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Select item 105454101.

Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease–related HCC

Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka

Hepatol Commun. 2023 Oct; 7(10): e0277. Published online 2023 Oct 2. doi: 10.1097/HC9.0000000000000277

PMCID:: PMC10545410

Abstract Article PDF–1.5M

Select item 104860682.

Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3

Chie Kobori, Ryo Takagi, Ryo Yokomizo, Sakie Yoshihara, Mai Mori, Hiroto Takahashi, Palaksha Kanive Javaregowda, Tomohiko Akiyama, Minoru S. H. Ko, Kazuo Kishi, Akihiro Umezawa

Stem Cell Res Ther. 2023; 14: 242. Published online 2023 Sep 8. doi: 10.1186/s13287-023-03479-1

PMCID:: PMC10486068

Abstract Article PDF–6.6M

Select item 95347023.

Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients

Shuaihantian Luo, Yuming Xie, Junke Huang, Juan Liu, Qing Zhang

J Immunol Res. 2022; 2022: 3690892. Published online 2022 Sep 28. doi: 10.1155/2022/3690892

PMCID:: PMC9534702

Abstract Article PDF–1023K

Select item 94165624.

JMJD3 Promotes Porphyromonas gingivalis Lipopolysaccharide-Induced Th17-Cell Differentiation by Modulating the STAT3-RORc Signaling Pathway

Doudou Huang, Chi Zhang, Panpan Wang, Xiting Li, Li Gao, Chuanjiang Zhao

DNA Cell Biol. August 2022; 41(8): 778–787. Published online 2022 Aug 4. doi: 10.1089/dna.2022.0149

PMCID:: PMC9416562

Abstract Article PDF–582K

Select item 82549725.

JMJD3: a critical epigenetic regulator in stem cell fate

Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian, Maryam Farzaneh

Cell Commun Signal. 2021; 19: 72. Published online 2021 Jul 3. doi: 10.1186/s12964-021-00753-8

PMCID:: PMC8254972

Abstract Article PDF–1.4M

Select item 79858286.

NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas

Nathan A Dahl, Andrew M Donson, Bridget Sanford, Dong Wang, Faye M Walker, Ahmed Gilani, Nicholas K Foreman, Christopher L Tinkle, Suzanne J Baker, Lindsey M Hoffman, Sujatha Venkataraman, Rajeev Vibhakar

J Neuropathol Exp Neurol. 2021 Apr; 80(4): 345–353. Published online 2021 Mar 22. doi: 10.1093/jnen/nlab016

PMCID:: PMC7985828

Abstract Article PDF–851K

Select item 78358907.

The Functions of the Demethylase JMJD3 in Cancer

Anna Sanchez, Fatma Zohra Houfaf Khoufaf, Mouhamed Idrissou, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon

Int J Mol Sci. 2021 Jan; 22(2): 968. Published online 2021 Jan 19. doi: 10.3390/ijms22020968

PMCID:: PMC7835890

Abstract Article PDF–374K

Select item 58181738.

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

Adam Cribbs, Edward S. Hookway, Graham Wells, Morten Lindow, Susanna Obad, Henrik Oerum, Rab K. Prinjha, Nick Athanasou, Aneka Sowman, Martin Philpott, Henry Penn, Kalle Soderstrom, Marc Feldmann, Udo Oppermann

J Biol Chem. 2018 Feb 16; 293(7): 2422–2437. Published online 2018 Jan 4. doi: 10.1074/jbc.RA117.000698

PMCID:: PMC5818173

Abstract Article PDF–4.4M

Select item 56814489.

KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

Hiroto Ohguchi, Takeshi Harada, Morihiko Sagawa, Shohei Kikuchi, Yu-Tzu Tai, Paul G. Richardson, Teru Hideshima, Kenneth C. Anderson

Leukemia. Author manuscript; available in PMC 2017 Nov 13.

Published in final edited form as: Leukemia. 2017 Dec; 31(12): 2661–2669. Published online 2017 May 10. doi: 10.1038/leu.2017.141

PMCID:: PMC5681448

Abstract Article PDF–1.9M

Select item 508764010.

Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells

Tomohiko Akiyama, Shunichi Wakabayashi, Atsumi Soma, Saeko Sato, Yuhki Nakatake, Mayumi Oda, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru B. H. Ko, Minoru S. H. Ko

Development. 2016 Oct 15; 143(20): 3674–3685. doi: 10.1242/dev.139360

PMCID:: PMC5087640

Abstract Article

Select item 504540311.

JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms

Yan Zhang, Long Shen, Dwayne G. Stupack, Nan Bai, Jing Xun, Guosheng Ren, Jihong Han, Luyuan Li, Yunping Luo, Rong Xiang, Xiaoyue Tan

Oncotarget. 2016 May 17; 7(20): 29387–29399. Published online 2016 Apr 19. doi: 10.18632/oncotarget.8836

PMCID:: PMC5045403

Abstract Article PDF–11M

Select item 484454412.

The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell-attracting Cytokines

Patrick M. Perrigue, Michael E. Silva, Charles D. Warden, Nathan L. Feng, Michael A. Reid, Daniel J. Mota, Lauren P. Joseph, Yangzi Isabel Tian, Carlotta A. Glackin, Margarita Gutova, Joseph Najbauer, Karen S. Aboody, Michael E. Barish

Mol Cancer Res. Author manuscript; available in PMC 2016 Apr 25.

Published in final edited form as: Mol Cancer Res. 2015 Apr; 13(4): 636–650. Published online 2015 Feb 4. doi: 10.1158/1541-7786.MCR-13-0268

PMCID:: PMC4844544

Abstract Article PDF–2.5M

Select item 456378813.

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

L Zhao, Y Zhang, Y Gao, P Geng, Y Lu, X Liu, R Yao, P Hou, D Liu, J Lu, B Huang

Cell Death Differ. 2015 Oct; 22(10): 1630–1640. Published online 2015 Feb 20. doi: 10.1038/cdd.2015.6

PMCID:: PMC4563788

Abstract Article PDF–2.9M

Select item 452584314.

KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG

Qiang Li, Liejun Hou, Guofu Ding, Yinglong Li, Jiangping Wang, Biao Qian, Jianguo Sun, Qinzhang Wang

Int J Clin Exp Pathol. 2015; 8(6): 6334–6344. Published online 2015 Jun 1.

PMCID:: PMC4525843

Abstract Article PDF–1.0M

Select item 447631015.

Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells

Yue Wei, Rui Chen, Sophie Dimicoli, Carlos Bueso-Ramos, Donna Neuberg, Sherry Pierce, Hui Wang, Hui Yang, Yu Jia, Hong Zheng, Zhihong Fang, Martin Nguyen, Irene Ganan-Gomez, Benjamin Ebert, Ross Levine, Hagop Kantarjian, Guillermo Garcia-Manero

Leukemia. Author manuscript; available in PMC 2015 Jun 22.

Published in final edited form as: Leukemia. 2013 Nov; 27(11): 2177–2186. Published online 2013 Mar 29. doi: 10.1038/leu.2013.91

PMCID:: PMC4476310

Abstract Article PDF–616K

Select item 414889416.

DNA Methylation-mediated Repression of miR-941 Enhances Lysine (K)-specific Demethylase 6B Expression in Hepatoma Cells

Pei-Pei Zhang, Xiang-ling Wang, Wei Zhao, Bing Qi, Qian Yang, Hai-Ying Wan, Ze-yu Shuang, Min Liu, Xin Li, Shengping Li, Hua Tang

J Biol Chem. 2014 Aug 29; 289(35): 24724–24735. Published online 2014 Jul 21. doi: 10.1074/jbc.M114.567818

PMCID:: PMC4148894

Abstract Article PDF–4.4M

Select item 406518117.

The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated

Yasunao F Kamikawa, Mary E Donohoe

Epigenetics. 2014 Jun 1; 9(6): 834–841. Published online 2014 Mar 19. doi: 10.4161/epi.28524

PMCID:: PMC4065181

Abstract Article PDF–1.8M

Select item 401047118.

The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner

Kristine Williams, Jesper Christensen, Juri Rappsilber, Anders Lærke Nielsen, Jens Vilstrup Johansen, Kristian Helin

PLoS One. 2014; 9(5): e96545. Published online 2014 May 5. doi: 10.1371/journal.pone.0096545

PMCID:: PMC4010471

Abstract Article PDF–1.4M

Select item 396731919.

KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells

Juan Xu, Bo Yu, Christine Hong, Cun-Yu Wang

Int J Oral Sci. 2013 Dec; 5(4): 200–205. Published online 2013 Oct 25. doi: 10.1038/ijos.2013.77

PMCID:: PMC3967319

Abstract Article PDF–1019K

Select item 351752420.

Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization

Chibawanye I. Ene, Lincoln Edwards, Gregory Riddick, Mehmet Baysan, Kevin Woolard, Svetlana Kotliarova, Chen Lai, Galina Belova, Maggie Cam, Jennifer Walling, Ming Zhou, Holly Stevenson, Hong Sug Kim, Keith Killian, Timothy Veenstra, Rolanda Bailey, Hua Song, Wei Zhang, Howard A. Fine

PLoS One. 2012; 7(12): e51407. Published online 2012 Dec 7. doi: 10.1371/journal.pone.0051407

PMCID:: PMC3517524

Abstract Article PDF–896K

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