6. Published online 2019 Dec 30. doi: 10.1016/j.neuron.2019.12.003

PMCID:: PMC7060123

Abstract Article PDF–1.7M

Select item 48051778.

ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size

Rotem Kadir, Tamar Harel, Barak Markus, Yonatan Perez, Anna Bakhrat, Idan Cohen, Michael Volodarsky, Miora Feintsein-Linial, Elana Chervinski, Joel Zlotogora, Sara Sivan, Ramon Y. Birnbaum, Uri Abdu, Stavit Shalev, Ohad S. Birk

PLoS Genet. 2016 Mar; 12(3): e1005919. Published online 2016 Mar 23. doi: 10.1371/journal.pgen.1005919

PMCID:: PMC4805177

Abstract Article PDF–9.3M

Select item 62936339.

Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model

Hui Guo, Tianyun Wang, Huidan Wu, Min Long, Bradley P. Coe, Honghui Li, Guanglei Xun, Jianjun Ou, Biyuan Chen, Guiqin Duan, Ting Bai, Ningxia Zhao, Yidong Shen, Yun Li, Yazhe Wang, Yu Zhang, Carl Baker, Yanling Liu, Nan Pang, Lian Huang, Lin Han, Xiangbin Jia, Cenying Liu, Hailun Ni, Xinyi Yang, Lu Xia, Jingjing Chen, Lu Shen, Ying Li, Rongjuan Zhao, Wenjing Zhao, Jing Peng, Qian Pan, Zhigao Long, Wei Su, Jieqiong Tan, Xiaogang Du, Xiaoyan Ke, Meiling Yao, Zhengmao Hu, Xiaobing Zou, Jingping Zhao, Raphael A. Bernier, Evan E. Eichler, Kun Xia

Mol Autism. 2018; 9: 64. Published online 2018 Dec 13. doi: 10.1186/s13229-018-0247-z

PMCID:: PMC6293633

Abstract Article PDF–1.1M

Select item 978999910.

A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis

Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M. Moore, Jian Cui, Chenyi Xue, Katherine R. Croce, Arif Yurdagul, Jr, John G. Doench, Wei Li, Konstantinos S. Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang

Nat Commun. 2022; 13: 7929. Published online 2022 Dec 24. doi: 10.1038/s41467-022-35604-8

PMCID:: PMC9789999

Abstract Article PDF–3.7M

Select item 500373711.

Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis

Dennis J. Wu, Ran Gu, Ritu Sarin, Regina Zavodovskaya, Chia-Pei Chen, Blaine A. Christiansen, Iannis E. Adamopoulos

J Autoimmun. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: J Autoimmun. 2016 Sep; 73: 73–84. Published online 2016 Jun 18. doi: 10.1016/j.jaut.2016.06.004

Correction in:: J Autoimmun. 2017 Jul 27

PMCID:: PMC5003737

Abstract Article PDF–3.2M

Select item 421008312.

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

Alf Håkon Lystad, Yoshinobu Ichimura, Kenji Takagi, Yinjie Yang, Serhiy Pankiv, Yumi Kanegae, Shun Kageyama, Mariko Suzuki, Izumu Saito, Tsunehiro Mizushima, Masaaki Komatsu, Anne Simonsen

EMBO Rep. 2014 May; 15(5): 557–565. Published online 2014 Mar 25. doi: 10.1002/embr.201338003

PMCID:: PMC4210083

Abstract Article PDF–1.3M

Select item 368995813.

Lacritin Rescues Stressed Epithelia via Rapid Forkhead Box O3 (FOXO3)-associated Autophagy That Restores Metabolism

Ningning Wang, Keith Zimmerman, Ronald W. Raab, Robert L. McKown, Cindy M. L. Hutnik, Venu Talla, Milton F. Tyler, IV, Jae K. Lee, Gordon W. Laurie

J Biol Chem. 2013 Jun 21; 288(25): 18146–18161. Published online 2013 May 2. doi: 10.1074/jbc.M112.436584

PMCID:: PMC3689958

Abstract Article PDF–4.0M

Select item 510516114.

De novo genic mutations among a Chinese autism spectrum disorder cohort

Tianyun Wang, Hui Guo, Bo Xiong, Holly A.F. Stessman, Huidan Wu, Bradley P. Coe, Tychele N. Turner, Yanling Liu, Wenjing Zhao, Kendra Hoekzema, Laura Vives, Lu Xia, Meina Tang, Jianjun Ou, Biyuan Chen, Yidong Shen, Guanglei Xun, Min Long, Janice Lin, Zev N. Kronenberg, Yu Peng, Ting Bai, Honghui Li, Xiaoyan Ke, Zhengmao Hu, Jingping Zhao, Xiaobing Zou, Kun Xia, Evan E. Eichler

Nat Commun. 2016; 7: 13316. Published online 2016 Nov 8. doi: 10.1038/ncomms13316

PMCID:: PMC5105161

Abstract Article PDF–584K

Select item 503008215.

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

Joanna M Dragich, Takaaki Kuwajima, Megumi Hirose-Ikeda, Michael S Yoon, Evelien Eenjes, Joan R Bosco, Leora M Fox, Alf H Lystad, Tinmarla F Oo, Olga Yarygina, Tomohiro Mita, Satoshi Waguri, Yoshinobu Ichimura, Masaaki Komatsu, Anne Simonsen, Robert E Burke, Carol A Mason, Ai Yamamoto

eLife. 2016; 5: e14810. Published online 2016 Sep 20. doi: 10.7554/eLife.14810

PMCID:: PMC5030082

Abstract Article PDF–8.1M

Select item 286724516.

The selective macroautophagic degradation of aggregated proteins requires the phosphatidylinositol 3-phosphate binding protein Alfy

Maria Filimonenko, Pauline Isakson, Kim D. Finley, Monique Anderson, Thomas J. Melia, Hyun Jeong, Bryan J. Bartlett, Katherine M. Myers, Hanne C.G. Birkeland, Trond Lamark, Dimitri Krainc, Andreas Brech, Harald Stenmark, Anne Simonsen, Ai Yamamoto

Mol Cell. Author manuscript; available in PMC 2011 Apr 23.

Published in final edited form as: Mol Cell. 2010 Apr 23; 38(2): 265–279. doi: 10.1016/j.molcel.2010.04.007

PMCID:: PMC2867245

Abstract Article PDF–3.7M

Select item 190426717.

Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human

German Gaston Leparc, Robi David Mitra

Nucleic Acids Res. 2007 May; 35(10): 3192–3202. Published online 2007 Apr 22. doi: 10.1093/nar/gkm187

PMCID:: PMC1904267

Abstract Article PDF–1.1M

Select item 335172918.

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

Nicolas Simonis, Jean-François Rual, Irma Lemmens, Mathieu Boxus, Tomoko Hirozane-Kishikawa, Jean-Stéphane Gatot, Amélie Dricot, Tong Hao, Didier Vertommen, Sébastien Legros, Sarah Daakour, Niels Klitgord, Maud Martin, Jean-François Willaert, Franck Dequiedt, Vincent Navratil, Michael E Cusick, Arsène Burny, Carine Van Lint, David E Hill, Jan Tavernier, Richard Kettmann, Marc Vidal, Jean-Claude Twizere

Retrovirology. 2012; 9: 26. Published online 2012 Mar 29. doi: 10.1186/1742-4690-9-26

PMCID:: PMC3351729

Abstract Article PDF–1.3M

Select item 727904919.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

Select item 849099720.

BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters

Ashari R Kannangara, Daniel M Poole, Colten M McEwan, Joshua C Youngs, Vajira K Weerasekara, Alex M Thornock, Misael T Lazaro, Eranga R Balasooriya, Laura M Oh, Erik J Soderblom, Jonathan J Lee, Daniel L Simmons, Joshua L Andersen

EMBO Rep. 2021 Oct 5; 22(10): e51136. Published online 2021 Aug 9. doi: 10.15252/embr.202051136

PMCID:: PMC8490997

Abstract Article PDF–4.5M

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