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Select item 84226571.

Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer

Jinshan Xing, Jingyan Yi

J Ovarian Res. 2021; 14: 117. Published online 2021 Sep 7. doi: 10.1186/s13048-021-00868-z

PMCID:: PMC8422657

Abstract Article PDF–3.1M

Select item 75797152.

CERS6 required for cell migration and metastasis in lung cancer

Motoshi Suzuki, Ke Cao, Seiichi Kato, Naoki Mizutani, Kouji Tanaka, Chinatsu Arima, Mei Chee Tai, Norie Nakatani, Kiyoshi Yanagisawa, Toshiyuki Takeuchi, Hanxiao Shi, Yasuyoshi Mizutani, Atsuko Niimi, Tetsuo Taniguchi, Takayuki Fukui, Kohei Yokoi, Keiko Wakahara, Yoshinori Hasegawa, Yukiko Mizutani, Soichiro Iwaki, Satoshi Fujii, Akira Satou, Keiko Tamiya‐Koizumi, Takashi Murate, Mamoru Kyogashima, Shuta Tomida, Takashi Takahashi

J Cell Mol Med. 2020 Oct; 24(20): 11949–11959. Published online 2020 Sep 9. doi: 10.1111/jcmm.15817

PMCID:: PMC7579715

Abstract Article PDF–1.4M

Select item 63158133.

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution

Roger S. Holmes, Keri A. Barron, Natalia I. Krupenko

Biomolecules. 2018 Dec; 8(4): 111. Published online 2018 Oct 8. doi: 10.3390/biom8040111

PMCID:: PMC6315813

Abstract Article PDF–3.3M

Select item 61339724.

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia

Dattesh Verlekar, Sung-Jen Wei, Hwangeui Cho, Shengping Yang, Min H. Kang

Cell Death Dis. 2018 Sep; 9(9): 925. Published online 2018 Sep 11. doi: 10.1038/s41419-018-0964-4

PMCID:: PMC6133972

Abstract Article PDF–2.3M

Select item 47185955.

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

Baharan Fekry, Amin Esmaeilniakooshkghazi, Sergey A. Krupenko, Natalia I. Krupenko

PLoS One. 2016; 11(1): e0146618. Published online 2016 Jan 19. doi: 10.1371/journal.pone.0146618

PMCID:: PMC4718595

Abstract Article PDF–2.7M

Select item 45055706.

Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner

Tejas S. Tirodkar, Ping Lu, Aiping Bai, Matthew J. Scheffel, Salih Gencer, Elizabeth Garrett-Mayer, Alicja Bielawska, Besim Ogretmen, Christina Voelkel-Johnson

J Biol Chem. 2015 May 22; 290(21): 13157–13167. Published online 2015 Apr 3. doi: 10.1074/jbc.M114.631325

PMCID:: PMC4505570

Abstract Article PDF–1.8M

Select item 105611217.

Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation

Sookyoung Jeon, Eleonora Scorletti, Joseph Dempsey, Delfin Buyco, Chelsea Lin, Yedidya Saiman, Susovon Bayen, Julia Harkin, Jasmin Martin, Royce Hooks, Besim Ogretmen, Josepmaria Argemi, Luma Melo, Ramon Bataller, Rotonya M. Carr

Mol Metab. 2023 Dec; 78: 101804. Published online 2023 Sep 14. doi: 10.1016/j.molmet.2023.101804

PMCID:: PMC10561121

Abstract Article PDF–3.3M

Select item 82532948.

CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation

Hanxiao Shi, Atsuko Niimi, Toshiyuki Takeuchi, Kazuya Shiogama, Yasuyoshi Mizutani, Taisuke Kajino, Kenichi Inada, Tetsunari Hase, Takahiro Hatta, Hirofumi Shibata, Takayuki Fukui, Toyofumi Fengshi Chen‐Yoshikawa, Kazuki Nagano, Takashi Murate, Yoshiyuki Kawamoto, Shuta Tomida, Takashi Takahashi, Motoshi Suzuki

Cancer Sci. 2021 Jul; 112(7): 2770–2780. Published online 2021 May 4. doi: 10.1111/cas.14928

PMCID:: PMC8253294

Abstract Article PDF–1.6M

Select item 57317939.

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis

Bianca Williams, Jason Correnti, Amanke Oranu, Annie Lin, Victoria Scott, Maxine Annoh, James Beck, Emma Furth, Victoria Mitchell, Can E. Senkal, Lina Obeid, Rotonya M. Carr

FASEB J. 2018 Jan; 32(1): 130–142. Published online 2017 Sep 1. doi: 10.1096/fj.201601142R

PMCID:: PMC5731793

Abstract Article

Select item 497437410.

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Besim Ogretmen, Sergey A. Krupenko, Natalia I. Krupenko

J Biol Chem. 2016 Aug 5; 291(32): 16586–16596. Published online 2016 Jun 14. doi: 10.1074/jbc.M116.716902

PMCID:: PMC4974374

Abstract Article PDF–1.6M

Select item 438594011.

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6

S Schüll, S D Günther, S Brodesser, J M Seeger, B Tosetti, K Wiegmann, C Pongratz, F Diaz, A Witt, M Andree, K Brinkmann, M Krönke, R J Wiesner, H Kashkar

Cell Death Dis. 2015 Mar; 6(3): e1691. Published online 2015 Mar 12. doi: 10.1038/cddis.2015.62

PMCID:: PMC4385940

Abstract Article PDF–2.9M

Select item 364233112.

Folate Stress Induces Apoptosis via p53-dependent de Novo Ceramide Synthesis and Up-regulation of Ceramide Synthase 6

L. Alexis Hoeferlin, Baharan Fekry, Besim Ogretmen, Sergey A. Krupenko, Natalia I. Krupenko

J Biol Chem. 2013 May 3; 288(18): 12880–12890. Published online 2013 Mar 21. doi: 10.1074/jbc.M113.461798

PMCID:: PMC3642331

Abstract Article PDF–1.9M

Select item 880419613.

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L. Kim, Jason S. Pierce, Besim Ogretmen, Anthony H. Futerman, Frank Thévenod

J Biol Chem. 2022 Feb; 298(2): 101492. Published online 2021 Dec 13. doi: 10.1016/j.jbc.2021.101492

PMCID:: PMC8804196

Abstract Article PDF–13M

Select item 694315914.

Long noncoding RNA CERS6‐AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA

Gang Bao, Jianjun Huang, Wei Pan, Xing Li, Tian Zhou

Cancer Med. 2020 Jan; 9(1): 278–289. Published online 2019 Nov 8. doi: 10.1002/cam4.2675

PMCID:: PMC6943159

Abstract Article PDF–1.7M

Select item 469501115.

By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts

Seong-Hoon Yun, Eun-Seon Park, Sung-Won Shin, Mi-Ha Ju, Jin-Yeong Han, Jin-Sook Jeong, Sung-Hyun Kim, Valentin A. Stonik, Jong-Young Kwak, Joo-In Park

Oncotarget. 2015 Sep 29; 6(29): 27596–27612. Published online 2015 Jul 30. doi: 10.18632/oncotarget.4820

PMCID:: PMC4695011

Abstract Article PDF–8.4M

Select item 434800516.

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

Judith Mesicek, Hyunmi Lee, Taya Feldman, Xuejun Jiang, Anastasia Skobeleva, Evgeny V. Berdyshev, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick

Cell Signal. Author manuscript; available in PMC 2015 Mar 3.

Published in final edited form as: Cell Signal. 2010 Sep; 22(9): 1300–1307. Published online 2010 Apr 18. doi: 10.1016/j.cellsig.2010.04.006

PMCID:: PMC4348005

Abstract Article PDF–933K

Select item 279703217.

Antiapoptotic roles of ceramide-synthase-6-generated C₁₆-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

Can E. Senkal, Suriyan Ponnusamy, Jacek Bielawski, Yusuf A. Hannun, Besim Ogretmen

FASEB J. 2010 Jan; 24(1): 296–308. doi: 10.1096/fj.09-135087

PMCID:: PMC2797032

Abstract Article

Select item 323495918.

Alteration of Ceramide Synthase 6/C₁₆-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca²⁺ and ER/Golgi Membrane Network

Can E. Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers-Needham, Sahar A. Saddoughi, Archana Mukhopadyay, Paul Dent, Jacek Bielawski, Besim Ogretmen

J Biol Chem. 2011 Dec 9; 286(49): 42446–42458. Published online 2011 Oct 19. doi: 10.1074/jbc.M111.287383

PMCID:: PMC3234959

Abstract Article PDF–3.9M

Select item 289007119.

PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Adly Yacoub, Hossein A. Hamed, Jeremy Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Ogretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher, Paul Dent

Cancer Res. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Cancer Res. 2010 Feb 1; 70(3): 1120–1129. Published online 2010 Jan 26. doi: 10.1158/0008-5472.CAN-09-4043

PMCID:: PMC2890071

Abstract Article PDF–1.8M

Select item 227614220.

Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis

Chunyu Liu, Franak Batliwalla, Wentian Li, Annette Lee, Ronenn Roubenoff, Evan Beckman, Houman Khalili, Aarti Damle, Marlena Kern, Robert M. Plenge, Marieke Coenen, Timothy W. Behrens, Richard Furie, John P. Carulli, Peter K. Gregersen

Mol Med. 2008 Sep-Oct; 14(9-10): 575–581. Published online 2008 Jul 10. doi: 10.2119/2008-00056.Liu

PMCID:: PMC2276142

Abstract Article PDF–1.4M

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