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Select item 86283611.

Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes

Ajay C Donepudi, Yoojin Lee, Ji-Young Lee, John D. Schuetz, José E Manautou

FASEB J. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: FASEB J. 2021 Feb; 35(2): e21304. doi: 10.1096/fj.202001299RR

PMCID:: PMC8628361

Abstract Article PDF–1.7M

Select item 46266632.

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice

Benoit Decouture, Elise Dreano, Tiphaine Belleville-Rolland, Orjeta Kuci, Blandine Dizier, Amine Bazaa, Bérard Coqueran, Anne-Marie Lompre, Cécile V. Denis, Jean-Sébastien Hulot, Christilla Bachelot-Loza, Pascale Gaussem

Blood. 2015 Oct 8; 126(15): 1823–1830. Prepublished online 2015 Aug 27. doi: 10.1182/blood-2015-02-631044

PMCID:: PMC4626663

Abstract Article

Select item 44378523.

PKA and Actin Play Critical Roles as Downstream Effectors in MRP4-Mediated Regulation of Fibroblast Migration

Chandrima Sinha, Aixia Ren, Kavisha Arora, Chang Suk Moon, Sunitha Yarlagadda, Koryse Woodrooffe, Songbai Lin, John D. Schuetz, Assem G. Ziady, Anjaparavanda P. Naren

Cell Signal. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Cell Signal. 2015 Jul; 27(7): 1345–1355. Published online 2015 Apr 2. doi: 10.1016/j.cellsig.2015.03.022

PMCID:: PMC4437852

Abstract Article PDF–2.9M

Select item 36325564.

The Absence of Mrp4 Has No Effect on the Recruitment of Neutrophils and Eosinophils into the Lung after LPS, Cigarette Smoke or Allergen Challenge

Jürgen Schymeinsky, Hannah Mayer, Christopher Tomsic, Cornelia Tilp, John D. Schuetz, Yunhai Cui, Lutz Wollin, Florian Gantner, Klaus J. Erb

PLoS One. 2013; 8(4): e61193. Published online 2013 Apr 22. doi: 10.1371/journal.pone.0061193

PMCID:: PMC3632556

Abstract Article PDF–902K

Select item 35676335.

Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides

Chandrima Sinha, Aixia Ren, Kavisha Arora, Chang-Suk Moon, Sunitha Yarlagadda, Weiqiang Zhang, Satish B. Cheepala, John D. Schuetz, Anjaparavanda P. Naren

J Biol Chem. 2013 Feb 8; 288(6): 3786–3794. Published online 2012 Dec 22. doi: 10.1074/jbc.M112.435925

PMCID:: PMC3567633

Abstract Article PDF–2.2M

Select item 35172706.

Forskolin Modifies Retinal Vascular Development in Mrp4-Knockout Mice

Wataru Matsumiya, Sentaro Kusuhara, Keiko Hayashibe, Kazuichi Maruyama, Hiroyuki Kusuhara, Mizuki Tagami, John D. Schuetz, Akira Negi

Invest Ophthalmol Vis Sci. 2012 Dec; 53(13): 8029–8035. Published online 2012 Dec 7. doi: 10.1167/iovs.12-10781

PMCID:: PMC3517270

Abstract Article PDF–884K

Select item 33402717.

Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice

Jessica A. Morgan, Satish B. Cheepala, Yao Wang, Geoff Neale, Masashi Adachi, Deepa Nachagari, Mark Leggas, Wenchen Zhao, Kelli Boyd, Raman Venkataramanan, John D. Schuetz

J Biol Chem. 2012 Apr 27; 287(18): 14456–14466. Published online 2012 Feb 28. doi: 10.1074/jbc.M111.319681

PMCID:: PMC3340271

Abstract Article PDF–2.5M

Select item 32894998.

Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes

Yassine Sassi, Aniella Abi-Gerges, Jeremy Fauconnier, Nathalie Mougenot, Steven Reiken, Kobra Haghighi, Evangelia G. Kranias, Andrew R. Marks, Alain Lacampagne, Stefan Engelhardt, Stephane N. Hatem, Anne-Marie Lompre, Jean-Sébastien Hulot

FASEB J. 2012 Mar; 26(3): 1009–1017. doi: 10.1096/fj.11-194027

PMCID:: PMC3289499

Abstract Article

Select item 32305999.

Characterization of Abcc4 Gene Amplification in Stepwise-Selected Mouse J774 Macrophages Resistant to the Topoisomerase II Inhibitor Ciprofloxacin

Béatrice Marquez, Geneviève Ameye, Coralie M. Vallet, Paul M. Tulkens, Hélène A. Poirel, Françoise Van Bambeke

PLoS One. 2011; 6(12): e28368. Published online 2011 Dec 5. doi: 10.1371/journal.pone.0028368

PMCID:: PMC3230599

Abstract Article PDF–700K

Select item 322383010.

Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice

Yannis Hara, Yassine Sassi, Christelle Guibert, Natacha Gambaryan, Peter Dorfmüller, Saadia Eddahibi, Anne-Marie Lompré, Marc Humbert, Jean-Sébastien Hulot

J Clin Invest. 2011 Jul 1; 121(7): 2888–2897. Published online 2011 Jun 13. doi: 10.1172/JCI45023

PMCID:: PMC3223830

Abstract Article PDF–2.7M

Select item 278033511.

Disruption of cAMP and Prostaglandin E₂ Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response

Z. Ping Lin, Yong-Lian Zhu, Dennis R. Johnson, Kevin P. Rice, Timothy Nottoli, Bryan C. Hains, James McGrath, Stephen G. Waxman, Alan C. Sartorelli

Mol Pharmacol. Author manuscript; available in PMC 2009 Nov 20.

Published in final edited form as: Mol Pharmacol. 2008 Jan; 73(1): 243–251. Published online 2007 Oct 24. doi: 10.1124/mol.107.039594

PMCID:: PMC2780335

Abstract Article PDF–934K

Select item 273429812.

Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes

Lauren M. Aleksunes, Sarah N. Campion, Michael J. Goedken, José E. Manautou

Toxicol Sci. 2008 Aug; 104(2): 261–273. Published online 2008 May 8. doi: 10.1093/toxsci/kfn093

PMCID:: PMC2734298

Abstract Article PDF–2.0M

Select item 251985913.

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

Sarah N. Campion, Rachel Johnson, Lauren M. Aleksunes, Michael J. Goedken, Nico van Rooijen, George L. Scheffer, Nathan J. Cherrington, José E. Manautou

Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2): G294–G304. Published online 2008 Jun 12. doi: 10.1152/ajpgi.00541.2007

PMCID:: PMC2519859

Abstract Article

Select item 50699914.

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

Markos Leggas, Masashi Adachi, George L. Scheffer, Daxi Sun, Peter Wielinga, Guoqing Du, Kelly E. Mercer, Yanli Zhuang, John C. Panetta, Brad Johnston, Rik J. Scheper, Clinton F. Stewart, John D. Schuetz

Mol Cell Biol. 2004 Sep; 24(17): 7612–7621. doi: 10.1128/MCB.24.17.7612-7621.2004

PMCID:: PMC506999

Abstract Article PDF–869K

Select item 741669715.

An ABC transporter drives the Sonic Hedgehog pathway contributing to medulloblastoma pathogenesis

Juwina Wijaya, BaoHan T Vo, Jingjing Liu, Beisi Xu, Gang Wu, Yao Wang, Junmin Peng, Jin Zhang, Laura J Janke, Brent A Orr, Jiyang Yu, Martine F Roussel, John D Schuetz

Cancer Res. Author manuscript; available in PMC 2020 Aug 10.

Published in final edited form as: Cancer Res. 2020 Apr 1; 80(7): 1524–1537. Published online 2020 Jan 16. doi: 10.1158/0008-5472.CAN-19-2054

PMCID:: PMC7416697

Abstract Article PDF–3.4M

Select item 490572016.

ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression

CD Drenberg, S Hu, L Li, DR Buelow, SJ Orwick, AA Gibson, JD Schuetz, A Sparreboom, SD Baker

Clin Transl Sci. 2016 Feb; 9(1): 51–59. Published online 2016 Feb 4. doi: 10.1111/cts.12366

PMCID:: PMC4905720

Abstract Article PDF–598K

Select item 464300517.

The ABCC4 membrane transporter modulates platelet aggregation

Satish B. Cheepala, Aaron Pitre, Yu Fukuda, Kazumasa Takenaka, Yuanyuan Zhang, Yao Wang, Sharon Frase, Tamara Pestina, T. Kent Gartner, Carl Jackson, John D. Schuetz

Blood. 2015 Nov 12; 126(20): 2307–2319. Prepublished online 2015 Sep 24. doi: 10.1182/blood-2014-08-595942

PMCID:: PMC4643005

Abstract Article

Select item 375290118.

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

Brian D. Furmanski, Shuiying Hu, Ken-ichi Fujita, Lie Li, Alice A. Gibson, Laura J. Janke, Richard T. Williams, John D. Schuetz, Alex Sparreboom, Sharyn D. Baker

Clin Cancer Res. Author manuscript; available in PMC 2014 Aug 15.

Published in final edited form as: Clin Cancer Res. 2013 Aug 15; 19(16): 4359–4370. Published online 2013 Jun 21. doi: 10.1158/1078-0432.CCR-13-0980

PMCID:: PMC3752901

Abstract Article PDF–1.1M

Select item 310363619.

Tenofovir Renal Proximal Tubular Toxicity Is Regulated By OAT1 and MRP4 Transporters

James J. Kohler, Seyed H. Hosseini, Elgin Green, Allison Abuin, Tomika Ludaway, Rodney Russ, Robert Santoianni, William Lewis

Lab Invest. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Lab Invest. 2011 Jun; 91(6): 852–858. Published online 2011 Mar 14. doi: 10.1038/labinvest.2011.48

PMCID:: PMC3103636

Abstract Article PDF–814K

Select item 449002820.

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Aksana Vasilyeva, Selvi Durmus, Lie Li, Els Wagenaar, Shuiying Hu, Alice A. Gibson, John C. Panetta, Sridhar Mani, Alex Sparreboom, Sharyn D. Baker, Alfred H. Schinkel

Cancer Res. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Cancer Res. 2015 Jul 1; 75(13): 2729–2736. Published online 2015 May 7. doi: 10.1158/0008-5472.CAN-15-0280