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Select item 81909571.

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić, Pollyanna A. Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Y. Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh L. O’Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, N. Ray Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, Rosalyn Hithersay, Carla Startin, Sarah Hamburg, Margaret Phillips, Konstantin Pervushin, Mark Turmaine, David Wallon, Anne Rovelet-Lecrux, Hilkka Soininen, Emanuela Volpi, Joanne E. Martin, Jia Nee Foo, David L. Becker, Agueda Rostagno, Jorge Ghiso, Željka Krsnik, Goran Šimić, Ivica Kostović, Dinko Mitrečić, LonDownS Consortium, Paul T. Francis, Kaj Blennow, Andre Strydom, John Hardy, Henrik Zetterberg, Dean Nižetić

Mol Psychiatry. 2021; 26(10): 5766–5788. Published online 2020 Jul 10. doi: 10.1038/s41380-020-0806-5

Correction in:: Mol Psychiatry. 2021; 26(10): 5789.

PMCID:: PMC8190957

Abstract Article PDF–8.2M

Select item 81784452.

m⁶A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma

Fanglin He, Jie Yu, Jie Yang, Shaoyun Wang, Ai Zhuang, Hanhan Shi, Xiang Gu, Xiaofang Xu, Peiwei Chai, Renbing Jia

Mol Ther. 2021 Jun 2; 29(6): 2121–2133. Published online 2021 Feb 15. doi: 10.1016/j.ymthe.2021.02.014

PMCID:: PMC8178445

Abstract Article PDF–4.0M

Select item 70667613.

BACE2 degradation is mediated by both the proteasome and lysosome pathways

Kaixin Qiu, Wenping Liang, Shuai Wang, Tingting Kong, Xin Wang, Chunyan Li, Zhe Wang, Yili Wu

BMC Mol Cell Biol. 2020; 21: 13. Published online 2020 Mar 11. doi: 10.1186/s12860-020-00260-7

PMCID:: PMC7066761

Abstract Article PDF–918K

Select item 66106204.

Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers

Matt Huentelman, Matthew De Both, Wayne Jepsen, Ignazio S. Piras, Joshua S. Talboom, Mari Willeman, Eric M. Reiman, John Hardy, Amanda J. Myers

Sci Rep. 2019; 9: 9640. Published online 2019 Jul 3. doi: 10.1038/s41598-019-45896-4

PMCID:: PMC6610620

Abstract Article PDF–1.2M

Select item 34709435.

Identification of BACE2 as an avid ß-amyloid-degrading protease

Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring

Mol Neurodegener. 2012; 7: 46. Published online 2012 Sep 17. doi: 10.1186/1750-1326-7-46

PMCID:: PMC3470943

Abstract Article PDF–1.3M

Select item 77917846.

Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells

Zihang Chen, Huizhi Wang, Zongpu Zhang, Jianye Xu, Yanhua Qi, Hao Xue, Zijie Gao, Rongrong Zhao, Shaobo Wang, Shouji Zhang, Wei Qiu, Xing Guo, Gang Li

J Exp Clin Cancer Res. 2021; 40: 20. Published online 2021 Jan 7. doi: 10.1186/s13046-020-01807-4

PMCID:: PMC7791784

Abstract Article PDF–7.8M

Select item 72937317.

RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation

Kaixin Qiu, Shuai Wang, Xin Wang, Fengting Wang, Yili Wu

Biomed Res Int. 2020; 2020: 1920789. Published online 2020 Jun 5. doi: 10.1155/2020/1920789

PMCID:: PMC7293731

Abstract Article PDF–931K

Select item 69983908.

TGFβ1‐induced beta‐site APP‐cleaving enzyme 2 upregulation promotes tumorigenesis through the NF‐κB signalling pathway in human gliomas

Huizhi Wang, Zihang Chen, Shaobo Wang, Xiao Gao, Mingyu Qian, Wei Qiu, Zongpu Zhang, Shouji Zhang, Yanhua Qi, Xiaopeng Sun, Hao Xue, Xing Guo, Rongrong Zhao, Gang Li

Mol Oncol. 2020 Feb; 14(2): 407–425. Published online 2020 Jan 7. doi: 10.1002/1878-0261.12623

PMCID:: PMC6998390

Abstract Article PDF–13M

Select item 41648079.

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method

Hoda Mirsafian, Adiratna Mat Ripen, Amir Feisal Merican, Saharuddin Bin Mohamad

ScientificWorldJournal. 2014; 2014: 482463. Published online 2014 Aug 28. doi: 10.1155/2014/482463

PMCID:: PMC4164807

Abstract Article PDF–1.7M

Select item 281956410.

BACE1 and BACE2 Enzymatic Activities in Alzheimer’s Disease

Rachel R. Ahmed, Christopher J. Holler, Robin L. Webb, Feng Li, Tina L. Beckett, M. Paul Murphy

J Neurochem. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: J Neurochem. 2010 Feb; 112(4): 1045–1053. Published online 2009 Dec 4. doi: 10.1111/j.1471-4159.2009.06528.x

PMCID:: PMC2819564

Abstract Article PDF–910K

Select item 1059935311.

BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells

Tongrong He, Livius V. d’Uscio, Zvonimir S. Katusic

J Neurochem. Author manuscript; available in PMC 2023 Oct 25.

Published in final edited form as: J Neurochem. 2023 Sep; 166(6): 928–942. Published online 2023 Aug 7. doi: 10.1111/jnc.15929

PMCID:: PMC10599353

Abstract Article PDF–1.2M

Select item 1693012.

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

Michael Farzan, Christine E. Schnitzler, Natalya Vasilieva, Doris Leung, Hyeryun Choe

Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17): 9712–9717. Published online 2000 Aug 8. doi: 10.1073/pnas.160115697

PMCID:: PMC16930

Abstract Article PDF–164K

Select item 473969813.

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Ingrid C. Rulifson, Ping Cao, Li Miao, David Kopecky, Linda Huang, Ryan D. White, Kim Samayoa, Jonitha Gardner, Xiaosu Wu, Kui Chen, Trace Tsuruda, Oliver Homann, Helene Baribault, Harvey Yamane, Tim Carlson, Jed Wiltzius, Yang Li

PLoS One. 2016; 11(2): e0147254. Published online 2016 Feb 3. doi: 10.1371/journal.pone.0147254

PMCID:: PMC4739698

Abstract Article PDF–4.3M

Select item 2645514.

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

Xinli Lin, Gerald Koelsch, Shili Wu, Debbie Downs, Azar Dashti, Jordan Tang

Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4): 1456–1460. doi: 10.1073/pnas.97.4.1456

PMCID:: PMC26455

Abstract Article PDF–234K

Select item 384366415.

HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein

Jiyoung Kim, Jee-Hyun Yoon, Yeon-Soo Kim

PLoS One. 2013; 8(11): e77972. Published online 2013 Nov 29. doi: 10.1371/journal.pone.0077972

PMCID:: PMC3843664

Abstract Article PDF–1.2M

Select item 369681716.

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

Leila Rochin, Ilse Hurbain, Lutgarde Serneels, Cecile Fort, Brenda Watt, Pascal Leblanc, Michael S. Marks, Bart De Strooper, Graça Raposo, Guillaume van Niel

Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26): 10658–10663. Published online 2013 Jun 10. doi: 10.1073/pnas.1220748110

PMCID:: PMC3696817

Abstract Article PDF–1018K

Select item 483967517.

Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners

Antônio Francisco Alves da Silva, Filipe Brum Machado, Érika Cristina Pavarino, Joice Matos Biselli-Périco, Bruna Lancia Zampieri, Ronaldo da Silva Francisco Junior, Pedro Thyago Mozer Rodrigues, Douglas Terra Machado, Cíntia Barros Santos-Rebouças, Maria Gomes Fernandes, Susana Marina Chuva de Sousa Lopes, Álvaro Fabricio Lopes Rios, Enrique Medina-Acosta

PLoS One. 2016; 11(4): e0154108. Published online 2016 Apr 21. doi: 10.1371/journal.pone.0154108

PMCID:: PMC4839675

Abstract Article PDF–3.5M

Select item 374932618.

Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies

M. Geoffrey Hayes, Margrit Urbanek, Marie-France Hivert, Loren L. Armstrong, Jean Morrison, Cong Guo, Lynn P. Lowe, Douglas A. Scheftner, Anna Pluzhnikov, David M. Levine, Caitlin P. McHugh, Christine M. Ackerman, Luigi Bouchard, Diane Brisson, Brian T. Layden, Daniel Mirel, Kimberly F. Doheny, Marysa V. Leya, Rachel N. Lown-Hecht, Alan R. Dyer, Boyd E. Metzger, Timothy E. Reddy, Nancy J. Cox, William L. Lowe, Jr., for the HAPO Study Cooperative Research Group

Diabetes. 2013 Sep; 62(9): 3282–3291. Published online 2013 Aug 15. doi: 10.2337/db12-1692

Correction in:: Diabetes. 2013 Oct; 62(10): 3641.

PMCID:: PMC3749326

Abstract Article PDF–1.0M

Select item 295285719.

Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters

Hans-Jörg Warnatz, Robert Querfurth, Anna Guerasimova, Xi Cheng, Stefan A. Haas, Andrew L. Hufton, Thomas Manke, Dominique Vanhecke, Wilfried Nietfeld, Martin Vingron, Michal Janitz, Hans Lehrach, Marie-Laure Yaspo

Nucleic Acids Res. 2010 Oct; 38(18): 6112–6123. Published online 2010 May 21. doi: 10.1093/nar/gkq402

PMCID:: PMC2952857

Abstract Article PDF–4.0M

Select item 418331320.

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Cornelius A. Rietveld, Tõnu Esko, Gail Davies, Tune H. Pers, Patrick Turley, Beben Benyamin, Christopher F. Chabris, Valur Emilsson, Andrew D. Johnson, James J. Lee, Christiaan de Leeuw, Riccardo E. Marioni, Sarah E. Medland, Michael B. Miller, Olga Rostapshova, Sven J. van der Lee, Anna A. E. Vinkhuyzen, Najaf Amin, Dalton Conley, Jaime Derringer, Cornelia M. van Duijn, Rudolf Fehrmann, Lude Franke, Edward L. Glaeser, Narelle K. Hansell, Caroline Hayward, William G. Iacono, Carla Ibrahim-Verbaas, Vincent Jaddoe, Juha Karjalainen, David Laibson, Paul Lichtenstein, David C. Liewald, Patrik K. E. Magnusson, Nicholas G. Martin, Matt McGue, George McMahon, Nancy L. Pedersen, Steven Pinker, David J. Porteous, Danielle Posthuma, Fernando Rivadeneira, Blair H. Smith, John M. Starr, Henning Tiemeier, Nicholas J. Timpson, Maciej Trzaskowski, André G. Uitterlinden, Frank C. Verhulst, Mary E. Ward, Margaret J. Wright, George Davey Smith, Ian J. Deary, Magnus Johannesson, Robert Plomin, Peter M. Visscher, Daniel J. Benjamin, David Cesarini, Philipp D. Koellinger

Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38): 13790–13794. Published online 2014 Sep 8. doi: 10.1073/pnas.1404623111

Correction in:: Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4): E380.

PMCID:: PMC4183313

Abstract Article PDF–650K

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